Hsp100 data display in Table. Kd, Ki, IC50, EC50, GI50 values are in μM.

HSPMdb Accession Number PMID Target HSP Name of HSP Organism Localization Enzymatic Activity Cellular Activity Compound Name IUPAC Name SMILES Class Enzymatic Inhibition Kd Value Ki Value IC50 EC50 GI50 Site of Interaction Type of Enzymatic Assay % Cell Growth Inhibition Cellular Assay Cell Lines Disease
HSPMDB00148425299406Hsp100Hsp104YeastCytosolInhibition of ATPase activityNAHexachlorophene3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxyphenyl)methyl]phenolOc1c(Cl)cc(Cl)c(Cl)c1Cc2c(O)c(Cl)cc(Cl)c2ClNIH, Spectrum, and Hit finder collection80.21% at 10 uMNANANANANANANANucleotide binding domainATPase assayNANA
HSPMDB00148525299406Hsp100Hsp104YeastCytosolInhibition of ATPase activityNATannic acid[2,3-dihydroxy-5-[[(2R,3R,4S,5R,6S)-3,4,5,6-tetrakis[[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyl)oxybenzoyl]oxy]oxan-2-yl]methoxycarbonyl]phenyl] 3,4,5 trihydroxybenzoateOc1cc(cc(O)c1O)C(=O)Oc2cc(cc(O)c2O)C(=O)OC[C@H]3O[C@@H](OC(=O)c4cc(O)c(O)c(OC(=O)c5cc(O)c(O)c(O)c5)c4)[C@H](OC(=O)c6cc(O)c(O)c(OC(=O)c7cc(O)c(O)c(O)c7)c6)[C@@H](OC(=O)c8cc(O)c(O)c(OC(=O)c9cc(O)c(O)c(O)c9)c8)[C@@H]3OC(=O)c%10cc(O)c(O)c(OC(=O)c%11cc(O)c(O)c(O)c%11)c%10NIH, Spectrum, and Hit finder collection79.79% at 10 uMNANANANANANANANucleotide binding domainATPase assayNANA
HSPMDB00148625299406Hsp100Hsp104YeastCytosolInhibition of ATPase activityNACisplatindichloroplatinumN.N.Cl[Pt]ClNIH, Spectrum, and Hit finder collection76.58% at 10 uMNANANANANANANANucleotide binding domainATPase assayNANA
HSPMDB00148725299406Hsp100Hsp104YeastCytosolInhibition of ATPase activityNAcarboplatincyclobutane-1,1-dicarboxylate platinumC1CC(C1)(C(=O)O)C(=O)O.N.N.[Pt]NIH, Spectrum, and Hit finder collection73.75% at 10 uMNANANANANANANANucleotide binding domainATPase assayNANA
HSPMDB00148825299406Hsp100Hsp104YeastCytosolInhibition of ATPase activityNATheaflavin monogallates[(2R,3R)-5,7-dihydroxy-2-[3,4,5-trihydroxy-6-oxo-1-[(2R,3R)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-2-yl]benzo[7]annulen-8-yl]-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoateO[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1C3=CC(=C(O)C4=C(O)C(=O)C=C(C=C34)[C@H]5Oc6cc(O)cc(O)c6C[C@H]5OC(=O)c7cc(O)c(O)c(O)c7)ONIH, Spectrum, and Hit finder collection57.25% at 10 uMNANANANANANANANucleotide binding domainATPase assayNANA
HSPMDB00148925299406Hsp100Hsp104YeastCytosolInhibition of ATPase activityNASuramin8-[[4-methyl-3-[[3-[[3-[[2-methyl-5-[(4,6,8-trisulfonatonaphthalen-1-yl)carbamoyl]phenyl]carbamoyl]phenyl]carbamoylamino]benzoyl]amino]benzoyl]amino]naphthalene-1,3,5-trisulfonateCC1=C(C=C(C(=O)NC2=CC=C(C=3C=C(C=C(C23)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])C=C1)NC(C1=CC(=CC=C1)NC(NC1=CC(=CC=C1)C(NC1=C(C=CC(=C1)C(NC1=CC=C(C2=CC(=CC(=C12)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])=O)C)=O)=O)=ONIH, Spectrum, and Hit finder collection50.83% at 10 uMNANANANANANANANucleotide binding domainATPase assayNANA
HSPMDB00149025299406Hsp100Hsp104YeastCytosolInhibition of ATPase activityNAGossypol-acetic acid complex7-(8-formyl-1,6,7-trihydroxy-3-methyl-5-propan-2-ylnaphthalen-2-yl)-2,3,8-trihydroxy-6-methyl-4-propan-2-ylnaphthalene-1-carbaldehydeC(=O)C=1C(=C(C(=C2C=C(C(=C(C12)O)C1=C(C=C2C(=C(C(=C(C2=C1O)C=O)O)O)C(C)C)C)C)C(C)C)O)ONIH, Spectrum, and Hit finder collection47.92%at 10 uMNANANANANANANANucleotide binding domainATPase assayNANA
HSPMDB00149125299406Hsp100Hsp104YeastCytosolInhibition of ATPase activityNAHematein4,6a,9,10-tetrahydroxy-6,7-dihydroindeno[2,1-c]chromen-3-oneOc1cc2CC3(O)COC4=C(O)C(=O)C=CC4=C3c2cc1ONIH, Spectrum, and Hit finder collection45.71% at 10 uMNANANANANANANANucleotide binding domainATPase assayNANA
HSPMDB00149225299406Hsp100Hsp104YeastCytosolInhibition of ATPase activityNAGossypol7-(8-formyl-1,6,7-trihydroxy-3-methyl-5-propan-2-ylnaphthalen-2-yl)-2,3,8-trihydroxy-6-methyl-4-propan-2-ylnaphthalene-1-carbaldehydeCC(C)c1c(O)c(O)c(C=O)c2c(O)c(c(C)cc12)c3c(C)cc4c(C(C)C)c(O)c(O)c(C=O)c4c3ONIH, Spectrum, and Hit finder collection42.33% at 10 uMNANANANANANANANucleotide binding domainATPase assayNANA
HSPMDB00149325299406Hsp100Hsp104YeastCytosolInhibition of ATPase activityNAchlorophyllide Cu complex Na salt3-[20-(carboxylatomethyl)-18-(dioxidomethylidene)-8-ethenyl-13-ethyl-3,7,12,17-tetramethyl-2,3-dihydroporphyrin-2,3-id-2-yl]propanoateCCC1=C2C=C3C(=C4C(=O)C(C(=C4[N-]3)C5=C(C(=C([N-]5)C=C6C(=C(C(=CC(=C1C)[N-]2)[N-]6)C=C)C)C)CCC(=O)[O-])C(=O)[O-])C.[Na+].[Na+].[Cu]NIH, Spectrum, and Hit finder collection33.79% at 10 uMNANANANANANANANucleotide binding domainATPase assayNANA
HSPMDB00149425299406Hsp100Hsp104YeastCytosolInhibition of ATPase activityNAMethacycline hydrochloride4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methylidene-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide hydrochlorideCl.CN(C1C(C(=C(C2(C(C3=C(C4=C(C=CC=C4C(C3C(C12)O)=C)O)O)=O)O)O)C(=O)N)=O)CNIH, Spectrum, and Hit finder collection33.33% at 10 uMNANANANANANANANucleotide binding domainATPase assayNANA
HSPMDB00149525299406Hsp100Hsp104YeastCytosolInhibition of ATPase activityNASucralfate sodium[(2R,3R,4S,5R,6R)-2-[(2S,3S,4R,5R)-3,4-bis(?1-alumanyloxysulfonyloxy)-2,5-bis(?1-alumanyloxysulfonyloxymethyl)oxolan-2-yl]oxy-3,5-bis(?1-alumanyloxysulfonyloxy)-6-(?1-alumanyloxysulfonyloxymethyl)oxan-4-yl]oxysulfonyloxyaluminum;hexadecahydrateO.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.[Al]OS(=O)(=O)O[C@@H]1[C@](O[C@@H]([C@H]1OS(=O)(=O)O[Al])COS(=O)(=O)O[Al])(COS(=O)(=O)O[Al])O[C@H]1O[C@@H]([C@H]([C@@H]([C@H]1OS(=O)(=O)O[Al])OS(=O)(=O)O[Al])OS(=O)(=O)O[Al])COS(=O)(=O)O[Al]NIH, Spectrum, and Hit finder collection25.67% at 10 uMNANANANANANANANucleotide binding domainATPase assayNANA
HSPMDB00149625299406Hsp100Hsp104YeastCytosolInhibition of ATPase activityNAAurin tricarboxylic acid5-[(3-carboxy-4-hydroxyphenyl)-(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-2-hydroxybenzoic acidOC(=O)c1cc(ccc1O)C(c2ccc(O)c(c2)C(O)=O)=C3C=CC(=O)C(=C3)C(O)=ONIH, Spectrum, and Hit finder collection24.25% at 10 uMNANANANANANANANucleotide binding domainATPase assayNANA
HSPMDB00149725299406Hsp100Hsp104YeastCytosolInhibition of ATPase activityNAEpigallocatechin 3,5-digallate(2R,3R)-7-hydroxy-5-(3,4,5-trihydroxybenzoyl)oxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoateOC=1C=C(C(=O)O[C@H]2[C@H](OC3=CC(=CC(=C3C2)OC(C2=CC(=C(C(=C2)O)O)O)=O)O)C2=CC(=C(C(=C2)O)O)O)C=C(C1O)ONIH, Spectrum, and Hit finder collection21.88% at 10 uMNANANANANANANANucleotide binding domainATPase assayNANA
HSPMDB00149825299406Hsp100Hsp104YeastCytosolInhibition of ATPase activityNAMerbromin(2',7'-dibromo-3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-4'-yl)mercury(1+)Oc1cc2Oc3c([Hg+])c(O)c(Br)cc3C4(OC(=O)c5ccccc45)c2cc1BrNIH, Spectrum, and Hit finder collection21.17% at 10 uMNANANANANANANANucleotide binding domainATPase assayNANA
HSPMDB00149925299406Hsp100Hsp104YeastCytosolInhibition of ATPase activityNASennoside a(9R)-9-[(9R)-2-carboxy-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracen-9-yl]-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracene-2-carboxylic acidOC[C@H]1O[C@@H](Oc2cccc3[C@@H]([C@@H]4c5cccc(O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)c5C(=O)c7c(O)cc(cc47)C(O)=O)c8cc(cc(O)c8C(=O)c23)C(O)=O)[C@H](O)[C@@H](O)[C@@H]1ONIH, Spectrum, and Hit finder collection19.92% at 10 uMNANANANANANANANucleotide binding domainATPase assayNANA
HSPMDB00150025299406Hsp100Hsp104YeastCytosolInhibition of chaperone activityNASuramin8-[[4-methyl-3-[[3-[[3-[[2-methyl-5-[(4,6,8-trisulfonatonaphthalen-1-yl)carbamoyl]phenyl]carbamoyl]phenyl]carbamoylamino]benzoyl]amino]benzoyl]amino]naphthalene-1,3,5-trisulfonateCC1=C(C=C(C(=O)NC2=CC=C(C=3C=C(C=C(C23)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])C=C1)NC(C1=CC(=CC=C1)NC(NC1=CC(=CC=C1)C(NC1=C(C=CC(=C1)C(NC1=CC=C(C2=CC(=CC(=C12)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])=O)C)=O)=O)=ONIH, Spectrum, and Hit finder collectionNANANA10.1NANANANANucleotide binding domainLuciferase aggregate reactivation assayNANA
HSPMDB00150125212124Hsp100ClpPBacteriaCytosolNAAntibacterial activity1(S)-2-(((benzyloxy)carbonyl)amino)-3-methoxy-3-oxopropyl acetyl-L-prolinateCOC(=O)[C@H](COC(=O)[C@@H]1CCCN1C(C)=O)NC(=O)OCc2ccccc2Fragments of a cyclic acyldepsipeptideNANANANANANANANANANANANA
HSPMDB00150225212124Hsp100ClpPBacteriaCytosolNAAntibacterial activity2(2S,3S)-3-(((benzyloxy)carbonyl)amino)-4-methoxy-4-oxobutan-2-yl acetyl-L-prolinateCOC(=O)[C@@H](NC(=O)OCc1ccccc1)[C@H](C)OC(=O)[C@@H]2CCCN2C(C)=OFragments of a cyclic acyldepsipeptideNANANANANANANANANANANANA
HSPMDB00150325212124Hsp100ClpPBacteriaCytosolNAAntibacterial activity3(2R,3S)-3-(((benzyloxy)carbonyl)amino)-4-methoxy-4-oxobutan-2-yl acetyl-L-prolinateCOC(=O)[C@@H](NC(=O)OCc1ccccc1)[C@@H](C)OC(=O)[C@@H]2CCCN2C(C)=OFragments of a cyclic acyldepsipeptideNANANANANANANANANANANANA
HSPMDB00150425212124Hsp100ClpPBacteriaCytosolNAAntibacterial activity4(S)-2-((S)-3-(3,5-difluorophenyl)-2-((E)-hex-2-enamido)propanamido)-3-methoxy-3-oxopropyl acetyl-L-prolinateCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)N[C@@H](COC(=O)[C@@H]2CCCN2C(C)=O)C(=O)OCFragments of a cyclic acyldepsipeptideNANANANANANANANANANANANA
HSPMDB00150525212124Hsp100ClpPBacteriaCytosolNAAntibacterial activity5Methyl (S,E)-3-(3,5-difluorophenyl)-2-(hept-2-enamido)propanoateCCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)OCFragments of a cyclic acyldepsipeptideNANANANANANANANANANANANA
HSPMDB00150625212124Hsp100ClpPBacteriaCytosolNAAntibacterial activity4(S)-2-((S)-3-(3,5-difluorophenyl)-2-((E)-hex-2-enamido)propanamido)-3-methoxy-3-oxopropyl acetyl-L-prolinateCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)N[C@@H](COC(=O)[C@@H]2CCCN2C(C)=O)C(=O)OCN-acyldifluorophenylalanine fragment analogueNANANANANANANANANANANANA
HSPMDB00150725212124Hsp100ClpPBacteriaCytosolNAAntibacterial activity5Methyl (S,E)-3-(3,5-difluorophenyl)-2-(hept-2-enamido)propanoateCCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)OCN-acyldifluorophenylalanine fragment analogueNANANANANANANANANANANANA
HSPMDB00150825212124Hsp100ClpPBacteriaCytosolNAAntibacterial activity6(2S,3S)-3-((S)-3-(3,5-difluorophenyl)-2-((E)-hex-2-enamido)propanamido)-4-methoxy-4-oxobutan-2-yl acetyl-L-prolinateCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)N[C@@H]([C@H](C)OC(=O)[C@@H]2CCCN2C(C)=O)C(=O)OCN-acyldifluorophenylalanine fragment analogueNANANANANANANANANANANANA
HSPMDB00150925212124Hsp100ClpPBacteriaCytosolNAAntibacterial activity7(2R,3S)-3-((S)-3-(3,5-difluorophenyl)-2-((E)-hex-2-enamido)propanamido)-4-methoxy-4-oxobutan-2-yl acetyl?L-prolinateCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)N[C@@H]([C@@H](C)OC(=O)[C@@H]2CCCN2C(C)=O)C(=O)OCN-acyldifluorophenylalanine fragment analogueNANANANANANANANANANANANA
HSPMDB00151025212124Hsp100ClpPBacteriaCytosolNAAntibacterial activity8Methyl (S,E)-2-(3-cyclohexylacrylamido)-3-(3,5-difluorophenyl)propanoateCOC(=O)[C@H](Cc1cc(F)cc(F)c1)NC(=O)/C=C/C2CCCCC2N-acyldifluorophenylalanine fragment analogueNANANANANANANANANANANANA
HSPMDB00151125212124Hsp100ClpPBacteriaCytosolNAAntibacterial activity9Methyl (S)-3-(3,5-difluorophenyl)-2-((2E,4E,6E)-octa-2,4,6-trienamido)propanoateCOC(=O)[C@H](Cc1cc(F)cc(F)c1)NC(=O)\C=C\C=C\C=C\CN-acyldifluorophenylalanine fragment analogueNANANANANANANANANANANANA
HSPMDB00151225212124Hsp100ClpPBacteriaCytosolNAAntibacterial activity10Methyl (2S)-3-(3,5-difluorophenyl)-2-((E)-5-methylhept-2-enamido)propanoateCCC(C)C/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)OCN-acyldifluorophenylalanine fragment analogueNANANANANANANANANANANANA
HSPMDB00151325212124Hsp100ClpPBacteriaCytosolNAAntibacterial activity11Methyl (S,E)-3-(3,5-difluorophenyl)-2-(hept-2?enamido)propanoateCCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)OCN-acyldifluorophenylalanine fragment analogueNANANANANANANANANANANANA
HSPMDB00151425212124Hsp100ClpPBacteriaCytosolNAAntibacterial activity12Methyl (S)-2-(3-cyclohexylpropanamido)-3-(3,5-difluorophenyl)propanoateCOC(=O)[C@H](Cc1cc(F)cc(F)c1)NC(=O)CCC2CCCCC2N-acyldifluorophenylalanine fragment analogueNANANANANANANANANANANANA
HSPMDB00151525212124Hsp100ClpPBacteriaCytosolNAAntibacterial activity13Methyl (E)-hept-2-enoyl-L-phenylalaninateCCCC/C=C/C(=O)N[C@@H](Cc1ccccc1)C(=O)OCN-acyldifluorophenylalanine fragment analogueNANANANANANANANANANANANA
HSPMDB00151625212124Hsp100ClpPBacteriaCytosolNAAntibacterial activity14Methyl (E)-hept-2-enoyl-L-leucinateCCCC/C=C/C(=O)N[C@@H](CC(C)C)C(=O)OCN-acyldifluorophenylalanine fragment analogueNANANANANANANANANANANANA
HSPMDB00151725212124Hsp100ClpPBacteriaCytosolNAAntibacterial activity153-(3,5-difluorophenyl)-2-[(2E)-hex-2-enamido]propanoic acidCCC/C=C/C(=O)NC(Cc1cc(F)cc(F)c1)C(O)=ON-acyldifluorophenylalanine fragment analogueNANANANANANANANANANANANA
HSPMDB00151825212124Hsp100ClpPBacteriaCytosolNAAntibacterial activity16(S,E)-N-(1-amino-3-(3,5-difluorophenyl)-1-oxopropan-2-yl)hept-2-enamideCCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(N)=ON-acyldifluorophenylalanine fragment analogueNANANANANANANANANANANANA
HSPMDB00151925212124Hsp100ClpPBacteriaCytosolNAAntibacterial activity17(S,E)-N-(3-(3,5-difluorophenyl)-1-(methylamino)-1-oxopropan-2-yl)hept-2-enamideCCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)NCN-acyldifluorophenylalanine fragment analogueNANANANANANANANANANANANA
HSPMDB00152025212124Hsp100ClpPBacteriaCytosolNAAntibacterial activity18(S,E)-N-(3-(3,5-difluorophenyl)-1-(dimethylamino)-1-oxopropan-2-yl)hept-2-enamideCCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)N(C)CN-acyldifluorophenylalanine fragment analogueNANANANANANANANANANANANA
HSPMDB00152125212124Hsp100ClpPBacteriaCytosolNAAntibacterial activity19(furan-2-yl)methyl (2S)-3-(3,5-difluorophenyl)-2-[(2E)-hex-2-enamido]propanoateCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)OCc2occc2N-acyldifluorophenylalanine fragment analogueNANANANANANANANANANANANA
HSPMDB00152225212124Hsp100ClpPBacteriaCytosolNAAntibacterial activity20Benzyl (S,E)-3-(3,5-difluorophenyl)-2-(hept-2?enamido)propanoateCCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)OCc2ccccc2N-acyldifluorophenylalanine fragment analogueNANANANANANANANANANANANA
HSPMDB00152325212124Hsp100ClpPBacteriaCytosolNAAntibacterial activity21Prop-2-yn-1-yl (S,E)-3-(3,5-difluorophenyl)-2-(hept-2-enamido)propanoateCCCC/C=C/C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)OCC#CN-acyldifluorophenylalanine fragment analogueNANANANANANANANANANANANA
HSPMDB00152423961953Hsp100ClpBBacteriaCytosolInhibition of chaperone activityNA1(3Z)-3-[3-(4-Chlorophenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5- ylidene]-5-nitro-1,3-dihydro-2H-indol-2-one[O-][N+](=O)c1ccc2NC(=O)\C(=C3/SC(=S)N(C3=O)c4ccc(Cl)cc4)c2c1MyriaScreen diversity collectionNANANA10NANANANANucleotide binding domainLuciferase aggregate reactivation assayNANA
HSPMDB00152523961953Hsp100ClpBBacteriaCytosolInhibition of chaperone activityNA2(5Z)-5-(5-Bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-3-phenyl1,3-thiazolidine-2,4-dioneBrc1ccc2NC(=O)C(=C/3SC(=O)N(C3=O)c4ccccc4)/c2c1MyriaScreen diversity collectionNANANA30NANANANANucleotide binding domainLuciferase aggregate reactivation assayNANA
HSPMDB00152623961953Hsp100ClpBBacteriaCytosolInhibition of chaperone activityNA35-(2-Chlorobenzyl)-2-hydroxy-3-nitrobenzaldehydeOc1c(C=O)cc(Cc2ccccc2Cl)cc1[N+]([O-])=OMyriaScreen diversity collectionNANANA7NANANANANucleotide binding domainLuciferase aggregate reactivation assayNANA
HSPMDB00152723961953Hsp100ClpBBacteriaCytosolInhibition of chaperone activityNA43,4-Dichloro-N-(3-nitrophenyl)-1-benzothiophene-2-carboxamide[O-][N+](=O)c1cccc(NC(=O)c2sc3cccc(Cl)c3c2Cl)c1MyriaScreen diversity collectionNANANA90NANANANANucleotide binding domainLuciferase aggregate reactivation assayNANA
HSPMDB00152823961953Hsp100ClpBBacteriaCytosolInhibition of chaperone activityNA5(4Z)-1-(4-Chlorophenyl)-4-{4-[(4-fluorobenzyl)oxy]-3- methoxybenzylidene}-3,5-pyrazolidinedioneCOc1cc(ccc1OCc2ccc(F)cc2)/C=C3/C(=O)NN(C3=O)c4ccc(Cl)cc4MyriaScreen diversity collectionNANANA7.5NANANANANucleotide binding domainLuciferase aggregate reactivation assayNANA
HSPMDB00152923961953Hsp100ClpBBacteriaCytosolInhibition of chaperone activityNA62-{[(3,4-Dichlorophenyl)carbamothioyl]sulfanyl}ethyl phenylcarbamateClc1ccc(NC(=S)SCCOC(=O)Nc2ccccc2)cc1ClMyriaScreen diversity collectionNANANA20NANANANANucleotide binding domainLuciferase aggregate reactivation assayNANA
HSPMDB00153023961953Hsp100ClpBBacteriaCytosolInhibition of chaperone activityNA7(3Z)-3-(3-Allyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3- dihydro-2H-indol-2-oneC=CCN1C(=S)S\C(C1=O)=C2/C(=O)Nc3ccccc23MyriaScreen diversity collectionNANANA>100NANANANANucleotide binding domainLuciferase aggregate reactivation assayNANA
HSPMDB00153123961953Hsp100ClpBBacteriaCytosolInhibition of chaperone activityNA82-(4-Chloro-5-methyl-3-nitro-1H-pyrazol-1-yl)-N-[3-(2,4- dichlorophenoxy)-5-nitrophenyl]acetamideCc1n(CC(=O)Nc2cc(Oc3ccc(Cl)cc3Cl)cc(c2)[N+]([O-])=O)nc(c1Cl)[N+]([O-])=OMyriaScreen diversity collectionNANANA>100NANANANANucleotide binding domainLuciferase aggregate reactivation assayNANA
HSPMDB00153223961953Hsp100ClpBBacteriaCytosolInhibition of chaperone activityNA92-[(5Z)-5-(5-Bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-4-oxo-2- thioxo-1,3-thiazolidin-3-yl]-3-methylbutanoic acidCC(C)C(N1C(=S)SC(/C1=O)=C/2C(=O)Nc3ccc(Br)cc23)C(O)=OMyriaScreen diversity collectionNANANA>100NANANANANucleotide binding domainLuciferase aggregate reactivation assayNANA
HSPMDB00153323961953Hsp100ClpBBacteriaCytosolInhibition of chaperone activityNA101-Ethyl-4-hydroxy-N-(3-hydroxyphenyl)-2-oxo-1,2-dihydro-3- quinolinecarboxamideCCN1C(=O)C(=C(O)c2ccccc12)C(=O)Nc3cccc(O)c3MyriaScreen diversity collectionNANANA65NANANANANucleotide binding domainLuciferase aggregate reactivation assayNANA
HSPMDB00153423961953Hsp100ClpBBacteriaCytosolInhibition of chaperone activityNA11(1E,3E,5E)-N,N'-Diphenyl-1,3,5-hexatriene-1,6-diamine hydrochloride (1:1)Cl.N(\C=C\C=C\C=C\Nc1ccccc1)c2ccccc2MyriaScreen diversity collectionNANANA>100NANANANANucleotide binding domainLuciferase aggregate reactivation assayNANA
HSPMDB00153523961953Hsp100ClpBBacteriaCytosolInhibition of chaperone activityNA12(3Z)-5-Bromo-3-[3-(3-methoxypropyl)-4-oxo-2-thioxo-1,3- thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-oneCOCCCN1C(=S)SC(/C1=O)=C/2C(=O)Nc3ccc(Br)cc23MyriaScreen diversity collectionNANANA>100NANANANANucleotide binding domainLuciferase aggregate reactivation assayNANA
HSPMDB00153623961953Hsp100ClpBBacteriaCytosolNAAntibacterial activity35-(2-Chlorobenzyl)-2-hydroxy-3-nitrobenzaldehydeOc1c(C=O)cc(Cc2ccccc2Cl)cc1[N+]([O-])=OMyriaScreen diversity collectionNANANANANANANANANANANABacterial growth inhibition assay (OD based)
HSPMDB00153723961953Hsp100ClpBBacteriaCytosolNAAntibacterial activity62-{[(3,4-Dichlorophenyl)carbamothioyl]sulfanyl}ethyl phenylcarbamateClc1ccc(NC(=S)SCCOC(=O)Nc2ccccc2)cc1ClMyriaScreen diversity collectionNANANANANANANANANANANABacterial growth inhibition assay (OD based)
HSPMDB00153823961953Hsp100NAHumanNANAAntiproliferative activity35-(2-Chlorobenzyl)-2-hydroxy-3-nitrobenzaldehydeOc1c(C=O)cc(Cc2ccccc2Cl)cc1[N+]([O-])=OMyriaScreen diversity collectionNANANANANANANANANANA30-50%MTT viability assay
HSPMDB00153923961953Hsp100NAHumanNANAAntiproliferative activity62-{[(3,4-Dichlorophenyl)carbamothioyl]sulfanyl}ethyl phenylcarbamateClc1ccc(NC(=S)SCCOC(=O)Nc2ccccc2)cc1ClMyriaScreen diversity collectionNANANANANANANANANANA30-50%MTT viability assay
HSPMDB00154023961953Hsp100NAHumanNANAAntiproliferative activity35-(2-Chlorobenzyl)-2-hydroxy-3-nitrobenzaldehydeOc1c(C=O)cc(Cc2ccccc2Cl)cc1[N+]([O-])=OMyriaScreen diversity collectionNANANANANANANANANANA30-50%MTT viability assay
HSPMDB00154123961953Hsp100NAHumanNANAAntiproliferative activity62-{[(3,4-Dichlorophenyl)carbamothioyl]sulfanyl}ethyl phenylcarbamateClc1ccc(NC(=S)SCCOC(=O)Nc2ccccc2)cc1ClMyriaScreen diversity collectionNANANANANANANANANANA30-50%MTT viability assay
HSPMDB00154223961953Hsp100ClpBBacteriaCytosolBinding affinityNA35-(2-Chlorobenzyl)-2-hydroxy-3-nitrobenzaldehydeOc1c(C=O)cc(Cc2ccccc2Cl)cc1[N+]([O-])=OMyriaScreen diversity collectionNA12.9NANANANANANANASurface plasmon resonance (SPR)NANA
HSPMDB00154323961953Hsp100ClpBBacteriaCytosolBinding affinityNA62-{[(3,4-Dichlorophenyl)carbamothioyl]sulfanyl}ethyl phenylcarbamateClc1ccc(NC(=S)SCCOC(=O)Nc2ccccc2)cc1ClMyriaScreen diversity collectionNA19NANANANANANANASurface plasmon resonance (SPR)NANA
HSPMDB00154421944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityADEPA1(2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide[H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\CLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00154521944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityADEPA1(2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide[H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\CLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00154621944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityADEPA1(2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide[H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\CLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00154721944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityADEPA1(2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide[H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\CLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00154821944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityADEPA1(2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide[H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\CLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00154921944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityADEPA1(2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide[H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\CLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00155021944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityADEPA1(2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide[H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\CLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00155121944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityADEPA1(2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide[H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\CLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00155221944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityADEPA1(2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide[H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\CLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00155321944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityADEPA1(2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide[H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\CLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00155421944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP1N-1-[2-(phenylthio)ethyl]-2-methyl-2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}propanamideCC(C)(C(=O)NCCSC1=CC=CC=C1Cl)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)FLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00155521944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP1N-1-[2-(phenylthio)ethyl]-2-methyl-2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}propanamideCC(C)(C(=O)NCCSC1=CC=CC=C1Cl)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)FLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00155621944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP1N-1-[2-(phenylthio)ethyl]-2-methyl-2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}propanamideCC(C)(C(=O)NCCSC1=CC=CC=C1Cl)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)FLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00155721944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP1N-1-[2-(phenylthio)ethyl]-2-methyl-2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}propanamideCC(C)(C(=O)NCCSC1=CC=CC=C1Cl)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)FLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00155821944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP1N-1-[2-(phenylthio)ethyl]-2-methyl-2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}propanamideCC(C)(C(=O)NCCSC1=CC=CC=C1Cl)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)FLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00155921944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP1N-1-[2-(phenylthio)ethyl]-2-methyl-2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}propanamideCC(C)(C(=O)NCCSC1=CC=CC=C1Cl)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)FLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00156021944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP1N-1-[2-(phenylthio)ethyl]-2-methyl-2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}propanamideCC(C)(C(=O)NCCSC1=CC=CC=C1Cl)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)FLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00156121944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP1N-1-[2-(phenylthio)ethyl]-2-methyl-2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}propanamideCC(C)(C(=O)NCCSC1=CC=CC=C1Cl)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)FLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00156221944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP1N-1-[2-(phenylthio)ethyl]-2-methyl-2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}propanamideCC(C)(C(=O)NCCSC1=CC=CC=C1Cl)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)FLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00156321944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP1N-1-[2-(phenylthio)ethyl]-2-methyl-2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}propanamideCC(C)(C(=O)NCCSC1=CC=CC=C1Cl)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)FLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00156421944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP23-(tertbutoxy)-2-{[2-[(5-(tertbutoxy)-2-{[(9-H-9-fluorenylmethoxy)carbonyl]amino}-5-oxopentanoyl)amino]-3-(tertbutylsulfanyl)propanoyl]amino}butanoic acidC[C@@H](OC(C)(C)C)[C@H](NC(=O)[C@H](CS(C)(C)C)NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OCC1C2=CC=CC=C2C2=C1C=CC=C2)C(O)=CLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00156521944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP23-(tertbutoxy)-2-{[2-[(5-(tertbutoxy)-2-{[(9-H-9-fluorenylmethoxy)carbonyl]amino}-5-oxopentanoyl)amino]-3-(tertbutylsulfanyl)propanoyl]amino}butanoic acidC[C@@H](OC(C)(C)C)[C@H](NC(=O)[C@H](CS(C)(C)C)NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OCC1C2=CC=CC=C2C2=C1C=CC=C2)C(O)=CLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00156621944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP23-(tertbutoxy)-2-{[2-[(5-(tertbutoxy)-2-{[(9-H-9-fluorenylmethoxy)carbonyl]amino}-5-oxopentanoyl)amino]-3-(tertbutylsulfanyl)propanoyl]amino}butanoic acidC[C@@H](OC(C)(C)C)[C@H](NC(=O)[C@H](CS(C)(C)C)NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OCC1C2=CC=CC=C2C2=C1C=CC=C2)C(O)=CLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00156721944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP23-(tertbutoxy)-2-{[2-[(5-(tertbutoxy)-2-{[(9-H-9-fluorenylmethoxy)carbonyl]amino}-5-oxopentanoyl)amino]-3-(tertbutylsulfanyl)propanoyl]amino}butanoic acidC[C@@H](OC(C)(C)C)[C@H](NC(=O)[C@H](CS(C)(C)C)NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OCC1C2=CC=CC=C2C2=C1C=CC=C2)C(O)=CLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00156821944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP23-(tertbutoxy)-2-{[2-[(5-(tertbutoxy)-2-{[(9-H-9-fluorenylmethoxy)carbonyl]amino}-5-oxopentanoyl)amino]-3-(tertbutylsulfanyl)propanoyl]amino}butanoic acidC[C@@H](OC(C)(C)C)[C@H](NC(=O)[C@H](CS(C)(C)C)NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OCC1C2=CC=CC=C2C2=C1C=CC=C2)C(O)=CLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00156921944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP23-(tertbutoxy)-2-{[2-[(5-(tertbutoxy)-2-{[(9-H-9-fluorenylmethoxy)carbonyl]amino}-5-oxopentanoyl)amino]-3-(tertbutylsulfanyl)propanoyl]amino}butanoic acidC[C@@H](OC(C)(C)C)[C@H](NC(=O)[C@H](CS(C)(C)C)NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OCC1C2=CC=CC=C2C2=C1C=CC=C2)C(O)=CLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00157021944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP23-(tertbutoxy)-2-{[2-[(5-(tertbutoxy)-2-{[(9-H-9-fluorenylmethoxy)carbonyl]amino}-5-oxopentanoyl)amino]-3-(tertbutylsulfanyl)propanoyl]amino}butanoic acidC[C@@H](OC(C)(C)C)[C@H](NC(=O)[C@H](CS(C)(C)C)NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OCC1C2=CC=CC=C2C2=C1C=CC=C2)C(O)=CLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00157121944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP23-(tertbutoxy)-2-{[2-[(5-(tertbutoxy)-2-{[(9-H-9-fluorenylmethoxy)carbonyl]amino}-5-oxopentanoyl)amino]-3-(tertbutylsulfanyl)propanoyl]amino}butanoic acidC[C@@H](OC(C)(C)C)[C@H](NC(=O)[C@H](CS(C)(C)C)NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OCC1C2=CC=CC=C2C2=C1C=CC=C2)C(O)=CLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00157221944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP23-(tertbutoxy)-2-{[2-[(5-(tertbutoxy)-2-{[(9-H-9-fluorenylmethoxy)carbonyl]amino}-5-oxopentanoyl)amino]-3-(tertbutylsulfanyl)propanoyl]amino}butanoic acidC[C@@H](OC(C)(C)C)[C@H](NC(=O)[C@H](CS(C)(C)C)NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OCC1C2=CC=CC=C2C2=C1C=CC=C2)C(O)=CLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00157321944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP23-(tertbutoxy)-2-{[2-[(5-(tertbutoxy)-2-{[(9-H-9-fluorenylmethoxy)carbonyl]amino}-5-oxopentanoyl)amino]-3-(tertbutylsulfanyl)propanoyl]amino}butanoic acidC[C@@H](OC(C)(C)C)[C@H](NC(=O)[C@H](CS(C)(C)C)NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OCC1C2=CC=CC=C2C2=C1C=CC=C2)C(O)=CLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00157421944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP3[4-(7-chloroquinolin-4-yl)piperazino](cyclohexyl)methanoneClC1=CC2=C(C=C1)C(=CC=N2)N1CCN(CC1)C(=O)C1CCCCC1LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00157521944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP3[4-(7-chloroquinolin-4-yl)piperazino](cyclohexyl)methanoneClC1=CC2=C(C=C1)C(=CC=N2)N1CCN(CC1)C(=O)C1CCCCC1LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00157621944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP3[4-(7-chloroquinolin-4-yl)piperazino](cyclohexyl)methanoneClC1=CC2=C(C=C1)C(=CC=N2)N1CCN(CC1)C(=O)C1CCCCC1LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00157721944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP3[4-(7-chloroquinolin-4-yl)piperazino](cyclohexyl)methanoneClC1=CC2=C(C=C1)C(=CC=N2)N1CCN(CC1)C(=O)C1CCCCC1LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00157821944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP3[4-(7-chloroquinolin-4-yl)piperazino](cyclohexyl)methanoneClC1=CC2=C(C=C1)C(=CC=N2)N1CCN(CC1)C(=O)C1CCCCC1LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00157921944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP3[4-(7-chloroquinolin-4-yl)piperazino](cyclohexyl)methanoneClC1=CC2=C(C=C1)C(=CC=N2)N1CCN(CC1)C(=O)C1CCCCC1LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00158021944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP3[4-(7-chloroquinolin-4-yl)piperazino](cyclohexyl)methanoneClC1=CC2=C(C=C1)C(=CC=N2)N1CCN(CC1)C(=O)C1CCCCC1LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00158121944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP3[4-(7-chloroquinolin-4-yl)piperazino](cyclohexyl)methanoneClC1=CC2=C(C=C1)C(=CC=N2)N1CCN(CC1)C(=O)C1CCCCC1LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00158221944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP3[4-(7-chloroquinolin-4-yl)piperazino](cyclohexyl)methanoneClC1=CC2=C(C=C1)C(=CC=N2)N1CCN(CC1)C(=O)C1CCCCC1LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00158321944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP3[4-(7-chloroquinolin-4-yl)piperazino](cyclohexyl)methanoneClC1=CC2=C(C=C1)C(=CC=N2)N1CCN(CC1)C(=O)C1CCCCC1LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00158421944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP4ethyl 2-(2,2-dichlorovinyl)-4-hydroxy-4-(3-nitrophenyl)-6-oxocyclohexanecarboxylate[H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(C=C1)N(=O)=OLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00158521944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP4ethyl 2-(2,2-dichlorovinyl)-4-hydroxy-4-(3-nitrophenyl)-6-oxocyclohexanecarboxylate[H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(C=C1)N(=O)=OLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00158621944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP4ethyl 2-(2,2-dichlorovinyl)-4-hydroxy-4-(3-nitrophenyl)-6-oxocyclohexanecarboxylate[H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(C=C1)N(=O)=OLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00158721944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP4ethyl 2-(2,2-dichlorovinyl)-4-hydroxy-4-(3-nitrophenyl)-6-oxocyclohexanecarboxylate[H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(C=C1)N(=O)=OLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00158821944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP4ethyl 2-(2,2-dichlorovinyl)-4-hydroxy-4-(3-nitrophenyl)-6-oxocyclohexanecarboxylate[H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(C=C1)N(=O)=OLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00158921944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP4ethyl 2-(2,2-dichlorovinyl)-4-hydroxy-4-(3-nitrophenyl)-6-oxocyclohexanecarboxylate[H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(C=C1)N(=O)=OLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00159021944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP4ethyl 2-(2,2-dichlorovinyl)-4-hydroxy-4-(3-nitrophenyl)-6-oxocyclohexanecarboxylate[H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(C=C1)N(=O)=OLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00159121944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP4ethyl 2-(2,2-dichlorovinyl)-4-hydroxy-4-(3-nitrophenyl)-6-oxocyclohexanecarboxylate[H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(C=C1)N(=O)=OLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00159221944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP4ethyl 2-(2,2-dichlorovinyl)-4-hydroxy-4-(3-nitrophenyl)-6-oxocyclohexanecarboxylate[H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(C=C1)N(=O)=OLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00159321944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP4ethyl 2-(2,2-dichlorovinyl)-4-hydroxy-4-(3-nitrophenyl)-6-oxocyclohexanecarboxylate[H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(C=C1)N(=O)=OLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00159421944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP5ethyl 4-(4-bromophenyl)-2-(2,2-dichlorovinyl)-4-hydroxy-6-oxocyclohexanecarboxylate[H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(Br)C=C1LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00159521944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP5ethyl 4-(4-bromophenyl)-2-(2,2-dichlorovinyl)-4-hydroxy-6-oxocyclohexanecarboxylate[H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(Br)C=C1LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00159621944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP5ethyl 4-(4-bromophenyl)-2-(2,2-dichlorovinyl)-4-hydroxy-6-oxocyclohexanecarboxylate[H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(Br)C=C1LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00159721944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP5ethyl 4-(4-bromophenyl)-2-(2,2-dichlorovinyl)-4-hydroxy-6-oxocyclohexanecarboxylate[H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(Br)C=C1LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00159821944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP5ethyl 4-(4-bromophenyl)-2-(2,2-dichlorovinyl)-4-hydroxy-6-oxocyclohexanecarboxylate[H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(Br)C=C1LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00159921944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP5ethyl 4-(4-bromophenyl)-2-(2,2-dichlorovinyl)-4-hydroxy-6-oxocyclohexanecarboxylate[H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(Br)C=C1LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00160021944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP5ethyl 4-(4-bromophenyl)-2-(2,2-dichlorovinyl)-4-hydroxy-6-oxocyclohexanecarboxylate[H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(Br)C=C1LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00160121944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP5ethyl 4-(4-bromophenyl)-2-(2,2-dichlorovinyl)-4-hydroxy-6-oxocyclohexanecarboxylate[H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(Br)C=C1LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00160221944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP5ethyl 4-(4-bromophenyl)-2-(2,2-dichlorovinyl)-4-hydroxy-6-oxocyclohexanecarboxylate[H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(Br)C=C1LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00160321944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP5ethyl 4-(4-bromophenyl)-2-(2,2-dichlorovinyl)-4-hydroxy-6-oxocyclohexanecarboxylate[H]COC(=O)C1C(C=C(Cl)Cl)C(O)C(CC1=O)C1=CC=C(Br)C=C1LOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00160421944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP1a2-methyl-N-(4-phenylbutan-2-yl)-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamideCC(CCC1=CC=CC=C1)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)FLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00160521944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP1a2-methyl-N-(4-phenylbutan-2-yl)-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamideCC(CCC1=CC=CC=C1)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)FLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00160621944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP1a2-methyl-N-(4-phenylbutan-2-yl)-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamideCC(CCC1=CC=CC=C1)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)FLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00160721944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP1a2-methyl-N-(4-phenylbutan-2-yl)-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamideCC(CCC1=CC=CC=C1)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)FLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00160821944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP1a2-methyl-N-(4-phenylbutan-2-yl)-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamideCC(CCC1=CC=CC=C1)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)FLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00160921944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP1a2-methyl-N-(4-phenylbutan-2-yl)-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamideCC(CCC1=CC=CC=C1)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)FLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00161021944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP1a2-methyl-N-(4-phenylbutan-2-yl)-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamideCC(CCC1=CC=CC=C1)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)FLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00161121944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP1a2-methyl-N-(4-phenylbutan-2-yl)-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamideCC(CCC1=CC=CC=C1)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)FLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00161221944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP1bN-{1-[(2-chlorophenyl)sulfanyl]propan-2-yl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamideCC(CSC1=CC=CC=C1Cl)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)FLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00161321944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP1bN-{1-[(2-chlorophenyl)sulfanyl]propan-2-yl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamideCC(CSC1=CC=CC=C1Cl)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)FLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00161421944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP1bN-{1-[(2-chlorophenyl)sulfanyl]propan-2-yl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamideCC(CSC1=CC=CC=C1Cl)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)FLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00161521944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP1bN-{1-[(2-chlorophenyl)sulfanyl]propan-2-yl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamideCC(CSC1=CC=CC=C1Cl)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)FLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00161621944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP1bN-{1-[(2-chlorophenyl)sulfanyl]propan-2-yl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamideCC(CSC1=CC=CC=C1Cl)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)FLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00161721944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP1bN-{1-[(2-chlorophenyl)sulfanyl]propan-2-yl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamideCC(CSC1=CC=CC=C1Cl)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)FLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00161821944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP1bN-{1-[(2-chlorophenyl)sulfanyl]propan-2-yl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamideCC(CSC1=CC=CC=C1Cl)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)FLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00161921944755Hsp100ClpPBacteriaCytosolNAAntibacterial activityACP1bN-{1-[(2-chlorophenyl)sulfanyl]propan-2-yl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamideCC(CSC1=CC=CC=C1Cl)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)FLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNANANANANANANANANANANANA
HSPMDB00162021944755Hsp100ClpPBacteriaCytosolBinding affinity NAADEP1A(2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide[H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\CLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNA0.3,n=14.6NANANANANANANucleotide binding domainIsothermal titration calorimetry (ITC)NANA
HSPMDB00162121944755Hsp100ClpPBacteriaCytosolBinding affinity NAADEP1B(2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-13,16,17-trimethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide[H]C1CN2C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C(=O)C3([H])CCCN3C(=O)C(COC(=O)C2([H])C1)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\CLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNA0.7, n=11.0NANANANANANANucleotide binding domainIsothermal titration calorimetry (ITC)NANA
HSPMDB00162221944755Hsp100ClpPBacteriaCytosolBinding affinity NAACP1bN-{1-[(2-chlorophenyl)sulfanyl]propan-2-yl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamideCC(CSC1=CC=CC=C1Cl)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)FLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNA3.2, n=16.1NANANANANANANucleotide binding domainIsothermal titration calorimetry (ITC)NANA
HSPMDB00162321944755Hsp100ClpPBacteriaCytosolBinding affinity NAADEP1A(2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide[H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\CLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNA0.3, n=15.0NANANANANANANucleotide binding domainIsothermal titration calorimetry (ITC)NANA
