HSPMdb Accession No | HSPMDB002394 |
PMID | 18847196 |
Target | Hsp100 |
HSP Name | ClpP |
Organism | Bacteria |
Localization | Cytosol |
Enzymatic activity | Inhibition of peptidase activity |
Compound Name | Lactone E2 |
IUPAC Name | 3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one |
SMILES | COC1=CC=C(C=C1)C1C(CCCC#C)OC1=O |
Class | Beta lactone analogue |
IC50 (µM) | 4 |
Site of Interaction | Nucleotide binding domain |
Type of Enzymatic Assay | Peptidase assay (SLY-AMC) |
Cellular Model | S. aureus |
Disease | Bacterial infection |