HSPMdb Accession NoHSPMDB002207
PMID26083639
TargetHsp100
HSP NameClpP
OrganismBacteria
LocalizationCytosol
Enzymatic activityInhibition of protease activity
Compound NameAV167
IUPAC Name4-(1,3,4-oxadiazol-2-yl)phenyl 2-{naphtho[2,1-b]furan-1-yl}acetate
SMILESO=C(CC1=COC2=C1C1=C(C=CC=C1)C=C2)OC1=CC=C(C=C1)C1=NN=CO1
ClassNon beta lactone inhibitor
% Enzymatic Inhibition/Fold Change5% at 1 uM
Site of InteractionNucleotide binding domain
Type of Enzymatic AssaySubstrate degradation assay (GFP-ssrA)
DiseaseBacterial infection

Structure



HSPMDB002207

AV167

Physicochemical Properties