HSPMDB00162421944755Hsp100ClpPBacteriaCytosolBinding affinity NAADEP1B(2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-13,16,17-trimethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide[H]C1CN2C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C(=O)C3([H])CCCN3C(=O)C(COC(=O)C2([H])C1)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\CLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNA0.7, n=11.0NANANANANANANucleotide binding domainIsothermal titration calorimetry (ITC)NANA
HSPMDB00162521944755Hsp100ClpPBacteriaCytosolBinding affinity NAACP1bN-{1-[(2-chlorophenyl)sulfanyl]propan-2-yl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamideCC(CSC1=CC=CC=C1Cl)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)FLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNA3.3, n=16.0NANANANANANANucleotide binding domainIsothermal titration calorimetry (ITC)NANA
HSPMDB00162621944755Hsp100ClpPBacteriaCytosolBinding affinity NAADEP1A(2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide[H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\CLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNA0.4, n=14.0NANANANANANANucleotide binding domainIsothermal titration calorimetry (ITC)NANA
HSPMDB00162721944755Hsp100ClpPBacteriaCytosolBinding affinity NAADEP1B(2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-13,16,17-trimethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide[H]C1CN2C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C(=O)C3([H])CCCN3C(=O)C(COC(=O)C2([H])C1)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\CLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNA0.7, n=14.0NANANANANANANucleotide binding domainIsothermal titration calorimetry (ITC)NANA
HSPMDB00162821944755Hsp100ClpPBacteriaCytosolBinding affinity NAACP1bN-{1-[(2-chlorophenyl)sulfanyl]propan-2-yl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamideCC(CSC1=CC=CC=C1Cl)NC(=O)C(C)(C)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)FLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNA4.1, n=14.0NANANANANANANucleotide binding domainIsothermal titration calorimetry (ITC)NANA
HSPMDB00162921944755Hsp100ClpPBacteriaCytosolBinding affinity NAADEP1A(2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide[H]C12CCCN1C(=O)C(COC(=O)C1([H])CC(C)CN1C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C2=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\CLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNA1.1NANANANANANANucleotide binding domainSurface plasmon resonance (SPR)NANA
HSPMDB00163021944755Hsp100ClpPBacteriaCytosolBinding affinity NAADEP1B(2E,4E,6E)-N-(2-phenyl-1-{[(13S,16S)-13,16,17-trimethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetraazatricyclo[17.3.0.0?,¹¹]docosan-3-yl]carbamoyl}ethyl)octa-2,4,6-trienamide[H]C1CN2C(=O)[C@H](C)NC(=O)[C@H](C)N(C)C(=O)C3([H])CCCN3C(=O)C(COC(=O)C2([H])C1)NC(=O)C(CC1=CC=CC=C1)NC(=O)\C=C\C=C\C=C\CLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNA1.4NANANANANANANucleotide binding domainSurface plasmon resonance (SPR)NANA
HSPMDB00163121944755Hsp100ClpPBacteriaCytosolBinding affinity NAACP1N-1-[2-(phenylthio)ethyl]-2-methyl-2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}propanamideCC(C)(C(=O)NCCSC1=CC=CC=C1Cl)S(=O)(=O)C1=CC=C(C=N1)C(F)(F)FLOPAC 1280 , Prestwick, SPECTRUM, Maybridge, and Chembridge DIVERSetNA128NANANANANANANucleotide binding domainSurface plasmon resonance (SPR)NANA
HSPMDB00163228906057Hsp100ClpXBacteriaCytosolInhibition of protease activityNA3345,11-Dihydro-11-(3-hydroxyphenyl)-12H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-oneOc1cccc(c1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45Synthetic chemical compoundsNANANA<50NANANANANucleotide binding domainSubstrate degradation assay (GFP)NANA
HSPMDB00163328906057Hsp100ClpXBacteriaCytosolInhibition of protease activityNA3585,11-Dihydro-11-(3-bromo-5-hydroxyphenyl)-12H-benzo[b]indeno[1,2-e][1,4]thiazepin12-oneOc1cc(Br)cc(c1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45Synthetic chemical compoundsNANANA<50NANANANANucleotide binding domainSubstrate degradation assay (GFP)NANA
HSPMDB00163428906057Hsp100ClpXBacteriaCytosolInhibition of protease activityNA3692-(3-hydroxyphenyl)-17-oxo-N-(prop-2-yn-1-yl)-2?³-thia-9-azatetracyclo[8.7.0.0³,?.0¹¹,¹?]heptadeca-1(10),3(8),4,6,11,13,15-heptaene-14-carboxamideOC=1C=C(C=CC1)[S]1C=2C(C3=CC(=CC=C3C2NC=2C=CC=CC12)C(=O)NCC#C)=OSynthetic chemical compoundsNANANA<50NANANANANucleotide binding domainSubstrate degradation assay (GFP)NANA
HSPMDB00163528906057Hsp100ClpXBacteriaCytosolInhibition of protease activityNA3445,11-Dihydro-11-(3-hydroxy-5-methoxyphenyl)-12H-benzo[b]indeno[1,2- e][1,4]thiazepin-12-oneCOc1cc(O)cc(c1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45Synthetic chemical compoundsNANANA<50NANANANANucleotide binding domainSubstrate degradation assay (GFP)NANA
HSPMDB00163628906057Hsp100ClpXBacteriaCytosolInhibition of protease activityNA3475,11-Dihydro-11-(3,5-dihydroxyphenyl)-12H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-oneOc1cc(O)cc(c1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45Synthetic chemical compoundsNANANA<50NANANANANucleotide binding domainSubstrate degradation assay (GFP)NANA
HSPMDB00163728906057Hsp100ClpXBacteriaCytosolInhibition of protease activityNA33610-(thiophen-2-yl)-9-thia-2-azatetracyclo[9.7.0.0³,?.0¹³,¹?]octadeca-1(11),3(8),4,6,13(18),14,16-heptaen-12-oneO=C1c2ccccc2C3=C1C(Sc4ccccc4N3)c5sccc5Synthetic chemical compoundsNANANA<50NANANANANucleotide binding domainSubstrate degradation assay (GFP)NANA
HSPMDB00163828906057Hsp100ClpXBacteriaCytosolInhibition of protease activityNA376N-{2-[3-(but-3-yn-1-yl)-3H-diazirin-3-yl]ethyl}-2-(3-hydroxyphenyl)-17-oxo-2?³-thia-9-azatetracyclo[8.7.0.0³,?.0¹¹,¹?]heptadeca-1(10),3(8),4,6,11,13,15-heptaene-14-carboxamideC(CC#C)C1(N=N1)CCNC(=O)C1=CC=C2C=3NC=4C=CC=CC4[S](C3C(C2=C1)=O)C1=CC(=CC=C1)OSynthetic chemical compoundsNANANA<50NANANANANucleotide binding domainSubstrate degradation assay (GFP)NANA
HSPMDB00163928906057Hsp100ClpXBacteriaCytosolInhibition of protease activityNA34811-(3-Fluorophenyl)-5,11-dihydro-12H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-oneFc1cccc(c1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45Synthetic chemical compoundsNANANA<50NANANANANucleotide binding domainSubstrate degradation assay (GFP)NANA
HSPMDB00164028906057Hsp100ClpXBacteriaCytosolInhibition of protease activityNA3662,3-Dichloro-5,11-dihydro-11-(3-hydroxyphenyl)-12H-benzo[b]indeno[1,2- e][1,4]thiazepin-12-oneOc1cccc(c1)C2Sc3ccccc3NC4=C2C(=O)c5cc(Cl)c(Cl)cc45Synthetic chemical compoundsNANANA<50NANANANANucleotide binding domainSubstrate degradation assay (GFP)NANA
HSPMDB00164128906057Hsp100ClpXBacteriaCytosolInhibition of protease activityNA3505,11-Dihydro-11-(3-hydroxy-5-(hex-5-ynyloxy)-phenyl)-12H-benzo[b]indeno[1,2- e][1,4]thiazepin-12-oneOc1cc(OCCCCC#C)cc(c1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45Synthetic chemical compoundsNANANA<50NANANANANucleotide binding domainSubstrate degradation assay (GFP)NANA
HSPMDB00164228906057Hsp100ClpXBacteriaCytosolInhibition of protease activityNA3534-{12-oxo-9-thia-2-azatetracyclo[9.7.0.0³,?.0¹³,¹?]octadeca-1(11),3(8),4,6,13(18),14,16-heptaen-10-yl}phenyl formateO=COc1ccc(cc1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45Synthetic chemical compoundsNANANA<50NANANANANucleotide binding domainSubstrate degradation assay (GFP)NANA
HSPMDB00164328906057Hsp100ClpXBacteriaCytosolInhibition of protease activityNA3562-Ethynyl-5,11-dihydro-11-(3-hydroxyphenyl)-12H-benzo[b]indeno[1,2- e][1,4]thiazepin-12-oneOc1cccc(c1)C2Sc3ccccc3NC4=C2C(=O)c5cc(ccc45)C#CSynthetic chemical compoundsNANANA<50NANANANANucleotide binding domainSubstrate degradation assay (GFP)NANA
HSPMDB00164428906057Hsp100ClpXBacteriaCytosolInhibition of protease activityNA3405,11-Dihydro-11-phenyl-12H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-oneO=C1c2ccccc2C3=C1C(Sc4ccccc4N3)c5ccccc5Synthetic chemical compoundsNANANA<50NANANANANucleotide binding domainSubstrate degradation assay (GFP)NANA
HSPMDB00164528906057Hsp100ClpXBacteriaCytosolInhibition of protease activityNA3435,11-Dihydro-11-(4-hydroxyphenyl)-12H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-oneOc1ccc(cc1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45Synthetic chemical compoundsNANANA<50NANANANANucleotide binding domainSubstrate degradation assay (GFP)NANA
HSPMDB00164628906057Hsp100ClpXBacteriaCytosolInhibition of protease activityNA3415,11-Dihydro-11-(3-methoxyphenyl)-12H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-oneCOc1cccc(c1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45Synthetic chemical compoundsNANANA<50NANANANANucleotide binding domainSubstrate degradation assay (GFP)NANA
HSPMDB00164728906057Hsp100ClpXBacteriaCytosolInhibition of protease activityNA3682-(3-hydroxyphenyl)-17-oxo-N-(prop-2-yn-1-yl)-2?³-thia-9-azatetracyclo[8.7.0.0³,?.0¹¹,¹?]heptadeca-1(10),3(8),4,6,11,13,15-heptaene-13-carboxamideOC=1C=C(C=CC1)[S]1C=2C(C3=CC=C(C=C3C2NC=2C=CC=CC12)C(=O)NCC#C)=OSynthetic chemical compoundsNANANA<50NANANANANucleotide binding domainSubstrate degradation assay (GFP)NANA
HSPMDB00164828906057Hsp100ClpXBacteriaCytosolInhibition of protease activityNA3595,11-Dihydro-11-(3-aminophenyl)-12H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-oneNc1cccc(c1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45Synthetic chemical compoundsNANANA<50NANANANANucleotide binding domainSubstrate degradation assay (GFP)NANA
HSPMDB00164928906057Hsp100ClpXBacteriaCytosolInhibition of protease activityNA3702-(3-hydroxyphenyl)-17-oxo-N-(prop-2-yn-1-yl)-2?³-thia-9-azatetracyclo[8.7.0.0³,?.0¹¹,¹?]heptadeca-1(10),3(8),4,6,11,13,15-heptaene-13-carboxamideOC=1C=C(C=CC1)[S]1C=2C(C3=CC=C(C=C3C2NC=2C=CC=CC12)C(=O)NCC#C)=OSynthetic chemical compoundsNANANA<50NANANANANucleotide binding domainSubstrate degradation assay (GFP)NANA
HSPMDB00165028906057Hsp100ClpXBacteriaCytosolInhibition of protease activityNA3515,11-Dihydro-11-(2-hydroxyphenyl)-12H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-oneOc1ccccc1C2Sc3ccccc3NC4=C2C(=O)c5ccccc45Synthetic chemical compoundsNANANA<50NANANANANucleotide binding domainSubstrate degradation assay (GFP)NANA
HSPMDB00165128906057Hsp100ClpXBacteriaCytosolInhibition of protease activityNA3675,11-Dihydro-11-(3-(hydroxymethyl)phenyl)-12H-benzo[b]indeno[1,2-e][1,4]thiazepin12-oneOCc1cccc(c1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45Synthetic chemical compoundsNANANA<50NANANANANucleotide binding domainSubstrate degradation assay (GFP)NANA
HSPMDB00165228906057Hsp100ClpXBacteriaCytosolInhibition of protease activityNA35511-(3-hydroxyphenyl)-5H-benzo[b]indeno[1,2-e][1,4]thiazepin-12(11H)-one 10,10- dioxideOc1cccc(c1)C2C3=C(Nc4ccccc4[S]2(=O)=O)c5ccccc5C3=OSynthetic chemical compoundsNANANA<50NANANANANucleotide binding domainSubstrate degradation assay (GFP)NANA
HSPMDB00165328906057Hsp100ClpXBacteriaCytosolInhibition of protease activityNA35210-(pyridin-2-yl)-9-thia-2-azatetracyclo[9.7.0.0³,?.0¹³,¹?]octadeca-1(11),3(8),4,6,13(18),14,16-heptaen-12-oneO=C1c2ccccc2C3=C1C(Sc4ccccc4N3)c5ccccn5Synthetic chemical compoundsNANANA<50NANANANANucleotide binding domainSubstrate degradation assay (GFP)NANA
HSPMDB00165428906057Hsp100ClpXBacteriaCytosolInhibition of protease activityNA3455,11-Dihydro-11-(3-hydroxyphenyl)-8-methoxy-12H-benzo[b]indeno[1,2- e][1,4]thiazepin-12-oneCOc1ccc2NC3=C(C(Sc2c1)c4cccc(O)c4)C(=O)c5ccccc35Synthetic chemical compoundsNANANA<50NANANANANucleotide binding domainSubstrate degradation assay (GFP)NANA
HSPMDB00165528906057Hsp100ClpXBacteriaCytosolInhibition of protease activityNA34611-(4-Fluorophenyl)-5,11-dihydro-12H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-oneFc1ccc(cc1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45Synthetic chemical compoundsNANANA<50NANANANANucleotide binding domainSubstrate degradation assay (GFP)NANA
HSPMDB00165628906057Hsp100ClpXBacteriaCytosolInhibition of protease activityNA34911-(4-Carboxyphenyl)-5,11-dihydro-12H-benzo[b]indeno[1,2-e][1,4]thiazepin-12-oneOC(=O)c1ccc(cc1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45Synthetic chemical compoundsNANANA<50NANANANANucleotide binding domainSubstrate degradation assay (GFP)NANA
HSPMDB00165728906057Hsp100ClpXBacteriaCytosolInhibition of protease activityNA36011-(4-(trifluoromethyl)phenyl)-5H-benzo[b]indeno[1,2-e][1,4]thiazepin-12(11H)-oneFC(F)(F)c1ccc(cc1)C2Sc3ccccc3NC4=C2C(=O)c5ccccc45Synthetic chemical compoundsNANANA<50NANANANANucleotide binding domainSubstrate degradation assay (GFP)NANA
HSPMDB00165828906057Hsp100ClpXBacteriaCytosolInhibition of protease activityNA35411-(4-fluorophenyl)-5H-benzo[b]indeno[1,2-e][1,4]thiazepin-12(11H)-one 10,10-dioxideFc1ccc(cc1)C2C3=C(Nc4ccccc4[S]2(=O)=O)c5ccccc5C3=OSynthetic chemical compoundsNANANA<50NANANANANucleotide binding domainSubstrate degradation assay (GFP)NANA
HSPMDB00165928906057Hsp100ClpXBacteriaCytosolInhibition of protease activityNA374N-{2-[3-(but-3-yn-1-yl)-3H-diazirin-3-yl]ethyl}-2-(3-methoxyphenyl)-17-oxo-2?³-thia-9-azatetracyclo[8.7.0.0³,?.0¹¹,¹?]heptadeca-1(10),3(8),4,6,11,13,15-heptaene-14-carboxamide[H]C1=C(C=C2C(=O)C3=C(NC4=C(C=CC=C4)[S]3C3=CC=CC(OC)=C3)C2=C1)C(=O)NCCC1(CCC#C)N=N1Synthetic chemical compoundsNANANA<50NANANANANucleotide binding domainSubstrate degradation assay (GFP)NANA
HSPMDB00166028906057Hsp100ClpXBacteriaCytosolInhibition of protease activityNA36211-(3-methoxyphenyl)-5H-benzo[b]indeno[1,2-e][1,4]thiazepin-12(11H)-one 10,10- dioxideCOc1cccc(c1)C2C3=C(Nc4ccccc4[S]2(=O)=O)c5ccccc5C3=OSynthetic chemical compoundsNANANA<50NANANANANucleotide binding domainSubstrate degradation assay (GFP)NANA
HSPMDB00166128906057Hsp100ClpXBacteriaCytosolInhibition of protease activityNA36411-(4-(trifluoromethyl)phenyl)-5H-benzo[b]indeno[1,2-e][1,4]thiazepin-12(11H)-one 10,10-dioxideFC(F)(F)c1ccc(cc1)C2C3=C(Nc4ccccc4[S]2(=O)=O)c5ccccc5C3=OSynthetic chemical compoundsNANANA<50NANANANANucleotide binding domainSubstrate degradation assay (GFP)NANA
HSPMDB00166228906057Hsp100ClpXBacteriaCytosolInhibition of protease activityNA36311-([1,1'-biphenyl]-4-yl)-5H-benzo[b]indeno[1,2-e][1,4]thiazepin-12(11H)-one 10,10- dioxideO=C1c2ccccc2C3=C1C(c4ccc(cc4)c5ccccc5)[S](=O)(=O)c6ccccc6N3Synthetic chemical compoundsNANANA<50NANANANANucleotide binding domainSubstrate degradation assay (GFP)NANA
HSPMDB00166328906057Hsp100ClpXBacteriaCytosolInhibition of protease activityNA36511-([1,1'-biphenyl]-4-yl)-5H-benzo[b]indeno[1,2-e][1,4]thiazepin-12(11H)-oneO=C1c2ccccc2C3=C1C(Sc4ccccc4N3)c5ccc(cc5)c6ccccc6Synthetic chemical compoundsNANANA<50NANANANANucleotide binding domainSubstrate degradation assay (GFP)NANA
HSPMDB00166428906057Hsp100ClpXBacteriaCytosolInhibition of protease activityNA375N-{2-[3-(but-3-yn-1-yl)-3H-diazirin-3-yl]ethyl}-2-(3-methoxyphenyl)-17-oxo-2?³-thia-9-azatetracyclo[8.7.0.0³,?.0¹¹,¹?]heptadeca-1(10),3(8),4,6,11,13,15-heptaene-14-carboxamide[H]C1=C(C=C2C(=O)C3=C(NC4=C(C=CC=C4)[S]3C3=CC=CC(OC)=C3)C2=C1)C(=O)NCCC1(CCC#C)N=N1Synthetic chemical compoundsNANANA<50NANANANANucleotide binding domainSubstrate degradation assay (GFP)NANA
HSPMDB00166524047344Hsp100ClpPBacteriaCytosolNAAntibacterial activity2Trans 4-butyl 3-pentyloxetan-2-oneCCCCC[C@H]1[C@H](CCCC)OC1=OBeta lactone analogueNANANANANANANANANANANABacterial growth inhibition assay (OD based)
HSPMDB00166624047344Hsp100ClpPBacteriaCytosolNAAntibacterial activity3 Trans-4-butyl 3-heptyloxetan-2-oneCCCCCCC[C@H]1[C@H](CCCC)OC1=OBeta lactone analogueNANANANANANANANANANANABacterial growth inhibition assay (OD based)
HSPMDB00166724047344Hsp100ClpPBacteriaCytosolNAAntibacterial activity4 Trans-4-butyl-3-(non-8-en-1-yl)oxetan-2-oneCCCC[C@@H]1OC(=O)[C@H]1CCCCCCCC=CBeta lactone analogueNANANANANANANANANANANABacterial growth inhibition assay (OD based)
HSPMDB00166824047344Hsp100ClpPBacteriaCytosolNAAntibacterial activity7 Trans-3-benzyl-4-propyloxetan-2-one CCC[C@@H]1OC(=O)[C@H]1Cc2ccccc2Beta lactone analogueNANANANANANANANANANANABacterial growth inhibition assay (OD based)
HSPMDB00166924047344Hsp100ClpPBacteriaCytosolNAAntibacterial activity4 Trans-4-butyl-3-(non-8-en-1-yl)oxetan-2-oneCCCC[C@@H]1OC(=O)[C@H]1CCCCCCCC=CBeta lactone analogueNANANANANANANANANANANABacterial growth inhibition assay (OD based)
HSPMDB00167024047344Hsp100ClpPBacteriaCytosolNAAntibacterial activity7 Trans-3-benzyl-4-propyloxetan-2-one CCC[C@@H]1OC(=O)[C@H]1Cc2ccccc2Beta lactone analogueNANANANANANANANANANANABacterial growth inhibition assay (OD based)
HSPMDB00167124047344Hsp100ClpPBacteriaCytosolNAAntibacterial activity3 Trans-4-butyl 3-heptyloxetan-2-oneCCCCCCC[C@H]1[C@H](CCCC)OC1=OBeta lactone analogueNANANANANANANANANANANABacterial growth inhibition assay (OD based)
HSPMDB00167224047344Hsp100ClpPBacteriaCytosolNAAntibacterial activity4 Trans-4-butyl-3-(non-8-en-1-yl)oxetan-2-oneCCCC[C@@H]1OC(=O)[C@H]1CCCCCCCC=CBeta lactone analogueNANANANANANANANANANANABacterial growth inhibition assay (OD based)
HSPMDB00167324047344Hsp100ClpPBacteriaCytosolNAAntibacterial activity7 Trans-3-benzyl-4-propyloxetan-2-one CCC[C@@H]1OC(=O)[C@H]1Cc2ccccc2Beta lactone analogueNANANANANANANANANANANABacterial growth inhibition assay (OD based)
HSPMDB00167424047344Hsp100ClpPBacteriaCytosolNAAntibacterial activity3 Trans-4-butyl 3-heptyloxetan-2-oneCCCCCCC[C@H]1[C@H](CCCC)OC1=OBeta lactone analogueNANANANANANANANANANANABacterial growth inhibition assay (OD based)
HSPMDB00167524047344Hsp100ClpPBacteriaCytosolNAAntibacterial activity4 Trans-4-butyl-3-(non-8-en-1-yl)oxetan-2-oneCCCC[C@@H]1OC(=O)[C@H]1CCCCCCCC=CBeta lactone analogueNANANANANANANANANANANABacterial growth inhibition assay (OD based)
HSPMDB00167624047344Hsp100ClpPBacteriaCytosolNAAntibacterial activity7 Trans-3-benzyl-4-propyloxetan-2-one CCC[C@@H]1OC(=O)[C@H]1Cc2ccccc2Beta lactone analogueNANANANANANANANANANANABacterial growth inhibition assay (OD based)
HSPMDB00167725759383Hsp100ClpP1P2HumanMitochondriaInhibition of peptidase activityNAAc-Pro-Lys-boroMetNANABoronate compoundsNANA2.4NANANANANANAPeptide specific clevage assayNANA
HSPMDB00167825759383Hsp100ClpP1P2HumanMitochondriaInhibition of peptidase activityNAAc-His-Lys-boroMetNANABoronate compoundsNANA6.8NANANANANANAPeptide specific clevage assayNANA
HSPMDB00167925759383Hsp100ClpP1P2HumanMitochondriaInhibition of peptidase activityNAAc-Ala-Lys-boroMetNANABoronate compoundsNANA2.1NANANANANANAPeptide specific clevage assayNANA
HSPMDB00168025759383Hsp100ClpP1P2HumanMitochondriaInhibition of peptidase activityNA Ala(1-naphtyl)-Lys-boroLeuNANABoronate compoundsNANA1.46NANANANANANAPeptide specific clevage assayNANA
HSPMDB00168125759383Hsp100ClpP1P2HumanMitochondriaInhibition of peptidase activityNA N-(Picolinoyl)-Trp-Lys-boroMetNANABoronate compoundsNANA0.96NANANANANANAPeptide specific clevage assayNANA
HSPMDB00168225759383Hsp100ClpP1P2HumanMitochondriaInhibition of peptidase activityNAN-(Picolinoyl)-Ala-Lys-boroMetNANABoronate compoundsNANA1.7NANANANANANAPeptide specific clevage assayNANA
HSPMDB00168325759383Hsp100ClpP1P2HumanMitochondriaInhibition of peptidase activityNA N-(Picolinoyl)-Pro-Lys-boroMetNANABoronate compoundsNANA4.2NANANANANANAPeptide specific clevage assayNANA
HSPMDB00168425759383Hsp100ClpP1P2HumanMitochondriaInhibition of peptidase activityNA N-(Picolinoyl)-Lys-boroMetNANABoronate compoundsNANA5.8NANANANANANAPeptide specific clevage assayNANA
HSPMDB00168525759383Hsp100ClpP1P2HumanMitochondriaInhibition of peptidase activityNAN-(3-Phenyl)propanoyl)-Lys-boroMetNANABoronate compoundsNANA0.9NANANANANANAPeptide specific clevage assayNANA
HSPMDB00168625759383Hsp100ClpP1P2HumanMitochondriaInhibition of peptidase activityNAN-(Benzyl)-Lys-boroMetNANABoronate compoundsNANA2.4NANANANANANAPeptide specific clevage assayNANA
HSPMDB00168725759383Hsp100ClpP1P2HumanMitochondriaInhibition of peptidase activityNA N-(2-(3,5-Difluorophenyl)acetyl)-Lys-boroMetNANABoronate compoundsNANA0.75NANANANANANAPeptide specific clevage assayNANA
HSPMDB00168825759383Hsp100ClpP1P2HumanMitochondriaInhibition of peptidase activityNAN-(2-(3,5-Difluorophenyl)acetyl-Trp-boroMetNANABoronate compoundsNANA0.34NANANANANANAPeptide specific clevage assayNANA
HSPMDB00168925759383Hsp100ClpP1P2HumanMitochondriaInhibition of peptidase activityNAN-(1H-benzo(b)thiophene-7-carbonyl-Lys-boroMetNANABoronate compoundsNANA0.4NANANANANANAPeptide specific clevage assayNANA
HSPMDB00169025759383Hsp100ClpP1P2HumanMitochondriaInhibition of peptidase activityNAN-(Phenylmetanesulfonyl)-Lys-boroMetNANABoronate compoundsNANA11.6NANANANANANAPeptide specific clevage assayNANA
HSPMDB00169125759383Hsp100ClpP1P2BacteriaCytosolInhibition of peptidase activityNAAc-Pro-Lys-boroMetNANABoronate compoundsNANA0.46NANANANANANucleotide binding domainPeptide specific clevage assayNANA
HSPMDB00169225759383Hsp100ClpP1P2BacteriaCytosolInhibition of peptidase activityNAAc-His-Lys-boroMetNANABoronate compoundsNANA0.78NANANANANANucleotide binding domainPeptide specific clevage assayNANA
HSPMDB00169325759383Hsp100ClpP1P2BacteriaCytosolInhibition of peptidase activityNAAc-Ala-Lys-boroMetNANABoronate compoundsNANA0.8NANANANANANucleotide binding domainPeptide specific clevage assayNANA
HSPMDB00169425759383Hsp100ClpP1P2BacteriaCytosolInhibition of peptidase activityNA Ala(1-naphtyl)-Lys-boroLeuNANABoronate compoundsNANA3.2NANANANANANucleotide binding domainPeptide specific clevage assayNANA
HSPMDB00169525759383Hsp100ClpP1P2BacteriaCytosolInhibition of peptidase activityNA N-(Picolinoyl)-Trp-Lys-boroMetNANABoronate compoundsNANA0.18NANANANANANucleotide binding domainPeptide specific clevage assayNANA
HSPMDB00169625759383Hsp100ClpP1P2BacteriaCytosolInhibition of peptidase activityNAN-(Picolinoyl)-Ala-Lys-boroMetNANABoronate compoundsNANA0.24NANANANANANucleotide binding domainPeptide specific clevage assayNANA
HSPMDB00169725759383Hsp100ClpP1P2BacteriaCytosolInhibition of peptidase activityNA N-(Picolinoyl)-Pro-Lys-boroMetNANABoronate compoundsNANA0.82NANANANANANucleotide binding domainPeptide specific clevage assayNANA
HSPMDB00169825759383Hsp100ClpP1P2BacteriaCytosolInhibition of peptidase activityNA N-(Picolinoyl)-Lys-boroMetNANABoronate compoundsNANA0..34NANANANANANucleotide binding domainPeptide specific clevage assayNANA
HSPMDB00169925759383Hsp100ClpP1P2BacteriaCytosolInhibition of peptidase activityNAN-(3-Phenyl)propanoyl)-Lys-boroMetNANABoronate compoundsNANA0.23NANANANANANucleotide binding domainPeptide specific clevage assayNANA
HSPMDB00170025759383Hsp100ClpP1P2BacteriaCytosolInhibition of peptidase activityNAN-(Benzyl)-Lys-boroMetNANABoronate compoundsNANA0.18NANANANANANucleotide binding domainPeptide specific clevage assayNANA
HSPMDB00170125759383Hsp100ClpP1P2BacteriaCytosolInhibition of peptidase activityNA N-(2-(3,5-Difluorophenyl)acetyl)-Lys-boroMetNANABoronate compoundsNANA0.0625NANANANANANucleotide binding domainPeptide specific clevage assayNANA
HSPMDB00170225759383Hsp100ClpP1P2BacteriaCytosolInhibition of peptidase activityNAN-(2-(3,5-Difluorophenyl)acetyl-Trp-boroMetNANABoronate compoundsNANA0.29NANANANANANucleotide binding domainPeptide specific clevage assayNANA
HSPMDB00170325759383Hsp100ClpP1P2BacteriaCytosolInhibition of peptidase activityNAN-(1H-benzo(b)thiophene-7-carbonyl-Lys-boroMetNANABoronate compoundsNANA0.12NANANANANANucleotide binding domainPeptide specific clevage assayNANA
HSPMDB00170425759383Hsp100ClpP1P2BacteriaCytosolInhibition of peptidase activityNAN-(Phenylmetanesulfonyl)-Lys-boroMetNANABoronate compoundsNANA13NANANANANANucleotide binding domainPeptide specific clevage assayNANA
HSPMDB00170525759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activityAc-Pro-Lys-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00170625759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activityAc-His-Lys-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00170725759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activityAc-Ala-Lys-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00170825759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activity Ala(1-naphtyl)-Lys-boroLeuNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00170925759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activity N-(Picolinoyl)-Trp-Lys-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00171025759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activityN-(Picolinoyl)-Ala-Lys-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00171125759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activity N-(Picolinoyl)-Pro-Lys-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00171225759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activity N-(Picolinoyl)-Lys-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00171325759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activityN-(3-Phenyl)propanoyl)-Lys-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00171425759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activityN-(Benzyl)-Lys-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00171525759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activity N-(2-(3,5-Difluorophenyl)acetyl)-Lys-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00171625759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activityN-(2-(3,5-Difluorophenyl)acetyl-Trp-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00171725759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activityN-(1H-benzo(b)thiophene-7-carbonyl-Lys-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00171825759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activityN-(Phenylmetanesulfonyl)-Lys-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00171925759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activityAc-Pro-Lys-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00172025759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activityAc-His-Lys-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00172125759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activityAc-Ala-Lys-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00172225759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activity Ala(1-naphtyl)-Lys-boroLeuNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00172325759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activity N-(Picolinoyl)-Trp-Lys-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00172425759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activityN-(Picolinoyl)-Ala-Lys-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00172525759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activity N-(Picolinoyl)-Pro-Lys-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00172625759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activity N-(Picolinoyl)-Lys-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00172725759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activityN-(3-Phenyl)propanoyl)-Lys-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00172825759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activityN-(Benzyl)-Lys-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00172925759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activity N-(2-(3,5-Difluorophenyl)acetyl)-Lys-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00173025759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activityN-(2-(3,5-Difluorophenyl)acetyl-Trp-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00173125759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activityN-(1H-benzo(b)thiophene-7-carbonyl-Lys-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00173225759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activityN-(Phenylmetanesulfonyl)-Lys-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00173325759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activityAc-Pro-Lys-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00173425759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activityAc-His-Lys-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00173525759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activityAc-Ala-Lys-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00173625759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activity Ala(1-naphtyl)-Lys-boroLeuNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00173725759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activity N-(Picolinoyl)-Trp-Lys-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00173825759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activityN-(Picolinoyl)-Ala-Lys-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00173925759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activity N-(Picolinoyl)-Pro-Lys-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00174025759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activity N-(Picolinoyl)-Lys-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00174125759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activityN-(3-Phenyl)propanoyl)-Lys-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00174225759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activityN-(Benzyl)-Lys-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00174325759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activity N-(2-(3,5-Difluorophenyl)acetyl)-Lys-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00174425759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activityN-(2-(3,5-Difluorophenyl)acetyl-Trp-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00174525759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activityN-(1H-benzo(b)thiophene-7-carbonyl-Lys-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00174625759383Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activityN-(Phenylmetanesulfonyl)-Lys-boroMetNANABoronate compoundsNANANANANANANANANANANAResazurin based viability assay
HSPMDB00174725759383Hsp100ClpP1P2BacteriaCytosolInhibition of protease activityNAN-(1H-benzo(b)thiophene-7-carbonyl-Lys-boroMetNANABoronate compoundsNANANA0.14NANANANANucleotide binding domainPeptidase assay (Ac-PKM-amc)NANA
HSPMDB00174825759383Hsp100ClpP1P2BacteriaCytosolInhibition of protease activityNAN-(1H-benzo(b)thiophene-7-carbonyl-Lys-boroMetNANABoronate compoundsNANANA5.8NANANANANucleotide binding domainSubstrate degradation assay (GFP-ssrA)NANA
HSPMDB00174925759383Hsp100ClpP1P2BacteriaCytosolInhibition of protease activityNAN-(1H-benzo(b)thiophene-7-carbonyl-Lys-boroMetNANABoronate compoundsNANANA3.2NANANANANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00175030109319Hsp100hClpPHumanMitochondriaInhibition of peptidase activityNAD33-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-oneC=CCCCCCCCC1C(CCCC#C)OC1=ONaphthofuran derivative with 8-methoxynaphthofuran moietyNANANA6.99NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00175130109319Hsp100hClpPHumanMitochondriaInhibition of peptidase activityNAAV1764-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetateO=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1Naphthofuran derivative with 8-methoxynaphthofuran moietyNANANA1.54NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00175230109319Hsp100hClpPHumanMitochondriaInhibition of peptidase activityNATG424-(1,3,4-Oxadiazol-2-yl)phenyl 2-(2-ethynylnaphtho[2,1-b]furan-1-yl)acetateO=C(Cc1c(oc2ccc3ccccc3c12)C#C)Oc4ccc(cc4)c5ocnn5Naphthofuran derivative with 8-methoxynaphthofuran moietyNANANA0.39NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00175330109319Hsp100hClpPHumanMitochondriaInhibition of peptidase activityNATG434-(1,3,4-Oxadiazol-2-yl)phenyl 2-(2-ethynylnaphtho[2,1-b]furan-1-yl)acetateO=C(Cc1c(oc2ccc3ccccc3c12)C#C)Oc4ccc(cc4)c5ocnn5Naphthofuran derivative with 8-methoxynaphthofuran moietyNANANA0.57NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00175430109319Hsp100hClpPHumanMitochondriaInhibition of peptidase activityNATG534-(1,3,4-Oxadiazol-2-yl)phenyl 2-(2-ethynylnaphtho[2,1-b]furan-1-yl)acetateO=C(Cc1c(oc2ccc3ccccc3c12)C#C)Oc4ccc(cc4)c5ocnn5Naphthofuran derivative with 8-methoxynaphthofuran moietyNANANA0.33NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00175530109319Hsp100hClpPHumanMitochondriaInhibition of peptidase activityNATG544-(1,3,4-Oxadiazol-2-yl)phenyl 2-(2-ethynylnaphtho[2,1-b]furan-1-yl)acetateO=C(Cc1c(oc2ccc3ccccc3c12)C#C)Oc4ccc(cc4)c5ocnn5Naphthofuran derivative with 8-methoxynaphthofuran moietyNANANA1.49NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00175630109319Hsp100hClpPBacteriaCytosolInhibition of peptidase activityNAD33-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-oneC=CCCCCCCCC1C(CCCC#C)OC1=ONaphthofuran derivative with 8-methoxynaphthofuran moietyNANANA4.01NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00175730109319Hsp100hClpPBacteriaCytosolInhibition of peptidase activityNAAV1674-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetateO=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1Naphthofuran derivative with 8-methoxynaphthofuran moietyNANANA1.44NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00175830109319Hsp100hClpPBacteriaCytosolInhibition of peptidase activityNATG424-(1,3,4-Oxadiazol-2-yl)phenyl 2-(2-ethynylnaphtho[2,1-b]furan-1-yl)acetateO=C(Cc1c(oc2ccc3ccccc3c12)C#C)Oc4ccc(cc4)c5ocnn5Naphthofuran derivative with 8-methoxynaphthofuran moietyNANANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00175930109319Hsp100hClpPBacteriaCytosolInhibition of peptidase activityNATG434-(1,3,4-Oxadiazol-2-yl)phenyl 2-(2-ethynylnaphtho[2,1-b]furan-1-yl)acetateO=C(Cc1c(oc2ccc3ccccc3c12)C#C)Oc4ccc(cc4)c5ocnn5Naphthofuran derivative with 8-methoxynaphthofuran moietyNANANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00176030109319Hsp100hClpPBacteriaCytosolInhibition of peptidase activityNATG534-(1,3,4-Oxadiazol-2-yl)phenyl 2-(2-ethynylnaphtho[2,1-b]furan-1-yl)acetateO=C(Cc1c(oc2ccc3ccccc3c12)C#C)Oc4ccc(cc4)c5ocnn5Naphthofuran derivative with 8-methoxynaphthofuran moietyNANANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00176130109319Hsp100hClpPBacteriaCytosolInhibition of peptidase activityNATG544-(1,3,4-Oxadiazol-2-yl)phenyl 2-(2-ethynylnaphtho[2,1-b]furan-1-yl)acetateO=C(Cc1c(oc2ccc3ccccc3c12)C#C)Oc4ccc(cc4)c5ocnn5Naphthofuran derivative with 8-methoxynaphthofuran moietyNANANA2.74NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00176224022489Hsp100ClpC1BacteriaCytosolBinding affinityNACymA1(3S,6S,9S,12S,15S,18S,21S)-3-[(R)-[1-[(3S)-4-(3-aminopropylamino)-3-hydroxy-2-methylbutan-2-yl]indol-3-yl]-hydroxymethyl]-21-[(2R)-3-hydroxy-2-methylpropyl]-15-[(R)-methoxy(phenyl)methyl]-1,10,18-trimethyl-6-[(2R)-4-methylpent-3-en-2-yl]-9-(2-methylpropyl)-12-propan-2-yl-1,4,7,10,13,16,19-heptazacyclohenicosane-2,5,8,11,14,17,20-heptoneCC1C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N1)CC(C)CO)C)C(C2=CN(C3=CC=CC=C32)C(C)(C)C(CNCCCN)O)O)C(C)C=C(C)C)CC(C)C)C)C(C)C)C(C4=CC=CC=C4)OCCyclomarine A (CymA) derivativeNA0.012NANANANANANANAIsothermal titration calorimetry (ITC)NANA
HSPMDB00176324022489Hsp100ClpC1BacteriaCytosolNAAntibacterial activityCymA1(3S,6S,9S,12S,15S,18S,21S)-3-[(R)-[1-[(3S)-4-(3-aminopropylamino)-3-hydroxy-2-methylbutan-2-yl]indol-3-yl]-hydroxymethyl]-21-[(2R)-3-hydroxy-2-methylpropyl]-15-[(R)-methoxy(phenyl)methyl]-1,10,18-trimethyl-6-[(2R)-4-methylpent-3-en-2-yl]-9-(2-methylpropyl)-12-propan-2-yl-1,4,7,10,13,16,19-heptazacyclohenicosane-2,5,8,11,14,17,20-heptoneCC1C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N1)CC(C)CO)C)C(C2=CN(C3=CC=CC=C32)C(C)(C)C(CNCCCN)O)O)C(C)C=C(C)C)CC(C)C)C)C(C)C)C(C4=CC=CC=C4)OCCyclomarine A (CymA) derivativeNANANANANANANANANANA50%Bacterial growth inhibition assay (OD based)
HSPMDB00176424022489Hsp100ClpC1BacteriaCytosolNAAntibacterial activityCymA1(3S,6S,9S,12S,15S,18S,21S)-3-[(R)-[1-[(3S)-4-(3-aminopropylamino)-3-hydroxy-2-methylbutan-2-yl]indol-3-yl]-hydroxymethyl]-21-[(2R)-3-hydroxy-2-methylpropyl]-15-[(R)-methoxy(phenyl)methyl]-1,10,18-trimethyl-6-[(2R)-4-methylpent-3-en-2-yl]-9-(2-methylpropyl)-12-propan-2-yl-1,4,7,10,13,16,19-heptazacyclohenicosane-2,5,8,11,14,17,20-heptoneCC1C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N1)CC(C)CO)C)C(C2=CN(C3=CC=CC=C32)C(C)(C)C(CNCCCN)O)O)C(C)C=C(C)C)CC(C)C)C)C(C)C)C(C4=CC=CC=C4)OCCyclomarine A (CymA) derivativeNANANANANANANANANANA50%Bacterial growth inhibition assay (OD based)
HSPMDB00176530571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA10Benzyl (1-(Diphenoxyphosphoryl)-2-phenylethyl)carbamateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=CC=C4Serine protease inhibitor library7% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00176630571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA11Benzyl (1-(Diphenoxyphosphoryl)-2-(p-tolyl)ethyl)carbamateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C(C)C=C4Serine protease inhibitor library7% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00176730571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA12Benzyl (1-(Diphenoxyphosphoryl)-2-(4-methoxyphenyl)ethyl)-carbamateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C(OC)C=C4Serine protease inhibitor library6% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00176830571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA13Benzyl (Benzofuran-5-yl(diphenoxyphosphoryl)methyl)-carbamateO=C(OCC1=CC=CC=C1)NC(C2=CC=C3OC=CC3=C2)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=OSerine protease inhibitor library6% at 200uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00176930571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA14Benzyl (1-(Diphenoxyphosphoryl)-2-(naphthalen-2-yl)ethyl)-carbamateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C5C=CC=CC5=C4Serine protease inhibitor library<1% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00177030571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA15Benzyl (1-(Diphenoxyphosphoryl)-2-(4-fluorophenyl)ethyl)-carbamateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C(F)C=C4Serine protease inhibitor library13% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00177130571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA16Benzyl (1-(Diphenoxyphosphoryl)-2-(4-(trifluoromethyl)phenyl)-ethyl) carbamateO=C(OC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)CC3=CC=C(C(F)(F)F)C=C3)NCC4=CC=CC=C4Serine protease inhibitor library100% at 200 uMNANA14.2NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00177230571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA17Benzyl (1-(Diphenoxyphosphoryl)-3-(methylthio)propyl)-carbamateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CCSCSerine protease inhibitor library9% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00177330571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA18Benzyl ((Diphenoxyphosphoryl)(6-hydroxynaphthalen-2-yl)-methyl)carbamateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=C5C=C(O)C=CC5=C4Serine protease inhibitor library<1% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00177430571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA21Benzyl (1-(Diphenoxyphosphoryl)-2-(4-hydroxyphenyl)ethyl)-carbamateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C(O)C=C4Serine protease inhibitor library<1% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00177530571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA22Benzyl (1-(Diphenoxyphosphoryl)-2-(3-hydroxyphenyl)ethyl)-carbamateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=CC(O)=C4Serine protease inhibitor library3% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00177630571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA23Benzyl (1-((4-Acetamidobenzyl)(4-acetamidophenoxy)-phosphoryl)-2-phenylethyl)carbamateO=C(OC(P(OC1=CC=C(NC(C)=O)C=C1)(CC2=CC=C(NC(C)=O)C=C2)=O)CC3=CC=CC=C3)NCC4=CC=CC=C4Serine protease inhibitor library9% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00177730571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA24Benzyl (1-(Hydroxy(phenoxy)phosphoryl)-2-(4-hydroxyphenyl)-ethyl)carbamateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(O)=O)CC3=CC=C(O)C=C3Serine protease inhibitor library11% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00177830571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA25Benzyl (2-(4-Hydroxyphenyl)-1-(methoxy(phenoxy)phosphoryl)-ethyl)carbamateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC)=O)CC3=CC=C(O)C=C3Serine protease inhibitor library14% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00177930571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA29Benzyl (S)-(1-Cyano-2-(4-hydroxyphenyl)ethyl)carbamateO=C(OCC1=CC=CC=C1)N[C@H](C#N)CC2=CC=C(O)C=C2Serine protease inhibitor library<1% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00178030571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA30Benzyl (S)-(1-Cyano-2-phenylethyl)carbamateO=C(OCC1=CC=CC=C1)N[C@H](C#N)CC2=CC=CC=C2Serine protease inhibitor library<1% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00178130571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA32Benzyl ((2S)-1-((1-(Diphenoxyphosphoryl)-2-(4-hydroxyphenyl)-ethyl)amino)-4-methyl-1-oxopentan-2-yl)carbamateO=C(OCC1=CC=CC=C1)N[C@@H](CC(C)C)C(NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C(O)C=C4)=OSerine protease inhibitor library<1% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00178230571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA36Benzyl ((2S)-6-Amino-1-((1-(diphenoxyphosphoryl)-3-(methylthio)propyl)amino)-1-oxohexan-2-yl)carbamate HydrochlorideO=C(OCC1=CC=CC=C1)N[C@@H](CCCCN)C(NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CCSC)=O.