HSPMdb Accession NoHSPMDB002394
PMID18847196
TargetHsp100
HSP NameClpP
OrganismBacteria
LocalizationCytosol
Enzymatic activityInhibition of peptidase activity
Compound NameLactone E2
IUPAC Name3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one
SMILESCOC1=CC=C(C=C1)C1C(CCCC#C)OC1=O
ClassBeta lactone analogue
IC50 (µM)4
Site of InteractionNucleotide binding domain
Type of Enzymatic AssayPeptidase assay (SLY-AMC)
Cellular ModelS. aureus
DiseaseBacterial infection

Structure



HSPMDB002394

Lactone E2

Physicochemical Properties