HSPMdb Accession No | HSPMDB002469 |
PMID | 28917450 |
Target | Hsp100 |
HSP Name | ClpP |
Organism | Plasmodium falciparum |
Localization | Cytosol |
Enzymatic activity | Inhibition of protease activity |
Compound Name | 36 |
IUPAC Name | 1-Benzyl-2-(2-(4-hydroxyphenyl)-2-oxoethylthio)-6-oxo-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamide |
SMILES | O=C(CSC1=NC=C(C(=O)NCCCc2ccccc2)C(=O)N1Cc3ccccc3)c4ccc(cc4)C#N |
Class | Library of small molecule structures |
Ki (µM) | 21.6 |
Site of Interaction | Nucleotide binding domain |
Type of Enzymatic Assay | Peptidase assay (SLY-AMC) |
Cellular Model | P. falciparum |
Disease | Malaria |