[H]ClSerine protease inhibitor library4% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00178330571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA41Benzyl ((S)-1-(((S)-1-Cyano-2-(4-hydroxyphenyl)ethyl)amino)-4-methyl-1-oxopentan-2-yl)carbamateO=C(OCC1=CC=CC=C1)N[C@@H](CC(C)C)C(N[C@H](C#N)CC2=CC=C(O)C=C2)=OSerine protease inhibitor library13% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00178430571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA42Diphenyl ((1-Carbamimidoy l p i p e r i d i n - 4 - y l ) ( 2 - ( 4 -methoxyphenyl)acetamido)methyl)phosphonate 2,2,2-trifluoroacetateO=C(NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3CCN(C(N)=N)CC3)CC4=CC=C(OC)C=C4.O=C(O)C(F)(F)FSerine protease inhibitor library13% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00178530571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA43Diphenyl ((1-Carbamimidoylpiperidin-4-yl)(nicotinamido)-methyl)phosphonate 2,2,2-trifluoroacetateO=C(NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3CCN(C(N)=N)CC3)C4=CN=CC=C4.O=C(O)C(F)(F)FSerine protease inhibitor library13% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00178630571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA44Diphenyl ((1-Carbamimidoylpiperidin-4-yl)(furan-2-carboxamido)methyl)phosphonate 2,2,2-trifluoroacetateO=C(C1=CC=CO1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4CCN(C(N)=N)CC4.O=C(O)C(F)(F)FSerine protease inhibitor library24% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00178730571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA45Diphenyl ((1-Carbamimidoylpiperidin-4-yl)(cinnamamido)-methyl)phosphonate Bis(2,2,2-trifluoroacetate)O=C(NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3CCN(C(N)=N)CC3)/C=C/C4=CC=CC=C4.O=C(O)C(F)(F)F.O=C(O)C(F)(F)FSerine protease inhibitor library18% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00178830571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA46D i p h e n y l ( ( 1 - C a rbami m i d o y l p i p e r i d i n - 4 - y l ) ( 2 -phenoxyethylsulfonamido)methyl)phosphonate 2,2,2-trifluoroacetateO=S(NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3CCN(C(N)=N)CC3)(CCOC4=CC=CC=C4)=O.O=C(O)C(F)(F)FSerine protease inhibitor library27% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00178930571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA47Diphenyl ((1-Carbamimidoylpiperidin-4-yl)(3-(piperidin-4-yl)-propanamido)methyl)phosphonate bis(2,2,2-trifluoroacetate)O=C(NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3CCN(C(N)=N)CC3)CCC4CCNCC4.O=C(O)C(F)(F)F.O=C(O)C(F)(F)FSerine protease inhibitor library6% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00179030571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA48Diphenyl (E)-Diphenyl ((3-(Benzo[d][1,3]dioxol-5-yl)acrylamido)-(1-carbamimidoylpiperidin-4-yl)methyl)phosphonate 2,2,2-TrifluoroacetateNC(N1CCC(C(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)NC(/C=C/C4=CC=C(OCO5)C5=C4)=O)CC1)=N.O=C(O)C(F)(F)FSerine protease inhibitor library4% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00179130571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA49Diphenyl ((3-(Benzo[d][1,3]dioxol-5-yl)propiolamido)(1-carbamimidoylpiperidin-4-yl)methyl)phosphonateNC(N1CCC(C(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)NC(C#CC4=CC=C(OCO5)C5=C4)=O)CC1)=NSerine protease inhibitor library24% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00179230571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA50Diphenyl ((1-Carbamimidoylpiperidin-4-yl)((5-phenylpyrimidin-2-yl)amino)methyl)phosphonate 2,2,2-trifluoroacetateNC(N1CCC(C(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)NC4=NC=C(C5=CC=CC=C5)C=N4)CC1)=N.O=C(O)C(F)(F)FSerine protease inhibitor library12% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00179330571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA51(Z)-Diphenyl ((1-Carbamimidoylpiperidin - 4 - y l ) ( 3 -phenylacrylamido)methyl)phosphonate 2,2,2-TrifluoroacetateO=C(NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3CCN(C(N)=N)CC3)/C=C\C4=CC=CC=C4.O=C(O)C(F)(F)FSerine protease inhibitor library11% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00179430571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA52Methyl (1-(Diphenoxyphosphoryl)-2-(4-guanidinophenyl)ethyl)-carbamateO=C(OC)NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)CC3=CC=C(NC(N)=N)C=C3Serine protease inhibitor library27% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00179530571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA53Diphenyl (2-(4-Guanidinophenyl)-1-((S)-2-((S)-3-hydroxy-2-(thiophene-2-carboxamido)propanamido)propanamido)ethyl)-phosphonateC[C@H](NC([C@@H](NC(C1=CC=CS1)=O)CO)=O)C(NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C(NC(N)=N)C=C4)=OSerine protease inhibitor library90% at 200 uMNANA49.5NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00179630571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA54P e n t - 4 - y n - 1 - y l ( 1 - ( d i p h e n o x y p h o s p h o r y l ) - 2 - ( 4 -guanidinophenyl)ethyl)carbamateO=C(OCCCC#C)NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)CC3=CC=C(NC(N)=N)C=C3Serine protease inhibitor library23% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00179730571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA552-(2-Azidoethoxy)ethyl (1-(diphenoxyphosphoryl)-2-(4-guanidinophenyl)ethyl)carbamateO=C(OCCOCCN=[N+]=[N-])NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)CC3=CC=C(NC(N)=N)C=C3Serine protease inhibitor library68% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00179830571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA56(Perfluorophenyl)methyl (1-(Diphenoxyphosphoryl)-2-(4-guanidinophenyl)ethyl)carbamate 2,2,2-TrifluoroacetateO=C(OCC1=C(F)C(F)=C(F)C(F)=C1F)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C(NC(N)=N)C=C4Serine protease inhibitor library25% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00179930571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA573,3,4,4,5,5,6,6,7,8,8,8-Dodecafluoro-7-(trifluoromethyl)octyl 1-(Diphenoxyphosphoryl)-2-(4-guanidinophenyl)ethylcarbamate2,2,2-TrifluoroacetateO=C(OCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(C(F)(F)F)(F)C(F)(F)F)NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)CC3=CC=C(NC(N)=N)C=C3.O=C(O)C(F)(F)FSerine protease inhibitor library55% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00180030571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA58Benzyl ((4-Aminophenyl)(diphenoxyphosphoryl)methyl)-carbamateO=C(OCC1=CC=CC=C1)NC(C2=CC=C(N)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=OSerine protease inhibitor library96% at 200 uMNANA39.8NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00180130571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA592-Phenoxyethyl ((4-Aminophenyl)(diphenoxyphosphoryl)-methyl)carbamateO=C(OCCOC1=CC=CC=C1)NC(C2=CC=C(N)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=OSerine protease inhibitor library1% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00180230571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA604,4,4-Trifluorobutyl ((4-Aminophenyl)(diphenoxyphosphoryl)-methyl)carbamateO=C(OCCCC(F)(F)F)NC(C1=CC=C(N)C=C1)P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=OSerine protease inhibitor library<1% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00180330571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA61( P e r fl u o r o p h e n y l ) m e t h y l ( ( 4 - A m i n o p h e n y l ) -(diphenoxyphosphoryl)methyl)carbamateO=C(OCC1=C(F)C(F)=C(F)C(F)=C1F)NC(C2=CC=C(N)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=OSerine protease inhibitor library28% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00180430571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA62Diphenyl ((4-Guanidinophenyl)((4-(trifluoromethyl)phenyl)-sulfonamido)methyl)phosphonateO=S(NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3=CC=C(NC(N)=N)C=C3)(C4=CC=C(C(F)(F)F)C=C4)=OSerine protease inhibitor library27% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00180530571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA63Diphenyl ((4-Guanidinophenyl)(phenylsulfonamido)methyl)-phosphonateO=S(NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3=CC=C(NC(N)=N)C=C3)(C4=CC=CC=C4)=OSerine protease inhibitor library29% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00180630571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA64(Perfluorophenyl)methyl ((Diphenoxyphosphoryl)(4-guanidinophenyl)methyl)carbamateO=C(OCC1=C(F)C(F)=C(F)C(F)=C1F)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=C(NC(N)=N)C=C4Serine protease inhibitor library48% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00180730571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA65Methyl ((Diphenoxyphosphoryl)(4-(2,2,2-trifluoroacetamido)-phenyl)methyl)carbamateO=C(OC)NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3=CC=C(NC(C(F)(F)F)=O)C=C3Serine protease inhibitor library64% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00180830571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA66Benzo[d][1,3]dioxol-5-ylmethyl ((Diphenoxyphosphoryl)(4-(2,2,2-trifluoroacetamido)phenyl)methyl)carbamateO=C(OCC1=CC=C(OCO2)C2=C1)NC(P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O)C5=CC=C(NC(C(F)(F)F)=O)C=C5Serine protease inhibitor library93% at 200 uMNANA8.2NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00180930571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA672-Ami n o e t h y l ((Diphenoxyphosph o r y l ) ( 4 - ( 2 , 2 , 2 -trifluoroacetamido)phenyl)methyl)carbamate 2,2,2-TrifluoroacetateO=C(OCCN)NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3=CC=C(NC(C(F)(F)F)=O)C=C3.O=C(O)C(F)(F)FSerine protease inhibitor library73% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00181030571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA68B e n z y l 2 - ( 4 - ( 3 , 3 - D i m e t h y l u r e i d o ) p h e n y l ) - 1 -(diphenoxyphosphoryl)ethylcarbamateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C(NC(N(C)C)=O)C=C4Serine protease inhibitor library9% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00181130571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA69Benzyl ((4-(2-Aminoethoxy)phenyl)(diphenoxyphosphoryl)-methyl)carbamate 2,2,2-trifluoroacetateO=C(OCC1=CC=CC=C1)NC(C2=CC=C(OCCN)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O.O=C(O)C(F)(F)FSerine protease inhibitor library15% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00181230571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA70Benzyl (1-(Diphenoxyphosphoryl)-3-(4-nitrophenyl)propyl)-carbamateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CCC4=CC=C([N+]([O-])=O)C=C4Serine protease inhibitor library100% at 200 uMNANA13.1NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00181330571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA71Methyl ((4-Carbamimidoylphenyl)(diphenoxyphosphoryl)-methyl)carbamateO=C(OC)NC(C1=CC=C(C(N)=N)C=C1)P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=OSerine protease inhibitor library93% at 200 uMNANA48.1NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00181430571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA72Methyl ((Diphenoxyphosphoryl)(5-nitronaphthalen-1-yl)-methyl)carbamateO=C(OC)NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3=C4C=CC=C([N+]([O-])=O)C4=CC=C3Serine protease inhibitor library17% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00181530571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA73Diphenyl ((1-Carbamimidoylazetidin-3-yl)(pyrimidin-2-ylamino)methyl)phosphonate 2,2,2-trifluoroacetateNC(N1CC(C(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)NC4=NC=CC=N4)C1)=N.O=C(O)C(F)(F)FSerine protease inhibitor library12% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00181630571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA74Diphenyl ((3-(N-Hydroxycarbamimidoyl)phenyl)(pyrimidin-2-ylamino)methyl)phosphonateN=C(C1=CC(C(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)NC4=NC=CC=N4)=CC=C1)NOSerine protease inhibitor library23% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00181730571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA752-(2-(Prop-2-yn-1-yloxy)ethoxy)ethyl (Diphenoxyphosphoryl)(4-(piperazin-1-yl)phenyl)methylcarbamate 2,2,2-TrifluoroacetateO=C(O)C(F)(F)F.O=C(OCCOCCOCC#C)NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3=CC=C(N4CCNCC4)C=C3Serine protease inhibitor library25% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00181830571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA76Benzyl (1-(Diphenoxyphosphoryl)-4-guanidinobutyl)carbamateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CCCNC(N)=NSerine protease inhibitor library15% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00181930571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA77Benzyl (Benzo[d][1,3]dioxol-5-yl(diphenoxyphosphoryl)methyl)-carbamateO=C(OCC1=CC=CC=C1)NC(C2=CC=C(OCO3)C3=C2)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=OSerine protease inhibitor library6% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00182030571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA78Benzyl ((4-(Dimethylamino)phenyl)(diphenoxyphosphoryl)-methyl)carbamateO=C(OCC1=CC=CC=C1)NC(C2=CC=C(N(C)C)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=OSerine protease inhibitor library100% at 200 uMNANA0.6NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00182130571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA79Benzyl ((Diphenoxyphosphoryl)(pyridin-3-yl)methyl)carbamateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=CN=C4Serine protease inhibitor library27% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00182230571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA80Benzyl ((Diphenoxyphosphoryl)(3-nitrophenyl)methyl)-carbamateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=CC([N+]([O-])=O)=C4Serine protease inhibitor library6% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00182330571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA81Benzyl (1-(Diphenoxyphosphoryl)ethyl)carbamateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CSerine protease inhibitor library3% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00182430571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA82Benzyl (1-(Diphenoxyphosphoryl)-3-methylbutyl)carbamateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC(C)CSerine protease inhibitor library4% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00182530571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA83Benzyl ((Diphenoxyphosphoryl)(4-guanidinophenyl)methyl)-carbamateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=C(NC(N)=N)C=C4Serine protease inhibitor library29% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00182630571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA84Benzyl (2-(Benzyloxy)-1-(diphenoxyphosphoryl)ethyl)carbamateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)COCC4=CC=CC=C4Serine protease inhibitor library4% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00182730571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA85Benzyl ((3-Aminophenyl)(diphenoxyphosphoryl)methyl)-carbamateO=C(OCC1=CC=CC=C1)NC(C2=CC=CC(N)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=OSerine protease inhibitor library100% at 200 uMNANA0.5NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00182830571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA86Benzyl ((Diphenoxyphosphoryl)(6-methoxypyridin-2-yl)methyl)-carbamateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=NC(OC)=CC=C4Serine protease inhibitor library100% at 200 uMNANA38NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00182930571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA87Benzyl ((2-Chloro-5-nitrophenyl)(diphenoxyphosphoryl)methyl)-carbamateO=C(OCC1=CC=CC=C1)NC(C2=CC([N+]([O-])=O)=CC=C2Cl)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=OSerine protease inhibitor library6% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00183030571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA88Benzyl ((4-Carbamimidoylphenyl)(diphenoxyphosphoryl)-methyl)carbamateO=C(OCC1=CC=CC=C1)NC(C2=CC=C(C(N)=N)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=OSerine protease inhibitor library30% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00183130571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA89Benzyl ((5-Chloro-1H-indol-3-yl)(diphenoxyphosphoryl)methyl)-carbamateO=C(OCC1=CC=CC=C1)NC(C2=CNC3=C2C=C(Cl)C=C3)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=OSerine protease inhibitor library88% at 200 uMNANA100.5NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00183230571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA90B e n z y l ( ( 6 - C a r b a m i m i d o y l n a p h t h a l e n - 2 - y l ) -(diphenoxyphosphoryl)methyl)carbamateO=C(OCC1=CC=CC=C1)NC(C2=CC=C3C=C(C(N)=N)C=CC3=C2)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=OSerine protease inhibitor library81% at 200 uMNANA79.7NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00183330571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA91Benzyl ((Diphenoxyphosphoryl)(4-nitrophenyl)methyl)-carbamateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=C([N+]([O-])=O)C=C4Serine protease inhibitor library71% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00183430571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA92Benzyl ((3-Carbamimidoylphenyl)(diphenoxyphosphoryl)-methyl)carbamateO=C(OCC1=CC=CC=C1)NC(C2=CC=CC(C(N)=N)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=OSerine protease inhibitor library100% at 200 uMNANA0.5NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00183530571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA93Benzyl (1-(Diphenoxyphosphoryl)-3-phenylpropyl)carbamateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CCC4=CC=CC=C4Serine protease inhibitor library<1% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00183630571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA94Benzyl ((Diphenoxyphosphoryl)(naphthalen-1-yl)methyl)-carbamateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=C5C=CC=CC5=CC=C4Serine protease inhibitor library6% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00183730571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA95Benzyl ((Diphenoxyphosphoryl)(naphthalen-2-yl)methyl)-carbamateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=C5C=CC=CC5=C4Serine protease inhibitor library51% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00183830571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA96Benzyl ((3-Cyanophenyl)(diphenoxyphosphoryl)methyl)-carbamateO=C(OCC1=CC=CC=C1)NC(C2=CC=CC(C#N)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=OSerine protease inhibitor library15% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00183930571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA97B e n z y l ( ( 4 - ( D i m e t h y l a m i n o) n a p h t h a l e n - 1 - y l ) -(diphenoxyphosphoryl)methyl)carbamateO=C(OCC1=CC=CC=C1)NC(C2=C3C=CC=CC3=C(N(C)C)C=C2)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=OSerine protease inhibitor library<1% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00184030571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA98Benzyl ((Diphenoxyphosphoryl)(4-(2,2,2-trifluoroacetamido)-phenyl)methyl)carbamateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=C(NC(C(F)(F)F)=O)C=C4Serine protease inhibitor library15% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00184130571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA107Benzyl ((Diphenoxyphosphoryl)(4-(piperazin-1-yl)phenyl)-methyl)carbamate 2,2,2-trifluoroacetateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=C(N5CCNCC5)C=C4.O=C(O)C(F)(F)FSerine protease inhibitor library100% at 200 uMNANA0.6NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00184230571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA108B e n z y l ( ( 3 - C y a n o - 4 - ( p i p e r a z i n - 1 - y l ) p h e n y l ) -(diphenoxyphosphoryl)methyl)carbamate 2,2,2-trifluoroacetateO=C(OCC1=CC=CC=C1)NC(C2=CC=C(N3CCNCC3)C(C#N)=C2)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=O.O=C(O)C(F)(F)FSerine protease inhibitor library10% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00184330571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA109Benzyl ((Diphenoxyphosphoryl)(piperidin-4-yl)methyl)-carbamate 2,2,2-TrifluoroacetateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4CCNCC4.O=C(O)C(F)(F)FSerine protease inhibitor library30% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00184430571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA110Benzyl 1-(Diphenoxyphosphoryl)-2-(piperidin-4-yl)-ethylcarbamate 2,2,2-TrifluoroacetateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4CCNCC4.O=C(O)C(F)(F)FSerine protease inhibitor library16% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00184530571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA111Benzyl ((4-(Aminomethyl)cyclohexyl)(diphenoxyphosphoryl)-methyl)carbamate 2,2,2-TrifluoroacetateO=C(OCC1=CC=CC=C1)NC(C2CCC(CN)CC2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O.O=C(O)C(F)(F)FSerine protease inhibitor library15% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00184630571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA114Benzyl ((6-Aminonaphthalen-2-yl)(diphenoxyphosphoryl)-methyl)carbamateO=C(OCC1=CC=CC=C1)NC(C2=CC=C3C=C(N)C=CC3=C2)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=OSerine protease inhibitor library<1% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00184730571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA115Benzyl ((1-Carbamimidoylazetidin-3-yl)(diphenoxyphosphoryl)-methyl)carbamate 2,2,2-trifluoroacetateO=C(OCC1=CC=CC=C1)NC(C2CN(C(N)=N)C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O.O=C(O)C(F)(F)FSerine protease inhibitor library100% at 200 uMNANA71.3NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00184830571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA116Benzyl 2-(4-Acetamidophenyl)-1-(diphenoxyphosphoryl)-ethylcarbamateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C(NC(C)=O)C=C4Serine protease inhibitor library18% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00184930571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA117Benzyl ((Diphenoxyphosphoryl)(5-nitronaphthalen-1-yl)methyl)-carbamateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=C5C=CC=C([N+]([O-])=O)C5=CC=C4Serine protease inhibitor library49% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00185030571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA118B e n z y l ( ( 4 - ( D i m e t h y l a m i n o ) - 3 - n i t r o p h e n y l ) -(diphenoxyphosphoryl)methyl)carbamateO=C(OCC1=CC=CC=C1)NC(C2=CC=C(N(C)C)C([N+]([O-])=O)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=OSerine protease inhibitor library39% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00185130571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA120Benzyl (3-(4-Aminophenyl)-1-(diphenoxyphosphoryl)propyl)-carbamateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CCC4=CC=C(N)C=C4Serine protease inhibitor library13% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00185230571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA121B e n z y l ( ( 3 - A m i n o - 4 - ( d i m e t h y l a m i n o ) p h e n y l ) -(diphenoxyphosphoryl)methyl)carbamateO=C(OCC1=CC=CC=C1)NC(C2=CC=C(N(C)C)C(N)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=OSerine protease inhibitor library22% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00185330571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA122Benzyl ((4-Acetamidophenyl)(diphenoxyphosphoryl)methyl)-carbamateO=C(OCC1=CC=CC=C1)NC(C2=CC=C(NC(C)=O)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=OSerine protease inhibitor library8% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00185430571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA123Benzyl ((4-(3,3-Dimethylureido)phenyl)(diphenoxyphosphoryl)-methyl)carbamateO=C(OCC1=CC=CC=C1)NC(C2=CC=C(NC(N(C)C)=O)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=OSerine protease inhibitor library22% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00185530571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA124Benzyl ((Diphenoxyphosphoryl)(3-guanidinophenyl)methyl)-carbamate 2,2,2-trifluoroacetateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=CC(NC(N)=N)=C4.O=C(O)C(F)(F)FSerine protease inhibitor library15% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00185630571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA125Benzyl ((Diphenoxyphosphoryl)(5-guanidinonaphthalen-1-yl)-methyl)carbamate 2,2,2-trifluoroacetateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=C5C=CC=C(NC(N)=N)C5=CC=C4.O=C(O)C(F)(F)FSerine protease inhibitor library38% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00185730571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA126Benzyl (1-(Diphenoxyphosphoryl)-3-(4-(methylsulfonamido)-phenyl)propyl)carbamateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CCC4=CC=C(NS(=O)(C)=O)C=C4Serine protease inhibitor library10% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00185830571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA127Benzyl ((4-(Dimethylamino)-3-(methylsulfonamido)phenyl)-(diphenoxyphosphoryl)methyl)carbamateO=C(OCC1=CC=CC=C1)NC(C2=CC=C(N(C)C)C(NS(=O)(C)=O)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=OSerine protease inhibitor library46% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00185930571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA128Methyl ((Diphenoxyphosphoryl)(3-(trifluoromethyl)phenyl)-methyl)carbamateO=C(OC)NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3=CC=CC(C(F)(F)F)=C3Serine protease inhibitor library4% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00186030571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA129Benzyl (1-(Bis(4-acetamidophenoxy)phosphoryl)-2-(4-(trifluoromethyl)phenyl)ethyl)carbamateO=C(OC(P(OC1=CC=C(NC(C)=O)C=C1)(OC2=CC=C(NC(C)=O)C=C2)=O)CC3=CC=C(C(F)(F)F)C=C3)NCC4=CC=CC=C4Serine protease inhibitor library1% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00186130571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA130Methyl (1-(Bis(4-acetamidophenoxy)phosphoryl)-2-(4-(trifluoromethyl)phenyl)ethyl)carbamateO=C(OC)NC(P(OC1=CC=C(NC(C)=O)C=C1)(OC2=CC=C(NC(C)=O)C=C2)=O)CC3=CC=C(C(F)(F)F)C=C3Serine protease inhibitor library20% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00186230571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA135Methyl ((3-Aminophenyl)(diphenoxyphosphoryl)methyl)-carbamateO=C(OC)NC(C1=CC=CC(N)=C1)P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=OSerine protease inhibitor library7% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00186330571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA136Benzo[d][1,3]dioxol-5-ylmethyl ((3-Aminophenyl)-(diphenoxyphosphoryl)methyl)carbamateO=C(OCC1=CC=C(OCO2)C2=C1)NC(C3=CC=CC(N)=C3)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=OSerine protease inhibitor library20% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00186430571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA137Benzyl ((3-Aminophenyl)(bis(4-acetamidophenoxy)phosphoryl)-methyl)carbamateO=C(OCC1=CC=CC=C1)NC(C2=CC=CC(N)=C2)P(OC3=CC=C(NC(C)=O)C=C3)(OC4=CC=C(NC(C)=O)C=C4)=OSerine protease inhibitor library21% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00186530571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA138Methyl ((3-Aminophenyl)(bis(4-acetamidophenoxy)phosphoryl)-methyl)carbamateO=C(OC)NC(C1=CC=CC(N)=C1)P(OC2=CC=C(NC(C)=O)C=C2)(OC3=CC=C(NC(C)=O)C=C3)=OSerine protease inhibitor library12% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00186630571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA145Methyl ((3-Carbamimidoylphenyl)(diphenoxyphosphoryl)-methyl)carbamateO=C(OC)NC(C1=CC=CC(C(N)=N)=C1)P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=OSerine protease inhibitor library30% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00186730571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA146Benzyl ( ( B is(4-acetamidophenoxy)phosphoryl)( 3-carbamimidoylphenyl)methyl)carbamateO=C(OC(P(OC1=CC=C(NC(C)=O)C=C1)(OC2=CC=C(NC(C)=O)C=C2)=O)C3=CC=CC(C(N)=N)=C3)NCC4=CC=CC=C4Serine protease inhibitor library29% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00186830571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA147Methyl ((Bis(4-acetamidophenoxy)phosphoryl)(3-carbamimidoylphenyl)methyl)carbamateO=C(OC(P(OC1=CC=C(NC(C)=O)C=C1)(OC2=CC=C(NC(C)=O)C=C2)=O)C3=CC=CC(C(N)=N)=C3)NCSerine protease inhibitor library12% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00186930571121Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA151(S)-Benzyl ((3-Aminophenyl)(cyano)methyl)carbamateO=C(OCC1=CC=CC=C1)N[C@@H](C2=CC=CC(N)=C2)C#NSerine protease inhibitor library8% at 200 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00187030571121Hsp100NAHumanNANAAntiproliferative activity16Benzyl (1-(Diphenoxyphosphoryl)-2-(4-(trifluoromethyl)phenyl)-ethyl) carbamateO=C(OC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)CC3=CC=C(C(F)(F)F)C=C3)NCC4=CC=CC=C4Serine protease inhibitor libraryNANANANA100NANANANANANALuminescence based viability assay
HSPMDB00187130571121Hsp100NAHumanNANAAntiproliferative activity53Diphenyl (2-(4-Guanidinophenyl)-1-((S)-2-((S)-3-hydroxy-2-(thiophene-2-carboxamido)propanamido)propanamido)ethyl)-phosphonateC[C@H](NC([C@@H](NC(C1=CC=CS1)=O)CO)=O)C(NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C(NC(N)=N)C=C4)=OSerine protease inhibitor libraryNANANANA100NANANANANANALuminescence based viability assay
HSPMDB00187230571121Hsp100NAHumanNANAAntiproliferative activity58Benzyl ((4-Aminophenyl)(diphenoxyphosphoryl)methyl)-carbamateO=C(OCC1=CC=CC=C1)NC(C2=CC=C(N)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=OSerine protease inhibitor libraryNANANANA100NANANANANANALuminescence based viability assay
HSPMDB00187330571121Hsp100NAHumanNANAAntiproliferative activity66Benzo[d][1,3]dioxol-5-ylmethyl ((Diphenoxyphosphoryl)(4-(2,2,2-trifluoroacetamido)phenyl)methyl)carbamateO=C(OCC1=CC=C(OCO2)C2=C1)NC(P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O)C5=CC=C(NC(C(F)(F)F)=O)C=C5Serine protease inhibitor libraryNANANANA100NANANANANANALuminescence based viability assay
HSPMDB00187430571121Hsp100NAHumanNANAAntiproliferative activity70Benzyl (1-(Diphenoxyphosphoryl)-3-(4-nitrophenyl)propyl)-carbamateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CCC4=CC=C([N+]([O-])=O)C=C4Serine protease inhibitor libraryNANANANA100NANANANANANALuminescence based viability assay
HSPMDB00187530571121Hsp100NAHumanNANAAntiproliferative activity71Methyl ((4-Carbamimidoylphenyl)(diphenoxyphosphoryl)-methyl)carbamateO=C(OC)NC(C1=CC=C(C(N)=N)C=C1)P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=OSerine protease inhibitor libraryNANANANA100NANANANANANALuminescence based viability assay
HSPMDB00187630571121Hsp100NAHumanNANAAntiproliferative activity78Benzyl ((4-(Dimethylamino)phenyl)(diphenoxyphosphoryl)-methyl)carbamateO=C(OCC1=CC=CC=C1)NC(C2=CC=C(N(C)C)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=OSerine protease inhibitor libraryNANANANA100NANANANANANALuminescence based viability assay
HSPMDB00187730571121Hsp100NAHumanNANAAntiproliferative activity85Benzyl ((3-Aminophenyl)(diphenoxyphosphoryl)methyl)-carbamateO=C(OCC1=CC=CC=C1)NC(C2=CC=CC(N)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=OSerine protease inhibitor libraryNANANANA100NANANANANANALuminescence based viability assay
HSPMDB00187830571121Hsp100NAHumanNANAAntiproliferative activity86Benzyl ((Diphenoxyphosphoryl)(6-methoxypyridin-2-yl)methyl)-carbamateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=NC(OC)=CC=C4Serine protease inhibitor libraryNANANANA100NANANANANANALuminescence based viability assay
HSPMDB00187930571121Hsp100NAHumanNANAAntiproliferative activity89Benzyl ((5-Chloro-1H-indol-3-yl)(diphenoxyphosphoryl)methyl)-carbamateO=C(OCC1=CC=CC=C1)NC(C2=CNC3=C2C=C(Cl)C=C3)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=OSerine protease inhibitor libraryNANANANA19.9NANANANANANALuminescence based viability assay
HSPMDB00188030571121Hsp100NAHumanNANAAntiproliferative activity90B e n z y l ( ( 6 - C a r b a m i m i d o y l n a p h t h a l e n - 2 - y l ) -(diphenoxyphosphoryl)methyl)carbamateO=C(OCC1=CC=CC=C1)NC(C2=CC=C3C=C(C(N)=N)C=CC3=C2)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=OSerine protease inhibitor libraryNANANANA19.9NANANANANANALuminescence based viability assay
HSPMDB00188130571121Hsp100NAHumanNANAAntiproliferative activity92Benzyl ((3-Carbamimidoylphenyl)(diphenoxyphosphoryl)-methyl)carbamateO=C(OCC1=CC=CC=C1)NC(C2=CC=CC(C(N)=N)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=OSerine protease inhibitor libraryNANANANA100NANANANANANALuminescence based viability assay
HSPMDB00188230571121Hsp100NAHumanNANAAntiproliferative activity107B e n z y l ( ( 3 - C y a n o - 4 - ( p i p e r a z i n - 1 - y l ) p h e n y l ) -(diphenoxyphosphoryl)methyl)carbamate 2,2,2-trifluoroacetateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=C(N5CCNCC5)C=C4.O=C(O)C(F)(F)FSerine protease inhibitor libraryNANANANA8.6NANANANANANALuminescence based viability assay
HSPMDB00188330571121Hsp100NAHumanNANAAntiproliferative activity115Benzyl ((1-Carbamimidoylazetidin-3-yl)(diphenoxyphosphoryl)-methyl)carbamate 2,2,2-trifluoroacetateO=C(OCC1=CC=CC=C1)NC(C2CN(C(N)=N)C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O.O=C(O)C(F)(F)FSerine protease inhibitor libraryNANANANA100NANANANANANALuminescence based viability assay
HSPMDB00188430571121Hsp100NAHumanNANAAntiproliferative activity16Benzyl (1-(Diphenoxyphosphoryl)-2-(4-(trifluoromethyl)phenyl)-ethyl) carbamateO=C(OC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)CC3=CC=C(C(F)(F)F)C=C3)NCC4=CC=CC=C4Serine protease inhibitor libraryNANANANA100NANANANANANALuminescence based viability assay
HSPMDB00188530571121Hsp100NAHumanNANAAntiproliferative activity53Diphenyl (2-(4-Guanidinophenyl)-1-((S)-2-((S)-3-hydroxy-2-(thiophene-2-carboxamido)propanamido)propanamido)ethyl)-phosphonateC[C@H](NC([C@@H](NC(C1=CC=CS1)=O)CO)=O)C(NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C(NC(N)=N)C=C4)=OSerine protease inhibitor libraryNANANANA100NANANANANANALuminescence based viability assay
HSPMDB00188630571121Hsp100NAHumanNANAAntiproliferative activity58Benzyl ((4-Aminophenyl)(diphenoxyphosphoryl)methyl)-carbamateO=C(OCC1=CC=CC=C1)NC(C2=CC=C(N)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=OSerine protease inhibitor libraryNANANANA100NANANANANANALuminescence based viability assay
HSPMDB00188730571121Hsp100NAHumanNANAAntiproliferative activity66Benzo[d][1,3]dioxol-5-ylmethyl ((Diphenoxyphosphoryl)(4-(2,2,2-trifluoroacetamido)phenyl)methyl)carbamateO=C(OCC1=CC=C(OCO2)C2=C1)NC(P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O)C5=CC=C(NC(C(F)(F)F)=O)C=C5Serine protease inhibitor libraryNANANANA100NANANANANANALuminescence based viability assay
HSPMDB00188830571121Hsp100NAHumanNANAAntiproliferative activity70Benzyl (1-(Diphenoxyphosphoryl)-3-(4-nitrophenyl)propyl)-carbamateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CCC4=CC=C([N+]([O-])=O)C=C4Serine protease inhibitor libraryNANANANA100NANANANANANALuminescence based viability assay
HSPMDB00188930571121Hsp100NAHumanNANAAntiproliferative activity71Methyl ((4-Carbamimidoylphenyl)(diphenoxyphosphoryl)-methyl)carbamateO=C(OC)NC(C1=CC=C(C(N)=N)C=C1)P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=OSerine protease inhibitor libraryNANANANA100NANANANANANALuminescence based viability assay
HSPMDB00189030571121Hsp100NAHumanNANAAntiproliferative activity78Benzyl ((4-(Dimethylamino)phenyl)(diphenoxyphosphoryl)-methyl)carbamateO=C(OCC1=CC=CC=C1)NC(C2=CC=C(N(C)C)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=OSerine protease inhibitor libraryNANANANA28.4NANANANANANALuminescence based viability assay
HSPMDB00189130571121Hsp100NAHumanNANAAntiproliferative activity85Benzyl ((3-Aminophenyl)(diphenoxyphosphoryl)methyl)-carbamateO=C(OCC1=CC=CC=C1)NC(C2=CC=CC(N)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=OSerine protease inhibitor libraryNANANANA23.8NANANANANANALuminescence based viability assay
HSPMDB00189230571121Hsp100NAHumanNANAAntiproliferative activity86Benzyl ((Diphenoxyphosphoryl)(6-methoxypyridin-2-yl)methyl)-carbamateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=NC(OC)=CC=C4Serine protease inhibitor libraryNANANANA100NANANANANANALuminescence based viability assay
HSPMDB00189330571121Hsp100NAHumanNANAAntiproliferative activity89Benzyl ((5-Chloro-1H-indol-3-yl)(diphenoxyphosphoryl)methyl)-carbamateO=C(OCC1=CC=CC=C1)NC(C2=CNC3=C2C=C(Cl)C=C3)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=OSerine protease inhibitor libraryNANANANA10.5NANANANANANALuminescence based viability assay
HSPMDB00189430571121Hsp100NAHumanNANAAntiproliferative activity90B e n z y l ( ( 6 - C a r b a m i m i d o y l n a p h t h a l e n - 2 - y l ) -(diphenoxyphosphoryl)methyl)carbamateO=C(OCC1=CC=CC=C1)NC(C2=CC=C3C=C(C(N)=N)C=CC3=C2)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=OSerine protease inhibitor libraryNANANANA28.3NANANANANANALuminescence based viability assay
HSPMDB00189530571121Hsp100NAHumanNANAAntiproliferative activity92Benzyl ((3-Carbamimidoylphenyl)(diphenoxyphosphoryl)-methyl)carbamateO=C(OCC1=CC=CC=C1)NC(C2=CC=CC(C(N)=N)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=OSerine protease inhibitor libraryNANANANA100NANANANANANALuminescence based viability assay
HSPMDB00189630571121Hsp100NAHumanNANAAntiproliferative activity107B e n z y l ( ( 3 - C y a n o - 4 - ( p i p e r a z i n - 1 - y l ) p h e n y l ) -(diphenoxyphosphoryl)methyl)carbamate 2,2,2-trifluoroacetateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=C(N5CCNCC5)C=C4.O=C(O)C(F)(F)FSerine protease inhibitor libraryNANANANA1.1NANANANANANALuminescence based viability assay
HSPMDB00189730571121Hsp100NAHumanNANAAntiproliferative activity115Benzyl ((1-Carbamimidoylazetidin-3-yl)(diphenoxyphosphoryl)-methyl)carbamate 2,2,2-trifluoroacetateO=C(OCC1=CC=CC=C1)NC(C2CN(C(N)=N)C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O.O=C(O)C(F)(F)FSerine protease inhibitor libraryNANANANA100NANANANANANALuminescence based viability assay
HSPMDB00189830571121Hsp100NAHumanNANAAntiproliferative activity16Benzyl (1-(Diphenoxyphosphoryl)-2-(4-(trifluoromethyl)phenyl)-ethyl) carbamateO=C(OC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)CC3=CC=C(C(F)(F)F)C=C3)NCC4=CC=CC=C4Serine protease inhibitor libraryNANANANA100NANANANANANALuminescence based viability assay
HSPMDB00189930571121Hsp100NAHumanNANAAntiproliferative activity53Diphenyl (2-(4-Guanidinophenyl)-1-((S)-2-((S)-3-hydroxy-2-(thiophene-2-carboxamido)propanamido)propanamido)ethyl)-phosphonateC[C@H](NC([C@@H](NC(C1=CC=CS1)=O)CO)=O)C(NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C(NC(N)=N)C=C4)=OSerine protease inhibitor libraryNANANANA100NANANANANANALuminescence based viability assay
HSPMDB00190030571121Hsp100NAHumanNANAAntiproliferative activity58Benzyl ((4-Aminophenyl)(diphenoxyphosphoryl)methyl)-carbamateO=C(OCC1=CC=CC=C1)NC(C2=CC=C(N)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=OSerine protease inhibitor libraryNANANANA57.8NANANANANANALuminescence based viability assay
HSPMDB00190130571121Hsp100NAHumanNANAAntiproliferative activity66Benzo[d][1,3]dioxol-5-ylmethyl ((Diphenoxyphosphoryl)(4-(2,2,2-trifluoroacetamido)phenyl)methyl)carbamateO=C(OCC1=CC=C(OCO2)C2=C1)NC(P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O)C5=CC=C(NC(C(F)(F)F)=O)C=C5Serine protease inhibitor libraryNANANANA41.5NANANANANANALuminescence based viability assay
HSPMDB00190230571121Hsp100NAHumanNANAAntiproliferative activity70Benzyl (1-(Diphenoxyphosphoryl)-3-(4-nitrophenyl)propyl)-carbamateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CCC4=CC=C([N+]([O-])=O)C=C4Serine protease inhibitor libraryNANANANA100NANANANANANALuminescence based viability assay
HSPMDB00190330571121Hsp100NAHumanNANAAntiproliferative activity71Methyl ((4-Carbamimidoylphenyl)(diphenoxyphosphoryl)-methyl)carbamateO=C(OC)NC(C1=CC=C(C(N)=N)C=C1)P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=OSerine protease inhibitor libraryNANANANA100NANANANANANALuminescence based viability assay
HSPMDB00190430571121Hsp100NAHumanNANAAntiproliferative activity78Benzyl ((4-(Dimethylamino)phenyl)(diphenoxyphosphoryl)-methyl)carbamateO=C(OCC1=CC=CC=C1)NC(C2=CC=C(N(C)C)C=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=OSerine protease inhibitor libraryNANANANA65.6NANANANANANALuminescence based viability assay
HSPMDB00190530571121Hsp100NAHumanNANAAntiproliferative activity85Benzyl ((3-Aminophenyl)(diphenoxyphosphoryl)methyl)-carbamateO=C(OCC1=CC=CC=C1)NC(C2=CC=CC(N)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=OSerine protease inhibitor libraryNANANANA27.5NANANANANANALuminescence based viability assay
HSPMDB00190630571121Hsp100NAHumanNANAAntiproliferative activity86Benzyl ((Diphenoxyphosphoryl)(6-methoxypyridin-2-yl)methyl)-carbamateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=NC(OC)=CC=C4Serine protease inhibitor libraryNANANANA100NANANANANANALuminescence based viability assay
HSPMDB00190730571121Hsp100NAHumanNANAAntiproliferative activity89Benzyl ((5-Chloro-1H-indol-3-yl)(diphenoxyphosphoryl)methyl)-carbamateO=C(OCC1=CC=CC=C1)NC(C2=CNC3=C2C=C(Cl)C=C3)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=OSerine protease inhibitor libraryNANANANA5.9NANANANANANALuminescence based viability assay
HSPMDB00190830571121Hsp100NAHumanNANAAntiproliferative activity90B e n z y l ( ( 6 - C a r b a m i m i d o y l n a p h t h a l e n - 2 - y l ) -(diphenoxyphosphoryl)methyl)carbamateO=C(OCC1=CC=CC=C1)NC(C2=CC=C3C=C(C(N)=N)C=CC3=C2)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=OSerine protease inhibitor libraryNANANANA25.6NANANANANANALuminescence based viability assay
HSPMDB00190930571121Hsp100NAHumanNANAAntiproliferative activity92Benzyl ((3-Carbamimidoylphenyl)(diphenoxyphosphoryl)-methyl)carbamateO=C(OCC1=CC=CC=C1)NC(C2=CC=CC(C(N)=N)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=OSerine protease inhibitor libraryNANANANA100NANANANANANALuminescence based viability assay
HSPMDB00191030571121Hsp100NAHumanNANAAntiproliferative activity107B e n z y l ( ( 3 - C y a n o - 4 - ( p i p e r a z i n - 1 - y l ) p h e n y l ) -(diphenoxyphosphoryl)methyl)carbamate 2,2,2-trifluoroacetateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=C(N5CCNCC5)C=C4.O=C(O)C(F)(F)FSerine protease inhibitor libraryNANANANA0.4NANANANANANALuminescence based viability assay
HSPMDB00191130571121Hsp100NAHumanNANAAntiproliferative activity115Benzyl ((1-Carbamimidoylazetidin-3-yl)(diphenoxyphosphoryl)-methyl)carbamate 2,2,2-trifluoroacetateO=C(OCC1=CC=CC=C1)NC(C2CN(C(N)=N)C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O.O=C(O)C(F)(F)FSerine protease inhibitor libraryNANANANA100NANANANANANALuminescence based viability assay
HSPMDB00191230571121Hsp100NABacteriaNANAAntibacterial activity115Benzyl ((1-Carbamimidoylazetidin-3-yl)(diphenoxyphosphoryl)-methyl)carbamate 2,2,2-trifluoroacetateO=C(OCC1=CC=CC=C1)NC(C2CN(C(N)=N)C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O.O=C(O)C(F)(F)FSerine protease inhibitor libraryNANANANANANANANANANA99.90%Bacterial growth inhibition assay (OD based)
HSPMDB00191330571121Hsp100NABacteriaNANAAntibacterial activity90B e n z y l ( ( 6 - C a r b a m i m i d o y l n a p h t h a l e n - 2 - y l ) -(diphenoxyphosphoryl)methyl)carbamateO=C(OCC1=CC=CC=C1)NC(C2=CC=C3C=C(C(N)=N)C=CC3=C2)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=OSerine protease inhibitor libraryNANANANANANANANANANA98.90%Bacterial growth inhibition assay (OD based)
HSPMDB00191430571121Hsp100NABacteriaNANAAntibacterial activity107B e n z y l ( ( 3 - C y a n o - 4 - ( p i p e r a z i n - 1 - y l ) p h e n y l ) -(diphenoxyphosphoryl)methyl)carbamate 2,2,2-trifluoroacetateO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=C(N5CCNCC5)C=C4.O=C(O)C(F)(F)FSerine protease inhibitor libraryNANANANANANANANANANA69.90%Bacterial growth inhibition assay (OD based)
HSPMDB00191530571121Hsp100NABacteriaNANAAntibacterial activity115Benzyl ((1-Carbamimidoylazetidin-3-yl)(diphenoxyphosphoryl)-methyl)carbamate 2,2,2-trifluoroacetateO=C(OCC1=CC=CC=C1)NC(C2CN(C(N)=N)C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O.O=C(O)C(F)(F)FSerine protease inhibitor libraryNANANANANANANANANANA99%Bacterial growth inhibition assay (OD based)
HSPMDB00191630571121Hsp100NABacteriaNANAAntibacterial activity90B e n z y l ( ( 6 - C a r b a m i m i d o y l n a p h t h a l e n - 2 - y l ) -(diphenoxyphosphoryl)methyl)carbamateO=C(OCC1=CC=CC=C1)NC(C2=CC=C3C=C(C(N)=N)C=CC3=C2)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=OSerine protease inhibitor libraryNANANANANANANANANANA98.50%Bacterial growth inhibition assay (OD based)
HSPMDB00191730571121Hsp100NABacteriaNANAAntibacterial activity90B e n z y l ( ( 6 - C a r b a m i m i d o y l n a p h t h a l e n - 2 - y l ) -(diphenoxyphosphoryl)methyl)carbamateO=C(OCC1=CC=CC=C1)NC(C2=CC=C3C=C(C(N)=N)C=CC3=C2)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=OSerine protease inhibitor libraryNANANANANANANANANANA99.40%Bacterial growth inhibition assay (OD based)
HSPMDB00191830571121Hsp100NABacteriaNANAAntibacterial activity85Benzyl ((3-Aminophenyl)(diphenoxyphosphoryl)methyl)-carbamateO=C(OCC1=CC=CC=C1)NC(C2=CC=CC(N)=C2)P(OC3=CC=CC=C3)(OC4=CC=CC=C4)=OSerine protease inhibitor libraryNANANANANANANANANANANABacterial growth inhibition assay (OD based)
HSPMDB00191921383145Hsp100p97HumanCytosolInhibition of ATPase activity NACID16472035/CID6763522-N,4-N-dibenzylquinazoline-2,4-diamine;hydrochlorideCl.C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4Maybridge, Hitfinder, and NIH molecular librariesNANANA50NANANANANucleotide binding domainATPase assayNANA
HSPMDB00192021383145Hsp100p97HumanCytosolInhibition of ATPase activity NAKSC-1-150/CID8868132-N,4-N-dibenzylquinazoline-2,4-diamine;hydrochlorideCl.C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4Maybridge, Hitfinder, and NIH molecular librariesNANANA50NANANANANucleotide binding domainATPase assayNANA
HSPMDB00192121383145Hsp100p97HumanCytosolInhibition of ATPase activity NAJFD03665(10E)-10-(hydroxymethylidene)-9,10-dihydrophenanthren-9-oneO\C=C1\C(=O)C2=C(C=CC=C2)C2=C1C=CC=C2Maybridge, Hitfinder, and NIH molecular librariesNANANA>50NANANANANucleotide binding domainATPase assayNANA
