HSPMdb Accession No | HSPMDB002433 |
PMID | 28917450 |
Target | Hsp100 |
HSP Name | ClpP |
Organism | Plasmodium falciparum |
Localization | Cytosol |
Enzymatic activity | Inhibition of protease activity |
Compound Name | 12 |
IUPAC Name | N-Benzyl-2-((6-isopropyl-4-oxo-3-phenethyl-3,5,6,8-tetrahydro-4H-pyrano[40,30:4,5]thieno[2,3-d]pyrimidin-2-yl)thio)acetamide |
SMILES | CCCC1=CC(=O)Oc2cc(OCC(=O)N[C@@H](CSCc3ccccc3)C(O)=O)ccc12 |
Class | Library of small molecule structures |
IC50 (µM) | >100 |
Site of Interaction | Nucleotide binding domain |
Type of Enzymatic Assay | Peptidase assay (SLY-AMC) |
Cellular Model | P. falciparum |
Disease | Malaria |