HSPMDB00192221383145Hsp100p97HumanCytosolInhibition of ATPase activity NAKSC-1-127/CID6763phenanthrene-9,10-dioneC1=CC=C2C(=C1)C3=CC=CC=C3C(=O)C2=OMaybridge, Hitfinder, and NIH molecular librariesNANANA50NANANANANucleotide binding domainATPase assayNANA
HSPMDB00192321383145Hsp100p97HumanCytosolInhibition of ATPase activity NAJFD023421-(4-Methylphenyl)-3-phenyl-2-propyn-1-oneCC1=CC=C(C=C1)C(=O)C#CC2=CC=CC=C2Maybridge, Hitfinder, and NIH molecular librariesNANANA47NANANANANucleotide binding domainATPase assayNANA
HSPMDB00192421383145Hsp100p97HumanCytosolInhibition of ATPase activity NACID9343212-chloro-1-(1-methylindol-3-yl)ethanoneCN1C=C(C2=CC=CC=C21)C(=O)CClMaybridge, Hitfinder, and NIH molecular librariesNANANA50NANANANANucleotide binding domainATPase assayNANA
HSPMDB00192521383145Hsp100p97HumanCytosolInhibition of ATPase activity NAS097569-[(E)-2-nitroethenyl]anthracene[O-][N+](=O)\C=C\C1=C2C=CC=CC2=CC2=C1C=CC=C2Maybridge, Hitfinder, and NIH molecular librariesNANANA0.28NANANANANucleotide binding domainATPase assayNANA
HSPMDB00192621383145Hsp100p97HumanCytosolInhibition of ATPase activity NAJFD005973-(1,3-benzoxazol-2-ylthio)-5,5-dimethylcyclohex-2-en-1-oneO1C(=NC2=C1C=CC=C2)SC2=CC(CC(C2)(C)C)=OMaybridge, Hitfinder, and NIH molecular librariesNANANA>50NANANANANucleotide binding domainATPase assayNANA
HSPMDB00192721383145Hsp100p97HumanCytosolInhibition of ATPase activity NASEW051825-({5-[2-chloro-5-(trifluoromethyl)phenyl]furan-2-yl}methylidene)-2,2-dimethyl-1,3-dioxane-4,6-dioneCC1(C)OC(=O)C(=CC2=CC=C(O2)C2=C(Cl)C=CC(=C2)C(F)(F)F)C(=O)O1Maybridge, Hitfinder, and NIH molecular librariesNANANA10NANANANANucleotide binding domainATPase assayNANA
HSPMDB00192821383145Hsp100p97HumanCytosolInhibition of ATPase activity NACID11094685-amino-4-cyano-N-[(2-methoxynaphthalen-1-yl)methylideneamino]-3-methylthiophene-2-carboxamideCC1=C(SC(=C1C#N)N)C(=O)NN=CC2=C(C=CC3=CC=CC=C32)OCMaybridge, Hitfinder, and NIH molecular librariesNANANA2.6NANANANANucleotide binding domainATPase assayNANA
HSPMDB00192921383145Hsp100p97HumanCytosolInhibition of ATPase activity NAKSC-1-132/CID29396782-[1-hydroxy-4-[(3-nitrophenyl)sulfonylamino]naphthalen-2-yl]sulfanylacetic acidC1=CC=C2C(=C1)C(=CC(=C2O)SCC(=O)O)NS(=O)(=O)C3=CC=CC(=C3)[N+](=O)[O-]Maybridge, Hitfinder, and NIH molecular librariesNANANA50NANANANANucleotide binding domainATPase assayNANA
HSPMDB00193021383145Hsp100p97HumanCytosolInhibition of ATPase activity NAKSC-1-130/CID95864972-[(E)-[4-[(2,4-dichlorophenyl)methoxy]phenyl]methylideneamino]guanidineC1=CC(=CC=C1C=NN=C(N)N)OCC2=C(C=C(C=C2)Cl)ClMaybridge, Hitfinder, and NIH molecular librariesNANANA51NANANANANucleotide binding domainATPase assayNANA
HSPMDB00193121383145Hsp100p97HumanCytosolInhibition of ATPase activity NAKSC-1-204/CID35000862-(5-chloro-1-ethyl-3-nitro-6-oxopyridazin-4-yl)-2-[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]acetonitrileCCN1C(=O)C(=C(C(=N1)[N+](=O)[O-])C(C#N)C2=NC3=C(S2)C=CC(=C3)C(F)(F)F)ClMaybridge, Hitfinder, and NIH molecular librariesNANANA52NANANANANucleotide binding domainATPase assayNANA
HSPMDB00193221383145Hsp100p97HumanCytosolInhibition of ATPase activity NACID54136432-[4-methyl-6-(phenylamino)pyrimidin-2-yl]phenolCC1=CC(NC2=CC=CC=C2)=NC(=N1)C1=C(O)C=CC=C1Maybridge, Hitfinder, and NIH molecular librariesNANANA53NANANANANucleotide binding domainATPase assayNANA
HSPMDB00193321383145Hsp100p97HumanCytosolInhibition of ATPase activity NAKSC-1-131/CID2867539/CID/95672103-[(2E)-2-[(4-methoxyphenyl)methylidene]hydrazinyl]-6-phenyl-4H-1,2,4-triazin-5-oneCOC1=CC=C(C=C1)C=NNC2=NN=C(C(=O)N2)C3=CC=CC=C3Maybridge, Hitfinder, and NIH molecular librariesNANANA54NANANANANucleotide binding domainATPase assayNANA
HSPMDB00193421383145Hsp100p97HumanCytosolInhibition of ATPase activity NAKSC-1-128/CID987585N-(1-benzyl-3-cyanopyrrolo[3,2-b]quinoxalin-2-yl)-2-chlorobenzamideC1=CC=C(C=C1)CN2C(=C(C3=NC4=CC=CC=C4N=C32)C#N)NC(=O)C5=CC=CC=C5ClMaybridge, Hitfinder, and NIH molecular librariesNANANA55NANANANANucleotide binding domainATPase assayNANA
HSPMDB00193521383145Hsp100p97HumanCytosolInhibition of ATPase activity NACID6524677(4Z)-4-[[2-(7-chloroquinolin-4-yl)hydrazinyl]methylidene]-2-hydroxycyclohexa-2,5-dien-1-oneC1=CC2=C(C=CN=C2C=C1Cl)NNC=C3C=CC(=O)C(=C3)OMaybridge, Hitfinder, and NIH molecular librariesNANANA36NANANANANucleotide binding domainATPase assayNANA
HSPMDB00193621383145Hsp100p97HumanCytosolInhibition of ATPase activity NASPB01017[1-(1,3-dithiolan-2-yl)naphthalen-2-yl] thiophene-2-carboxylateC1CSC(S1)C2=C(C=CC3=CC=CC=C32)OC(=O)C4=CC=CS4Maybridge, Hitfinder, and NIH molecular librariesNANANA>50NANANANANucleotide binding domainATPase assayNANA
HSPMDB00193721383145Hsp100p97HumanCytosolInhibition of ATPase activity NAHTS01888N-[4-(3-Chloro-4-methylphenyl)-5-methyl-1,3-thiazol-2-yl]-2,1,3-benzoxadiazole-4-sulfonamideCc1ccc(cc1Cl)c2nc(NS(=O)(=O)c3cccc4nonc34)sc2CMaybridge, Hitfinder, and NIH molecular librariesNANANA14.5NANANANANucleotide binding domainATPase assayNANA
HSPMDB00193821383145Hsp100p97HumanCytosolInhibition of ATPase activity NAKSC-1-129/CID801956methyl 2-[(2-methylbenzoyl)carbamothioylamino]benzoateCC1=CC=CC=C1C(=O)NC(=S)NC2=CC=CC=C2C(=O)OCMaybridge, Hitfinder, and NIH molecular librariesNANANA50NANANANANucleotide binding domainATPase assayNANA
HSPMDB00193921383145Hsp100p97HumanCytosolInhibition of ATPase activity NACID5756550(5Z)-5-[(2-phenyl-1H-indol-3-yl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-oneC1=CC=C(C=C1)C2=C(C3=CC=CC=C3N2)C=C4C(=O)NC(=S)S4Maybridge, Hitfinder, and NIH molecular librariesNANANA50NANANANANucleotide binding domainATPase assayNANA
HSPMDB00194021383145Hsp100p97HumanCytosolInhibition of ATPase activity NACD075816-[(2-chlorophenyl)amino]-2-(2,6-dichlorophenyl)-4-oxo-3,4-dihydro-2H-1,3-thiazine-5-carbonitrileClC1=CC=CC=C1NC1=C(C#N)C(=O)NC(S1)C1=C(Cl)C=CC=C1ClMaybridge, Hitfinder, and NIH molecular librariesNANANA5.9NANANANANucleotide binding domainATPase assayNANA
HSPMDB00194121383145Hsp100p97HumanCytosolInhibition of ATPase activity NACD02660methyl 3-[(E)-[(3,5-dichloro-2-hydroxyphenyl)methylidene]amino]-4-oxo-3,4-dihydroquinazoline-2-carboxylate[H]COC(=O)C1=NC2=C(C=CC=C2)C(=O)N1\N=C\C1=C(O)C(Cl)=CC(Cl)=C1Maybridge, Hitfinder, and NIH molecular librariesNANANA2.5NANANANANucleotide binding domainATPase assayNANA
HSPMDB00194221383145Hsp100p97HumanCytosolInhibition of ATPase activity NASP010863-(5-tert-butyl-2-methylfuran-3-yl)-4-methyl-5-(methylsulfanyl)-1H-pyrazoleCSC1=C(C)C(=NN1)C1=C(C)OC(=C1)C(C)(C)CMaybridge, Hitfinder, and NIH molecular librariesNANANA25NANANANANucleotide binding domainATPase assayNANA
HSPMDB00194321383145Hsp100p97HumanCytosolInhibition of ATPase activity NACID35983,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxyphenyl)methyl]phenolC1=C(C(=C(C(=C1Cl)Cl)CC2=C(C(=CC(=C2Cl)Cl)Cl)O)O)ClMaybridge, Hitfinder, and NIH molecular librariesNANANA5.5NANANANANucleotide binding domainATPase assayNANA
HSPMDB00194421383145Hsp100p97HumanCytosolInhibition of ATPase activity NACID28848852,2-dichloro-N-(4-fluorophenyl)-3-phenylcyclopropane-1-carboxamideC1=CC=C(C=C1)C2C(C2(Cl)Cl)C(=O)NC3=CC=C(C=C3)FMaybridge, Hitfinder, and NIH molecular librariesNANANA50NANANANANucleotide binding domainATPase assayNANA
HSPMDB00194521383145Hsp100p97HumanCytosolInhibition of ATPase activity NACID4099282-[3-(dibutylamino)propyl]isoindole-1,3-dioneCCCCN(CCCC)CCCN1C(=O)C2=CC=CC=C2C1=OMaybridge, Hitfinder, and NIH molecular librariesNANANA50NANANANANucleotide binding domainATPase assayNANA
HSPMDB00194621383145Hsp100p97HumanCytosolInhibition of ATPase activity NACID58751825-amino-6-[(Z)-(2-methylindol-3-ylidene)methyl]-3-methylsulfanyl-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-oneCC1=NC2=CC=CC=C2C1=CC3=C(N4C(=NC3=O)SN=C4SC)NMaybridge, Hitfinder, and NIH molecular librariesNANANA22NANANANANucleotide binding domainATPase assayNANA
HSPMDB00194721383145Hsp100p97HumanCytosolInhibition of ATPase activity NACID161943095-amino-6-[(Z)-(2-methylindol-3-ylidene)methyl]-3-(2-methylpropylsulfonyl)-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-oneCC1=NC2=CC=CC=C2C1=CC3=C(N4C(=NC3=O)SN=C4S(=O)(=O)CC(C)C)NMaybridge, Hitfinder, and NIH molecular librariesNANANA12NANANANANucleotide binding domainATPase assayNANA
HSPMDB00194821383145Hsp100p97HumanCytosolInhibition of ATPase activity NACID56918572-[(6,7-dihydroxy-2-oxochromen-4-yl)methylsulfanyl]-3-(3-methoxyphenyl)quinazolin-4-oneCOC1=CC=CC(=C1)N2C(=O)C3=CC=CC=C3N=C2SCC4=CC(=O)OC5=CC(=C(C=C45)O)OMaybridge, Hitfinder, and NIH molecular librariesNANANA21NANANANANucleotide binding domainATPase assayNANA
HSPMDB00194921383145Hsp100p97HumanCytosolInhibition of ATPase activity NAKSC-1-1206/CID23845382-(chloromethyl)-1H-pyrimido[1,2-a]benzimidazol-4-oneC1=CC=C2C(=C1)N=C3N2C(=O)C=C(N3)CClMaybridge, Hitfinder, and NIH molecular librariesNANANA50NANANANANucleotide binding domainATPase assayNANA
HSPMDB00195021383145Hsp100p97HumanCytosolInhibition of ATPase activity NAKSC-1-202/CID28104452,6-dichloro-N-(2-hydroxy-1,3-dioxoinden-2-yl)benzamideC1=CC=C2C(=C1)C(=O)C(C2=O)(NC(=O)C3=C(C=CC=C3Cl)Cl)OMaybridge, Hitfinder, and NIH molecular librariesNANANA50NANANANANucleotide binding domainATPase assayNANA
HSPMDB00195121383145Hsp100p97HumanCytosolInhibition of ATPase activity NACID21755564-[[4-(2,4-dihydroxyphenyl)-1,3-thiazol-2-yl]amino]benzenesulfonamideC1=CC(=CC=C1NC2=NC(=CS2)C3=C(C=C(C=C3)O)O)S(=O)(=O)NMaybridge, Hitfinder, and NIH molecular librariesNANANA24NANANANANucleotide binding domainATPase assayNANA
HSPMDB00195221383145Hsp100p97HumanCytosolInhibition of ATPase activity NAKSC-1-201/CID28101552-methyl-N-(7-methyl-4-oxothieno[3,2-d][1,3]thiazin-2-yl)benzamideCC1=CC=CC=C1C(=O)NC2=NC3=C(C(=O)S2)SC=C3CMaybridge, Hitfinder, and NIH molecular librariesNANANA50NANANANANucleotide binding domainATPase assayNANA
HSPMDB00195321383145Hsp100p97HumanCytosolInhibition of ATPase activity NAKSC-1-209/CID2472581[2-(1H-indol-3-yl)-2-oxoethyl] 5-nitrothiophene-2-carboxylateC1=CC=C2C(=C1)C(=CN2)C(=O)COC(=O)C3=CC=C(S3)[N+](=O)[O-]Maybridge, Hitfinder, and NIH molecular librariesNANANA51NANANANANucleotide binding domainATPase assayNANA
HSPMDB00195421383145Hsp100p97HumanCytosolInhibition of ATPase activity NAKSC-1-199/CID4072379N'-acridin-9-yl-2,4-dihydroxybenzohydrazideC1=CC=C2C(=C1)C(=C3C=CC=CC3=N2)NNC(=O)C4=C(C=C(C=C4)O)OMaybridge, Hitfinder, and NIH molecular librariesNANANA52NANANANANucleotide binding domainATPase assayNANA
HSPMDB00195521383145Hsp100p97HumanCytosolInhibition of ATPase activity NACID16256804-[5-[(Z)-2-carboxy-2-[(5-methyl-1H-1,2,4-triazol-3-yl)sulfanyl]ethenyl]furan-2-yl]-2-chlorobenzoic acidCC1=NC(=NN1)SC(=CC2=CC=C(O2)C3=CC(=C(C=C3)C(=O)O)Cl)C(=O)OMaybridge, Hitfinder, and NIH molecular librariesNANANA53NANANANANucleotide binding domainATPase assayNANA
HSPMDB00195621383145Hsp100p97HumanCytosolInhibition of ATPase activity NAKM089953-(5-acetylthiophen-2-yl)prop-2-ynyl N-phenylcarbamateCC(=O)C1=CC=C(S1)C#CCOC(=O)NC2=CC=CC=C2Maybridge, Hitfinder, and NIH molecular librariesNANANA7.5NANANANANucleotide binding domainATPase assayNANA
HSPMDB00195721383145Hsp100p97HumanCytosolInhibition of ATPase activity NACID1976446(6E)-5-imino-6-[(4-oxochromen-3-yl)methylidene]-2-pyridin-4-yl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-oneC1=CC=C2C(=C1)C(=O)C(=CO2)C=C3C(=N)N4C(=NC3=O)SC(=N4)C5=CC=NC=C5Maybridge, Hitfinder, and NIH molecular librariesNANANA11NANANANANucleotide binding domainATPase assayNANA
HSPMDB00195821383145Hsp100p97HumanCytosolInhibition of ATPase activity NACID9302387-propan-2-yl-10-thia-8,13,15-triazatetracyclo[7.7.0.02,6.011,16]hexadeca-1,6,8,11(16),13-pentaene-12-thioneCC(C)C1=C2CCCC2=C3C4=C(C(=S)N=CN4)SC3=N1Maybridge, Hitfinder, and NIH molecular librariesNANANA42NANANANANucleotide binding domainATPase assayNANA
HSPMDB00195921383145Hsp100p97HumanCytosolInhibition of ATPase activity NACID29784604-[[4-(2-fluorophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]sulfonylamino]benzoic acidC1C=CC2C1C(NC3=C2C=C(C=C3)S(=O)(=O)NC4=CC=C(C=C4)C(=O)O)C5=CC=CC=C5FMaybridge, Hitfinder, and NIH molecular librariesNANANA19NANANANANucleotide binding domainATPase assayNANA
HSPMDB00196021383145Hsp100p97HumanCytosolInhibition of ATPase activity NACD008233-(1H-indol-3-ylmethylidene)indolin-2-oneO=c1nc2ccccc2c1=Cc1cnc2ccccc21Maybridge, Hitfinder, and NIH molecular librariesNANANA>50NANANANANucleotide binding domainATPase assayNANA
HSPMDB00196121383145Hsp100p97HumanCytosolInhibition of ATPase activity NAJFD015604-pyren-1-ylbutanoic acidC1=CC2=C3C(=C1)C=CC4=C(C=CC(=C43)C=C2)CCCC(=O)OMaybridge, Hitfinder, and NIH molecular librariesNANANA10NANANANANucleotide binding domainATPase assayNANA
HSPMDB00196221383145Hsp100p97HumanCytosolInhibition of ATPase activity NAKSC-1-133/CID5559718(Z)-2-(1,3-benzothiazol-2-yl)-3-hydroxy-4-(4-methylphenyl)sulfanylbut-2-enenitrileCC1=CC=C(C=C1)SCC(=C(C#N)C2=NC3=CC=CC=C3S2)OMaybridge, Hitfinder, and NIH molecular librariesNANANA50NANANANANucleotide binding domainATPase assayNANA
HSPMDB00196321383145Hsp100p97HumanCytosolInhibition of ATPase activity NAKSC-1-205/CID59826533-nitro-4-[(2E)-2-[(2,3,4-trihydroxyphenyl)methylidene]hydrazinyl]benzenesulfonamideC1=CC(=C(C=C1S(=O)(=O)N)[N+](=O)[O-])NN=CC2=C(C(=C(C=C2)O)O)OMaybridge, Hitfinder, and NIH molecular librariesNANANA50NANANANANucleotide binding domainATPase assayNANA
HSPMDB00196421383145Hsp100p97HumanCytosolInhibition of ATPase activity NAKSC-1-232/CID3787408N-[3-(benzenesulfonyl)-1-butylpyrrolo[3,2-b]quinoxalin-2-yl]-4-methylbenzenesulfonamideCCCCN1C(=C(C2=NC3=CC=CC=C3N=C21)S(=O)(=O)C4=CC=CC=C4)NS(=O)(=O)C5=CC=C(C=C5)CMaybridge, Hitfinder, and NIH molecular librariesNANANA50NANANANANucleotide binding domainATPase assayNANA
HSPMDB00196521383145Hsp100p97HumanCytosolInhibition of ATPase activity NAKSC-1-233/CID2044030N-(1-benzylpyrrolo[3,2-b]quinoxalin-2-yl)-4-chlorobenzenesulfonamideC1=CC=C(C=C1)CN2C(=CC3=NC4=CC=CC=C4N=C32)NS(=O)(=O)C5=CC=C(C=C5)ClMaybridge, Hitfinder, and NIH molecular librariesNANANA50NANANANANucleotide binding domainATPase assayNANA
HSPMDB00196621383145Hsp100p97HumanCytosolInhibition of ATPase activity NACD025063-{bicyclo[2.2.1]hept-5-en-2-yl}-1-{[(4-bromo-3-chlorophenyl)carbamothioyl]amino}thioureaClC1=CC(NC(=S)NNC(=S)NC2CC3CC2C=C3)=CC=C1BrMaybridge, Hitfinder, and NIH molecular librariesNANANA3.2NANANANANucleotide binding domainATPase assayNANA
HSPMDB00196721383145Hsp100p97HumanCytosolInhibition of ATPase activity NACD06082N-{[(2,5-dichlorophenyl)carbamothioyl]amino}-2-{[(E)-[(2,4-dichlorophenyl)methylidene]amino]oxy}acetamideClC1=CC(Cl)=C(\C=N\OCC(=O)NNC(=S)NC2=C(Cl)C=CC(Cl)=C2)C=C1Maybridge, Hitfinder, and NIH molecular librariesNANANA2.2NANANANANucleotide binding domainATPase assayNANA
HSPMDB00196821383145Hsp100p97HumanCytosolInhibition of ATPase activity NACID1601155,6,8-trihydroxy-2-methyl-9-(5,6,8-trihydroxy-2-methyl-4-oxo-2,3-dihydrobenzo[g]chromen-9-yl)-2,3-dihydrobenzo[g]chromen-4-oneCC1CC(=O)C2=C(O1)C=C3C(=C2O)C(=CC(=C3C4=C(C=C(C5=C(C6=C(C=C54)OC(CC6=O)C)O)O)O)O)OMaybridge, Hitfinder, and NIH molecular librariesNANANA44NANANANANucleotide binding domainATPase assayNANA
HSPMDB00196921383145Hsp100p97HumanCytosolInhibition of ATPase activity NACID16472035/CID6763522-N,4-N-dibenzylquinazoline-2,4-diamine;hydrochlorideC1=CC=C(C=C1)CNC2=NC(=NC3=CC=CC=C32)NCC4=CC=CC=C4.ClMaybridge, Hitfinder, and NIH molecular librariesNANANA1.5NANANANANucleotide binding domainATPase assayNANA
HSPMDB00197021383145Hsp100p97HumanCytosolInhibition of ATPase activity NAKSC-1-150/CID886813N-benzyl-2-(2-fluorophenyl)quinazolin-4-amineFc1ccccc1c2nc(NCc3ccccc3)c4ccccc4n2Maybridge, Hitfinder, and NIH molecular librariesNANANA3NANANANANucleotide binding domainATPase assayNANA
HSPMDB00197121383145Hsp100p97HumanCytosolInhibition of ATPase activity NAJFD03665(10E)-10-(hydroxymethylidene)-9,10-dihydrophenanthren-9-oneO\C=C1\C(=O)C2=C(C=CC=C2)C2=C1C=CC=C2Maybridge, Hitfinder, and NIH molecular librariesNANANA0.26NANANANANucleotide binding domainATPase assayNANA
HSPMDB00197221383145Hsp100p97HumanCytosolInhibition of ATPase activity NAKSC-1-127/CID6763phenanthrene-9,10-dioneC1=CC=C2C(=C1)C3=CC=CC=C3C(=O)C2=OMaybridge, Hitfinder, and NIH molecular librariesNANANA3.5NANANANANucleotide binding domainATPase assayNANA
HSPMDB00197321383145Hsp100p97HumanCytosolInhibition of ATPase activity NAJFD023421-(4-Methylphenyl)-3-phenyl-2-propyn-1-oneCC1=CC=C(C=C1)C(=O)C#CC2=CC=CC=C2Maybridge, Hitfinder, and NIH molecular librariesNANANA0.2NANANANANucleotide binding domainATPase assayNANA
HSPMDB00197421383145Hsp100p97HumanCytosolInhibition of ATPase activity NACID9343212-chloro-1-(1-methylindol-3-yl)ethanoneCN1C=C(C2=CC=CC=C21)C(=O)CClMaybridge, Hitfinder, and NIH molecular librariesNANANA1.3NANANANANucleotide binding domainATPase assayNANA
HSPMDB00197521383145Hsp100p97HumanCytosolInhibition of ATPase activity NAS097569-[(E)-2-nitroethenyl]anthracene[O-][N+](=O)\C=C\C1=C2C=CC=CC2=CC2=C1C=CC=C2Maybridge, Hitfinder, and NIH molecular librariesNANANA0.8NANANANANucleotide binding domainATPase assayNANA
HSPMDB00197621383145Hsp100p97HumanCytosolInhibition of ATPase activity NAJFD005973-(1,3-benzoxazol-2-ylthio)-5,5-dimethylcyclohex-2-en-1-oneO1C(=NC2=C1C=CC=C2)SC2=CC(CC(C2)(C)C)=OMaybridge, Hitfinder, and NIH molecular librariesNANANA6.1NANANANANucleotide binding domainATPase assayNANA
HSPMDB00197721383145Hsp100p97HumanCytosolInhibition of ATPase activity NASEW051825-({5-[2-chloro-5-(trifluoromethyl)phenyl]furan-2-yl}methylidene)-2,2-dimethyl-1,3-dioxane-4,6-dioneCC1(C)OC(=O)C(=CC2=CC=C(O2)C2=C(Cl)C=CC(=C2)C(F)(F)F)C(=O)O1Maybridge, Hitfinder, and NIH molecular librariesNANANA13NANANANANucleotide binding domainATPase assayNANA
HSPMDB00197821383145Hsp100p97HumanCytosolInhibition of ATPase activity NACID11094685-amino-4-cyano-N-[(2-methoxynaphthalen-1-yl)methylideneamino]-3-methylthiophene-2-carboxamideCC1=C(SC(=C1C#N)N)C(=O)NN=CC2=C(C=CC3=CC=CC=C32)OCMaybridge, Hitfinder, and NIH molecular librariesNANANA2NANANANANucleotide binding domainATPase assayNANA
HSPMDB00197921383145Hsp100p97HumanCytosolInhibition of ATPase activity NAKSC-1-132/CID29396782-[1-hydroxy-4-[(3-nitrophenyl)sulfonylamino]naphthalen-2-yl]sulfanylacetic acidC1=CC=C2C(=C1)C(=CC(=C2O)SCC(=O)O)NS(=O)(=O)C3=CC=CC(=C3)[N+](=O)[O-]Maybridge, Hitfinder, and NIH molecular librariesNANANA24NANANANANucleotide binding domainATPase assayNANA
HSPMDB00198021383145Hsp100p97HumanCytosolInhibition of ATPase activity NAKSC-1-130/CID95864972-[(E)-[4-[(2,4-dichlorophenyl)methoxy]phenyl]methylideneamino]guanidineC1=CC(=CC=C1C=NN=C(N)N)OCC2=C(C=C(C=C2)Cl)ClMaybridge, Hitfinder, and NIH molecular librariesNANANA24NANANANANucleotide binding domainATPase assayNANA
HSPMDB00198121383145Hsp100p97HumanCytosolInhibition of ATPase activity NAKSC-1-204/CID35000862-(5-chloro-1-ethyl-3-nitro-6-oxopyridazin-4-yl)-2-[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]acetonitrileCCN1C(=O)C(=C(C(=N1)[N+](=O)[O-])C(C#N)C2=NC3=C(S2)C=CC(=C3)C(F)(F)F)ClMaybridge, Hitfinder, and NIH molecular librariesNANANA14NANANANANucleotide binding domainATPase assayNANA
HSPMDB00198221383145Hsp100p97HumanCytosolInhibition of ATPase activity NACID54136432-[4-methyl-6-(phenylamino)pyrimidin-2-yl]phenolCC1=CC(NC2=CC=CC=C2)=NC(=N1)C1=C(O)C=CC=C1Maybridge, Hitfinder, and NIH molecular librariesNANANA10NANANANANucleotide binding domainATPase assayNANA
HSPMDB00198321383145Hsp100p97HumanCytosolInhibition of ATPase activity NAKSC-1-131/CID2867539/CID/95672103-[(2E)-2-[(4-methoxyphenyl)methylidene]hydrazinyl]-6-phenyl-4H-1,2,4-triazin-5-oneCOC1=CC=C(C=C1)C=NNC2=NN=C(C(=O)N2)C3=CC=CC=C3Maybridge, Hitfinder, and NIH molecular librariesNANANA>30 NANANANANucleotide binding domainATPase assayNANA
HSPMDB00198421383145Hsp100p97HumanCytosolInhibition of ATPase activity NAKSC-1-128/CID987585N-(1-benzyl-3-cyanopyrrolo[3,2-b]quinoxalin-2-yl)-2-chlorobenzamideC1=CC=C(C=C1)CN2C(=C(C3=NC4=CC=CC=C4N=C32)C#N)NC(=O)C5=CC=CC=C5ClMaybridge, Hitfinder, and NIH molecular librariesNANANA147NANANANANucleotide binding domainATPase assayNANA
HSPMDB00198521383145Hsp100p97HumanCytosolInhibition of ATPase activity NACID6524677(4Z)-4-[[2-(7-chloroquinolin-4-yl)hydrazinyl]methylidene]-2-hydroxycyclohexa-2,5-dien-1-oneC1=CC2=C(C=CN=C2C=C1Cl)NNC=C3C=CC(=O)C(=C3)OMaybridge, Hitfinder, and NIH molecular librariesNANANA4.9NANANANANucleotide binding domainATPase assayNANA
HSPMDB00198621383145Hsp100p97HumanCytosolInhibition of ATPase activity NASPB01017[1-(1,3-dithiolan-2-yl)naphthalen-2-yl] thiophene-2-carboxylateC1CSC(S1)C2=C(C=CC3=CC=CC=C32)OC(=O)C4=CC=CS4Maybridge, Hitfinder, and NIH molecular librariesNANANA6.4NANANANANucleotide binding domainATPase assayNANA
HSPMDB00198721383145Hsp100p97HumanCytosolInhibition of ATPase activity NAHTS01888N-[4-(3-Chloro-4-methylphenyl)-5-methyl-1,3-thiazol-2-yl]-2,1,3-benzoxadiazole-4-sulfonamideCc1ccc(cc1Cl)c2nc(NS(=O)(=O)c3cccc4nonc34)sc2CMaybridge, Hitfinder, and NIH molecular librariesNANANA19NANANANANucleotide binding domainATPase assayNANA
HSPMDB00198821383145Hsp100p97HumanCytosolInhibition of ATPase activity NAKSC-1-129/CID801956methyl 2-[(2-methylbenzoyl)carbamothioylamino]benzoateCC1=CC=CC=C1C(=O)NC(=S)NC2=CC=CC=C2C(=O)OCMaybridge, Hitfinder, and NIH molecular librariesNANANA1.1NANANANANucleotide binding domainATPase assayNANA
HSPMDB00198921383145Hsp100p97HumanCytosolInhibition of ATPase activity NACID5756550(5Z)-5-[(2-phenyl-1H-indol-3-yl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-oneC1=CC=C(C=C1)C2=C(C3=CC=CC=C3N2)C=C4C(=O)NC(=S)S4Maybridge, Hitfinder, and NIH molecular librariesNANANA34NANANANANucleotide binding domainATPase assayNANA
HSPMDB00199021383145Hsp100p97HumanCytosolInhibition of ATPase activity NACD075816-[(2-chlorophenyl)amino]-2-(2,6-dichlorophenyl)-4-oxo-3,4-dihydro-2H-1,3-thiazine-5-carbonitrileClC1=CC=CC=C1NC1=C(C#N)C(=O)NC(S1)C1=C(Cl)C=CC=C1ClMaybridge, Hitfinder, and NIH molecular librariesNANANA4NANANANANucleotide binding domainATPase assayNANA
HSPMDB00199121383145Hsp100p97HumanCytosolInhibition of ATPase activity NACD02660ethyl 3-[(E)-[(3,5-dichloro-2-hydroxyphenyl)methylidene]amino]-4-oxo-3,4-dihydroquinazoline-2-carboxylateCCOC(=O)C1=NC2=C(C=CC=C2)C(=O)N1\N=C\C1=C(O)C(Cl)=CC(Cl)=C1Maybridge, Hitfinder, and NIH molecular librariesNANANA>50 NANANANANucleotide binding domainATPase assayNANA
HSPMDB00199221383145Hsp100p97HumanCytosolInhibition of ATPase activity NASP010863-(5-tert-butyl-2-methylfuran-3-yl)-4-methyl-5-(methylsulfanyl)-1H-pyrazoleCSC1=C(C)C(=NN1)C1=C(C)OC(=C1)C(C)(C)CMaybridge, Hitfinder, and NIH molecular librariesNANANA>50 NANANANANucleotide binding domainATPase assayNANA
HSPMDB00199321383145Hsp100p97HumanCytosolInhibition of ATPase activity NACID35983,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxyphenyl)methyl]phenolC1=C(C(=C(C(=C1Cl)Cl)CC2=C(C(=CC(=C2Cl)Cl)Cl)O)O)ClMaybridge, Hitfinder, and NIH molecular librariesNANANA2.7NANANANANucleotide binding domainATPase assayNANA
HSPMDB00199421383145Hsp100p97HumanCytosolInhibition of ATPase activity NACID28848852,2-dichloro-N-(4-fluorophenyl)-3-phenylcyclopropane-1-carboxamideC1=CC=C(C=C1)C2C(C2(Cl)Cl)C(=O)NC3=CC=C(C=C3)FMaybridge, Hitfinder, and NIH molecular librariesNANANA0.15NANANANANucleotide binding domainATPase assayNANA
HSPMDB00199521383145Hsp100p97HumanCytosolInhibition of ATPase activity NACID4099282-[3-(dibutylamino)propyl]isoindole-1,3-dioneCCCCN(CCCC)CCCN1C(=O)C2=CC=CC=C2C1=OMaybridge, Hitfinder, and NIH molecular librariesNANANA2.6NANANANANucleotide binding domainATPase assayNANA
HSPMDB00199621383145Hsp100p97HumanCytosolInhibition of ATPase activity NACID58751825-amino-6-[(Z)-(2-methylindol-3-ylidene)methyl]-3-methylsulfanyl-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-oneCC1=NC2=CC=CC=C2C1=CC3=C(N4C(=NC3=O)SN=C4SC)NMaybridge, Hitfinder, and NIH molecular librariesNANANA8.3NANANANANucleotide binding domainATPase assayNANA
HSPMDB00199721383145Hsp100p97HumanCytosolInhibition of ATPase activity NACID161943095-amino-6-[(Z)-(2-methylindol-3-ylidene)methyl]-3-(2-methylpropylsulfonyl)-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-oneCC1=NC2=CC=CC=C2C1=CC3=C(N4C(=NC3=O)SN=C4S(=O)(=O)CC(C)C)NMaybridge, Hitfinder, and NIH molecular librariesNANANA7.8NANANANANucleotide binding domainATPase assayNANA
HSPMDB00199821383145Hsp100p97HumanCytosolInhibition of ATPase activity NACID56918572-[(6,7-dihydroxy-2-oxochromen-4-yl)methylsulfanyl]-3-(3-methoxyphenyl)quinazolin-4-oneCOC1=CC=CC(=C1)N2C(=O)C3=CC=CC=C3N=C2SCC4=CC(=O)OC5=CC(=C(C=C45)O)OMaybridge, Hitfinder, and NIH molecular librariesNANANA4.1NANANANANucleotide binding domainATPase assayNANA
HSPMDB00199921383145Hsp100p97HumanCytosolInhibition of ATPase activity NAKSC-1-1206/CID23845382-(chloromethyl)-1H-pyrimido[1,2-a]benzimidazol-4-oneC1=CC=C2C(=C1)N=C3N2C(=O)C=C(N3)CClMaybridge, Hitfinder, and NIH molecular librariesNANANA3.9NANANANANucleotide binding domainATPase assayNANA
HSPMDB00200021383145Hsp100p97HumanCytosolInhibition of ATPase activity NAKSC-1-202/CID28104452,6-dichloro-N-(2-hydroxy-1,3-dioxoinden-2-yl)benzamideC1=CC=C2C(=C1)C(=O)C(C2=O)(NC(=O)C3=C(C=CC=C3Cl)Cl)OMaybridge, Hitfinder, and NIH molecular librariesNANANA>30 NANANANANucleotide binding domainATPase assayNANA
HSPMDB00200121383145Hsp100p97HumanCytosolInhibition of ATPase activity NACID21755564-[[4-(2,4-dihydroxyphenyl)-1,3-thiazol-2-yl]amino]benzenesulfonamideC1=CC(=CC=C1NC2=NC(=CS2)C3=C(C=C(C=C3)O)O)S(=O)(=O)NMaybridge, Hitfinder, and NIH molecular librariesNANANA3.7NANANANANucleotide binding domainATPase assayNANA
HSPMDB00200221383145Hsp100p97HumanCytosolInhibition of ATPase activity NAKSC-1-201/CID28101552-methyl-N-(7-methyl-4-oxothieno[3,2-d][1,3]thiazin-2-yl)benzamideCC1=CC=CC=C1C(=O)NC2=NC3=C(C(=O)S2)SC=C3CMaybridge, Hitfinder, and NIH molecular librariesNANANA104NANANANANucleotide binding domainATPase assayNANA
HSPMDB00200321383145Hsp100p97HumanCytosolInhibition of ATPase activity NAKSC-1-209/CID2472581[2-(1H-indol-3-yl)-2-oxoethyl] 5-nitrothiophene-2-carboxylateC1=CC=C2C(=C1)C(=CN2)C(=O)COC(=O)C3=CC=C(S3)[N+](=O)[O-]Maybridge, Hitfinder, and NIH molecular librariesNANANA92NANANANANucleotide binding domainATPase assayNANA
HSPMDB00200421383145Hsp100p97HumanCytosolInhibition of ATPase activity NAKSC-1-199/CID4072379N'-acridin-9-yl-2,4-dihydroxybenzohydrazideC1=CC=C2C(=C1)C(=C3C=CC=CC3=N2)NNC(=O)C4=C(C=C(C=C4)O)OMaybridge, Hitfinder, and NIH molecular librariesNANANA18NANANANANucleotide binding domainATPase assayNANA
HSPMDB00200521383145Hsp100p97HumanCytosolInhibition of ATPase activity NACID16256804-[5-[(Z)-2-carboxy-2-[(5-methyl-1H-1,2,4-triazol-3-yl)sulfanyl]ethenyl]furan-2-yl]-2-chlorobenzoic acidCC1=NC(=NN1)SC(=CC2=CC=C(O2)C3=CC(=C(C=C3)C(=O)O)Cl)C(=O)OMaybridge, Hitfinder, and NIH molecular librariesNANANA0.85NANANANANucleotide binding domainATPase assayNANA
HSPMDB00200621383145Hsp100p97HumanCytosolInhibition of ATPase activity NAKM089953-(5-acetylthiophen-2-yl)prop-2-ynyl N-phenylcarbamateCC(=O)C1=CC=C(S1)C#CCOC(=O)NC2=CC=CC=C2Maybridge, Hitfinder, and NIH molecular librariesNANANA1.4NANANANANucleotide binding domainATPase assayNANA
HSPMDB00200721383145Hsp100p97HumanCytosolInhibition of ATPase activity NACID1976446(6E)-5-imino-6-[(4-oxochromen-3-yl)methylidene]-2-pyridin-4-yl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-oneC1=CC=C2C(=C1)C(=O)C(=CO2)C=C3C(=N)N4C(=NC3=O)SC(=N4)C5=CC=NC=C5Maybridge, Hitfinder, and NIH molecular librariesNANANA3.6NANANANANucleotide binding domainATPase assayNANA
HSPMDB00200821383145Hsp100p97HumanCytosolInhibition of ATPase activity NACID9302387-propan-2-yl-10-thia-8,13,15-triazatetracyclo[7.7.0.02,6.011,16]hexadeca-1,6,8,11(16),13-pentaene-12-thioneCC(C)C1=C2CCCC2=C3C4=C(C(=S)N=CN4)SC3=N1Maybridge, Hitfinder, and NIH molecular librariesNANANA5.2NANANANANucleotide binding domainATPase assayNANA
HSPMDB00200921383145Hsp100p97HumanCytosolInhibition of ATPase activity NACID29784604-[[4-(2-fluorophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]sulfonylamino]benzoic acidC1C=CC2C1C(NC3=C2C=C(C=C3)S(=O)(=O)NC4=CC=C(C=C4)C(=O)O)C5=CC=CC=C5FMaybridge, Hitfinder, and NIH molecular librariesNANANA9NANANANANucleotide binding domainATPase assayNANA
HSPMDB00201021383145Hsp100p97HumanCytosolInhibition of ATPase activity NACD008233-(1H-indol-3-ylmethylidene)indolin-2-oneO=c1nc2ccccc2c1=Cc1cnc2ccccc21Maybridge, Hitfinder, and NIH molecular librariesNANANA9.2NANANANANucleotide binding domainATPase assayNANA
HSPMDB00201121383145Hsp100p97HumanCytosolInhibition of ATPase activity NAJFD015604-pyren-1-ylbutanoic acidC1=CC2=C3C(=C1)C=CC4=C(C=CC(=C43)C=C2)CCCC(=O)OMaybridge, Hitfinder, and NIH molecular librariesNANANA12NANANANANucleotide binding domainATPase assayNANA
HSPMDB00201221383145Hsp100p97HumanCytosolInhibition of ATPase activity NAKSC-1-133/CID5559718(Z)-2-(1,3-benzothiazol-2-yl)-3-hydroxy-4-(4-methylphenyl)sulfanylbut-2-enenitrileCC1=CC=C(C=C1)SCC(=C(C#N)C2=NC3=CC=CC=C3S2)OMaybridge, Hitfinder, and NIH molecular librariesNANANA8.8NANANANANucleotide binding domainATPase assayNANA
HSPMDB00201321383145Hsp100p97HumanCytosolInhibition of ATPase activity NAKSC-1-205/CID59826533-nitro-4-[(2E)-2-[(2,3,4-trihydroxyphenyl)methylidene]hydrazinyl]benzenesulfonamideC1=CC(=C(C=C1S(=O)(=O)N)[N+](=O)[O-])NN=CC2=C(C(=C(C=C2)O)O)OMaybridge, Hitfinder, and NIH molecular librariesNANANA>30NANANANANucleotide binding domainATPase assayNANA
HSPMDB00201421383145Hsp100p97HumanCytosolInhibition of ATPase activity NAKSC-1-232/CID3787408N-[3-(benzenesulfonyl)-1-butylpyrrolo[3,2-b]quinoxalin-2-yl]-4-methylbenzenesulfonamideCCCCN1C(=C(C2=NC3=CC=CC=C3N=C21)S(=O)(=O)C4=CC=CC=C4)NS(=O)(=O)C5=CC=C(C=C5)CMaybridge, Hitfinder, and NIH molecular librariesNANANA>30 NANANANANucleotide binding domainATPase assayNANA
HSPMDB00201521383145Hsp100p97HumanCytosolInhibition of ATPase activity NAKSC-1-233/CID2044030N-(1-benzylpyrrolo[3,2-b]quinoxalin-2-yl)-4-chlorobenzenesulfonamideC1=CC=C(C=C1)CN2C(=CC3=NC4=CC=CC=C4N=C32)NS(=O)(=O)C5=CC=C(C=C5)ClMaybridge, Hitfinder, and NIH molecular librariesNANANA80NANANANANucleotide binding domainATPase assayNANA
HSPMDB00201621383145Hsp100p97HumanCytosolInhibition of ATPase activity NACD025063-{bicyclo[2.2.1]hept-5-en-2-yl}-1-{[(4-bromo-3-chlorophenyl)carbamothioyl]amino}thioureaClC1=CC(NC(=S)NNC(=S)NC2CC3CC2C=C3)=CC=C1BrMaybridge, Hitfinder, and NIH molecular librariesNANANA>30NANANANANucleotide binding domainATPase assayNANA
HSPMDB00201721383145Hsp100p97HumanCytosolInhibition of ATPase activity NACD06082N-{[(2,5-dichlorophenyl)carbamothioyl]amino}-2-{[(E)-[(2,4-dichlorophenyl)methylidene]amino]oxy}acetamideClC1=CC(Cl)=C(\C=N\OCC(=O)NNC(=S)NC2=C(Cl)C=CC(Cl)=C2)C=C1Maybridge, Hitfinder, and NIH molecular librariesNANANA20NANANANANucleotide binding domainATPase assayNANA
HSPMDB00201821383145Hsp100p97HumanCytosolInhibition of ATPase activity NACID1601155,6,8-trihydroxy-2-methyl-9-(5,6,8-trihydroxy-2-methyl-4-oxo-2,3-dihydrobenzo[g]chromen-9-yl)-2,3-dihydrobenzo[g]chromen-4-oneCC1CC(=O)C2=C(O1)C=C3C(=C2O)C(=CC(=C3C4=C(C=C(C5=C(C6=C(C=C54)OC(CC6=O)C)O)O)O)O)OMaybridge, Hitfinder, and NIH molecular librariesNANANA>30NANANANANucleotide binding domainATPase assayNANA
HSPMDB00201921383145Hsp100p97HumanCytosolInhibition of ATPase activity NAEeyarestatin I (Eerl)2-[3-(4-chlorophenyl)-4-[(4-chlorophenyl)carbamoyl-hydroxyamino]-5,5-dimethyl-2-oxoimidazolidin-1-yl]-N-[(E)-[(E)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]acetamideCC1(C(N(C(=O)N1CC(=O)NN=CC=CC2=CC=C(O2)[N+](=O)[O-])C3=CC=C(C=C3)Cl)N(C(=O)NC4=CC=C(C=C4)Cl)O)CMaybridge, Hitfinder, and NIH molecular librariesNANANA>30NANANANANucleotide binding domainATPase assayNANA
HSPMDB00202021383145Hsp100p97HumanCytosolInhibition of ATPase activity NAMyriad 19/KSC-1-2754-[(4-phenyl-1,3-thiazol-2-yl)amino]phenolC1=CC=C(C=C1)C2=CSC(=N2)NC3=CC=C(C=C3)OMaybridge, Hitfinder, and NIH molecular librariesNANANA21NANANANANucleotide binding domainATPase assayNANA
HSPMDB00202121383145Hsp100p97HumanCytosolInhibition of ATPase activity NAMyriad 12/KSC-1-2774-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]amino]phenolC1=CC(=CC=C1C2=CSC(=N2)NC3=CC=C(C=C3)O)ClMaybridge, Hitfinder, and NIH molecular librariesNANANA20NANANANANucleotide binding domainATPase assayNANA
HSPMDB00202221383145Hsp100p97HumanCytosolInhibition of ATPase activity NAKSC-16-54-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]imino]cyclohexa-2,5-dien-1-oneC1=CC(=O)C=CC1=NC2=NC(=CS2)C3=CC=C(C=C3)ClMaybridge, Hitfinder, and NIH molecular librariesNANANA68NANANANANucleotide binding domainATPase assayNANA
HSPMDB00202321383145Hsp100p97HumanCytosolNASubstrate degradation activityCID16472035/CID6763522-N,4-N-dibenzylquinazoline-2,4-diamine;hydrochlorideC1=CC=C(C=C1)CNC2=NC(=NC3=CC=CC=C32)NCC4=CC=CC=C4.ClMaybridge, Hitfinder, and NIH molecular librariesNANANA2.6NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00202421383145Hsp100p97HumanCytosolNASubstrate degradation activityKSC-1-150/CID886813N-benzyl-2-(2-fluorophenyl)quinazolin-4-amineFc1ccccc1c2nc(NCc3ccccc3)c4ccccc4n2Maybridge, Hitfinder, and NIH molecular librariesNANANA9NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00202521383145Hsp100p97HumanCytosolNASubstrate degradation activityJFD03665(10E)-10-(hydroxymethylidene)-9,10-dihydrophenanthren-9-oneO\C=C1\C(=O)C2=C(C=CC=C2)C2=C1C=CC=C2Maybridge, Hitfinder, and NIH molecular librariesNANANA1.1NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00202621383145Hsp100p97HumanCytosolNASubstrate degradation activityKSC-1-127/CID6763phenanthrene-9,10-dioneC1=CC=C2C(=C1)C3=CC=CC=C3C(=O)C2=OMaybridge, Hitfinder, and NIH molecular librariesNANANA1.3NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00202721383145Hsp100p97HumanCytosolNASubstrate degradation activityJFD023421-(4-Methylphenyl)-3-phenyl-2-propyn-1-oneCC1=CC=C(C=C1)C(=O)C#CC2=CC=CC=C2Maybridge, Hitfinder, and NIH molecular librariesNANANA3.4NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00202821383145Hsp100p97HumanCytosolNASubstrate degradation activityCID9343212-chloro-1-(1-methylindol-3-yl)ethanoneCN1C=C(C2=CC=CC=C21)C(=O)CClMaybridge, Hitfinder, and NIH molecular librariesNANANA3.6NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00202921383145Hsp100p97HumanCytosolNASubstrate degradation activityS097569-[(E)-2-nitroethenyl]anthracene[O-][N+](=O)\C=C\C1=C2C=CC=CC2=CC2=C1C=CC=C2Maybridge, Hitfinder, and NIH molecular librariesNANANA5NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00203021383145Hsp100p97HumanCytosolNASubstrate degradation activityJFD005973-(1,3-benzoxazol-2-ylthio)-5,5-dimethylcyclohex-2-en-1-oneO1C(=NC2=C1C=CC=C2)SC2=CC(CC(C2)(C)C)=OMaybridge, Hitfinder, and NIH molecular librariesNANANA6.6NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00203121383145Hsp100p97HumanCytosolNASubstrate degradation activitySEW051825-({5-[2-chloro-5-(trifluoromethyl)phenyl]furan-2-yl}methylidene)-2,2-dimethyl-1,3-dioxane-4,6-dioneCC1(C)OC(=O)C(=CC2=CC=C(O2)C2=C(Cl)C=CC(=C2)C(F)(F)F)C(=O)O1Maybridge, Hitfinder, and NIH molecular librariesNANANA7.5NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00203221383145Hsp100p97HumanCytosolNASubstrate degradation activityCID11094685-amino-4-cyano-N-[(2-methoxynaphthalen-1-yl)methylideneamino]-3-methylthiophene-2-carboxamideCC1=C(SC(=C1C#N)N)C(=O)NN=CC2=C(C=CC3=CC=CC=C32)OCMaybridge, Hitfinder, and NIH molecular librariesNANANA10NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00203321383145Hsp100p97HumanCytosolNASubstrate degradation activityKSC-1-132/CID29396782-[1-hydroxy-4-[(3-nitrophenyl)sulfonylamino]naphthalen-2-yl]sulfanylacetic acidC1=CC=C2C(=C1)C(=CC(=C2O)SCC(=O)O)NS(=O)(=O)C3=CC=CC(=C3)[N+](=O)[O-]Maybridge, Hitfinder, and NIH molecular librariesNANANA8.4NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00203421383145Hsp100p97HumanCytosolNASubstrate degradation activityKSC-1-130/CID95864972-[(E)-[4-[(2,4-dichlorophenyl)methoxy]phenyl]methylideneamino]guanidineC1=CC(=CC=C1C=NN=C(N)N)OCC2=C(C=C(C=C2)Cl)ClMaybridge, Hitfinder, and NIH molecular librariesNANANA11NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00203521383145Hsp100p97HumanCytosolNASubstrate degradation activityKSC-1-204/cid35000862-(5-chloro-1-ethyl-3-nitro-6-oxopyridazin-4-yl)-2-[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]acetonitrileCCN1C(=O)C(=C(C(=N1)[N+](=O)[O-])C(C#N)C2=NC3=C(S2)C=CC(=C3)C(F)(F)F)ClMaybridge, Hitfinder, and NIH molecular librariesNANANA13NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00203621383145Hsp100p97HumanCytosolNASubstrate degradation activityCID54136432-[4-methyl-6-(phenylamino)pyrimidin-2-yl]phenolCC1=CC(NC2=CC=CC=C2)=NC(=N1)C1=C(O)C=CC=C1Maybridge, Hitfinder, and NIH molecular librariesNANANA16NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00203721383145Hsp100p97HumanCytosolNASubstrate degradation activityKSC-1-131/CID2867539/CID/95672103-[(2E)-2-[(4-methoxyphenyl)methylidene]hydrazinyl]-6-phenyl-4H-1,2,4-triazin-5-oneCOC1=CC=C(C=C1)C=NNC2=NN=C(C(=O)N2)C3=CC=CC=C3Maybridge, Hitfinder, and NIH molecular librariesNANANA16NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00203821383145Hsp100p97HumanCytosolNASubstrate degradation activityKSC-1-128/CID987585N-(1-benzyl-3-cyanopyrrolo[3,2-b]quinoxalin-2-yl)-2-chlorobenzamideC1=CC=C(C=C1)CN2C(=C(C3=NC4=CC=CC=C4N=C32)C#N)NC(=O)C5=CC=CC=C5ClMaybridge, Hitfinder, and NIH molecular librariesNANANA17NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00203921383145Hsp100p97HumanCytosolNASubstrate degradation activityCID6524677(4Z)-4-[[2-(7-chloroquinolin-4-yl)hydrazinyl]methylidene]-2-hydroxycyclohexa-2,5-dien-1-oneC1=CC2=C(C=CN=C2C=C1Cl)NNC=C3C=CC(=O)C(=C3)OMaybridge, Hitfinder, and NIH molecular librariesNANANA15NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00204021383145Hsp100p97HumanCytosolNASubstrate degradation activitySPB01017[1-(1,3-dithiolan-2-yl)naphthalen-2-yl] thiophene-2-carboxylateC1CSC(S1)C2=C(C=CC3=CC=CC=C32)OC(=O)C4=CC=CS4Maybridge, Hitfinder, and NIH molecular librariesNANANA19NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00204121383145Hsp100p97HumanCytosolNASubstrate degradation activityHTS01888N-[4-(3-Chloro-4-methylphenyl)-5-methyl-1,3-thiazol-2-yl]-2,1,3-benzoxadiazole-4-sulfonamideCc1ccc(cc1Cl)c2nc(NS(=O)(=O)c3cccc4nonc34)sc2CMaybridge, Hitfinder, and NIH molecular librariesNANANA19NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00204221383145Hsp100p97HumanCytosolNASubstrate degradation activityKSC-1-129/CID801956methyl 2-[(2-methylbenzoyl)carbamothioylamino]benzoateCC1=CC=CC=C1C(=O)NC(=S)NC2=CC=CC=C2C(=O)OCMaybridge, Hitfinder, and NIH molecular librariesNANANA21NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00204321383145Hsp100p97HumanCytosolNASubstrate degradation activityCID5756550(5Z)-5-[(2-phenyl-1H-indol-3-yl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-oneC1=CC=C(C=C1)C2=C(C3=CC=CC=C3N2)C=C4C(=O)NC(=S)S4Maybridge, Hitfinder, and NIH molecular librariesNANANA22NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00204421383145Hsp100p97HumanCytosolNASubstrate degradation activityCD075816-[(2-chlorophenyl)amino]-2-(2,6-dichlorophenyl)-4-oxo-3,4-dihydro-2H-1,3-thiazine-5-carbonitrileClC1=CC=CC=C1NC1=C(C#N)C(=O)NC(S1)C1=C(Cl)C=CC=C1ClMaybridge, Hitfinder, and NIH molecular librariesNANANA23NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00204521383145Hsp100p97HumanCytosolNASubstrate degradation activityCD02660ethyl 3-[(E)-[(3,5-dichloro-2-hydroxyphenyl)methylidene]amino]-4-oxo-3,4-dihydroquinazoline-2-carboxylateCCOC(=O)C1=NC2=C(C=CC=C2)C(=O)N1\N=C\C1=C(O)C(Cl)=CC(Cl)=C1Maybridge, Hitfinder, and NIH molecular librariesNANANA23NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00204621383145Hsp100p97HumanCytosolNASubstrate degradation activitySP010863-(5-tert-butyl-2-methylfuran-3-yl)-4-methyl-5-(methylsulfanyl)-1H-pyrazoleCSC1=C(C)C(=NN1)C1=C(C)OC(=C1)C(C)(C)CMaybridge, Hitfinder, and NIH molecular librariesNANANA23NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00204721383145Hsp100p97HumanCytosolNASubstrate degradation activityCID35983,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxyphenyl)methyl]phenolC1=C(C(=C(C(=C1Cl)Cl)CC2=C(C(=CC(=C2Cl)Cl)Cl)O)O)ClMaybridge, Hitfinder, and NIH molecular librariesNANANA27NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00204821383145Hsp100p97HumanCytosolNASubstrate degradation activityCID28848852,2-dichloro-N-(4-fluorophenyl)-3-phenylcyclopropane-1-carboxamideC1=CC=C(C=C1)C2C(C2(Cl)Cl)C(=O)NC3=CC=C(C=C3)FMaybridge, Hitfinder, and NIH molecular librariesNANANA27NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00204921383145Hsp100p97HumanCytosolNASubstrate degradation activityCID4099282-[3-(dibutylamino)propyl]isoindole-1,3-dioneCCCCN(CCCC)CCCN1C(=O)C2=CC=CC=C2C1=OMaybridge, Hitfinder, and NIH molecular librariesNANANA36NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00205021383145Hsp100p97HumanCytosolNASubstrate degradation activityCID58751825-amino-6-[(Z)-(2-methylindol-3-ylidene)methyl]-3-methylsulfanyl-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-oneCC1=NC2=CC=CC=C2C1=CC3=C(N4C(=NC3=O)SN=C4SC)NMaybridge, Hitfinder, and NIH molecular librariesNANANA31NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00205121383145Hsp100p97HumanCytosolNASubstrate degradation activityCID161943095-amino-6-[(Z)-(2-methylindol-3-ylidene)methyl]-3-(2-methylpropylsulfonyl)-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-oneCC1=NC2=CC=CC=C2C1=CC3=C(N4C(=NC3=O)SN=C4S(=O)(=O)CC(C)C)NMaybridge, Hitfinder, and NIH molecular librariesNANANA>30 NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00205221383145Hsp100p97HumanCytosolNASubstrate degradation activityCID56918572-[(6,7-dihydroxy-2-oxochromen-4-yl)methylsulfanyl]-3-(3-methoxyphenyl)quinazolin-4-oneCOC1=CC=CC(=C1)N2C(=O)C3=CC=CC=C3N=C2SCC4=CC(=O)OC5=CC(=C(C=C45)O)OMaybridge, Hitfinder, and NIH molecular librariesNANANA39NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00205321383145Hsp100p97HumanCytosolNASubstrate degradation activityKSC-1-1206/CID23845382-(chloromethyl)-1H-pyrimido[1,2-a]benzimidazol-4-oneC1=CC=C2C(=C1)N=C3N2C(=O)C=C(N3)CClMaybridge, Hitfinder, and NIH molecular librariesNANANA38NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00205421383145Hsp100p97HumanCytosolNASubstrate degradation activityKSC-1-202/CID28104452,6-dichloro-N-(2-hydroxy-1,3-dioxoinden-2-yl)benzamideC1=CC=C2C(=C1)C(=O)C(C2=O)(NC(=O)C3=C(C=CC=C3Cl)Cl)OMaybridge, Hitfinder, and NIH molecular librariesNANANA42NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00205521383145Hsp100p97HumanCytosolNASubstrate degradation activityCID21755564-[[4-(2,4-dihydroxyphenyl)-1,3-thiazol-2-yl]amino]benzenesulfonamideC1=CC(=CC=C1NC2=NC(=CS2)C3=C(C=C(C=C3)O)O)S(=O)(=O)NMaybridge, Hitfinder, and NIH molecular librariesNANANA60NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00205621383145Hsp100p97HumanCytosolNASubstrate degradation activityKSC-1-201/CID28101552-methyl-N-(7-methyl-4-oxothieno[3,2-d][1,3]thiazin-2-yl)benzamideCC1=CC=CC=C1C(=O)NC2=NC3=C(C(=O)S2)SC=C3CMaybridge, Hitfinder, and NIH molecular librariesNANANA62NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00205721383145Hsp100p97HumanCytosolNASubstrate degradation activityKSC-1-209/CID2472581[2-(1H-indol-3-yl)-2-oxoethyl] 5-nitrothiophene-2-carboxylateC1=CC=C2C(=C1)C(=CN2)C(=O)COC(=O)C3=CC=C(S3)[N+](=O)[O-]Maybridge, Hitfinder, and NIH molecular librariesNANANA66NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00205821383145Hsp100p97HumanCytosolNASubstrate degradation activityKSC-1-199/CID4072379N'-acridin-9-yl-2,4-dihydroxybenzohydrazideC1=CC=C2C(=C1)C(=C3C=CC=CC3=N2)NNC(=O)C4=C(C=C(C=C4)O)OMaybridge, Hitfinder, and NIH molecular librariesNANANA68NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00205921383145Hsp100p97HumanCytosolNASubstrate degradation activityCID16256804-[5-[(Z)-2-carboxy-2-[(5-methyl-1H-1,2,4-triazol-3-yl)sulfanyl]ethenyl]furan-2-yl]-2-chlorobenzoic acidCC1=NC(=NN1)SC(=CC2=CC=C(O2)C3=CC(=C(C=C3)C(=O)O)Cl)C(=O)OMaybridge, Hitfinder, and NIH molecular librariesNANANA>30 NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00206021383145Hsp100p97HumanCytosolNASubstrate degradation activityKM089953-(5-acetylthiophen-2-yl)prop-2-ynyl N-phenylcarbamateCC(=O)C1=CC=C(S1)C#CCOC(=O)NC2=CC=CC=C2Maybridge, Hitfinder, and NIH molecular librariesNANANA>30 NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00206121383145Hsp100p97HumanCytosolNASubstrate degradation activityCID1976446(6E)-5-imino-6-[(4-oxochromen-3-yl)methylidene]-2-pyridin-4-yl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-oneC1=CC=C2C(=C1)C(=O)C(=CO2)C=C3C(=N)N4C(=NC3=O)SC(=N4)C5=CC=NC=C5Maybridge, Hitfinder, and NIH molecular librariesNANANA>30 NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00206221383145Hsp100p97HumanCytosolNASubstrate degradation activityCID9302387-propan-2-yl-10-thia-8,13,15-triazatetracyclo[7.7.0.02,6.011,16]hexadeca-1,6,8,11(16),13-pentaene-12-thioneCC(C)C1=C2CCCC2=C3C4=C(C(=S)N=CN4)SC3=N1Maybridge, Hitfinder, and NIH molecular librariesNANANA>30 NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00206321383145Hsp100p97HumanCytosolNASubstrate degradation activityCID29784604-[[4-(2-fluorophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]sulfonylamino]benzoic acidC1C=CC2C1C(NC3=C2C=C(C=C3)S(=O)(=O)NC4=CC=C(C=C4)C(=O)O)C5=CC=CC=C5FMaybridge, Hitfinder, and NIH molecular librariesNANANA>30 NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00206421383145Hsp100p97HumanCytosolNASubstrate degradation activityCD008233-(1H-indol-3-ylmethylidene)indolin-2-oneO=c1nc2ccccc2c1=Cc1cnc2ccccc21Maybridge, Hitfinder, and NIH molecular librariesNANANA>30 NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00206521383145Hsp100p97HumanCytosolNASubstrate degradation activityJFD015604-pyren-1-ylbutanoic acidC1=CC2=C3C(=C1)C=CC4=C(C=CC(=C43)C=C2)CCCC(=O)OMaybridge, Hitfinder, and NIH molecular librariesNANANA>30 NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00206621383145Hsp100p97HumanCytosolNASubstrate degradation activityKSC-1-133/CID5559718(Z)-2-(1,3-benzothiazol-2-yl)-3-hydroxy-4-(4-methylphenyl)sulfanylbut-2-enenitrileCC1=CC=C(C=C1)SCC(=C(C#N)C2=NC3=CC=CC=C3S2)OMaybridge, Hitfinder, and NIH molecular librariesNANANA>30 NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00206721383145Hsp100p97HumanCytosolNASubstrate degradation activityKSC-1-205/CID59826533-nitro-4-[(2E)-2-[(2,3,4-trihydroxyphenyl)methylidene]hydrazinyl]benzenesulfonamideC1=CC(=C(C=C1S(=O)(=O)N)[N+](=O)[O-])NN=CC2=C(C(=C(C=C2)O)O)OMaybridge, Hitfinder, and NIH molecular librariesNANANA>30 NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00206821383145Hsp100p97HumanCytosolNASubstrate degradation activityKSC-1-232/CID3787408N-[3-(benzenesulfonyl)-1-butylpyrrolo[3,2-b]quinoxalin-2-yl]-4-methylbenzenesulfonamideCCCCN1C(=C(C2=NC3=CC=CC=C3N=C21)S(=O)(=O)C4=CC=CC=C4)NS(=O)(=O)C5=CC=C(C=C5)CMaybridge, Hitfinder, and NIH molecular librariesNANANA>30 NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00206921383145Hsp100p97HumanCytosolNASubstrate degradation activityKSC-1-233/CID2044030N-(1-benzylpyrrolo[3,2-b]quinoxalin-2-yl)-4-chlorobenzenesulfonamideC1=CC=C(C=C1)CN2C(=CC3=NC4=CC=CC=C4N=C32)NS(=O)(=O)C5=CC=C(C=C5)ClMaybridge, Hitfinder, and NIH molecular librariesNANANA>30 NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00207021383145Hsp100p97HumanCytosolNASubstrate degradation activityCD02506ethyl 3-[(E)-[(3,5-dichloro-2-hydroxyphenyl)methylidene]amino]-4-oxo-3,4-dihydroquinazoline-2-carboxylateCCOC(=O)C1=NC2=C(C=CC=C2)C(=O)N1\N=C\C1=C(O)C(Cl)=CC(Cl)=C1Maybridge, Hitfinder, and NIH molecular librariesNANANA>30 NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00207121383145Hsp100p97HumanCytosolNASubstrate degradation activityCD060823-(5-tert-butyl-2-methylfuran-3-yl)-4-methyl-5-(methylsulfanyl)-1H-pyrazoleCSC1=C(C)C(=NN1)C1=C(C)OC(=C1)C(C)(C)CMaybridge, Hitfinder, and NIH molecular librariesNANANA>30 NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00207221383145Hsp100p97HumanCytosolNASubstrate degradation activityCID1601155,6,8-trihydroxy-2-methyl-9-(5,6,8-trihydroxy-2-methyl-4-oxo-2,3-dihydrobenzo[g]chromen-9-yl)-2,3-dihydrobenzo[g]chromen-4-oneCC1CC(=O)C2=C(O1)C=C3C(=C2O)C(=CC(=C3C4=C(C=C(C5=C(C6=C(C=C54)OC(CC6=O)C)O)O)O)O)OMaybridge, Hitfinder, and NIH molecular librariesNANANA>30NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00207321383145Hsp100p97HumanCytosolNASubstrate degradation activityEeyarestatin I (Eerl)2-[3-(4-chlorophenyl)-4-[(4-chlorophenyl)carbamoyl-hydroxyamino]-5,5-dimethyl-2-oxoimidazolidin-1-yl]-N-[(E)-[(E)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]acetamideCC1(C(N(C(=O)N1CC(=O)NN=CC=CC2=CC=C(O2)[N+](=O)[O-])C3=CC=C(C=C3)Cl)N(C(=O)NC4=CC=C(C=C4)Cl)O)CMaybridge, Hitfinder, and NIH molecular librariesNANANA3.7NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00207421383145Hsp100p97HumanCytosolNASubstrate degradation activityMyriad 19/KSC-1-2754-[(4-phenyl-1,3-thiazol-2-yl)amino]phenolC1=CC=C(C=C1)C2=CSC(=N2)NC3=CC=C(C=C3)OMaybridge, Hitfinder, and NIH molecular librariesNANANA26NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00207521383145Hsp100p97HumanCytosolNASubstrate degradation activityMyriad 12/KSC-1-2774-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]amino]phenolC1=CC(=CC=C1C2=CSC(=N2)NC3=CC=C(C=C3)O)ClMaybridge, Hitfinder, and NIH molecular librariesNANANA16NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00207621383145Hsp100p97HumanCytosolNASubstrate degradation activityKSC-16-54-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]imino]cyclohexa-2,5-dien-1-oneC1=CC(=O)C=CC1=NC2=NC(=CS2)C3=CC=C(C=C3)ClMaybridge, Hitfinder, and NIH molecular librariesNANANA38NANANANANucleotide binding domainNANAReporter degradation assay (UbG76V-GFP)
HSPMDB00207721383145Hsp100p97HumanCytosolNAAntiproliferative activityMg132benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamateCC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1Maybridge, Hitfinder, and NIH molecular librariesNANANANANANANA0.4Nucleotide binding domainNA50%Luminescence based viability assay
HSPMDB00207821383145Hsp100p97HumanCytosolNAAntiproliferative activityMg132benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamateCC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1Maybridge, Hitfinder, and NIH molecular librariesNANANANANANANA0.2Nucleotide binding domainNA50%Luminescence based viability assay
HSPMDB00207921383145Hsp100p97HumanCytosolNAAntiproliferative activityMg132benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamateCC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1Maybridge, Hitfinder, and NIH molecular librariesNANANANANANANA1.5Nucleotide binding domainNA50%Luminescence based viability assay
HSPMDB00208021383145Hsp100p97HumanCytosolNAAntiproliferative activityMg132benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamateCC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1Maybridge, Hitfinder, and NIH molecular librariesNANANANANANANA0.14Nucleotide binding domainNA50%Luminescence based viability assay
HSPMDB00208121383145Hsp100p97HumanCytosolNAAntiproliferative activityDBeQN2 , N4 -dibenzylquinazoline-2,4-diamineC(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4Maybridge, Hitfinder, and NIH molecular librariesNANANANANANANA6.6Nucleotide binding domainNA50%Luminescence based viability assay
HSPMDB00208221383145Hsp100p97HumanCytosolNAAntiproliferative activityDBeQN2 , N4 -dibenzylquinazoline-2,4-diamineC(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4Maybridge, Hitfinder, and NIH molecular librariesNANANANANANANA4Nucleotide binding domainNA50%Luminescence based viability assay
HSPMDB00208321383145Hsp100p97HumanCytosolNAAntiproliferative activityDBeQN2 , N4 -dibenzylquinazoline-2,4-diamineC(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4Maybridge, Hitfinder, and NIH molecular librariesNANANANANANANA3.1Nucleotide binding domainNA50%Luminescence based viability assay
HSPMDB00208421383145Hsp100p97HumanCytosolNAAntiproliferative activityDBeQN2 , N4 -dibenzylquinazoline-2,4-diamineC(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4Maybridge, Hitfinder, and NIH molecular librariesNANANANANANANA1.2Nucleotide binding domainNA50%Luminescence based viability assay
HSPMDB00208526083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1264-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoateCC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1Non beta lactone inhibitorNANANA6.1NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00208626083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1274-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylateCC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=ONon beta lactone inhibitorNANANA5.9NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00208726083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV166(2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-oneCOC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1Non beta lactone inhibitorNANANA5.9NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00208826083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1674-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetateO=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1Non beta lactone inhibitorNANANA5.9NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00208926083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1684-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoateCN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1Non beta lactone inhibitorNANANA5.9NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00209026083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1704-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OCNon beta lactone inhibitorNANANA6.6NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00209126083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAPalmostatin M(3S,4S)-3-decyl-4-[4-[3-(dimethylamino)propylsulfonyl]butyl]oxetan-2-oneCCCCCCCCCCC1C(OC1=O)CCCCS(=O)(=O)CCCN(C)CNon beta lactone inhibitorNANANA21NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00209226083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1264-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoateCC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1Non beta lactone inhibitor100% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00209326083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1274-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylateCC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=ONon beta lactone inhibitor95% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00209426083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV166(2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-oneCOC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1Non beta lactone inhibitor100% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00209526083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1674-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetateO=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1Non beta lactone inhibitor75% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00209626083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1684-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoateCN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1Non beta lactone inhibitor70% at 100 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00209726083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1704-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OCNon beta lactone inhibitor100% at 100 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00209826083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAD33-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-oneC=CCCCCCCCC1C(CCCC#C)OC1=ONon beta lactone inhibitor95% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00209926083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAE23-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-oneCOC1=CC=C(C=C1)C1C(CCCC#C)OC1=ONon beta lactone inhibitor100% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00210026083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1264-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoateCC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1Non beta lactone inhibitor99% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00210126083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1274-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylateCC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=ONon beta lactone inhibitor45% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00210226083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV166(2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-oneCOC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1Non beta lactone inhibitor85% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00210326083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1674-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetateO=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1Non beta lactone inhibitor40% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00210426083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1684-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoateCN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1Non beta lactone inhibitor30% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00210526083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1704-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OCNon beta lactone inhibitor95% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00210626083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAD33-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-oneC=CCCCCCCCC1C(CCCC#C)OC1=ONon beta lactone inhibitor90% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00210726083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAE23-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-oneCOC1=CC=C(C=C1)C1C(CCCC#C)OC1=ONon beta lactone inhibitor80% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00210826083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1264-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoateCC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1Non beta lactone inhibitor40% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00210926083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1274-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylateCC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=ONon beta lactone inhibitor10% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00211026083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV166(2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-oneCOC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1Non beta lactone inhibitor30% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00211126083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1674-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetateO=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1Non beta lactone inhibitor5% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00211226083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1684-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoateCN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1Non beta lactone inhibitor10% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00211326083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1704-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OCNon beta lactone inhibitor25% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00211426083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAD33-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-oneC=CCCCCCCCC1C(CCCC#C)OC1=ONon beta lactone inhibitor25% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00211526083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAE23-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-oneCOC1=CC=C(C=C1)C1C(CCCC#C)OC1=ONon beta lactone inhibitor10% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00211626083639Hsp100ClpP2BacteriaCytosolInhibition of peptidase activityNAAV1264-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoateCC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1Non beta lactone inhibitor100% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00211726083639Hsp100ClpP2BacteriaCytosolInhibition of peptidase activityNAAV1274-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylateCC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=ONon beta lactone inhibitor100% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00211826083639Hsp100ClpP2BacteriaCytosolInhibition of peptidase activityNAAV166(2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-oneCOC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1Non beta lactone inhibitor100% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00211926083639Hsp100ClpP2BacteriaCytosolInhibition of peptidase activityNAAV1674-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetateO=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1Non beta lactone inhibitor60% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00212026083639Hsp100ClpP2BacteriaCytosolInhibition of peptidase activityNAAV1684-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoateCN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1Non beta lactone inhibitor20% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00212126083639Hsp100ClpP2BacteriaCytosolInhibition of peptidase activityNAAV1704-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OCNon beta lactone inhibitor100% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00212226083639Hsp100ClpP2BacteriaCytosolInhibition of peptidase activityNAD33-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-oneC=CCCCCCCCC1C(CCCC#C)OC1=ONon beta lactone inhibitor98% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00212326083639Hsp100ClpP2BacteriaCytosolInhibition of peptidase activityNAE23-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-oneCOC1=CC=C(C=C1)C1C(CCCC#C)OC1=ONon beta lactone inhibitor100% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00212426083639Hsp100ClpP2BacteriaCytosolInhibition of peptidase activityNAAV1264-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoateCC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1Non beta lactone inhibitor98% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00212526083639Hsp100ClpP2BacteriaCytosolInhibition of peptidase activityNAAV1274-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylateCC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=ONon beta lactone inhibitor30% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00212626083639Hsp100ClpP2BacteriaCytosolInhibition of peptidase activityNAAV166(2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-oneCOC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1Non beta lactone inhibitor100% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00212726083639Hsp100ClpP2BacteriaCytosolInhibition of peptidase activityNAAV1674-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetateO=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1Non beta lactone inhibitor45% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00212826083639Hsp100ClpP2BacteriaCytosolInhibition of peptidase activityNAAV1684-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoateCN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1Non beta lactone inhibitor15% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00212926083639Hsp100ClpP2BacteriaCytosolInhibition of peptidase activityNAAV1704-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OCNon beta lactone inhibitor100% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00213026083639Hsp100ClpP2BacteriaCytosolInhibition of peptidase activityNAD33-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-oneC=CCCCCCCCC1C(CCCC#C)OC1=ONon beta lactone inhibitor95% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00213126083639Hsp100ClpP2BacteriaCytosolInhibition of peptidase activityNAE23-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-oneCOC1=CC=C(C=C1)C1C(CCCC#C)OC1=ONon beta lactone inhibitor30% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00213226083639Hsp100ClpP2BacteriaCytosolInhibition of peptidase activityNAAV1264-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoateCC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1Non beta lactone inhibitor20% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00213326083639Hsp100ClpP2BacteriaCytosolInhibition of peptidase activityNAAV1274-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylateCC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=ONon beta lactone inhibitor0-5% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00213426083639Hsp100ClpP2BacteriaCytosolInhibition of peptidase activityNAAV166(2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-oneCOC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1Non beta lactone inhibitor80% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00213526083639Hsp100ClpP2BacteriaCytosolInhibition of peptidase activityNAAV1674-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetateO=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1Non beta lactone inhibitor0-5% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00213626083639Hsp100ClpP2BacteriaCytosolInhibition of peptidase activityNAAV1684-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoateCN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1Non beta lactone inhibitor10% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00213726083639Hsp100ClpP2BacteriaCytosolInhibition of peptidase activityNAAV1704-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OCNon beta lactone inhibitor75% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00213826083639Hsp100ClpP2BacteriaCytosolInhibition of peptidase activityNAD33-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-oneC=CCCCCCCCC1C(CCCC#C)OC1=ONon beta lactone inhibitor20% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00213926083639Hsp100ClpP2BacteriaCytosolInhibition of peptidase activityNAE23-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-oneCOC1=CC=C(C=C1)C1C(CCCC#C)OC1=ONon beta lactone inhibitor10% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00214026083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1264-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoateCC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1Non beta lactone inhibitor100% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00214126083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1274-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylateCC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=ONon beta lactone inhibitor100% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00214226083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV166(2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-oneCOC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1Non beta lactone inhibitor100% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00214326083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1674-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetateO=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1Non beta lactone inhibitor99% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00214426083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1684-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoateCN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1Non beta lactone inhibitor88% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00214526083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1704-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OCNon beta lactone inhibitor99% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00214626083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAD33-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-oneC=CCCCCCCCC1C(CCCC#C)OC1=ONon beta lactone inhibitor95% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00214726083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAE23-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-oneCOC1=CC=C(C=C1)C1C(CCCC#C)OC1=ONon beta lactone inhibitor100% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00214826083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1264-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoateCC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1Non beta lactone inhibitor100% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00214926083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1274-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylateCC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=ONon beta lactone inhibitor88% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00215026083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV166(2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-oneCOC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1Non beta lactone inhibitor95% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00215126083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1674-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetateO=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1Non beta lactone inhibitor100% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00215226083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1684-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoateCN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1Non beta lactone inhibitor80% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00215326083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1704-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OCNon beta lactone inhibitor99% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00215426083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAD33-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-oneC=CCCCCCCCC1C(CCCC#C)OC1=ONon beta lactone inhibitor90% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00215526083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAE23-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-oneCOC1=CC=C(C=C1)C1C(CCCC#C)OC1=ONon beta lactone inhibitor88% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00215626083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1264-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoateCC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1Non beta lactone inhibitor65% at 1 uMNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00215726083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1274-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylateCC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=ONon beta lactone inhibitor25% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00215826083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV166(2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-oneCOC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1Non beta lactone inhibitor60% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00215926083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1674-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetateO=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1Non beta lactone inhibitor40% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00216026083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1684-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoateCN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1Non beta lactone inhibitor45% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00216126083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1704-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OCNon beta lactone inhibitor80% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00216226083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAD33-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-oneC=CCCCCCCCC1C(CCCC#C)OC1=ONon beta lactone inhibitor5% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00216326083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAE23-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-oneCOC1=CC=C(C=C1)C1C(CCCC#C)OC1=ONon beta lactone inhibitor20% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00216426083639Hsp100ClpPHumanCytosolInhibition of peptidase activityNAAV1264-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoateCC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1Non beta lactone inhibitor20% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00216526083639Hsp100ClpPHumanCytosolInhibition of peptidase activityNAAV1274-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylateCC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=ONon beta lactone inhibitor25% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00216626083639Hsp100ClpPHumanCytosolInhibition of peptidase activityNAAV166(2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-oneCOC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1Non beta lactone inhibitor100% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00216726083639Hsp100ClpPHumanCytosolInhibition of peptidase activityNAAV1674-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetateO=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1Non beta lactone inhibitor100% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00216826083639Hsp100ClpPHumanCytosolInhibition of peptidase activityNAAV1684-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoateCN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1Non beta lactone inhibitor5% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00216926083639Hsp100ClpPHumanCytosolInhibition of peptidase activityNAAV1704-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OCNon beta lactone inhibitor80% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00217026083639Hsp100ClpPHumanCytosolInhibition of peptidase activityNAD33-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-oneC=CCCCCCCCC1C(CCCC#C)OC1=ONon beta lactone inhibitor40% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00217126083639Hsp100ClpPHumanCytosolInhibition of peptidase activityNAE23-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-oneCOC1=CC=C(C=C1)C1C(CCCC#C)OC1=ONon beta lactone inhibitor45% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00217226083639Hsp100ClpPHumanCytosolInhibition of peptidase activityNAAV1264-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoateCC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1Non beta lactone inhibitor0-5% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00217326083639Hsp100ClpPHumanCytosolInhibition of peptidase activityNAAV1274-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylateCC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=ONon beta lactone inhibitor0-5% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00217426083639Hsp100ClpPHumanCytosolInhibition of peptidase activityNAAV166(2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-oneCOC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1Non beta lactone inhibitor0-5% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00217526083639Hsp100ClpPHumanCytosolInhibition of peptidase activityNAAV1674-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetateO=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1Non beta lactone inhibitor10-15% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00217626083639Hsp100ClpPHumanCytosolInhibition of peptidase activityNAAV1684-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoateCN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1Non beta lactone inhibitor0-5% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00217726083639Hsp100ClpPHumanCytosolInhibition of peptidase activityNAAV1704-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OCNon beta lactone inhibitor20% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00217826083639Hsp100ClpPHumanCytosolInhibition of peptidase activityNAD33-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-oneC=CCCCCCCCC1C(CCCC#C)OC1=ONon beta lactone inhibitor50% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00217926083639Hsp100ClpPHumanCytosolInhibition of peptidase activityNAE23-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-oneCOC1=CC=C(C=C1)C1C(CCCC#C)OC1=ONon beta lactone inhibitor15% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00218026083639Hsp100ClpPHumanCytosolInhibition of peptidase activityNAAV1264-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoateCC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1Non beta lactone inhibitor0-5% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00218126083639Hsp100ClpPHumanCytosolInhibition of peptidase activityNAAV1274-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylateCC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=ONon beta lactone inhibitor0-5% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00218226083639Hsp100ClpPHumanCytosolInhibition of peptidase activityNAAV166(2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-oneCOC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1Non beta lactone inhibitor5-10% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00218326083639Hsp100ClpPHumanCytosolInhibition of peptidase activityNAAV1674-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetateO=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1Non beta lactone inhibitor50% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00218426083639Hsp100ClpPHumanCytosolInhibition of peptidase activityNAAV1684-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoateCN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1Non beta lactone inhibitor0-5% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00218526083639Hsp100ClpPHumanCytosolInhibition of peptidase activityNAAV1704-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OCNon beta lactone inhibitor10% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00218626083639Hsp100ClpPHumanCytosolInhibition of peptidase activityNAD33-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-oneC=CCCCCCCCC1C(CCCC#C)OC1=ONon beta lactone inhibitor10% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00218726083639Hsp100ClpPHumanCytosolInhibition of peptidase activityNAE23-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-oneCOC1=CC=C(C=C1)C1C(CCCC#C)OC1=ONon beta lactone inhibitor10% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00218826083639Hsp100ClpPBacteriaCytosolInhibition of protease activityNAAV1264-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoateCC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1Non beta lactone inhibitor90% at 100 uM NANANANANANANANucleotide binding domainSubstrate degradation assay (GFP-ssrA)NANA
HSPMDB00218926083639Hsp100ClpPBacteriaCytosolInhibition of protease activityNAAV1274-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylateCC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=ONon beta lactone inhibitor90% at 100 uM NANANANANANANANucleotide binding domainSubstrate degradation assay (GFP-ssrA)NANA
HSPMDB00219026083639Hsp100ClpPBacteriaCytosolInhibition of protease activityNAAV166(2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-oneCOC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1Non beta lactone inhibitor75% at 100 uM NANANANANANANANucleotide binding domainSubstrate degradation assay (GFP-ssrA)NANA
HSPMDB00219126083639Hsp100ClpPBacteriaCytosolInhibition of protease activityNAAV1674-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetateO=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1Non beta lactone inhibitor25% at 100 uM NANANANANANANANucleotide binding domainSubstrate degradation assay (GFP-ssrA)NANA
HSPMDB00219226083639Hsp100ClpPBacteriaCytosolInhibition of protease activityNAAV1684-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoateCN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1Non beta lactone inhibitor20% at 100 uM NANANANANANANANucleotide binding domainSubstrate degradation assay (GFP-ssrA)NANA
HSPMDB00219326083639Hsp100ClpPBacteriaCytosolInhibition of protease activityNAAV1704-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OCNon beta lactone inhibitor90% at 100 uM NANANANANANANANucleotide binding domainSubstrate degradation assay (GFP-ssrA)NANA
HSPMDB00219426083639Hsp100ClpPBacteriaCytosolInhibition of protease activityNAD33-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-oneC=CCCCCCCCC1C(CCCC#C)OC1=ONon beta lactone inhibitor70% at 100 uM NANANANANANANANucleotide binding domainSubstrate degradation assay (GFP-ssrA)NANA
HSPMDB00219526083639Hsp100ClpPBacteriaCytosolInhibition of protease activityNAE23-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-oneCOC1=CC=C(C=C1)C1C(CCCC#C)OC1=ONon beta lactone inhibitor85% at 100 uM NANANANANANANANucleotide binding domainSubstrate degradation assay (GFP-ssrA)NANA
HSPMDB00219626083639Hsp100ClpPBacteriaCytosolInhibition of protease activityNAAV1264-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoateCC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1Non beta lactone inhibitor80% at 10 uM NANANANANANANANucleotide binding domainSubstrate degradation assay (GFP-ssrA)NANA
HSPMDB00219726083639Hsp100ClpPBacteriaCytosolInhibition of protease activityNAAV1274-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylateCC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=ONon beta lactone inhibitor65% at 10 uM NANANANANANANANucleotide binding domainSubstrate degradation assay (GFP-ssrA)NANA
HSPMDB00219826083639Hsp100ClpPBacteriaCytosolInhibition of protease activityNAAV166(2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-oneCOC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1Non beta lactone inhibitor20% at 10 uM NANANANANANANANucleotide binding domainSubstrate degradation assay (GFP-ssrA)NANA
HSPMDB00219926083639Hsp100ClpPBacteriaCytosolInhibition of protease activityNAAV1674-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetateO=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1Non beta lactone inhibitor20% at 10 uM NANANANANANANANucleotide binding domainSubstrate degradation assay (GFP-ssrA)NANA
HSPMDB00220026083639Hsp100ClpPBacteriaCytosolInhibition of protease activityNAAV1684-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoateCN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1Non beta lactone inhibitor15% at 10 uM NANANANANANANANucleotide binding domainSubstrate degradation assay (GFP-ssrA)NANA
HSPMDB00220126083639Hsp100ClpPBacteriaCytosolInhibition of protease activityNAAV1704-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OCNon beta lactone inhibitor15% at 10 uM NANANANANANANANucleotide binding domainSubstrate degradation assay (GFP-ssrA)NANA
HSPMDB00220226083639Hsp100ClpPBacteriaCytosolInhibition of protease activityNAD33-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-oneC=CCCCCCCCC1C(CCCC#C)OC1=ONon beta lactone inhibitor90% at 10 uM NANANANANANANANucleotide binding domainSubstrate degradation assay (GFP-ssrA)NANA
HSPMDB00220326083639Hsp100ClpPBacteriaCytosolInhibition of protease activityNAE23-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-oneCOC1=CC=C(C=C1)C1C(CCCC#C)OC1=ONon beta lactone inhibitor25% at 10 uM NANANANANANANANucleotide binding domainSubstrate degradation assay (GFP-ssrA)NANA
HSPMDB00220426083639Hsp100ClpPBacteriaCytosolInhibition of protease activityNAAV1264-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoateCC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1Non beta lactone inhibitor5% at 1 uM NANANANANANANANucleotide binding domainSubstrate degradation assay (GFP-ssrA)NANA
HSPMDB00220526083639Hsp100ClpPBacteriaCytosolInhibition of protease activityNAAV1274-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylateCC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=ONon beta lactone inhibitor0-5% at 1 uM NANANANANANANANucleotide binding domainSubstrate degradation assay (GFP-ssrA)NANA
HSPMDB00220626083639Hsp100ClpPBacteriaCytosolInhibition of protease activityNAAV166(2Z)-3-(3,4-dimethoxyphenyl)-1-{3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1,2,4-triazol-4-yl}prop-2-en-1-oneCOC1=C(OC)C=C(\C=C/C(=O)N2C=NN=C2SCC(=O)C2=CC=CC=C2)C=C1Non beta lactone inhibitor0-5% at 1 uM NANANANANANANANucleotide binding domainSubstrate degradation assay (GFP-ssrA)NANA
HSPMDB00220726083639Hsp100ClpPBacteriaCytosolInhibition of protease activityNAAV1674-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetateO=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1Non beta lactone inhibitor5% at 1 uM NANANANANANANANucleotide binding domainSubstrate degradation assay (GFP-ssrA)NANA
HSPMDB00220826083639Hsp100ClpPBacteriaCytosolInhibition of protease activityNAAV1684-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoateCN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1Non beta lactone inhibitor5% at 1 uM NANANANANANANANucleotide binding domainSubstrate degradation assay (GFP-ssrA)NANA
HSPMDB00220926083639Hsp100ClpPBacteriaCytosolInhibition of protease activityNAAV1704-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOC1=CC(CCC(=O)OC2=CC=C(C=C2)C(C)=O)=CC(OC)=C1OCNon beta lactone inhibitor10% at 1 uM NANANANANANANANucleotide binding domainSubstrate degradation assay (GFP-ssrA)NANA
HSPMDB00221026083639Hsp100ClpPBacteriaCytosolInhibition of protease activityNAD33-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-oneC=CCCCCCCCC1C(CCCC#C)OC1=ONon beta lactone inhibitor0-5% at 1 uM NANANANANANANANucleotide binding domainSubstrate degradation assay (GFP-ssrA)NANA
HSPMDB00221126083639Hsp100ClpPBacteriaCytosolInhibition of protease activityNAE23-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-oneCOC1=CC=C(C=C1)C1C(CCCC#C)OC1=ONon beta lactone inhibitor15% at 1 uM NANANANANANANANucleotide binding domainSubstrate degradation assay (GFP-ssrA)NANA
HSPMDB00221226083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML16Methyl 4-((3-(3,5-dimethoxy-4-(prop-2-yn-1-yloxy)phenyl)propanoyl)oxy)benzoateC(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4Non beta lactone inhibitor (AV170 derivative)100% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00221326083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML21Methyl 4-(2-(3,4,5-trimethoxyphenyl)acetoxy)benzoateCOC(=O)c1ccc(OC(=O)CCc2cc(OC)c(OCC#C)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)95% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00221426083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML33Methyl 4-((3-(1H-indol-3-yl)propanoyl)oxy)benzoateCOC(=O)c1ccc(OC(=O)Cc2cc(OC)c(OC)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)90% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00221526083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML03Isopropyl 4-((3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoateCOC(=O)c1ccc(OC(=O)CCc2c[nH]c3ccccc23)cc1Non beta lactone inhibitor (AV170 derivative)0-5% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00221626083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML23methyl 3-{[3-(3,4,5-trimethoxyphenyl)propanoyl]oxy}benzoateCOc1cc(CCC(=O)Oc2ccc(cc2)C(=O)OC(C)C)cc(OC)c1OCNon beta lactone inhibitor (AV170 derivative)0-5% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00221726083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAMLIH184-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOC(=O)c1cccc(OC(=O)CCc2cc(OC)c(OC)c(OC)c2)c1Non beta lactone inhibitor (AV170 derivative)95% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00221826083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML14Butyl 3-(3,4,5-trimethoxyphenyl)propanoateCOc1cc(CCC(=O)Oc2ccc(cc2)c3noc(C)n3)cc(OC)c1OCNon beta lactone inhibitor (AV170 derivative)0-5% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00221926083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML274-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoateCCCCOC(=O)CCc1cc(OC)c(OC)c(OC)c1Non beta lactone inhibitor (AV170 derivative)0-5% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00222026083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAMLIH194-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOc1cc(CCC(=O)Oc2ccc(cc2)C(C)=O)cc(OC)c1OCNon beta lactone inhibitor (AV170 derivative)0-5% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00222126083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML254-formylphenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOc1cc(CCC(=O)Oc2ccc(cc2)c3oc(C)nn3)cc(OC)c1OCNon beta lactone inhibitor (AV170 derivative)95% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00222226083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML054-Methoxyphenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOc1cc(CCC(=O)Oc2ccc(C=O)cc2)cc(OC)c1OCNon beta lactone inhibitor (AV170 derivative)90% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00222326083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML06Phenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOc1ccc(OC(=O)CCc2cc(OC)c(OC)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)80% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00222426083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML284-(Dimethylamino)phenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOc1cc(CCC(=O)Oc2ccccc2)cc(OC)c1OCNon beta lactone inhibitor (AV170 derivative)60% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00222526083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML92Methyl 4-((3-(3,4-dimethoxyphenyl)propanoyl)oxy)benzoateCOc1cc(CCC(=O)Oc2ccc(cc2)N(C)C)cc(OC)c1OCNon beta lactone inhibitor (AV170 derivative)85% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00222626083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML57Methyl 4-((3-(3-acetylphenyl)propanoyl)oxy)benzoateCOC(=O)c1ccc(OC(=O)CCc2ccc(OC)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)55% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00222726083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML09Cyclohexyl 3-(3,4,5-trimethoxyphenyl)propanoateCOC(=O)c1ccc(OC(=O)CCc2cccc(c2)C(C)=O)cc1Non beta lactone inhibitor (AV170 derivative)10% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00222826083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML184-((3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoic acidCOc1cc(CCC(=O)OC2CCCCC2)cc(OC)c1OCNon beta lactone inhibitor (AV170 derivative)20% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00222926083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML20Methyl 4-(((3,4,5-trimethoxybenzyl)carbamoyl)oxy)benzoateCOc1cc(CCC(=O)Oc2ccc(cc2)C(O)=O)cc(OC)c1OCNon beta lactone inhibitor (AV170 derivative)30% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00223026083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML68methyl 4-{[3-(thiophen-2-yl)propanoyl]oxy}benzoateCOC(=O)C1=CC=C(OC(=O)CCC2=CC=CS2)C=C1Non beta lactone inhibitor (AV170 derivative)5% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00223126083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1341-(2,2-dimethylpropanoyl)-N-[4-(2-oxopyrrolidin-1-yl)phenyl]piperidine-4-sulfonamideCC(C)(C)C(=O)N1CCC(CC1)S(=O)(=O)NC1=CC=C(C=C1)N1CCCC1=ONon beta lactone inhibitor (AV170 derivative)0-5% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00223226083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML31Methyl 4-(hept-6-ynoyloxy)benzoateCOC(=O)c1ccc(OC(=O)CCCCC#C)cc1Non beta lactone inhibitor (AV170 derivative)15% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00223326083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML242-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOc1cc(CCC(=O)Oc2ccccc2C(C)=O)cc(OC)c1OCNon beta lactone inhibitor (AV170 derivative)55% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00223426083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML30Methyl 4-(undec-10-ynoyloxy)benzoateCOC(=O)c1ccc(OC(=O)CCCCCCCCC#C)cc1Non beta lactone inhibitor (AV170 derivative)0-5% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00223526083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML744-(Methoxycarbonyl)phenyl 3,4,5-trimethoxybenzoateCOC(=O)c1ccc(OC(=O)c2cc(OC)c(OC)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)75% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00223626083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML124-Nitrophenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOc1cc(CCC(=O)Oc2ccc(cc2)[N+]([O-])=O)cc(OC)c1OCNon beta lactone inhibitor (AV170 derivative)0-5% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00223726083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1371-(2,2-dimethylpropanoyl)-N-[4-(2-oxopyrrolidin-1-yl)phenyl]piperidine-4-carboxamideCC(C)(C)C(=O)N1CCC(CC1)C(=O)Nc2ccc(cc2)N3CCCC3=ONon beta lactone inhibitor (AV170 derivative)0-5% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00223826083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML16Methyl 4-((3-(3,5-dimethoxy-4-(prop-2-yn-1-yloxy)phenyl)propanoyl)oxy)benzoateCOC(=O)c1ccc(OC(=O)CCc2cc(OC)c(OCC#C)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)0-5% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00223926083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML21Methyl 4-(2-(3,4,5-trimethoxyphenyl)acetoxy)benzoateCOC(=O)c1ccc(OC(=O)Cc2cc(OC)c(OC)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)0-5% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00224026083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML33Methyl 4-((3-(1H-indol-3-yl)propanoyl)oxy)benzoateCOC(=O)c1ccc(OC(=O)CCc2c[nH]c3ccccc23)cc1Non beta lactone inhibitor (AV170 derivative)0-5% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00224126083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML03Isopropyl 4-((3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoateCOc1cc(CCC(=O)Oc2ccc(cc2)C(=O)OC(C)C)cc(OC)c1OCNon beta lactone inhibitor (AV170 derivative)90-95% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00224226083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML23methyl 3-{[3-(3,4,5-trimethoxyphenyl)propanoyl]oxy}benzoateCOC(=O)c1cccc(OC(=O)CCc2cc(OC)c(OC)c(OC)c2)c1Non beta lactone inhibitor (AV170 derivative)95% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00224326083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAMLIH184-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOc1cc(CCC(=O)Oc2ccc(cc2)c3noc(C)n3)cc(OC)c1OCNon beta lactone inhibitor (AV170 derivative)95% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00224426083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML14Butyl 3-(3,4,5-trimethoxyphenyl)propanoateCCCCOC(=O)CCc1cc(OC)c(OC)c(OC)c1Non beta lactone inhibitor (AV170 derivative)95% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00224526083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML274-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOc1cc(CCC(=O)Oc2ccc(cc2)C(C)=O)cc(OC)c1OCNon beta lactone inhibitor (AV170 derivative)92% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00224626083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAMLIH194-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOc1cc(CCC(=O)Oc2ccc(cc2)c3oc(C)nn3)cc(OC)c1OCNon beta lactone inhibitor (AV170 derivative)95% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00224726083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML254-formylphenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOc1cc(CCC(=O)Oc2ccc(C=O)cc2)cc(OC)c1OCNon beta lactone inhibitor (AV170 derivative)80% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00224826083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML054-Methoxyphenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOc1ccc(OC(=O)CCc2cc(OC)c(OC)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)30% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00224926083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML06Phenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOc1cc(CCC(=O)Oc2ccccc2)cc(OC)c1OCNon beta lactone inhibitor (AV170 derivative)15% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00225026083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML284-(Dimethylamino)phenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOc1cc(CCC(=O)Oc2ccc(cc2)N(C)C)cc(OC)c1OCNon beta lactone inhibitor (AV170 derivative)10% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00225126083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML92Methyl 4-((3-(3,4-dimethoxyphenyl)propanoyl)oxy)benzoateCOC(=O)c1ccc(OC(=O)CCc2ccc(OC)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)20% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00225226083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML57Methyl 4-((3-(3-acetylphenyl)propanoyl)oxy)benzoateCOC(=O)c1ccc(OC(=O)CCc2cccc(c2)C(C)=O)cc1Non beta lactone inhibitor (AV170 derivative)0-5% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00225326083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML09Cyclohexyl 3-(3,4,5-trimethoxyphenyl)propanoateCOc1cc(CCC(=O)OC2CCCCC2)cc(OC)c1OCNon beta lactone inhibitor (AV170 derivative)0-5% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00225426083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML184-((3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoic acidCOc1cc(CCC(=O)Oc2ccc(cc2)C(O)=O)cc(OC)c1OCNon beta lactone inhibitor (AV170 derivative)0-5% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00225526083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML20Methyl 4-(((3,4,5-trimethoxybenzyl)carbamoyl)oxy)benzoateCOC(=O)c1ccc(OC(=O)NCc2cc(OC)c(OC)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)0-5% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00225626083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML68methyl 4-{[3-(thiophen-2-yl)propanoyl]oxy}benzoateCOC(=O)c1ccc(OC(=O)CCc2sccc2)cc1Non beta lactone inhibitor (AV170 derivative)0-5% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00225726083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1341-(2,2-dimethylpropanoyl)-N-[4-(2-oxopyrrolidin-1-yl)phenyl]piperidine-4-sulfonamideCC(C)(C)C(=O)N1CCC(CC1)[S](=O)(=O)Nc2ccc(cc2)N3CCCC3=ONon beta lactone inhibitor (AV170 derivative)0-5% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00225826083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML31Methyl 4-(hept-6-ynoyloxy)benzoateCOC(=O)c1ccc(OC(=O)CCCCC#C)cc1Non beta lactone inhibitor (AV170 derivative)0-5% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00225926083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML242-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOc1cc(CCC(=O)Oc2ccccc2C(C)=O)cc(OC)c1OCNon beta lactone inhibitor (AV170 derivative)8% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00226026083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML30Methyl 4-(undec-10-ynoyloxy)benzoateCOC(=O)c1ccc(OC(=O)CCCCCCCCC#C)cc1Non beta lactone inhibitor (AV170 derivative)0-5% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00226126083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML744-(Methoxycarbonyl)phenyl 3,4,5-trimethoxybenzoateCOC(=O)c1ccc(OC(=O)c2cc(OC)c(OC)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)10% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00226226083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML124-Nitrophenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOc1cc(CCC(=O)Oc2ccc(cc2)[N+]([O-])=O)cc(OC)c1OCNon beta lactone inhibitor (AV170 derivative)15% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00226326083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1371-(2,2-dimethylpropanoyl)-N-[4-(2-oxopyrrolidin-1-yl)phenyl]piperidine-4-carboxamideCC(C)(C)C(=O)N1CCC(CC1)C(=O)Nc2ccc(cc2)N3CCCC3=ONon beta lactone inhibitor (AV170 derivative)0-5% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00226426083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML16Methyl 4-((3-(3,5-dimethoxy-4-(prop-2-yn-1-yloxy)phenyl)propanoyl)oxy)benzoateCOC(=O)c1ccc(OC(=O)CCc2cc(OC)c(OCC#C)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)0-5% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00226526083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML21Methyl 4-(2-(3,4,5-trimethoxyphenyl)acetoxy)benzoateCOC(=O)c1ccc(OC(=O)Cc2cc(OC)c(OC)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)75% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00226626083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML33Methyl 4-((3-(1H-indol-3-yl)propanoyl)oxy)benzoateCOC(=O)c1ccc(OC(=O)CCc2c[nH]c3ccccc23)cc1Non beta lactone inhibitor (AV170 derivative)70% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00226726083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML03Isopropyl 4-((3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoateCOc1cc(CCC(=O)Oc2ccc(cc2)C(=O)OC(C)C)cc(OC)c1OCNon beta lactone inhibitor (AV170 derivative)60% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00226826083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML23methyl 3-{[3-(3,4,5-trimethoxyphenyl)propanoyl]oxy}benzoateCOC(=O)c1cccc(OC(=O)CCc2cc(OC)c(OC)c(OC)c2)c1Non beta lactone inhibitor (AV170 derivative)55% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00226926083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAMLIH184-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOc1cc(CCC(=O)Oc2ccc(cc2)c3noc(C)n3)cc(OC)c1OCNon beta lactone inhibitor (AV170 derivative)50% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00227026083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML14Butyl 3-(3,4,5-trimethoxyphenyl)propanoateCCCCOC(=O)CCc1cc(OC)c(OC)c(OC)c1Non beta lactone inhibitor (AV170 derivative)50% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00227126083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML274-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOc1cc(CCC(=O)Oc2ccc(cc2)C(C)=O)cc(OC)c1OCNon beta lactone inhibitor (AV170 derivative)45% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00227226083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAMLIH194-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOc1cc(CCC(=O)Oc2ccc(cc2)c3oc(C)nn3)cc(OC)c1OCNon beta lactone inhibitor (AV170 derivative)35% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00227326083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML254-formylphenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOc1cc(CCC(=O)Oc2ccc(C=O)cc2)cc(OC)c1OCNon beta lactone inhibitor (AV170 derivative)30% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00227426083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML054-Methoxyphenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOc1ccc(OC(=O)CCc2cc(OC)c(OC)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)15% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00227526083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML06Phenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOc1cc(CCC(=O)Oc2ccccc2)cc(OC)c1OCNon beta lactone inhibitor (AV170 derivative)10% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00227626083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML284-(Dimethylamino)phenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOc1cc(CCC(=O)Oc2ccc(cc2)N(C)C)cc(OC)c1OCNon beta lactone inhibitor (AV170 derivative)10% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00227726083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML92Methyl 4-((3-(3,4-dimethoxyphenyl)propanoyl)oxy)benzoateCOC(=O)c1ccc(OC(=O)CCc2ccc(OC)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)10% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00227826083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML57Methyl 4-((3-(3-acetylphenyl)propanoyl)oxy)benzoateCOC(=O)c1ccc(OC(=O)CCc2cccc(c2)C(C)=O)cc1Non beta lactone inhibitor (AV170 derivative)10% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00227926083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML09Cyclohexyl 3-(3,4,5-trimethoxyphenyl)propanoateCOc1cc(CCC(=O)OC2CCCCC2)cc(OC)c1OCNon beta lactone inhibitor (AV170 derivative)10% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00228026083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML184-((3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoic acidCOc1cc(CCC(=O)Oc2ccc(cc2)C(O)=O)cc(OC)c1OCNon beta lactone inhibitor (AV170 derivative)10% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00228126083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML20Methyl 4-(((3,4,5-trimethoxybenzyl)carbamoyl)oxy)benzoateCOC(=O)c1ccc(OC(=O)NCc2cc(OC)c(OC)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)5% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00228226083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML68methyl 4-{[3-(thiophen-2-yl)propanoyl]oxy}benzoateCOC(=O)C1=CC=C(OC(=O)CCC2=CC=CS2)C=C1Non beta lactone inhibitor (AV170 derivative)0-5% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00228326083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1341-(2,2-dimethylpropanoyl)-N-[4-(2-oxopyrrolidin-1-yl)phenyl]piperidine-4-sulfonamideCC(C)(C)C(=O)N1CCC(CC1)S(=O)(=O)NC1=CC=C(C=C1)N1CCCC1=ONon beta lactone inhibitor (AV170 derivative)0-5% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00228426083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML31Methyl 4-(hept-6-ynoyloxy)benzoateCOC(=O)c1ccc(OC(=O)CCCCC#C)cc1Non beta lactone inhibitor (AV170 derivative)0-5% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00228526083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML242-acetylphenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOc1cc(CCC(=O)Oc2ccccc2C(C)=O)cc(OC)c1OCNon beta lactone inhibitor (AV170 derivative)0-5% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00228626083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML30Methyl 4-(undec-10-ynoyloxy)benzoateCOC(=O)c1ccc(OC(=O)CCCCCCCCC#C)cc1Non beta lactone inhibitor (AV170 derivative)0-5% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00228726083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML744-(Methoxycarbonyl)phenyl 3,4,5-trimethoxybenzoateCOC(=O)c1ccc(OC(=O)c2cc(OC)c(OC)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)0-5% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00228826083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML124-Nitrophenyl 3-(3,4,5-trimethoxyphenyl)propanoateCOc1cc(CCC(=O)Oc2ccc(cc2)[N+]([O-])=O)cc(OC)c1OCNon beta lactone inhibitor (AV170 derivative)0-5% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00228926083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV1371-(2,2-dimethylpropanoyl)-N-[4-(2-oxopyrrolidin-1-yl)phenyl]piperidine-4-carboxamideCC(C)(C)C(=O)N1CCC(CC1)C(=O)Nc2ccc(cc2)N3CCCC3=ONon beta lactone inhibitor (AV170 derivative)0-5% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00229026083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML73Methyl 4-((2-(3,4,5-trimethoxybenzyl)acryloyl)oxy)benzoateCOC(=O)c1ccc(OC(=O)C(=C)Cc2cc(OC)c(OC)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)0-5% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00229126083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML91Methyl (E)-4-((3-(3,4,5-trimethoxyphenyl)acryloyl)oxy)benzoateCOC(=O)c1ccc(OC(=O)/C=C/c2cc(OC)c(OC)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)95% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00229226083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML43Methyl 4-((2-methyl-3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoateCOC(=O)c1ccc(OC(=O)C(C)Cc2cc(OC)c(OC)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)100% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00229326083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML38Methyl (E)-4-((2-methyl-3-(3,4,5-trimethoxyphenyl)acryloyl)oxy)benzoateCOC(=O)c1ccc(OC(=O)C(/C)=C/c2cc(OC)c(OC)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)90% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00229426083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML37Methyl 3-methyl-4-((3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoateCOC(=O)c1ccc(OC(=O)CCc2cc(OC)c(OC)c(OC)c2)c(C)c1Non beta lactone inhibitor (AV170 derivative)20% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00229526083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML15Methyl 3,5-dimethyl-4-((3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoateCOC(=O)c1cc(C)c(OC(=O)CCc2cc(OC)c(OC)c(OC)c2)c(C)c1Non beta lactone inhibitor (AV170 derivative)0-5% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00229626083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML89Methyl (R)-4-((2-methyl-3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoateCOC(=O)c1ccc(OC(=O)[C@H](C)Cc2cc(OC)c(OC)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)0-5% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00229726083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML90Methyl (S)-4-((2-methyl-3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoateCOC(=O)c1ccc(OC(=O)[C@@H](C)Cc2cc(OC)c(OC)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)0-5% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00229826083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML95Methyl (R)-4-((2-(3,4,5-trimethoxybenzyl)butanoyl)oxy)benzoateCC[C@H](Cc1cc(OC)c(OC)c(OC)c1)C(=O)Oc2ccc(cc2)C(=O)OCNon beta lactone inhibitor (AV170 derivative)55% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00229926083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML96Methyl (S)-4-((2-(3,4,5-trimethoxybenzyl)butanoyl)oxy)benzoateCC[C@@H](Cc1cc(OC)c(OC)c(OC)c1)C(=O)Oc2ccc(cc2)C(=O)OCNon beta lactone inhibitor (AV170 derivative)10% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00230026083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML73Methyl 4-((2-(3,4,5-trimethoxybenzyl)acryloyl)oxy)benzoateCOC(=O)c1ccc(OC(=O)C(=C)Cc2cc(OC)c(OC)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)90% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00230126083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML91Methyl (E)-4-((3-(3,4,5-trimethoxyphenyl)acryloyl)oxy)benzoateCOC(=O)c1ccc(OC(=O)/C=C/c2cc(OC)c(OC)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)95% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00230226083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML43Methyl 4-((2-methyl-3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoateCOC(=O)c1ccc(OC(=O)C(C)Cc2cc(OC)c(OC)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)95% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00230326083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML38Methyl (E)-4-((2-methyl-3-(3,4,5-trimethoxyphenyl)acryloyl)oxy)benzoateCOC(=O)c1ccc(OC(=O)C(/C)=C/c2cc(OC)c(OC)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)70% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00230426083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML37Methyl 3-methyl-4-((3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoateCOC(=O)c1ccc(OC(=O)CCc2cc(OC)c(OC)c(OC)c2)c(C)c1Non beta lactone inhibitor (AV170 derivative)0-5% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00230526083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML15Methyl 3,5-dimethyl-4-((3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoateCOC(=O)c1cc(C)c(OC(=O)CCc2cc(OC)c(OC)c(OC)c2)c(C)c1Non beta lactone inhibitor (AV170 derivative)0-5% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00230626083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML89Methyl (R)-4-((2-methyl-3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoateCOC(=O)c1ccc(OC(=O)[C@H](C)Cc2cc(OC)c(OC)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)90% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00230726083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML90Methyl (S)-4-((2-methyl-3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoateCOC(=O)c1ccc(OC(=O)[C@@H](C)Cc2cc(OC)c(OC)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)60% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00230826083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML95Methyl (R)-4-((2-(3,4,5-trimethoxybenzyl)butanoyl)oxy)benzoateCC[C@H](Cc1cc(OC)c(OC)c(OC)c1)C(=O)Oc2ccc(cc2)C(=O)OCNon beta lactone inhibitor (AV170 derivative)10% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00230926083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML96Methyl (S)-4-((2-(3,4,5-trimethoxybenzyl)butanoyl)oxy)benzoateCC[C@@H](Cc1cc(OC)c(OC)c(OC)c1)C(=O)Oc2ccc(cc2)C(=O)OCNon beta lactone inhibitor (AV170 derivative)5% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00231026083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML73Methyl 4-((2-(3,4,5-trimethoxybenzyl)acryloyl)oxy)benzoateCOC(=O)c1ccc(OC(=O)C(=C)Cc2cc(OC)c(OC)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)60% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00231126083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML91Methyl (E)-4-((3-(3,4,5-trimethoxyphenyl)acryloyl)oxy)benzoateCOC(=O)c1ccc(OC(=O)/C=C/c2cc(OC)c(OC)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)20% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00231226083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML43Methyl 4-((2-methyl-3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoateCOC(=O)c1ccc(OC(=O)C(C)Cc2cc(OC)c(OC)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)15% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00231326083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML38Methyl (E)-4-((2-methyl-3-(3,4,5-trimethoxyphenyl)acryloyl)oxy)benzoateCOC(=O)c1ccc(OC(=O)C(/C)=C/c2cc(OC)c(OC)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)10% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00231426083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML37Methyl 3,5-dimethyl-4-((3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoateCOC(=O)c1cc(C)c(OC(=O)CCc2cc(OC)c(OC)c(OC)c2)c(C)c1Non beta lactone inhibitor (AV170 derivative)0-5% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00231526083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML15Methyl (R)-4-((2-methyl-3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoateCOC(=O)c1ccc(OC(=O)[C@H](C)Cc2cc(OC)c(OC)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)0-5% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00231626083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML89Methyl (S)-4-((2-methyl-3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoateCOC(=O)c1ccc(OC(=O)[C@@H](C)Cc2cc(OC)c(OC)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)20% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00231726083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML90Methyl (R)-4-((2-(3,4,5-trimethoxybenzyl)butanoyl)oxy)benzoateCC[C@H](Cc1cc(OC)c(OC)c(OC)c1)C(=O)Oc2ccc(cc2)C(=O)OCNon beta lactone inhibitor (AV170 derivative)15% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00231826083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML95Methyl (S)-4-((2-(3,4,5-trimethoxybenzyl)butanoyl)oxy)benzoateCC[C@@H](Cc1cc(OC)c(OC)c(OC)c1)C(=O)Oc2ccc(cc2)C(=O)OCNon beta lactone inhibitor (AV170 derivative)0-5% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00231926083639Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAML96Methyl (S)-4-((2-(3,4,5-trimethoxybenzyl)butanoyl)oxy)benzoateCC[C@@H](Cc1cc(OC)c(OC)c(OC)c1)C(=O)Oc2ccc(cc2)C(=O)OCNon beta lactone inhibitor (AV170 derivative)0-5% at 1 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00232026083639Hsp100NAHumanNANAAntiproliferative activityAV170methyl 4-{[3-(3,4,5-trimethoxyphenyl)propanoyl]oxy}benzoateCOC(=O)c1ccc(OC(=O)CCc2cc(OC)c(OC)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)NANANANANANANANANANA10MTT viability assay
HSPMDB00232126083639Hsp100NAHumanNANAAntiproliferative activityML21methyl 4-{[2-(3,4,5-trimethoxyphenyl)acetyl]oxy}benzoateCOC(=O)c1ccc(OC(=O)Cc2cc(OC)c(OC)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)NANANANANANANANANANA10MTT viability assay
HSPMDB00232226083639Hsp100NAHumanNANAAntiproliferative activityML89Methyl (R)-4-((2-methyl-3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoateCOC(=O)c1ccc(OC(=O)[C@H](C)Cc2cc(OC)c(OC)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)NANANANANANANANANANA10MTT viability assay
HSPMDB00232326083639Hsp100NAHumanNANAAntiproliferative activityML90Methyl (S)-4-((2-methyl-3-(3,4,5-trimethoxyphenyl)propanoyl)oxy)benzoateCOC(=O)c1ccc(OC(=O)[C@@H](C)Cc2cc(OC)c(OC)c(OC)c2)cc1Non beta lactone inhibitor (AV170 derivative)NANANANANANANANANANA5-OctMTT viability assay
HSPMDB00232426566002Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV145N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-Isopropyl-1H-pyrazolo[3,4-b]pyridine-5- carboxamideCC(C)n1ncc2cc(cnc12)C(=O)NCc3coc(n3)c4sccc4COMAS LibraryNANANA10NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00232526566002Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV280N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-(3,4-dimethylbenzyl)-1H-pyrazolo[3,4-b]pyridine5-carboxamide (AV280)Cc1ccc(Cn2ncc3cc(cnc23)C(=O)NCc4coc(n4)c5sccc5)cc1CCOMAS LibraryNANANA1.8NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00232626566002Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV191N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-Benzyl-1H-pyrazolo[3,4-b]pyridine-5- carboxamideO=C(NCc1coc(n1)c2sccc2)c3cnc4n(Cc5ccccc5)ncc4c3COMAS LibraryNANANA2NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00232726566002Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV267N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-(4-Methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamideCOc1ccc(Cn2ncc3cc(cnc23)C(=O)NCc4coc(n4)c5sccc5)cc1COMAS LibraryNANANA2.2NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00232826566002Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV261N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-(2-Phenethyl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamideCCc1ccccc1n2ncc3cc(cnc23)C(=O)NCc4coc(n4)c5sccc5COMAS LibraryNANANA2.3NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00232926566002Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV253N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-(4-Methylbenzyl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamideCc1ccc(Cn2ncc3cc(cnc23)C(=O)NCc4coc(n4)c5sccc5)cc1COMAS LibraryNANANA2.4NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00233026566002Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV259N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-(3-Phenylpropyl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamideO=C(NCc1coc(n1)c2sccc2)c3cnc4n(CCCc5ccccc5)ncc4c3COMAS LibraryNANANA3NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00233126566002Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV268N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-(3-Methylbenzyl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamideCc1cccc(Cn2ncc3cc(cnc23)C(=O)NCc4coc(n4)c5sccc5)c1COMAS LibraryNANANA3.8NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00233226566002Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV264N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-(3-Cyanobenzyl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamideO=C(NCc1coc(n1)c2sccc2)c3cnc4n(Cc5cccc(c5)C#N)ncc4c3COMAS LibraryNANANA4NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00233326566002Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV266N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-(3-Methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamideCOc1cccc(Cn2ncc3cc(cnc23)C(=O)NCc4coc(n4)c5sccc5)c1COMAS LibraryNANANA4.4NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00233426566002Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV265N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-(4-Cyanobenzyl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamideO=C(NCc1coc(n1)c2sccc2)c3cnc4n(Cc5ccc(cc5)C#N)ncc4c3COMAS LibraryNANANA5NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00233526566002Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV279N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-(4-Isopropylbenzyl)-1H-pyrazolo[3,4-b]pyridine5-carboxamideCC(C)c1ccc(Cn2ncc3cc(cnc23)C(=O)NCc4coc(n4)c5sccc5)cc1COMAS LibraryNANANA5.1NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00233626566002Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV145N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-Isopropyl-1H-pyrazolo[3,4-b]pyridine-5- carboxamideCC(C)n1ncc2cc(cnc12)C(=O)NCc3coc(n3)c4sccc4COMAS LibraryNANANA10NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00233726566002Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV286N-(2-(Thien-2-yl)oxazol-4-yl)methyl 4-(benzylaminocarbonylamino)benzamideO=C(NCc1ccccc1)Nc2ccc(cc2)C(=O)NCc3coc(n3)c4sccc4COMAS LibraryNANANA0.9NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00233826566002Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV241N-(2-(Thien-2-yl)oxazol-4-yl)methyl 4-(tert-butyloxycarbonylamino)benzamideCC(C)(C)OC(=O)Nc1ccc(cc1)C(=O)NCc2coc(n2)c3sccc3COMAS LibraryNANANA1.8NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00233926566002Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV285N-(2-(Thien-2-yl)oxazol-4-yl)methyl 4-(benzyloxycarbonylamino)benzamideO=C(Nc1ccc(cc1)C(=O)NCc2coc(n2)c3sccc3)OCc4ccccc4COMAS LibraryNANANA2.1NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00234026566002Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV2364-(4-ethoxybenzenesulfonamido)-N-{[2-(thiophen-2-yl)-1,3-oxazol-4-yl]methyl}benzamideCCOc1ccc(cc1)[S](=O)(=O)Nc2ccc(cc2)C(=O)NCc3coc(n3)c4sccc4COMAS LibraryNANANA4NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00234126566002Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV2434-(cyclopropylsulfamoyl)-N-{[2-(thiophen-2-yl)-1,3-oxazol-4-yl]methyl}benzamideO=C(NCc1coc(n1)c2sccc2)c3ccc(cc3)[S](=O)(=O)NC4CC4COMAS LibraryNANANA5.9NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00234226566002Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV2244-(dimethylsulfamoyl)-N-{[2-(thiophen-2-yl)-1,3-oxazol-4-yl]methyl}benzamideCN(C)[S](=O)(=O)c1ccc(cc1)C(=O)NCc2coc(n2)c3sccc3COMAS LibraryNANANA6NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00234326566002Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV2454-methanesulfonamido-N-{[2-(thiophen-2-yl)-1,3-oxazol-4-yl]methyl}benzamideC[S](=O)(=O)Nc1ccc(cc1)C(=O)NCc2coc(n2)c3sccc3COMAS LibraryNANANA8NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00234426566002Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAAV2354-Acetamido-N-((2-(thiophen-2-yl)oxazol-4-yl)methyl)benzamideCC(=O)Nc1ccc(cc1)C(=O)NCc2coc(n2)c3sccc3COMAS LibraryNANANA9.5NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00234526566002Hsp100ClpXPBacteriaCytosolInhibition of protease activityNAAV145N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-Isopropyl-1H-pyrazolo[3,4-b]pyridine-5- carboxamideCC(C)n1ncc2cc(cnc12)C(=O)NCc3coc(n3)c4sccc4COMAS Library98% at 100 uMNANANANANANANANucleotide binding domainSubstrate degradation assay (GFP-ssrA)NANA
HSPMDB00234626566002Hsp100ClpXPBacteriaCytosolInhibition of protease activityNAAV280N-(2-(Thien-2-yl)oxazol-4-yl)methyl 1-(3,4-dimethylbenzyl)-1H-pyrazolo[3,4-b]pyridine5-carboxamide (AV280)Cc1ccc(Cn2ncc3cc(cnc23)C(=O)NCc4coc(n4)c5sccc5)cc1CCOMAS Library90% at 100 uMNANANANANANANANucleotide binding domainSubstrate degradation assay (GFP-ssrA)NANA
HSPMDB00234726566002Hsp100ClpXPBacteriaCytosolInhibition of protease activityNAAV286N-(2-(Thien-2-yl)oxazol-4-yl)methyl 4-(benzylaminocarbonylamino)benzamideO=C(NCc1ccccc1)Nc2ccc(cc2)C(=O)NCc3coc(n3)c4sccc4COMAS Library55% at 100 uMNANANANANANANANucleotide binding domainSubstrate degradation assay (GFP-ssrA)NANA
HSPMDB00234826566002Hsp100ClpXPBacteriaCytosolInhibition of protease activityNAAV321N-(2-(Thien-2-yl)oxazol-4-yl)methyl 4-(2-(3-(But-3-ynyl)-3H-diazirin-3- yl)ethyloxycarbonylamino)benzamideO=C(Nc1ccc(cc1)C(=O)NCc2coc(n2)c3sccc3)OCCC4(CCC#C)N=N4COMAS Library85% at 100 uMNANANANANANANANucleotide binding domainSubstrate degradation assay (GFP-ssrA)NANA
HSPMDB00234926566002Hsp100ClpXPBacteriaCytosolInhibition of protease activityNAAV286N-(2-(Thien-2-yl)oxazol-4-yl)methyl 4-(benzylaminocarbonylamino)benzamideO=C(NCc1ccccc1)Nc2ccc(cc2)C(=O)NCc3coc(n3)c4sccc4COMAS LibraryNANANA2.1NANANANANucleotide binding domainSubstrate degradation assay (GFP-ssrA)NANA
HSPMDB00235026566002Hsp100ClpPBacteriaCytosolInhibition of protease activityNAAV287N-[2-(1H-1,3-benzodiazol-2-yl)ethyl]-4-(dimethylsulfamoyl)benzamideCN(C)S(=O)(=O)C1=CC=C(C=C1)C(=O)NCCC1=NC2=C(N1)C=CC=C2COMAS LibraryNANANA10.1NANANANANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00235126566002Hsp100ClpPBacteriaCytosolInhibition of protease activityNAAV287N-[2-(1H-1,3-benzodiazol-2-yl)ethyl]-4-(dimethylsulfamoyl)benzamideCN(C)S(=O)(=O)C1=CC=C(C=C1)C(=O)NCCC1=NC2=C(N1)C=CC=C3COMAS LibraryNANANA21.1NANANANANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00235226566002Hsp100ClpPBacteriaCytosolInhibition of protease activityNAAV287N-[2-(1H-1,3-benzodiazol-2-yl)ethyl]-4-(dimethylsulfamoyl)benzamideCN(C)S(=O)(=O)C1=CC=C(C=C1)C(=O)NCCC1=NC2=C(N1)C=CC=C4COMAS LibraryNANANA51.2NANANANANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00235326566002Hsp100ClpPBacteriaCytosolInhibition of protease activityNAAV287N-[2-(1H-1,3-benzodiazol-2-yl)ethyl]-4-(dimethylsulfamoyl)benzamideCN(C)S(=O)(=O)C1=CC=C(C=C1)C(=O)NCCC1=NC2=C(N1)C=CC=C5COMAS LibraryNANANA78.1NANANANANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00235426566002Hsp100ClpPBacteriaCytosolInhibition of protease activityNAAV287N-[2-(1H-1,3-benzodiazol-2-yl)ethyl]-4-(dimethylsulfamoyl)benzamideCN(C)S(=O)(=O)C1=CC=C(C=C1)C(=O)NCCC1=NC2=C(N1)C=CC=C6COMAS LibraryNANANA>95 NANANANANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00235525944857Hsp100ClpP1P2HumanCytosolNAAntibacterial activity100, (Bortezomib)[(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acidB(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)OPHARMAKON1600 library NANANANANANANANANucleotide binding domainNA90% at 50 uMBacterial growth inhibition assay (OD based)
HSPMDB00235625944857Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activity100, (Bortezomib)[(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acidB(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)OPHARMAKON1600 library NANANANANANANANANucleotide binding domainNA90% at 3 uMBacterial growth inhibition assay (OD based)
HSPMDB00235725944857Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activity100, (Bortezomib)[(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acidB(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)OPHARMAKON1600 library NANANANANANANANANucleotide binding domainNA30%Bacterial growth inhibition assay (OD based)
HSPMDB00235825944857Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activity100, (Bortezomib) + Amikacin[(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)OPHARMAKON1600 library NANANANANANANANANucleotide binding domainNA90%Bacterial growth inhibition assay (OD based)
HSPMDB00235925944857Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activity100, (Bortezomib) + streptomycin[(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)OPHARMAKON1600 library NANANANANANANANANucleotide binding domainNA95%Bacterial growth inhibition assay (OD based)
HSPMDB00236025944857Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activityBz-al(2S)-N-[(2S)-4-methyl-1-oxopentan-2-yl]-3-phenyl-2-[(pyrazin-2-yl)formamido]propanamideCC(C)C[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C1=NC=CN=C1)C=OBortezomib derivativeNANANANANANANANANucleotide binding domainNA5% at 50 uMBacterial growth inhibition assay (OD based)
HSPMDB00236125944857Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activityCEP-18770 (Delanzomib)[(1R)-1-[[(2S,3R)-3-hydroxy-2-[(6-phenylpyridine-2-carbonyl)amino]butanoyl]amino]-3-methylbutyl]boronic acidB(C(CC(C)C)NC(=O)C(C(C)O)NC(=O)C1=CC=CC(=N1)C2=CC=CC=C2)(O)OBortezomib derivativeNANANANANANANANANucleotide binding domainNA80% at 50 uMBacterial growth inhibition assay (OD based)
HSPMDB00236225944857Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activityMG-262[(1R)-3-methyl-1-[[(2S)-4-methyl-2-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]pentanoyl]amino]butyl]boronic acidB(C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1)(O)OBortezomib derivativeNANANANANANANANANucleotide binding domainNA45% at 50 uMBacterial growth inhibition assay (OD based)
HSPMDB00236325944857Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activityMG-132benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamateCC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1Bortezomib derivativeNANANANANANANANANucleotide binding domainNA10% at 50 uMBacterial growth inhibition assay (OD based)
HSPMDB00236425944857Hsp100ClpP1P2BacteriaCytosolNAAntibacterial activityMLN-2238 (Ixazomib)[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]boronic acidB(C(CC(C)C)NC(=O)CNC(=O)C1=C(C=CC(=C1)Cl)Cl)(O)OBortezomib derivativeNANANANANANANANANucleotide binding domainNA60% at 50 uMBacterial growth inhibition assay (OD based)
HSPMDB00236522123255Hsp100ClpP2BacteriaCytosolNAAntibacterial activityIDR-100011-[(3,5-difluorophenyl)methyl]-1-[(2E)-hept-2-enoyl]-3-[(3S,9S,13S,19S,22R)-19-methyl-2,8,12,18,21-pentaoxo-11-oxa-7,17,20-triazatetracyclo[20.4.0.0³,?.0¹³,¹?]hexacosan-9-yl]ureaFC=1C=C(C=C(C1)F)CN(C(=O)N[C@@H]1C(N2CCC[C@H]2C(C2CCCC[C@H]2C(N[C@H](C(N2CCC[C@H]2C(OC1)=O)=O)C)=O)=O)=O)C(\C=C\CCCC)=OAcyldepsipeptide analogueNANANANANANANANANucleotide binding domainNANABacterial growth inhibition assay (OD based)
HSPMDB00236622123255Hsp100ClpP2BacteriaCytosolNAAntibacterial activityADEP21-(3-cyclohexylpropanoyl)-1-[(3,5-difluorophenyl)methyl]-3-[(3S,9S,13S,15R,19S,22R)-15,19-dimethyl-2,8,12,18,21-pentaoxo-11-oxa-7,17,20-triazatetracyclo[20.4.0.0³,?.0¹³,¹?]hexacosan-9-yl]ureaC[C@@H]1C[C@@H]2N(C1)C(=O)[C@H](C)NC(=O)[C@@H]1CCCCC1C(=O)[C@@H]1CCCN1C(=O)[C@H](COC2=O)NC(=O)N(CC1=CC(F)=CC(F)=C1)C(=O)CCC1CCCCC1Acyldepsipeptide analogueNANANANANANANANANucleotide binding domainNANABacterial growth inhibition assay (OD based)
HSPMDB00236722123255Hsp100ClpP2BacteriaCytosolNAAntibacterial activityADEP31-(3-cyclohexylpropanoyl)-1-[(3,5-difluorophenyl)methyl]-3-[(3S,9S,13S,15R,19S,22R)-15,19-dimethyl-2,8,12,18,21-pentaoxo-11-oxa-7,17,20-triazatetracyclo[20.4.0.0³,?.0¹³,¹?]hexacosan-9-yl]ureaC[C@@H]1C[C@@H]2N(C1)C(=O)[C@H](C)NC(=O)[C@@H]1CCCCC1C(=O)[C@@H]1CCCN1C(=O)[C@H](COC2=O)NC(=O)N(CC1=CC(F)=CC(F)=C1)C(=O)CCC1CCCCC1Acyldepsipeptide analogueNANANANANANANANANucleotide binding domainNANABacterial growth inhibition assay (OD based)
HSPMDB00236822123255Hsp100ClpP2BacteriaCytosolNAAntibacterial activityADEP41-[(3,5-difluorophenyl)methyl]-3-[(3S,9S,13S,15R,19S,22R)-15,19-dimethyl-2,8,12,18,21-pentaoxo-11-oxa-7,17,20-triazatetracyclo[20.4.0.0³,?.0¹³,¹?]hexacosan-9-yl]-1-[(2E)-hept-2-enoyl]ureaCCCC\C=C\C(=O)N(CC1=CC(F)=CC(F)=C1)C(=O)N[C@H]1COC(=O)[C@@H]2C[C@@H](C)CN2C(=O)[C@H](C)NC(=O)[C@@H]2CCCCC2C(=O)[C@@H]2CCCN2C1=OAcyldepsipeptide analogueNANANANANANANANANucleotide binding domainNANABacterial growth inhibition assay (OD based)
HSPMDB00236922123255Hsp100ClpP2BacteriaCytosolNAAntibacterial activityIDR-100111-(3-cyclohexylpropanoyl)-1-[(3,5-difluorophenyl)methyl]-3-[(3S,9S,13S,19S,22R)-19-methyl-2,8,12,18,21-pentaoxo-11-oxa-7,17,20-triazatetracyclo[20.4.0.0³,?.0¹³,¹?]hexacosan-9-yl]ureaC[C@@H]1NC(=O)[C@@H]2CCCCC2C(=O)[C@@H]2CCCN2C(=O)[C@H](COC(=O)[C@@H]2CCCN2C1=O)NC(=O)N(CC1=CC(F)=CC(F)=C1)C(=O)CCC1CCCCC1Acyldepsipeptide analogueNANANANANANANANANucleotide binding domainNANABacterial growth inhibition assay (OD based)
HSPMDB00237022123255Hsp100ClpP2BacteriaCytosolNAAntibacterial activityIDR-100011-[(3,5-difluorophenyl)methyl]-1-[(2E)-hept-2-enoyl]-3-[(3S,9S,13S,19S,22R)-19-methyl-2,8,12,18,21-pentaoxo-11-oxa-7,17,20-triazatetracyclo[20.4.0.0³,?.0¹³,¹?]hexacosan-9-yl]ureaFC=1C=C(C=C(C1)F)CN(C(=O)N[C@@H]1C(N2CCC[C@H]2C(C2CCCC[C@H]2C(N[C@H](C(N2CCC[C@H]2C(OC1)=O)=O)C)=O)=O)=O)C(\C=C\CCCC)=OAcyldepsipeptide analogueNANANANANANANANANucleotide binding domainNANABacterial growth inhibition assay (OD based)
HSPMDB00237122123255Hsp100ClpP2BacteriaCytosolNAAntibacterial activityADEP21-(3-cyclohexylpropanoyl)-1-[(3,5-difluorophenyl)methyl]-3-[(3S,9S,13S,15R,19S,22R)-15,19-dimethyl-2,8,12,18,21-pentaoxo-11-oxa-7,17,20-triazatetracyclo[20.4.0.0³,?.0¹³,¹?]hexacosan-9-yl]ureaC[C@@H]1C[C@@H]2N(C1)C(=O)[C@H](C)NC(=O)[C@@H]1CCCCC1C(=O)[C@@H]1CCCN1C(=O)[C@H](COC2=O)NC(=O)N(CC1=CC(F)=CC(F)=C1)C(=O)CCC1CCCCC1Acyldepsipeptide analogueNANANANANANANANANucleotide binding domainNANABacterial growth inhibition assay (OD based)
HSPMDB00237222123255Hsp100ClpP2BacteriaCytosolNAAntibacterial activityADEP31-(3-cyclohexylpropanoyl)-1-[(3,5-difluorophenyl)methyl]-3-[(3S,9S,13S,15R,19S,22R)-15,19-dimethyl-2,8,12,18,21-pentaoxo-11-oxa-7,17,20-triazatetracyclo[20.4.0.0³,?.0¹³,¹?]hexacosan-9-yl]ureaC[C@@H]1C[C@@H]2N(C1)C(=O)[C@H](C)NC(=O)[C@@H]1CCCCC1C(=O)[C@@H]1CCCN1C(=O)[C@H](COC2=O)NC(=O)N(CC1=CC(F)=CC(F)=C1)C(=O)CCC1CCCCC1Acyldepsipeptide analogueNANANANANANANANANucleotide binding domainNANABacterial growth inhibition assay (OD based)
HSPMDB00237322123255Hsp100ClpP2BacteriaCytosolNAAntibacterial activityADEP41-[(3,5-difluorophenyl)methyl]-3-[(3S,9S,13S,15R,19S,22R)-15,19-dimethyl-2,8,12,18,21-pentaoxo-11-oxa-7,17,20-triazatetracyclo[20.4.0.0³,?.0¹³,¹?]hexacosan-9-yl]-1-[(2E)-hept-2-enoyl]ureaCCCC\C=C\C(=O)N(CC1=CC(F)=CC(F)=C1)C(=O)N[C@H]1COC(=O)[C@@H]2C[C@@H](C)CN2C(=O)[C@H](C)NC(=O)[C@@H]2CCCCC2C(=O)[C@@H]2CCCN2C1=OAcyldepsipeptide analogueNANANANANANANANANucleotide binding domainNANABacterial growth inhibition assay (OD based)
HSPMDB00237422123255Hsp100ClpP2BacteriaCytosolNAAntibacterial activityIDR-100111-(3-cyclohexylpropanoyl)-1-[(3,5-difluorophenyl)methyl]-3-[(3S,9S,13S,19S,22R)-19-methyl-2,8,12,18,21-pentaoxo-11-oxa-7,17,20-triazatetracyclo[20.4.0.0³,?.0¹³,¹?]hexacosan-9-yl]ureaC[C@@H]1NC(=O)[C@@H]2CCCCC2C(=O)[C@@H]2CCCN2C(=O)[C@H](COC(=O)[C@@H]2CCCN2C1=O)NC(=O)N(CC1=CC(F)=CC(F)=C1)C(=O)CCC1CCCCC1Acyldepsipeptide analogueNANANANANANANANANucleotide binding domainNANABacterial growth inhibition assay (OD based)
HSPMDB00237522123255Hsp100ClpP2BacteriaCytosolNAAntibacterial activityIDR-100011-[(3,5-difluorophenyl)methyl]-1-[(2E)-hept-2-enoyl]-3-[(3S,9S,13S,19S,22R)-19-methyl-2,8,12,18,21-pentaoxo-11-oxa-7,17,20-triazatetracyclo[20.4.0.0³,?.0¹³,¹?]hexacosan-9-yl]ureaFC=1C=C(C=C(C1)F)CN(C(=O)N[C@@H]1C(N2CCC[C@H]2C(C2CCCC[C@H]2C(N[C@H](C(N2CCC[C@H]2C(OC1)=O)=O)C)=O)=O)=O)C(\C=C\CCCC)=OAcyldepsipeptide analogueNANANANANANANANANANANABacterial growth inhibition assay (OD based)
HSPMDB00237622123255Hsp100ClpP2BacteriaCytosolNAAntibacterial activityIDR-100111-(3-cyclohexylpropanoyl)-1-[(3,5-difluorophenyl)methyl]-3-[(3S,9S,13S,19S,22R)-19-methyl-2,8,12,18,21-pentaoxo-11-oxa-7,17,20-triazatetracyclo[20.4.0.0³,?.0¹³,¹?]hexacosan-9-yl]ureaC[C@@H]1NC(=O)[C@@H]2CCCCC2C(=O)[C@@H]2CCCN2C(=O)[C@H](COC(=O)[C@@H]2CCCN2C1=O)NC(=O)N(CC1=CC(F)=CC(F)=C1)C(=O)CCC1CCCCC1Acyldepsipeptide analogueNANANANANANANANANANANABacterial growth inhibition assay (OD based)
HSPMDB00237719206121Hsp100ClpPBacteriaCytosolInhibition of protease activityNAR1trans-4-methyl-3-(8-nonen-1-yl)oxetan-2-oneC[C@@H]1OC(=O)[C@H]1CCCCCCCC=CBeta lactone analogueNANANA3NANANANANAPeptidase assay (SLY-AMC)NANA
HSPMDB00237819206121Hsp100ClpPBacteriaCytosolInhibition of protease activityNAU1trans-3-(8-Nonen-1-yl)-4-pheneth-1-yloxetan-2-oneCCC1(CC=CC=C1)[C@@H]2OC(=O)[C@H]2CCCCCCCC=CBeta lactone analogueNANANA7NANANANANAPeptidase assay (SLY-AMC)NANA
HSPMDB00237926675528Hsp100ClpPHumanCytosolNAAntiproliferative activityCisplatindichloroplatinumdiamineN.N.Cl[Pt]ClChemical compoundNANANANANANANANANANA<50%Bacterial growth inhibition assay (OD based)
HSPMDB00238024106749Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNADFPDiisopropyl fluorophosphateCC(C)O[P](F)(=O)OC(C)CChemical compound95%NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00238124106749Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAE23-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-oneCOc1ccc(cc1)C2C(CCCC#C)OC2=OChemical compound98%NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00238224106749Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNARKS094-(4-ethynylbenzoyl)-2-(undec-10-enoyl)-1??,2-thiazetidine-1,1-dioneC=CCCCCCCCCC(=O)N1CC(C(=O)c2ccc(cc2)C#C)[S]1(=O)=OChemical compound99%NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00238324106749Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNADCI3,4-DichloroisocoumarineClC1=C(Cl)c2ccccc2C(=O)O1Chemical compound60% at 25ºC for 1 hrNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00238424106749Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNACMKchloromethylketoneCC(Cl)=OChemical compound85% at 25ºC for 1 hrNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00238524106749Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAFPDiisopropyl fluorophosphateCC(C)O[P](F)(=O)OC(C)CChemical compound60% at 25ºC for 1 hrNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00238624106749Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNARKS022-(hex-5-ynoyl)-1??,2-thiazetidine-1,1-dioneO=C(CCCC#C)N1CC[S]1(=O)=OChemical compound75% at 25ºC for 1 hrNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00238724106749Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNADCI3,4-DichloroisocoumarineClC1=C(Cl)c2ccccc2C(=O)O1Chemical compound98% at 37ºC for 2 hrNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00238824106749Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNACMKchloromethylketoneCC(Cl)=OChemical compound98% at 37ºC for 2 hrNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00238924106749Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNAFPDiisopropyl fluorophosphateCC(C)O[P](F)(=O)OC(C)CChemical compound99% at 37ºC for 2 hrNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00239024106749Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNARKS022-(hex-5-ynoyl)-1??,2-thiazetidine-1,1-dioneO=C(CCCC#C)N1CCS1(=O)=OChemical compound98% at 37ºC for 2 hrNANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00239124106749Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNARKS072-acetyl-4-(4-ethynylbenzoyl)-1??,2-thiazetidine-1,1-dioneCC(=O)N1CC(C(=O)C2=CC=C(C=C2)C#C)S1(=O)=OChemical compoundNANANA0.98 at 1 uM NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00239224106749Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNARKS072-acetyl-4-(4-ethynylbenzoyl)-1??,2-thiazetidine-1,1-dioneCC(=O)N1CC(C(=O)C2=CC=C(C=C2)C#C)S1(=O)=OChemical compoundNANANA0.98 at 0.4 uM NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00239318847196Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNALactone D33-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-oneC=CCCCCCCCC1C(CCCC#C)OC1=OBeta lactone analogueNANANA6NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00239418847196Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNALactone E23-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-oneCOC1=CC=C(C=C1)C1C(CCCC#C)OC1=OBeta lactone analogueNANANA4NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00239518847196Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNALactone G24-(pent-4-yn-1-yl)-3-pentyloxetan-2-oneCCCCCC1C(CCCC#C)OC1=OBeta lactone analogueNANANA31NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00239623892893Hsp100p97YeastCytosol, Mitochondria, Endoplasmic reliculum, NucleousInhibition of ATPase activityNANMS-8592-chloro-N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)amino]-phenyl}acetamideClCC(=O)Nc1cccc(NC2=N[S](=O)(=O)c3ccccc23)c1Small moleculeNANANA0.37 uM at 60 uM ATPNANANANANucleotide binding domain (D2)Peptidase assay (SLY-AMC)NANA
HSPMDB00239723892893Hsp100p97YeastCytosol, Mitochondria, Endoplasmic reliculum, NucleousInhibition of ATPase activityNANMS-694N,N’-dibenzylquinazoline-2,4-diamineC(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4Small moleculeNANANA2 uM at 60 uM ATPNANANANANucleotide binding domain (D2)Peptidase assay (SLY-AMC)NANA
HSPMDB00239823892893Hsp100p97YeastCytosol, Mitochondria, Endoplasmic reliculum, NucleousInhibition of ATPase activityNANMS-485AN 4 -benzyl-N 2 -(3-fluorophenyl)quinazoline-2,4-diamineFc1cccc(Nc2nc(NCc3ccccc3)c4ccccc4n2)c1Small moleculeNANANA0.45 uM at 60 uM ATPNANANANANucleotide binding domain (D2)Peptidase assay (SLY-AMC)NANA
HSPMDB00239923892893Hsp100p97YeastCytosol, Mitochondria, Endoplasmic reliculum, NucleousInhibition of ATPase activityNANMS-8623-isopropylsulfanyl-5-phenoxymethyl-4-phenyl-4H-[1,2,4]triazoleCC(C)Sc1nnc(COc2ccccc2)n1c3ccccc3Small moleculeNANANA2.66 uM at 60 uM ATPNANANANANucleotide binding domain (D2)Peptidase assay (SLY-AMC)NANA
HSPMDB00240023892893Hsp100p97YeastCytosol, Mitochondria, Endoplasmic reliculum, NucleousInhibition of ATPase activityNANMS-8733-[3-cyclopentylsulfanyl-5-(4'-methanesulfonyl-2-methyl-biphenyl-4-yloxymethyl)- [1,2,4]triazol-4-yl]-pyridineCc1cc(OCc2nnc(SC3CCCC3)n2c4cccnc4)ccc1c5ccc(cc5)[S](C)(=O)=OSmall moleculeNANANA0.03 uM at 60 uM ATPNANANANANucleotide binding domain (D2)Peptidase assay (SLY-AMC)NANA
HSPMDB00240123892893Hsp100p97YeastCytosol, Mitochondria, Endoplasmic reliculum, NucleousInhibition of ATPase activityNANMS-8592-chloro-N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)amino]-phenyl}acetamideClCC(=O)Nc1cccc(NC2=N[S](=O)(=O)c3ccccc23)c1Small moleculeNANANA0.36 uM at 1 mM ATPNANANANANucleotide binding domain (D2)Peptidase assay (SLY-AMC)NANA
HSPMDB00240223892893Hsp100p97YeastCytosol, Mitochondria, Endoplasmic reliculum, NucleousInhibition of ATPase activityNANMS-694N,N’-dibenzylquinazoline-2,4-diamineC(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4Small moleculeNANANA9.13 uM at 1 mM ATPNANANANANucleotide binding domain (D2)Peptidase assay (SLY-AMC)NANA
HSPMDB00240323892893Hsp100p97YeastCytosol, Mitochondria, Endoplasmic reliculum, NucleousInhibition of ATPase activityNANMS-485AN 4 -benzyl-N 2 -(3-fluorophenyl)quinazoline-2,4-diamineFc1cccc(Nc2nc(NCc3ccccc3)c4ccccc4n2)c1Small moleculeNANANA2.47 uM at 1 mM ATPNANANANANucleotide binding domain (D2)Peptidase assay (SLY-AMC)NANA
HSPMDB00240423892893Hsp100p97YeastCytosol, Mitochondria, Endoplasmic reliculum, NucleousInhibition of ATPase activityNANMS-8623-isopropylsulfanyl-5-phenoxymethyl-4-phenyl-4H-[1,2,4]triazoleCC(C)Sc1nnc(COc2ccccc2)n1c3ccccc3Small moleculeNANANA2.79 uM at 1 mM ATPNANANANANucleotide binding domain (D2)Peptidase assay (SLY-AMC)NANA
HSPMDB00240523892893Hsp100p97YeastCytosol, Mitochondria, Endoplasmic reliculum, NucleousInhibition of ATPase activityNANMS-8733-[3-cyclopentylsulfanyl-5-(4'-methanesulfonyl-2-methyl-biphenyl-4-yloxymethyl)- [1,2,4]triazol-4-yl]-pyridineCc1cc(OCc2nnc(SC3CCCC3)n2c4cccnc4)ccc1c5ccc(cc5)[S](C)(=O)=OSmall moleculeNANANA0.02 uM at 1 mM ATPNANANANANucleotide binding domain (D2)Peptidase assay (SLY-AMC)NANA
HSPMDB00240623892893Hsp100p97YeastCytosol, Mitochondria, Endoplasmic reliculum, NucleousInhibition of ATPase activityNANMS-8592-chloro-N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)amino]-phenyl}acetamideClCC(=O)Nc1cccc(NC2=N[S](=O)(=O)c3ccccc23)c1Small moleculeNANANA20.7 uM at 0 minuteNANANANANucleotide binding domain (D2)Peptidase assay (SLY-AMC)NANA
HSPMDB00240723892893Hsp100p97YeastCytosol, Mitochondria, Endoplasmic reliculum, NucleousInhibition of ATPase activityNANMS-8592-chloro-N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)amino]-phenyl}acetamideClCC(=O)Nc1cccc(NC2=N[S](=O)(=O)c3ccccc23)c1Small moleculeNANANA1.13 uM at 7.5 minutesNANANANANucleotide binding domain (D2)Peptidase assay (SLY-AMC)NANA
HSPMDB00240823892893Hsp100p97YeastCytosol, Mitochondria, Endoplasmic reliculum, NucleousInhibition of ATPase activityNANMS-8592-chloro-N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)amino]-phenyl}acetamideClCC(=O)Nc1cccc(NC2=N[S](=O)(=O)c3ccccc23)c1Small moleculeNANANA0.504 uM at 15 minutesNANANANANucleotide binding domain (D2)Peptidase assay (SLY-AMC)NANA
HSPMDB00240923892893Hsp100p97YeastCytosol, Mitochondria, Endoplasmic reliculum, NucleousInhibition of ATPase activityNANMS-8592-chloro-N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)amino]-phenyl}acetamideClCC(=O)Nc1cccc(NC2=N[S](=O)(=O)c3ccccc23)c1Small moleculeNANANA0.196 uM at 30 minutesNANANANANucleotide binding domain (D2)Peptidase assay (SLY-AMC)NANA
HSPMDB00241023892893Hsp100p97YeastCytosol, Mitochondria, Endoplasmic reliculum, NucleousInhibition of ATPase activityNANMS-8592-chloro-N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)amino]-phenyl}acetamideClCC(=O)Nc1cccc(NC2=N[S](=O)(=O)c3ccccc23)c1Small moleculeNANANA0.166 uM at 60 minutesNANANANANucleotide binding domain (D2)Peptidase assay (SLY-AMC)NANA
HSPMDB00241123892893Hsp100NAHumanNANAAntiproliferative activityNMS-8592-chloro-N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)amino]-phenyl}acetamideClCC(=O)Nc1cccc(NC2=N[S](=O)(=O)c3ccccc23)c1Small moleculeNANANA3.5NANANANANucleotide binding domain (D2)NANALuminescence based viability assay
HSPMDB00241223892893Hsp100NAHumanNANAAntiproliferative activityNMS-694N,N’-dibenzylquinazoline-2,4-diamineC(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4Small moleculeNANANA3.2NANANANANucleotide binding domain (D2)NANALuminescence based viability assay
HSPMDB00241323892893Hsp100NAHumanNANAAntiproliferative activityNMS-485AN 4 -benzyl-N 2 -(3-fluorophenyl)quinazoline-2,4-diamineFc1cccc(Nc2nc(NCc3ccccc3)c4ccccc4n2)c1Small moleculeNANANA2.8NANANANANucleotide binding domain (D2)NANALuminescence based viability assay
HSPMDB00241423892893Hsp100NAHumanNANAAntiproliferative activityNMS-8623-isopropylsulfanyl-5-phenoxymethyl-4-phenyl-4H-[1,2,4]triazoleCC(C)Sc1nnc(COc2ccccc2)n1c3ccccc3Small moleculeNANANA>10 NANANANANucleotide binding domain (D2)NANALuminescence based viability assay
HSPMDB00241523892893Hsp100NAHumanNANAAntiproliferative activityNMS-8733-[3-cyclopentylsulfanyl-5-(4'-methanesulfonyl-2-methyl-biphenyl-4-yloxymethyl)- [1,2,4]triazol-4-yl]-pyridineCc1cc(OCc2nnc(SC3CCCC3)n2c4cccnc4)ccc1c5ccc(cc5)[S](C)(=O)=OSmall moleculeNANANA0.4NANANANANucleotide binding domain (D2)NANALuminescence based viability assay
HSPMDB00241623892893Hsp100NAHumanNANAAntiproliferative activityNMS-8592-chloro-N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)amino]-phenyl}acetamideClCC(=O)Nc1cccc(NC2=N[S](=O)(=O)c3ccccc23)c1Small moleculeNANANA3NANANANANucleotide binding domain (D2)NANALuminescence based viability assay
HSPMDB00241723892893Hsp100NAHumanNANAAntiproliferative activityNMS-694N,N’-dibenzylquinazoline-2,4-diamineC(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4Small moleculeNANANA3.6NANANANANucleotide binding domain (D2)NANALuminescence based viability assay
HSPMDB00241823892893Hsp100NAHumanNANAAntiproliferative activityNMS-485AN 4 -benzyl-N 2 -(3-fluorophenyl)quinazoline-2,4-diamineFc1cccc(Nc2nc(NCc3ccccc3)c4ccccc4n2)c1Small moleculeNANANA4.1NANANANANucleotide binding domain (D2)NANALuminescence based viability assay
HSPMDB00241923892893Hsp100NAHumanNANAAntiproliferative activityNMS-8623-isopropylsulfanyl-5-phenoxymethyl-4-phenyl-4H-[1,2,4]triazoleCC(C)Sc1nnc(COc2ccccc2)n1c3ccccc3Small moleculeNANANA>10NANANANANucleotide binding domain (D2)NANALuminescence based viability assay
HSPMDB00242023892893Hsp100NAHumanNANAAntiproliferative activityNMS-8733-[3-cyclopentylsulfanyl-5-(4'-methanesulfonyl-2-methyl-biphenyl-4-yloxymethyl)- [1,2,4]triazol-4-yl]-pyridineCc1cc(OCc2nnc(SC3CCCC3)n2c4cccnc4)ccc1c5ccc(cc5)[S](C)(=O)=OSmall moleculeNANANA0.7NANANANANucleotide binding domain (D2)NANALuminescence based viability assay
HSPMDB00242123892893Hsp100p97BacteriaCytosol, Mitochondria, Endoplasmic reliculum, NucleousBinding AffinityNANMS-2494-(5-cyclopentylsulfanyl-4-pyridin-3-yl-4H-[1,2,4]triazol-3-ylmethoxy)-benzoic acid methyl esterCOC(=O)c1ccc(OCc2nnc(SC3CCCC3)n2c4cccnc4)cc1Small moleculeNA1.03NANANANANANANucleotide binding domain (D2)Isothermal titration calorimetry (ITC)NANA
HSPMDB00242228917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA1N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-2-((5-(3-hydroxynaphthalen-2-yl)-4-(2-methoxyethyl)-4H-1,2,4-triazol-3-yl)thio)acetamideCCc1sc(NC(=O)CSc2nnc(n2CCOC)c3cc4ccccc4cc3O)nn1Library of small molecule structuresNANANA30NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00242328917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA22,20,200-((1,3,5-Triazin-2,4,6-triyl)tris(sulfanediyl))-tris-(N-(furan-2-ylmethyl)acetamide)O=C(CNC(=O)OCc1ccccc1)N[C@@H](CCC(=O)OCc2ccccc2)C(=O)OCc3ccccc3Library of small molecule structuresNANANA92NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00242428917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA3Dibenzyl ((benzyloxy)carbonyl)glycylglutamateC(C1=CC=CC=C1)OC(=O)NCC(=O)N[C@@H](CCC(=O)OCC1=CC=CC=C1)C(=O)OCC1=CC=CC=C1Library of small molecule structuresNANANA>100NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00242528917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA4N,N-(5-(Thiazol-2-ylcarbamoyl)-1,3-phenylene)bis(2-phenoxyacetamide)COc1ccc(CNC(=O)C(=O)N/N=C/c2oc(CN[S](=O)(=O)c3ccc(Br)cc3)cc2)cc1Library of small molecule structuresNANANA88NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00242628917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA5(E)-2-(2-((5-(((4-Bromophenyl)sulfonamido)methyl)furan-2-yl)methylene)hydrazinyl)-N-(4-methoxybenzyl)-2-oxoacetamideCc1cc(SCC(=O)N(N)C(=O)Cc2ccccc2)nc(SCC(=O)c3ccccc3)n1Library of small molecule structuresNANANA>100NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00242728917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA62-((6-Methyl-2-((2-oxo-2-phenylethyl)thio)pyrimidin-4-yl)thio)-N-(2-phenylacetyl)acetohydrazideCCCCOc1ccc(c(C)c1)c2nn(cc2\C=C(C#N)\C(=O)NCc3occc3)c4ccccc4Library of small molecule structuresNANANA26NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00242828917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA7(E)-3-(3-(4-Butoxy-2-methylphenyl)-1-phenyl-1H-pyrazol-4-yl)-2-cyano-N-(furan-2-ylmethyl)acrylamideCCCOc1ccc(cc1F)c2nn(cc2\C=C\3SC(=S)N(CCc4ccccc4)C3=O)c5ccccc5Library of small molecule structuresNANANA>100NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00242928917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA8(Z)-5-((3-(3-Fluoro-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)-3-phenethyl-2-thioxothiazolidin-4-oneCCc1ccc(CSc2ncc(Cl)c(n2)C(=O)NCCC(=O)Nc3ccc(Cl)cc3)cc1Library of small molecule structuresNANANA>100NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00243028917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA95-Chloro-N-(3-((4-chlorophenyl)amino)-3-oxopropyl)-2-((4-ethylbenzyl)thio)pyrimidine-4-carboxamideClC=1C(=NC(=NC1)SCC1=CC=C(C=C1)CC)C(=O)NCCC(=O)NC1=CC=C(C=C1)ClLibrary of small molecule structuresNANANA>100NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00243128917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA10N-(3-methoxyphenyl)-2-{[3-oxo-4-(2-phenylethyl)-12-(propan-2-yl)-11-oxa-8-thia-4,6-diazatricyclo[7.4.0.0²,?]trideca-1(9),2(7),5-trien-5-yl]sulfanyl}acetamideCOC1=CC=CC(NC(=O)CSC2=NC3=C(C4=C(COC(C4)C(C)C)S3)C(=O)N2CCC2=CC=CC=C2)=C1Library of small molecule structuresNANANA>100NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00243228917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA112-{[3-oxo-4-(2-phenylethyl)-12-(propan-2-yl)-11-oxa-8-thia-4,6-diazatricyclo[7.4.0.0²,?]trideca-1(9),2(7),5-trien-5-yl]sulfanyl}-N-(4-phenylbutan-2-yl)acetamideCC(CCC1=CC=CC=C1)NC(=O)CSC1=NC2=C(C3=C(COC(C3)C(C)C)S2)C(=O)N1CCC1=CC=CC=C1Library of small molecule structuresNANANA23NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00243328917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA12N-Benzyl-2-((6-isopropyl-4-oxo-3-phenethyl-3,5,6,8-tetrahydro-4H-pyrano[40,30:4,5]thieno[2,3-d]pyrimidin-2-yl)thio)acetamideCCCC1=CC(=O)Oc2cc(OCC(=O)N[C@@H](CSCc3ccccc3)C(O)=O)ccc12Library of small molecule structuresNANANA>100NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00243428917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA13S-Benzyl-N-(2-((2-oxo-4-propyl-2H-chromen-7-yl)oxy)acetyl)-cysteineCOc1ccc(cc1)C(=O)CSc2nc(C)cc(SCC(=O)N(N)C(=O)Cc3ccccc3)n2Library of small molecule structuresNANANA>100NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00243528917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA222-(2-(2-(4-Methoxyphenyl)-2-oxoethylthio)-6-methylpyrimidin-4-ylthio)-N-(2-phenylacetyl)acetohydrazideCOC1=CC=C(C=C1)C(CSC1=NC(=CC(=N1)SCC(=O)N(N)C(CC1=CC=CC=C1)=O)C)=OLibrary of small molecule structuresNANANA34.7NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00243628917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA232-(2-(2-(4-(Diethylamino)phenyl)-2-oxoethylthio)-6-methylpyrimidin-4-yl-thio)-N-(2-phenylacetyl)acetohydrazideCc1cc(SCC(=O)N(N)C(=O)Cc2ccccc2)nc(SCC(=O)N3CCOCC3)n1Library of small molecule structuresNANANA28.3NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00243728917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA242-(6-Methyl-2-(2-morpholino-2-oxoethylthio)pyrimidin-4-ylthio)-N-(2-phenylacetyl)acetohydrazideCc1cc(SCC(=O)N(N)C(=O)Cc2ccccc2)nc(SCCN3CCOCC3)n1Library of small molecule structuresNANANA28.8NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00243828917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA252-(6-Methyl-2-(2-morpholinoethylthio)pyrimidin-4-yl-thio)-N-(2-phenylacetyl)acetohydrazideCc1cc(SCC(=O)N(N)C(=O)Cc2ccccc2)nc(SCC(=O)c3ccc(cc3)C#N)n1Library of small molecule structuresNANANA30.3NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00243928917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA262-(2-(2-(4-Cyanophenyl)-2-oxoethylthio)-6-methylpyrimidin-4-yl-thio)-N-(2-phenylacetyl)acetohydrazideO=C(CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3)c4ccccc4Library of small molecule structuresNANANA37.4NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00244028917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA301-Benzyl-6-oxo-2-(2-oxo-2-phenylethylthio)-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamideCOc1ccc(cc1)C(=O)CSC2=NC=C(C(=O)NCCCc3ccccc3)C(=O)N2Cc4ccccc4Library of small molecule structuresNANANA24NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00244128917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA311-Benzyl-2-(2-(4-methoxyphenyl)-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6 dihydropyrimidine-5-carboxamideO=C(CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3)NNC(=O)Cc4ccccc4Library of small molecule structuresNANANA45NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00244228917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA321-Benzyl-6-oxo-2-(2-oxo-2-(2-(2-phenylacetyl)hydrazinyl)ethylthio)-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamideO=C(NCCCc1ccccc1)C2=CN=C(SCCN3CCOCC3)N(Cc4ccccc4)C2=OLibrary of small molecule structuresNANANA72.6NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00244328917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA331-Benzyl-2-(2-morpholinoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamideCCOC(=O)CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3Library of small molecule structuresNANANA10.5NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00244428917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA34Ethyl-2-(1-benzyl-6-oxo-5-(3-phenylpropylcarbamoyl)-1,6-dihydropyrimidin-2-ylthio)acetateCCN(CC)c1ccc(cc1)C(=O)CSC2=NC=C(C(=O)NCCCc3ccccc3)C(=O)N2Cc4ccccc4Library of small molecule structuresNANANA58.3NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00244528917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA351-Benzyl-2-(2-(4-(diethylamino)phenyl)-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamideOc1ccc(cc1)C(=O)CSC2=NC=C(C(=O)NCCCc3ccccc3)C(=O)N2Cc4ccccc4Library of small molecule structuresNANANA>100NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00244628917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA361-Benzyl-2-(2-(4-hydroxyphenyl)-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamideO=C(CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3)c4ccc(cc4)C#NLibrary of small molecule structuresNANANA53NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00244728917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA371-Benzyl-2-(2-(4-cyanophenyl)-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamideO=C(CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3)N4CCOCC4Library of small molecule structuresNANANA>100NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00244828917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA381-Benzyl-2-(2-morpholino-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamideC(C1=CC=CC=C1)N1C(=NC=C(C1=O)C(=O)NCCCC1=CC=CC=C1)SCC(=O)N1CCOCC1Library of small molecule structuresNANANA46NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00244928917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA40Ethyl-2-(2-oxo-2-(2-(2-phenylacetyl)hydrazinyl)ethylthio)-pyrimidin-4-one-5-carboxylateCCOC(=O)C1=CN=C(NC1=O)SCCN2CCOCC2Library of small molecule structuresNANANA42NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00245028917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA41Ethyl 2-(2-morpholinoethylthio)-6-oxo-1,6-dihydropyrimidine-5-carboxylateO1CCN(CC1)CCSC=1NC(C(=CN1)C(=O)OCC)=OLibrary of small molecule structuresNANANA>100NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00245128917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA42Ethyl 2-(2-morpholinoethylthio)-1-(2-oxo-2-phenylethyl)-pyrimidin-4-one-5-carboxylateOC(=O)C1=CN=C2SC(=C(CN2C1=O)c3ccccc3)CN4CCOCC4Library of small molecule structuresNANANA40NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00245228917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA432-(Morpholinomethyl)-6-oxo-3-phenyl-4,6-dihydropyrimido[2,1-b][1,3]thiazine-7-carboxylic acidO1CCN(CC1)CC1=C(CN2C(S1)=NC=C(C2=O)C(=O)O)C2=CC=CC=C2Library of small molecule structuresNANANA>100NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00245328917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA442-(2-Morpholinoethylthio)-N-(3-phenylpropyl)-pyrimidin-4-one-5-carboxamideCCc1sc(NC(=O)CSc2nnc(n2CCOC)c3cc4ccccc4cc3O)nn1Library of small molecule structuresNANANA44NANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00245428917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA1N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-2-((5-(3-hydroxynaphthalen-2-yl)-4-(2-methoxyethyl)-4H-1,2,4-triazol-3-yl)thio)acetamideC(C)C1=NN=C(S1)NC(CSC1=NN=C(N1CCOC)C1=CC2=CC=CC=C2C=C1O)=OLibrary of small molecule structuresNANA12.1NANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00245528917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA22,2,2-((1,3,5-Triazin-2,4,6-triyl)tris(sulfanediyl))-tris-(N-(furan-2-ylmethyl)acetamide)O=C(CNC(=O)OCc1ccccc1)N[C@@H](CCC(=O)OCc2ccccc2)C(=O)OCc3ccccc3Library of small molecule structuresNANA38NANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00245628917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA4N,N-(5-(Thiazol-2-ylcarbamoyl)-1,3-phenylene)bis(2-phenoxyacetamide)COc1ccc(CNC(=O)C(=O)N/N=C/c2oc(CN[S](=O)(=O)c3ccc(Br)cc3)cc2)cc1Library of small molecule structuresNANA36NANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00245728917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA62-((6-Methyl-2-((2-oxo-2-phenylethyl)thio)pyrimidin-4-yl)thio)-N0-(2-phenylacetyl)acetohydrazideCCCCOc1ccc(c(C)c1)c2nn(cc2\C=C(C#N)\C(=O)NCc3occc3)c4ccccc4Library of small molecule structuresNANA11NANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00245828917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA112-{[3-oxo-4-(2-phenylethyl)-12-(propan-2-yl)-11-oxa-8-thia-4,6-diazatricyclo[7.4.0.0²,?]trideca-1(9),2(7),5-trien-5-yl]sulfanyl}-N-(4-phenylbutan-2-yl)acetamideCC(CCC1=CC=CC=C1)NC(=O)CSC1=NC2=C(C3=C(COC(C3)C(C)C)S2)C(=O)N1CCC1=CC=CC=C1Library of small molecule structuresNANA9NANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00245928917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA222-(2-(2-(4-Methoxyphenyl)-2-oxoethylthio)-6-methylpyrimidin-4-ylthio)-N0-(2-phenylacetyl)acetohydrazideCCN(CC)c1ccc(cc1)C(=O)CSc2nc(C)cc(SCC(=O)N(N)C(=O)Cc3ccccc3)n2Library of small molecule structuresNANA14.2NANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00246028917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA232-(2-(2-(4-(Diethylamino)phenyl)-2-oxoethylthio)-6-methylpyrimidin-4-yl-thio)-N0-(2-^phenylacetyl)acetohydrazideCc1cc(SCC(=O)N(N)C(=O)Cc2ccccc2)nc(SCC(=O)N3CCOCC3)n1Library of small molecule structuresNANA11.6NANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00246128917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA242-(6-Methyl-2-(2-morpholino-2-oxoethylthio)pyrimidin-4-ylthio)-N0-(2-phenylacetyl)acetohydrazideCc1cc(SCC(=O)N(N)C(=O)Cc2ccccc2)nc(SCCN3CCOCC3)n1Library of small molecule structuresNANA11.8NANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00246228917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA252-(6-Methyl-2-(2-morpholinoethylthio)pyrimidin-4-yl-thio)-N0-(2-phenylacetyl)acetohydrazideCc1cc(SCC(=O)N(N)C(=O)Cc2ccccc2)nc(SCC(=O)c3ccc(cc3)C#N)n1Library of small molecule structuresNANA12.3NANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00246328917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA262-(2-(2-(4-Cyanophenyl)-2-oxoethylthio)-6-methylpyrimidin-4-yl-thio)-N0-(2-phenylacetyl)acetohydrazideO=C(CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3)c4ccccc4Library of small molecule structuresNANA15.3NANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00246428917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA301-Benzyl-6-oxo-2-(2-oxo-2-phenylethylthio)-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamideCOc1ccc(cc1)C(=O)CSC2=NC=C(C(=O)NCCCc3ccccc3)C(=O)N2Cc4ccccc4Library of small molecule structuresNANA10NANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00246528917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA311-Benzyl-2-(2-(4-methoxyphenyl)-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6 dihydropyrimidine-5-carboxamideO=C(CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3)NNC(=O)Cc4ccccc4Library of small molecule structuresNANA18NANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00246628917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA321-Benzyl-6-oxo-2-(2-oxo-2-(2-(2-phenylacetyl)hydrazinyl)ethylthio)-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamideO=C(NCCCc1ccccc1)C2=CN=C(SCCN3CCOCC3)N(Cc4ccccc4)C2=OLibrary of small molecule structuresNANA29.5NANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00246728917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA331-Benzyl-2-(2-morpholinoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamideCCOC(=O)CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3Library of small molecule structuresNANA2.3NANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00246828917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA34Ethyl-2-(1-benzyl-6-oxo-5-(3-phenylpropylcarbamoyl)-1,6-dihydropyrimidin-2-ylthio)acetateCCN(CC)c1ccc(cc1)C(=O)CSC2=NC=C(C(=O)NCCCc3ccccc3)C(=O)N2Cc4ccccc4Library of small molecule structuresNANA23.8NANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00246928917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA361-Benzyl-2-(2-(4-hydroxyphenyl)-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamideO=C(CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3)c4ccc(cc4)C#NLibrary of small molecule structuresNANA21.6NANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00247028917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA381-Benzyl-2-(2-morpholino-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamideC(C1=CC=CC=C1)N1C(=NC=C(C1=O)C(=O)NCCCC1=CC=CC=C1)SCC(=O)N1CCOCC1Library of small molecule structuresNANA18.8NANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00247128917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA40Ethyl-2-(2-oxo-2-(2-(2-phenylacetyl)hydrazinyl)ethylthio)-pyrimidin-4-one-5-carboxylateCCOC(=O)C1=CN=C(NC1=O)SCCN2CCOCC2Library of small molecule structuresNANA17NANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00247228917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA42Ethyl 2-(2-morpholinoethylthio)-1-(2-oxo-2-phenylethyl)-pyrimidin-4-one-5-carboxylateOC(=O)C1=CN=C2SC(=C(CN2C1=O)c3ccccc3)CN4CCOCC4Library of small molecule structuresNANA16NANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00247328917450Hsp100ClpPPlasmodium falciparumCytosolInhibition of protease activityNA442-(2-Morpholinoethylthio)-N-(3-phenylpropyl)-pyrimidin-4-one-5-carboxamideCCc1sc(NC(=O)CSc2nnc(n2CCOC)c3cc4ccccc4cc3O)nn1Library of small molecule structuresNANA18NANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00247428917450Hsp100ClpPPlasmodium falciparumCytosolNAAntiparasitic activity1N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-2-((5-(3-hydroxynaphthalen-2-yl)-4-(2-methoxyethyl)-4H-1,2,4-triazol-3-yl)thio)acetamideC(C)C1=NN=C(S1)NC(CSC1=NN=C(N1CCOC)C1=CC2=CC=CC=C2C=C1O)=OLibrary of small molecule structuresNANANA27NANANANANANANAParasite growth inhibition assay (SYBR green)
HSPMDB00247528917450Hsp100ClpPPlasmodium falciparumCytosolNAAntiparasitic activity62-((6-Methyl-2-((2-oxo-2-phenylethyl)thio)pyrimidin-4-yl)thio)-N0-(2-phenylacetyl)acetohydrazideCCCCOc1ccc(c(C)c1)c2nn(cc2\C=C(C#N)\C(=O)NCc3occc3)c4ccccc4Library of small molecule structuresNANANA75NANANANANANANAParasite growth inhibition assay (SYBR green)
HSPMDB00247628917450Hsp100ClpPPlasmodium falciparumCytosolNAAntiparasitic activity112-{[3-oxo-4-(2-phenylethyl)-12-(propan-2-yl)-11-oxa-8-thia-4,6-diazatricyclo[7.4.0.0²,?]trideca-1(9),2(7),5-trien-5-yl]sulfanyl}-N-(4-phenylbutan-2-yl)acetamideCC(CCC1=CC=CC=C1)NC(=O)CSC1=NC2=C(C3=C(COC(C3)C(C)C)S2)C(=O)N1CCC1=CC=CC=C1Library of small molecule structuresNANANA25NANANANANANANAParasite growth inhibition assay (SYBR green)
HSPMDB00247728917450Hsp100ClpPPlasmodium falciparumCytosolNAAntiparasitic activity222-(2-(2-(4-Methoxyphenyl)-2-oxoethylthio)-6-methylpyrimidin-4-ylthio)-N-(2-phenylacetyl)acetohydrazideCOC1=CC=C(C=C1)C(CSC1=NC(=CC(=N1)SCC(=O)N(N)C(CC1=CC=CC=C1)=O)C)=OLibrary of small molecule structuresNANANA11.8NANANANANANANAParasite growth inhibition assay (SYBR green)
HSPMDB00247828917450Hsp100ClpPPlasmodium falciparumCytosolNAAntiparasitic activity232-(2-(2-(4-(Diethylamino)phenyl)-2-oxoethylthio)-6-methylpyrimidin-4-yl-thio)-N-(2-phenylacetyl)acetohydrazideC(C)N(C1=CC=C(C=C1)C(CSC1=NC(=CC(=N1)SCC(=O)N(N)C(CC1=CC=CC=C1)=O)C)=O)CCLibrary of small molecule structuresNANANA12.14NANANANANANANAParasite growth inhibition assay (SYBR green)
HSPMDB00247928917450Hsp100ClpPPlasmodium falciparumCytosolNAAntiparasitic activity242-(6-Methyl-2-(2-morpholino-2-oxoethylthio)pyrimidin-4-ylthio)-N-(2-phenylacetyl)acetohydrazideCC1=CC(=NC(=N1)SCC(=O)N1CCOCC1)SCC(=O)N(N)C(CC1=CC=CC=C1)=OLibrary of small molecule structuresNANANA17.3NANANANANANANAParasite growth inhibition assay (SYBR green)
HSPMDB00248028917450Hsp100ClpPPlasmodium falciparumCytosolNAAntiparasitic activity252-(6-Methyl-2-(2-morpholinoethylthio)pyrimidin-4-yl-thio)-N-(2-phenylacetyl)acetohydrazideCC1=CC(=NC(=N1)SCCN1CCOCC1)SCC(=O)N(N)C(CC1=CC=CC=C1)=OLibrary of small molecule structuresNANANA14.4NANANANANANANAParasite growth inhibition assay (SYBR green)
HSPMDB00248128917450Hsp100ClpPPlasmodium falciparumCytosolNAAntiparasitic activity262-(2-(2-(4-Cyanophenyl)-2-oxoethylthio)-6-methylpyrimidin-4-yl-thio)-N-(2-phenylacetyl)acetohydrazideO=C(CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3)c4ccccc4Library of small molecule structuresNANANA12.4NANANANANANANAParasite growth inhibition assay (SYBR green)
HSPMDB00248228917450Hsp100ClpPPlasmodium falciparumCytosolNAAntiparasitic activity301-Benzyl-6-oxo-2-(2-oxo-2-phenylethylthio)-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamideCOc1ccc(cc1)C(=O)CSC2=NC=C(C(=O)NCCCc3ccccc3)C(=O)N2Cc4ccccc4Library of small molecule structuresNANANA20NANANANANANANAParasite growth inhibition assay (SYBR green)
HSPMDB00248328917450Hsp100ClpPPlasmodium falciparumCytosolNAAntiparasitic activity311-Benzyl-2-(2-(4-methoxyphenyl)-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6 dihydropyrimidine-5-carboxamideO=C(CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3)NNC(=O)Cc4ccccc4Library of small molecule structuresNANANA2.4NANANANANANANAParasite growth inhibition assay (SYBR green)
HSPMDB00248428917450Hsp100ClpPPlasmodium falciparumCytosolNAAntiparasitic activity331-Benzyl-2-(2-morpholinoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamideCCOC(=O)CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3Library of small molecule structuresNANANA9NANANANANANANAParasite growth inhibition assay (SYBR green)
HSPMDB00248528917450Hsp100ClpPPlasmodium falciparumCytosolNAAntiparasitic activity34Ethyl-2-(1-benzyl-6-oxo-5-(3-phenylpropylcarbamoyl)-1,6-dihydropyrimidin-2-ylthio)acetateCCN(CC)c1ccc(cc1)C(=O)CSC2=NC=C(C(=O)NCCCc3ccccc3)C(=O)N2Cc4ccccc4Library of small molecule structuresNANANA15.9NANANANANANANAParasite growth inhibition assay (SYBR green)
HSPMDB00248628917450Hsp100ClpPPlasmodium falciparumCytosolNAAntiparasitic activity351-Benzyl-2-(2-(4-(diethylamino)phenyl)-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamideOc1ccc(cc1)C(=O)CSC2=NC=C(C(=O)NCCCc3ccccc3)C(=O)N2Cc4ccccc4Library of small molecule structuresNANANA9.2NANANANANANANAParasite growth inhibition assay (SYBR green)
HSPMDB00248728917450Hsp100ClpPPlasmodium falciparumCytosolNAAntiparasitic activity361-Benzyl-2-(2-(4-hydroxyphenyl)-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamideO=C(CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3)c4ccc(cc4)C#NLibrary of small molecule structuresNANANA9.2NANANANANANANAParasite growth inhibition assay (SYBR green)
HSPMDB00248828917450Hsp100ClpPPlasmodium falciparumCytosolNAAntiparasitic activity371-Benzyl-2-(2-(4-cyanophenyl)-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamideC(C1=CC=CC=C1)N1C(=NC=C(C1=O)C(=O)NCCCC1=CC=CC=C1)SCC(=O)C1=CC=C(C=C1)C#NLibrary of small molecule structuresNANANA13.7NANANANANANANAParasite growth inhibition assay (SYBR green)
HSPMDB00248928917450Hsp100ClpPPlasmodium falciparumCytosolNAAntiparasitic activity381-Benzyl-2-(2-morpholino-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamideC(C1=CC=CC=C1)N1C(=NC=C(C1=O)C(=O)NCCCC1=CC=CC=C1)SCC(=O)N1CCOCC1Library of small molecule structuresNANANA11.7NANANANANANANAParasite growth inhibition assay (SYBR green)
HSPMDB00249028917450Hsp100ClpPPlasmodium falciparumCytosolNAAntiparasitic activity40Ethyl-2-(2-oxo-2-(2-(2-phenylacetyl)hydrazinyl)ethylthio)-pyrimidin-4-one-5-carboxylateC(C)OC(=O)C=1C(NC(=NC1)SCC(NNC(CC1=CC=CC=C1)=O)=O)=OLibrary of small molecule structuresNANANA82.5NANANANANANANAParasite growth inhibition assay (SYBR green)
HSPMDB00249128917450Hsp100ClpPPlasmodium falciparumCytosolNAAntiparasitic activity42Ethyl 2-(2-morpholinoethylthio)-1-(2-oxo-2-phenylethyl)-pyrimidin-4-one-5-carboxylateO1CCN(CC1)CCSC=1N(C=C(C(N1)=O)C(=O)OCC)CC(C1=CC=CC=C1)=OLibrary of small molecule structuresNANANA19NANANANANANANAParasite growth inhibition assay (SYBR green)
HSPMDB00249228917450Hsp100ClpPPlasmodium falciparumCytosolNAAntiparasitic activity432-(Morpholinomethyl)-6-oxo-3-phenyl-4,6-dihydropyrimido[2,1-b][1,3]thiazine-7-carboxylic acidO1CCN(CC1)CC1=C(CN2C(S1)=NC=C(C2=O)C(=O)O)C2=CC=CC=C2Library of small molecule structuresNANANA11NANANANANANANAParasite growth inhibition assay (SYBR green)
HSPMDB00249328917450Hsp100ClpPPlasmodium falciparumCytosolNAAntiparasitic activity442-(2-Morpholinoethylthio)-N-(3-phenylpropyl)-pyrimidin-4-one-5-carboxamideO1CCN(CC1)CCSC1=NC=C(C(N1)=O)C(=O)NCCCC1=CC=CC=C1Library of small molecule structuresNANANA22NANANANANANANAParasite growth inhibition assay (SYBR green)
HSPMDB00249425937012Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA1(3S,4S)-4-{2-[3-(dimethylamino)propanesulfonyl]ethyl}-3-undecyloxetan-2-oneCCCCCCCCCCC[C@H]1[C@H](CCS(=O)(=O)CCCN(C)C)OC1=OBeta lactone analogue99% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00249525937012Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA2(3S,4S)-4-{3-[3-(dimethylamino)propanesulfonyl]propyl}-3-undecyloxetan-2-oneCCCCCCCCCCC[C@H]1[C@H](CCCS(=O)(=O)CCCN(C)C)OC1=OBeta lactone analogue100% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00249625937012Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA3(3S,4S)-4-{4-[3-(dimethylamino)propanesulfonyl]butyl}-3-undecyloxetan-2-oneCCCCCCCCCCC[C@H]1[C@H](CCCCS(=O)(=O)CCCN(C)C)OC1=OBeta lactone analogue100% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00249725937012Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA4(3S,4S)-4-{5-[3-(dimethylamino)propanesulfonyl]pentyl}-3-undecyloxetan-2-oneCCCCCCCCCCC[C@H]1[C@H](CCCCCS(=O)(=O)CCCN(C)C)OC1=OBeta lactone analogue95% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00249825937012Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA5trimethyl(3-{3-[(2S,3S)-4-oxo-3-undecyloxetan-2-yl]propanesulfonyl}propyl)azanium iodide[I-].CCCCCCCCCCC[C@H]1[C@H](CCCS(=O)(=O)CCC[N+](C)(C)C)OC1=OBeta lactone analogue100% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00249925937012Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA6trimethyl(3-{4-[(2S,3S)-4-oxo-3-undecyloxetan-2-yl]butanesulfonyl}propyl)azanium iodide[I-].CCCCCCCCCCC[C@H]1[C@H](CCCCS(=O)(=O)CCC[N+](C)(C)C)OC1=OBeta lactone analogue64% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00250025937012Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA7trimethyl(3-{5-[(2S,3S)-4-oxo-3-undecyloxetan-2-yl]pentanesulfonyl}propyl)azanium iodide[I-].CCCCCCCCCCC[C@H]1[C@H](CCCCCS(=O)(=O)CCC[N+](C)(C)C)OC1=OBeta lactone analogue99% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00250125937012Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA8(3S,4S)-4-(2-{[3-(dimethylamino)propyl]sulfanyl}ethyl)-3-undecyloxetan-2-oneCCCCCCCCCCC[C@H]1[C@H](CCSCCCN(C)C)OC1=OBeta lactone analogue99% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00250225937012Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA9(3S,4S)-4-(3-{[3-(dimethylamino)propyl]sulfanyl}propyl)-3-undecyloxetan-2-oneCCCCCCCCCCC[C@H]1[C@H](CCCSCCCN(C)C)OC1=OBeta lactone analogue60% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00250325937012Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA10(3S,4S)-4-(4-{[3-(dimethylamino)propyl]sulfanyl}butyl)-3-undecyloxetan-2-oneCCCCCCCCCCC[C@H]1[C@H](CCCCSCCCN(C)C)OC1=OBeta lactone analogue100% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00250425937012Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA11(3S,4S)-4-(5-{[3-(dimethylamino)propyl]sulfanyl}pentyl)-3-undecyloxetan-2-oneCCCCCCCCCCC[C@H]1[C@H](CCCCCSCCCN(C)C)OC1=OBeta lactone analogue99% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00250525937012Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA12(3R,4R)-4-{2-[3-(dimethylamino)propanesulfonyl]ethyl}-3-undecyloxetan-2-oneCCCCCCCCCCC[C@@H]1[C@@H](CCS(=O)(=O)CCCN(C)C)OC1=OBeta lactone analogue63% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00250625937012Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA13(3R,4R)-4-{3-[3-(dimethylamino)propanesulfonyl]propyl}-3-undecyloxetan-2-oneCCCCCCCCCCC[C@@H]1[C@@H](CCCS(=O)(=O)CCCN(C)C)OC1=OBeta lactone analogue92% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00250725937012Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA14(3R,4R)-4-{4-[3-(dimethylamino)propanesulfonyl]butyl}-3-undecyloxetan-2-oneCCCCCCCCCCC[C@@H]1[C@@H](CCCCS(=O)(=O)CCCN(C)C)OC1=OBeta lactone analogue87% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00250825937012Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA15(3R,4R)-4-{5-[3-(dimethylamino)propanesulfonyl]pentyl}-3-undecyloxetan-2-oneCCCCCCCCCCC[C@@H]1[C@@H](CCCCCS(=O)(=O)CCCN(C)C)OC1=OBeta lactone analogue90% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00250925937012Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA16trimethyl(3-{3-[(2R,3R)-4-oxo-3-undecyloxetan-2-yl]propanesulfonyl}propyl)azanium iodide[I-].CCCCCCCCCCC[C@@H]1[C@@H](CCCS(=O)(=O)CCC[N+](C)(C)C)OC1=OBeta lactone analogue93% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00251025937012Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA17trimethyl(3-{4-[(2R,3R)-4-oxo-3-undecyloxetan-2-yl]butanesulfonyl}propyl)azanium iodide[I-].CCCCCCCCCCC[C@@H]1[C@@H](CCCCS(=O)(=O)CCC[N+](C)(C)C)OC1=OBeta lactone analogue91% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00251125937012Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA18trimethyl(3-{5-[(2R,3R)-4-oxo-3-undecyloxetan-2-yl]pentanesulfonyl}propyl)azanium iodide[I-].CCCCCCCCCCC[C@@H]1[C@@H](CCCCCS(=O)(=O)CCC[N+](C)(C)C)OC1=OBeta lactone analogue91% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00251225937012Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA19(3R,4R)-4-(2-{[3-(dimethylamino)propyl]sulfanyl}ethyl)-3-undecyloxetan-2-oneCCCCCCCCCCC[C@@H]1[C@@H](CCSCCCN(C)C)OC1=OBeta lactone analogue89% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00251325937012Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA20(3R,4R)-4-(3-{[3-(dimethylamino)propyl]sulfanyl}propyl)-3-undecyloxetan-2-oneCCCCCCCCCCC[C@@H]1[C@@H](CCCSCCCN(C)C)OC1=OBeta lactone analogue74% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00251425937012Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA21(3R,4R)-4-(4-{[3-(dimethylamino)propyl]sulfanyl}butyl)-3-undecyloxetan-2-oneCCCCCCCCCCC[C@@H]1[C@@H](CCCCSCCCN(C)C)OC1=OBeta lactone analogue94% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00251525937012Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA22(3R,4R)-4-(5-{[3-(dimethylamino)propyl]sulfanyl}pentyl)-3-undecyloxetan-2-oneCCCCCCCCCCC[C@@H]1[C@@H](CCCCCSCCCN(C)C)OC1=OBeta lactone analogue85% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00251625937012Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA23but-3-yn-1-yl N-(2-phenylethyl)carbamateO=C(NCCC1=CC=CC=C1)OCCC#CBeta lactone analogue8% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00251725937012Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA244-(but-3-yn-1-yl)-3-(non-8-en-1-yl)oxetan-2-oneC=CCCCCCCCC1C(CCC#C)OC1=OBeta lactone analogue95% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00251825937012Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA25but-3-yn-1-yl N-pentylcarbamateCCCCCNC(=O)OCCC#CBeta lactone analogue0-5% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00251925937012Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA26[(but-3-yn-1-yloxy)(hydroxy)methyl](non-8-en-1-yl)amineOC(NCCCCCCCC=C)OCCC#CBeta lactone analogue0-5% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00252025937012Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA27methyl undec-10-enoateCOC(=O)CCCCCCCCC=CBeta lactone analogue4% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00252125937012Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA28tert-butyl undec-10-enoateCC(C)(C)OC(=O)CCCCCCCCC=CBeta lactone analogue0-5% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00252225937012Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA29(4S)-4-(but-3-yn-1-yl)-3-dodecyloxetan-2-oneCCCCCCCCCCCCC1[C@H](CCC#C)OC1=OBeta lactone analogue5% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00252325937012Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA30(3R)-3-(2-phenylethyl)oxetan-2-oneO=C1OC[C@H]1CCC1=CC=CC=C1Beta lactone analogue0-5% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00252425937012Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA31(3S)-3-(2-phenylethyl)oxetan-2-oneO=C1OC[C@@H]1CCC1=CC=CC=C1Beta lactone analogue94% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00252525937012Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA323-(oct-7-en-1-yl)-4-(2-phenylethyl)oxetan-2-oneC=CCCCCCCC1C(CCC2=CC=CC=C2)OC1=OBeta lactone analogue30% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00252625937012Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA333-(oct-7-en-1-yl)-4-[2-(pyridin-3-yl)ethyl]oxetan-2-oneC=CCCCCCCC1C(CCC2=CN=CC=C2)OC1=OBeta lactone analogue100% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00252725937012Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA344-[2-(pyridin-3-yl)ethyl]-3-undecyloxetan-2-oneCCCCCCCCCCCC1C(CCC2=CN=CC=C2)OC1=OBeta lactone analogue5% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00252825937012Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA354-(dimethylamino)-N-{5-[3-(oct-7-en-1-yl)-4-oxooxetan-2-yl]pentyl}benzamideCN(C)C1=CC=C(C=C1)C(=O)NCCCCCC1OC(=O)C1CCCCCCC=CBeta lactone analogue70% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00252925937012Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA36tert-butyl N-{11-[3-(oct-7-en-1-yl)-4-oxooxetan-2-yl]undecyl}carbamateCC(C)(C)OC(=O)NCCCCCCCCCCCC1OC(=O)C1CCCCCCC=CBeta lactone analogue0-5% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00253025937012Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA37tert-butyl N-{8-[2-(non-8-en-1-yl)-4-oxooxetan-3-yl]octyl}carbamateCC(C)(C)OC(=O)NCCCCCCCCC1C(CCCCCCCC=C)OC1=OBeta lactone analogue5% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00253123361916Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA1(3S,4S)-3-decyl-4-{2-[3-(dimethylamino)propanesulfonyl]ethyl}oxetan-2-oneCCCCCCCCCC[C@H]1[C@H](CCS(=O)(=O)CCCN(C)C)OC1=O Beta lactone (library of enantiopure)80% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00253223361916Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA2(3S,4S)-3-decyl-4-{3-[3-(dimethylamino)propanesulfonyl]propyl}oxetan-2-oneCCCCCCCCCC[C@H]1[C@H](CCCS(=O)(=O)CCCN(C)C)OC1=O Beta lactone (library of enantiopure)95% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00253323361916Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA3(3S,4S)-3-decyl-4-{4-[3-(dimethylamino)propanesulfonyl]butyl}oxetan-2-oneCCCCCCCCCC[C@H]1[C@H](CCCCS(=O)(=O)CCCN(C)C)OC1=O Beta lactone (library of enantiopure)95% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00253423361916Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA5(3-{3-[(2S,3S)-3-decyl-4-oxooxetan-2-yl]propanesulfonyl}propyl)trimethylazanium iodide[I-].CCCCCCCCCC[C@H]1[C@H](CCCS(=O)(=O)CCC[N+](C)(C)C)OC1=O Beta lactone (library of enantiopure)93% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00253523361916Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA7(3-{5-[(2S,3S)-3-decyl-4-oxooxetan-2-yl]pentanesulfonyl}propyl)trimethylazanium iodide[I-].CCCCCCCCCC[C@H]1[C@H](CCCCCS(=O)(=O)CCC[N+](C)(C)C)OC1=O Beta lactone (library of enantiopure)93% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00253623361916Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA8(3S,4S)-3-decyl-4-(2-{[3-(dimethylamino)propyl]sulfanyl}ethyl)oxetan-2-oneCCCCCCCCCC[C@H]1[C@H](CCSCCCN(C)C)OC1=O Beta lactone (library of enantiopure)85% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00253723361916Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA10(3S,4S)-3-decyl-4-(4-{[3-(dimethylamino)propyl]sulfanyl}butyl)oxetan-2-oneCCCCCCCCCC[C@H]1[C@H](CCCCSCCCN(C)C)OC1=O Beta lactone (library of enantiopure)90% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00253823361916Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA11(3S,4S)-3-decyl-4-(5-{[3-(dimethylamino)propyl]sulfanyl}pentyl)oxetan-2-oneCCCCCCCCCC[C@H]1[C@H](CCCCCSCCCN(C)C)OC1=O Beta lactone (library of enantiopure)85% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00253923361916Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA22(3R,4R)-3-decyl-4-(5-{[3-(dimethylamino)propyl]sulfanyl}pentyl)oxetan-2-oneCCCCCCCCCC[C@@H]1[C@@H](CCCCCSCCCN(C)C)OC1=O Beta lactone (library of enantiopure)50% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00254023361916Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA303-decyloxetan-2-oneCCCCCCCCCCC1COC1=O Beta lactone (library of enantiopure)10% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00254123361916Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA303-decyloxetan-2-oneCCCCCCCCCCC1COC1=O Beta lactone (library of enantiopure)50% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00254223361916Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA303-decyloxetan-2-oneCCCCCCCCCCC1COC1=O Beta lactone (library of enantiopure)45% at 1000 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00254323361916Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA314-decyloxetan-2-oneCCCCCCCCCCC1CC(=O)O1 Beta lactone (library of enantiopure)1% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00254423361916Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA314-decyloxetan-2-oneCCCCCCCCCCC1CC(=O)O2 Beta lactone (library of enantiopure)1% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00254523361916Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA314-decyloxetan-2-oneCCCCCCCCCCC1CC(=O)O3 Beta lactone (library of enantiopure)5% at 1000 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00254623361916Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA323-(2-phenylethyl)oxetan-2-oneO=C1OCC1CCC1=CC=CC=C1 Beta lactone (library of enantiopure)20% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00254723361916Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA323-(2-phenylethyl)oxetan-2-oneO=C1OCC1CCC1=CC=CC=C2 Beta lactone (library of enantiopure)80% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00254823361916Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA323-(2-phenylethyl)oxetan-2-oneO=C1OCC1CCC1=CC=CC=C3 Beta lactone (library of enantiopure)95% at 1000 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00254923361916Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA334-(2-phenylethyl)oxetan-2-oneO=C1CC(CCC2=CC=CC=C2)O1 Beta lactone (library of enantiopure)1% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00255023361916Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA334-(2-phenylethyl)oxetan-2-oneO=C1CC(CCC2=CC=CC=C2)O2 Beta lactone (library of enantiopure)2% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00255123361916Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA334-(2-phenylethyl)oxetan-2-oneO=C1CC(CCC2=CC=CC=C2)O3 Beta lactone (library of enantiopure)1% at 1000 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00255223361916Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA34(3R)-3-(2-phenylethyl)oxetan-2-oneO=C1OC[C@H]1CCC1=CC=CC=C1 Beta lactone (library of enantiopure)0-5% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00255323361916Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA34(3R)-3-(2-phenylethyl)oxetan-2-oneO=C1OC[C@H]1CCC1=CC=CC=C2 Beta lactone (library of enantiopure)0-5% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00255423361916Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA34(3R)-3-(2-phenylethyl)oxetan-2-oneO=C1OC[C@H]1CCC1=CC=CC=C3 Beta lactone (library of enantiopure)40% at 1000 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00255523361916Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA35(3S)-3-(2-phenylethyl)oxetan-2-oneO=C1OC[C@@H]1CCC1=CC=CC=C1 Beta lactone (library of enantiopure)55% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00255623361916Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA35(3S)-3-(2-phenylethyl)oxetan-2-oneO=C1OC[C@@H]1CCC1=CC=CC=C2 Beta lactone (library of enantiopure)95% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00255723361916Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA35(3S)-3-(2-phenylethyl)oxetan-2-oneO=C1OC[C@@H]1CCC1=CC=CC=C3 Beta lactone (library of enantiopure)98% at 1000 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00255823361916Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA243-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one[H]C(=C)CCCCCCCC1C(CCCC#C)OC1=O Beta lactone (library of enantiopure)5% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00255923361916Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA29(3S,4S)-4-(pent-4-yn-1-yl)-3-tridecyloxetan-2-oneCCCCCCCCCCCCC[C@H]1[C@H](CCCC#C)OC1=O Beta lactone (library of enantiopure)13% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00256023361916Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA243-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one[H]C(=C)CCCCCCCC1C(CCCC#C)OC1=O Beta lactone (library of enantiopure)80% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00256123361916Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA29(3S,4S)-4-(pent-4-yn-1-yl)-3-tridecyloxetan-2-oneCCCCCCCCCCCCC[C@H]1[C@H](CCCC#C)OC1=O Beta lactone (library of enantiopure)15% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00256223361916Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA243-(non-8-en-1-yl)-4-(pent-4-yn-1-yl)oxetan-2-one[H]C(=C)CCCCCCCC1C(CCCC#C)OC1=O Beta lactone (library of enantiopure)70% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00256323361916Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA29(3S,4S)-4-(pent-4-yn-1-yl)-3-tridecyloxetan-2-oneCCCCCCCCCCCCC[C@H]1[C@H](CCCC#C)OC1=O Beta lactone (library of enantiopure)20% at 100 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00256421855356Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA1(3R,4R)-3-(8-Nonenyl)-4-(2-phenylethyl)oxetan-2-oneC(CCCCCCC=C)[C@H]1C(O[C@@H]1CCC1=CC=CC=C1)=OBeta lactone analogue30% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00256521855356Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA2(3R,4R)-3-(8-Nonenyl)-4-(2-(3-pyridyl)ethyl)oxetan-2-oneC(CCCCCCC=C)[C@H]1C(O[C@@H]1CCC=1C=NC=CC1)=OBeta lactone analogue90% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00256621855356Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA4(3R,4R)-4-(4-(N,N-Dimethylamino)benzamido-5-pentyl)-3-(non-8-enyl)oxetan-2-oneCN(C)C1=CC=C(C(=O)NC(CCCC)[C@H]2[C@H](C(O2)=O)CCCCCCCC=C)C=C1Beta lactone analogue55% at 10 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00256721855356Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA1(3R,4R)-3-(8-Nonenyl)-4-(2-phenylethyl)oxetan-2-oneC(CCCCCCC=C)[C@H]1C(O[C@@H]1CCC1=CC=CC=C1)=OBeta lactone analogue30% at 20 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00256821855356Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA2(3R,4R)-3-(8-Nonenyl)-4-(2-(3-pyridyl)ethyl)oxetan-2-oneC(CCCCCCC=C)[C@H]1C(O[C@@H]1CCC=1C=NC=CC1)=OBeta lactone analogue92% at 20 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00256921855356Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA4(3R,4R)-4-(4-(N,N-Dimethylamino)benzamido-5-pentyl)-3-(non-8-enyl)oxetan-2-oneCN(C)C1=CC=C(C(=O)NC(CCCC)[C@H]2[C@H](C(O2)=O)CCCCCCCC=C)C=C1Beta lactone analogue65% at 20 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00257021855356Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA1(3R,4R)-3-(8-Nonenyl)-4-(2-phenylethyl)oxetan-2-oneC(CCCCCCC=C)[C@H]1C(O[C@@H]1CCC1=CC=CC=C1)=OBeta lactone analogue25% at 40 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00257121855356Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA2(3R,4R)-3-(8-Nonenyl)-4-(2-(3-pyridyl)ethyl)oxetan-2-oneC(CCCCCCC=C)[C@H]1C(O[C@@H]1CCC=1C=NC=CC1)=OBeta lactone analogue90% at 40 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00257221855356Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA4(3R,4R)-4-(4-(N,N-Dimethylamino)benzamido-5-pentyl)-3-(non-8-enyl)oxetan-2-oneCN(C)C1=CC=C(C(=O)NC(CCCC)[C@H]2[C@H](C(O2)=O)CCCCCCCC=C)C=C1Beta lactone analogue50% at 40 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00257321855356Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA6(3R,4R)-3-(N-(tert-Butoxycarbonyl)-9-aminononyl)-4-(dec-9-enyl)oxetan-2-oneC(C)(C)(C)OC(=O)NCCCCCCCCC[C@H]1C(O[C@@H]1CCCCCCCCC=C)=OBeta lactone analogue12% at 200 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00257421855356Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA6(3R,4R)-3-(N-(tert-Butoxycarbonyl)-9-aminononyl)-4-(dec-9-enyl)oxetan-2-oneC(C)(C)(C)OC(=O)NCCCCCCCCC[C@H]1C(O[C@@H]1CCCCCCCCC=C)=OBeta lactone analogue15% at 400 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00257521855356Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA6(3R,4R)-3-(N-(tert-Butoxycarbonyl)-9-aminononyl)-4-(dec-9-enyl)oxetan-2-oneC(C)(C)(C)OC(=O)NCCCCCCCCC[C@H]1C(O[C@@H]1CCCCCCCCC=C)=OBeta lactone analogue20% at 600 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00257621855356Hsp100ClpPBacteriaCytosolInhibition of peptidase activityNA6(3R,4R)-3-(N-(tert-Butoxycarbonyl)-9-aminononyl)-4-(dec-9-enyl)oxetan-2-oneC(C)(C)(C)OC(=O)NCCCCCCCCC[C@H]1C(O[C@@H]1CCCCCCCCC=C)=OBeta lactone analogue10% at 800 uM NANANANANANANANucleotide binding domainPeptidase assay (SLY-AMC)NANA
HSPMDB00257730543804Hsp100ClpP1P2BacteriaCytosolInhibition of protease activityNADCCDicyclohexylcarbodiimideC1CCC(CC1)N=C=NC2CCCCC2GSK Library collectionNANANA80NANANANANucleotide binding domainSubstrate degradation assay (GFP-ssrA)NANA
HSPMDB00257830543804Hsp100ClpC1BacteriaCytosolInhibition of protease activityNAecumicin(2S,3R)-2-[[(2S)-2-[[(2S)-2-(dimethylamino)-3-methylbutanoyl]amino]-3-methylbutanoyl]-methylamino]-N-[(3S,6S,9S,12S,15S,18S,21S,24S,27S,30S,31R)-27-[(1R)-1-hydroxyethyl]-6-[(R)-hydroxy(phenyl)methyl]-12-[(4-methoxy-1H-indol-3-yl)methyl]-13,16,22,28,31-pentamethyl-21-(2-methylpropyl)-2,5,8,11,14,17,20,23,26,29-decaoxo-3,9,15,18,24-penta(propan-2-yl)-1-oxa-4,7,10,13,16,19,22,25,28-nonazacyclohentriacont-30-yl]-3-methylpentanamideCCC(C)C(C(=O)NC1C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(N(C(=O)C(N(C(=O)C(NC(=O)C(N(C(=O)C(NC(=O)C(N(C1=O)C)C(C)O)C(C)C)C)CC(C)C)C(C)C)C)C(C)C)C)CC2=CNC3=C2C(=CC=C3)OC)C(C)C)C(C4=CC=CC=C4)O)C(C)C)C)N(C)C(=O)C(C(C)C)NC(=O)C(C(C)C)N(C)CGSK Library collectionNANANA4NANANANANucleotide binding domainSubstrate degradation assay (GFP-ssrA)NANA
HSPMDB00257930126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-02NAO=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC=CC=C3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5CCC[C@@]5([H])C4=OAcyldepsipeptide analogueNANANANANANA1.08 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00258030126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-10NAO=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC=CC=C3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=OAcyldepsipeptide analogueNANANANANANA1.07 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00258130126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-18NAO=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/CCCCC)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=OAcyldepsipeptide analogueNANANANANANA1.06 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00258230126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-06NAO=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC(F)=CC(F)=C2)NC(/C=C/CCCC)=O)=O)CO3)=O)CCC1)=O)=O)N4C[C@H](C)C[C@@]4([H])C3=OAcyldepsipeptide analogueNANANANANANA1.04 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00258330126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-15NAO=C([C@H](C)NC([C@@](CCC1)([H])N1C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=OAcyldepsipeptide analogueNANANANANANA1.04 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00258430126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-20NAO=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC=C3)NC(/C=C/CCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=OAcyldepsipeptide analogueNANANANANANA1.03 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00258530126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-32NAO=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)CN4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=OAcyldepsipeptide analogueNANANANANANA1.03 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00258630126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-04NAO=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/C=C/CCC)=O)=O)CO3)=O)CCC1)=O)=O)N4C[C@H](C)C[C@@]4([H])C3=OAcyldepsipeptide analogueNANANANANANA1.02 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00258730126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-13NAO=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CC4CC4)=O)=O)[C@H](C)O5)=O)CCC2)=O)=O)N6C[C@H](C)C[C@@]6([H])C5=OAcyldepsipeptide analogueNANANANANANA1.02 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00258830126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-17NAO=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CC4CCCCC4)=O)=O)[C@H](C)O5)=O)CCC2)=O)=O)N6C[C@H](C)C[C@@]6([H])C5=OAcyldepsipeptide analogueNANANANANANA1.02 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00258930126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-21NAO=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3CCCCC3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=OAcyldepsipeptide analogueNANANANANANA1.00 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00259030126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-14NAO=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/C=C/CCC)=O)=O)[C@H](C)O4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=OAcyldepsipeptide analogueNANANANANANA0.99 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00259130126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-30NAO=C([C@H](C)NC([C@@]1([H])N(CC[C@H](C)C1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=OAcyldepsipeptide analogueNANANANANANA0.98 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00259230126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-05NAO=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/C=C/C=C/C)=O)=O)CO3)=O)CCC1)=O)=O)N4C[C@H](C)C[C@@]4([H])C3=OAcyldepsipeptide analogueNANANANANANA0.98 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00259330126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-25NAO=C([C@H](CC)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=OAcyldepsipeptide analogueNANANANANANA0.97 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00259430126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-08NAO=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/C=C/C=C/C)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=OAcyldepsipeptide analogueNANANANANANA0.97 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00259530126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-41NAO=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)[C@H](C)O4)=O)CCC2)=O)=O)N5CCC[C@@]5([H])C4=OAcyldepsipeptide analogueNANANANANANA0.96 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00259630126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-01NAO=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/CCCC)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=OAcyldepsipeptide analogueNANANANANANA0.96 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00259730126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-28NAO=C([C@H](C)NC([C@@]1([H])N(CC[C@H](C)C1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)[C@H](C)O4)=O)CCC2)=O)=O)N5CCC[C@@]5([H])C4=OAcyldepsipeptide analogueNANANANANANA0.95 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00259830126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-38NAO=C([C@H](C)NC([C@@]1([H])N(CC[C@H](C)C1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)[C@H](C)O4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=OAcyldepsipeptide analogueNANANANANANA0.95 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00259930126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-37NAO=C([C@H](C)NC([C@@]1([H])N(CCC2=C1C=CC=C2)C([C@@]3([H])N(C([C@@H](NC([C@H](CC4=CC(F)=CC(F)=C4)NC(/C=C/CCCC)=O)=O)CO5)=O)CCC3)=O)=O)N6C[C@H](C)C[C@@]6([H])C5=OAcyldepsipeptide analogueNANANANANANA0.92 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00260030126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-29NAO=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)[C@H](C)O4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=OAcyldepsipeptide analogueNANANANANANA0.92 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00260130126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-43NAO=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(C=CC=C4)=C4C=C3)NC(/C=C/CCCC)=O)=O)CO5)=O)CCC2)=O)=O)N6C[C@H](C)C[C@@]6([H])C5=OAcyldepsipeptide analogueNANANANANANA0.87 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00260230126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-42NAO=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CSC4=C3C=CC=C4)NC(/C=C/CCCC)=O)=O)CO5)=O)CCC2)=O)=O)N6C[C@H](C)C[C@@]6([H])C5=OAcyldepsipeptide analogueNANANANANANA0.87 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00260330126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-26NAO=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/C=C/C)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=OAcyldepsipeptide analogueNANANANANANA0.86 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00260430126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-39NAO=C([C@H](C)NC([C@@]1([H])N(CC[C@H](C)C1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/C4=CC=CC(C(F)(F)F)=C4)=O)=O)[C@H](C)O5)=O)CCC2)=O)=O)N6C[C@H](C)C[C@@]6([H])C5=OAcyldepsipeptide analogueNANANANANANA0.78 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00260530126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-11NAO=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=OAcyldepsipeptide analogueNANANANANANA0.77 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00260630126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-09NAO=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/CCC)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=OAcyldepsipeptide analogueNANANANANANA0.76 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00260730126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-03NAO=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/C=C/C)=O)=O)CO3)=O)CCC1)=O)=O)N4C[C@H](C)C[C@@]4([H])C3=OAcyldepsipeptide analogueNANANANANANA0.66 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00260830126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-27NAO=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(C#CCCCCC)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=OAcyldepsipeptide analogueNANANANANANA0.64 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00260930126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-07NAO=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCCC(O)=O)=O)=O)[C@H](C)O4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=OAcyldepsipeptide analogueNANANANANANA0.61 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00261030126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-44NAO=C([C@H](C)NC([C@@]1([H])N(CC[C@H](C)C1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/C4=CC=CC=C4C(F)(F)F)=O)=O)[C@H](C)O5)=O)CCC2)=O)=O)N6C[C@H](C)C[C@@]6([H])C5=OAcyldepsipeptide analogueNANANANANANA0.42 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00261130126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-12NAO=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(C#CCCCC)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=OAcyldepsipeptide analogueNANANANANANA0.36 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00261230126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-19NAO=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C\CCCC)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=OAcyldepsipeptide analogueNANANANANANA0.34 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00261330126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-45NAO=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC(C(F)=C3F)=C(F)C(F)=C3F)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=OAcyldepsipeptide analogueNANANANANANA0.29 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00261430126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-23NAO=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(C#CCCC)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=OAcyldepsipeptide analogueNANANANANANA0.12 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00261530126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-33NAO=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C\CCC)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=OAcyldepsipeptide analogueNANANANANANA0.07 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00261630126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-16NAO=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(OCC3=CC=CC=C3)=O)=O)CO4)=O)CCC1)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=OAcyldepsipeptide analogueNANANANANANA0.06 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00261730126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-46NAO=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/C=C/COC3([H])OCCCC3)=O)=O)CO4)=O)CCC1)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=OAcyldepsipeptide analogueNANANANANANA0.02 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00261830126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-36NAO=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/C=C/CO)=O)=O)CO3)=O)CCC1)=O)=O)N4C[C@H](C)C[C@@]4([H])C3=OAcyldepsipeptide analogueNANANANANANA0 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00261930126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-24NAO=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC=CC=C3)NC(C4=CC=C([N+]([O-])=O)C=C4)=O)=O)CO5)=O)CCC2)=O)=O)N6CCC[C@@]6([H])C5=OAcyldepsipeptide analogueNANANANANANA1 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00262030126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-34NAO=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(OC(C)(C)C)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=OAcyldepsipeptide analogueNANANANANANA2 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00262130126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-35NAO=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(OC(C)(C)C)=O)=O)CO3)=O)CCC1)=O)=O)N4C[C@H](C)C[C@@]4([H])C3=OAcyldepsipeptide analogueNANANANANANA3 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00262230126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-31NAO=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)N)=O)CO3)=O)CCC1)=O)=O)N4C[C@H](C)C[C@@]4([H])C3=OAcyldepsipeptide analogueNANANANANANA4 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00262330126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-22NAO=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(OCC3=CC=CC=C3)=O)=O)CO4)=O)CCC1)=O)=O)N5CCC[C@@]5([H])C4=OAcyldepsipeptide analogueNANANANANANA5 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00262430126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-40NAO=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)N)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=OAcyldepsipeptide analogueNANANANANANA6 at 25 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00262530126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-32NAO=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)CN4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=OAcyldepsipeptide analogueNANANANANANA0.9 at 5 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00262630126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-06NAO=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC(F)=CC(F)=C2)NC(/C=C/CCCC)=O)=O)CO3)=O)CCC1)=O)=O)N4C[C@H](C)C[C@@]4([H])C3=OAcyldepsipeptide analogueNANANANANANA0.94 at 5 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00262730126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-30NAO=C([C@H](C)NC([C@@]1([H])N(CC[C@H](C)C1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=OAcyldepsipeptide analogueNANANANANANA0.93 at 5 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00262830126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-41NAO=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)[C@H](C)O4)=O)CCC2)=O)=O)N5CCC[C@@]5([H])C4=OAcyldepsipeptide analogueNANANANANANA0.93 at 5 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00262930126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-28NAO=C([C@H](C)NC([C@@]1([H])N(CC[C@H](C)C1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)[C@H](C)O4)=O)CCC2)=O)=O)N5CCC[C@@]5([H])C4=OAcyldepsipeptide analogueNANANANANANA0.93 at 5 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00263030126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-25NAO=C([C@H](CC)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=OAcyldepsipeptide analogueNANANANANANA0.92 at 5 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00263130126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-14NAO=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/C=C/CCC)=O)=O)[C@H](C)O4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=OAcyldepsipeptide analogueNANANANANANA0.92 at 5 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00263230126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-15NAO=C([C@H](C)NC([C@@](CCC1)([H])N1C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=OAcyldepsipeptide analogueNANANANANANA0.92 at 5 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00263330126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-13NAO=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CC4CC4)=O)=O)[C@H](C)O5)=O)CCC2)=O)=O)N6C[C@H](C)C[C@@]6([H])C5=OAcyldepsipeptide analogueNANANANANANA0.91 at 5 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00263430126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-17NAO=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CC4CCCCC4)=O)=O)[C@H](C)O5)=O)CCC2)=O)=O)N6C[C@H](C)C[C@@]6([H])C5=OAcyldepsipeptide analogueNANANANANANA0.91 at 5 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00263530126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-20NAO=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC=C3)NC(/C=C/CCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=OAcyldepsipeptide analogueNANANANANANA0.90 at 5 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00263630126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-38NAO=C([C@H](C)NC([C@@]1([H])N(CC[C@H](C)C1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)[C@H](C)O4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=OAcyldepsipeptide analogueNANANANANANA0.89 at 5 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00263730126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-02NAO=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC=CC=C3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5CCC[C@@]5([H])C4=OAcyldepsipeptide analogueNANANANANANA0.88 at 5 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00263830126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-29NAO=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(F)=CC(F)=C3)NC(/C=C/CCCC)=O)=O)[C@H](C)O4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=OAcyldepsipeptide analogueNANANANANANA0.87 at 5 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00263930126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-37NAO=C([C@H](C)NC([C@@]1([H])N(CCC2=C1C=CC=C2)C([C@@]3([H])N(C([C@@H](NC([C@H](CC4=CC(F)=CC(F)=C4)NC(/C=C/CCCC)=O)=O)CO5)=O)CCC3)=O)=O)N6C[C@H](C)C[C@@]6([H])C5=OAcyldepsipeptide analogueNANANANANANA0.86 at 5 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00264030126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-10NAO=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC=CC=C3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=OAcyldepsipeptide analogueNANANANANANA0.85 at 5 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00264130126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-04NAO=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/C=C/CCC)=O)=O)CO3)=O)CCC1)=O)=O)N4C[C@H](C)C[C@@]4([H])C3=OAcyldepsipeptide analogueNANANANANANA0.78 at 5 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00264230126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-18NAO=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/CCCCC)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=OAcyldepsipeptide analogueNANANANANANA0.72 at 5 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00264330126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-21NAO=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3CCCCC3)NC(/C=C/CCCC)=O)=O)CO4)=O)CCC2)=O)=O)N5C[C@H](C)C[C@@]5([H])C4=OAcyldepsipeptide analogueNANANANANANA0.70 at 5 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00264430126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-01NAO=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/CCCC)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=OAcyldepsipeptide analogueNANANANANANA0.70 at 5 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00264530126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-05NAO=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/C=C/C=C/C)=O)=O)CO3)=O)CCC1)=O)=O)N4C[C@H](C)C[C@@]4([H])C3=OAcyldepsipeptide analogueNANANANANANA0.69 at 5 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00264630126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-43NAO=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CC(C=CC=C4)=C4C=C3)NC(/C=C/CCCC)=O)=O)CO5)=O)CCC2)=O)=O)N6C[C@H](C)C[C@@]6([H])C5=OAcyldepsipeptide analogueNANANANANANA0.55 at 5 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00264730126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-08NAO=C([C@H](C)NC([C@H](C)N(C)C([C@@]1([H])N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(/C=C/C=C/C=C/C)=O)=O)CO3)=O)CCC1)=O)=O)N4CCC[C@@]4([H])C3=OAcyldepsipeptide analogueNANANANANANA0.52 at 5 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00264830126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-42NAO=C([C@H](C)NC([C@@]1([H])N(CCCC1)C([C@@]2([H])N(C([C@@H](NC([C@H](CC3=CSC4=C3C=CC=C4)NC(/C=C/CCCC)=O)=O)CO5)=O)CCC2)=O)=O)N6C[C@H](C)C[C@@]6([H])C5=OAcyldepsipeptide analogueNANANANANANA0.49 at 5 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00264930126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-17NAO=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H]([C@@H](OC2=O)C)NC([C@@H](NC(/C=C/CC5CCCCC5)=O)CC6=CC(F)=CC(F)=C6)=O)=O)[H])=O)CCCC3)[H])=O)CAcyldepsipeptide analogueNANANANANANA0.81 at 1 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00265030126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-28NAO=C(N1CCC[C@]12[H])[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H]([C@@H](OC2=O)C)NC([C@@H](NC(/C=C/CCCC)=O)CC5=CC(F)=CC(F)=C5)=O)=O)[H])=O)CC[C@@H](C3)C)[H])=O)CAcyldepsipeptide analogueNANANANANANA0.82 at 1 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00265130126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-14NAO=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H]([C@@H](OC2=O)C)NC([C@@H](NC(/C=C/C=C/CCC)=O)CC5=CC(F)=CC(F)=C5)=O)=O)[H])=O)CCCC3)[H])=O)CAcyldepsipeptide analogueNANANANANANA0.79 at 1 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00265230126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-41NAO=C(N1CCC[C@]12[H])[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H]([C@@H](OC2=O)C)NC([C@@H](NC(/C=C/CCCC)=O)CC5=CC(F)=CC(F)=C5)=O)=O)[H])=O)CCCC3)[H])=O)CAcyldepsipeptide analogueNANANANANANA0.79 at 1 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00265330126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-32NAO=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H](CNC2=O)NC([C@@H](NC(/C=C/CCCC)=O)CC5=CC(F)=CC(F)=C5)=O)=O)[H])=O)CCCC3)[H])=O)CAcyldepsipeptide analogueNANANANANANA0.79 at 1 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00265430126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-29NAO=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H]([C@@H](OC2=O)C)NC([C@@H](NC(/C=C/CCCC)=O)CC5=CC(F)=CC(F)=C5)=O)=O)[H])=O)CCCC3)[H])=O)CAcyldepsipeptide analogueNANANANANANA0.76 at 1 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00265530126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-38NAO=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H]([C@@H](OC2=O)C)NC([C@@H](NC(/C=C/CCCC)=O)CC5=CC(F)=CC(F)=C5)=O)=O)[H])=O)CC[C@@H](C3)C)[H])=O)CAcyldepsipeptide analogueNANANANANANA0.76 at 1 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00265630126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-30NAO=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H](COC2=O)NC([C@@H](NC(/C=C/CCCC)=O)CC5=CC(F)=CC(F)=C5)=O)=O)[H])=O)CC[C@@H](C3)C)[H])=O)CAcyldepsipeptide analogueNANANANANANA0.69 at 1 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00265730126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-37NAO=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H](COC2=O)NC([C@@H](NC(/C=C/CCCC)=O)CC5=CC(F)=CC(F)=C5)=O)=O)[H])=O)CCC6=C3C=CC=C6)[H])=O)CAcyldepsipeptide analogueNANANANANANA0.68 at 1 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00265830126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-06NAO=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@@H](N(C([C@]3(N(CCC3)C([C@H](COC2=O)NC([C@@H](NC(/C=C/CCCC)=O)CC4=CC(F)=CC(F)=C4)=O)=O)[H])=O)C)C)=O)CAcyldepsipeptide analogueNANANANANANA0.64 at 1 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00265930126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-25NAO=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H](COC2=O)NC([C@@H](NC(/C=C/CCCC)=O)CC5=CC(F)=CC(F)=C5)=O)=O)[H])=O)CCCC3)[H])=O)CCAcyldepsipeptide analogueNANANANANANA0.61 at 1 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00266030126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-13NAO=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H]([C@@H](OC2=O)C)NC([C@@H](NC(/C=C/CC5CC5)=O)CC6=CC(F)=CC(F)=C6)=O)=O)[H])=O)CCCC3)[H])=O)CAcyldepsipeptide analogueNANANANANANA0.59 at 1 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00266130126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-15NAO=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@]3([H])CCCN3C([C@]4(N(CCC4)C([C@H](COC2=O)NC([C@H](NC(/C=C/CCCC)=O)CC5=CC(F)=CC(F)=C5)=O)=O)[H])=O)=O)CAcyldepsipeptide analogueNANANANANANA0.58 at 1 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00266230126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-20NAO=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H](COC2=O)NC([C@H](NC(/C=C/CCC)=O)CC5=CC(F)=CC=C5)=O)=O)[H])=O)CCCC3)[H])=O)CAcyldepsipeptide analogueNANANANANANA0.53 at 1 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00266330126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-02NAO=C(N1CCC[C@]12[H])[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H](COC2=O)NC([C@H](NC(/C=C/CCCC)=O)CC5=CC=CC=C5)=O)=O)[H])=O)CCCC3)[H])=O)CAcyldepsipeptide analogueNANANANANANA0.52 at 1 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00266430126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-10NAO=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@]3(N(C([C@]4(N(CCC4)C([C@H](COC2=O)NC([C@H](NC(/C=C/CCCC)=O)CC5=CC=CC=C5)=O)=O)[H])=O)CCCC3)[H])=O)CAcyldepsipeptide analogueNANANANANANA0.44 at 1 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00266530126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-04NAO=C(N1C[C@@H](C[C@]12[H])C)[C@@H](NC([C@@H](N(C([C@]3(N(CCC3)C([C@H](COC2=O)NC([C@H](NC(/C=C/C=C/CCC)=O)CC4=CC=CC=C4)=O)=O)[H])=O)C)C)=O)CAcyldepsipeptide analogueNANANANANANA0.32 at 1 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
HSPMDB00266630126533Hsp100ClpPHumanMitochondriaInhibition of protease activityNAADEP-01NAO=C(N1CCC[C@]12[H])[C@@H](NC([C@@H](N(C([C@]3(N(CCC3)C([C@H](COC2=O)NC([C@H](NC(/C=C/CCCC)=O)CC4=CC=CC=C4)=O)=O)[H])=O)C)C)=O)CAcyldepsipeptide analogueNANANANANANA0.22 at 1 uM NANucleotide binding domainSubstrate degradation assay (FITC-casein)NANA
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