HSPMdb Accession NoHSPMDB002442
PMID28917450
TargetHsp100
HSP NameClpP
OrganismPlasmodium falciparum
LocalizationCytosol
Enzymatic activityInhibition of protease activity
Compound Name32
IUPAC Name1-Benzyl-6-oxo-2-(2-oxo-2-(2-(2-phenylacetyl)hydrazinyl)ethylthio)-N-(3-phenylpropyl)-1,6-dihydropyrimidine-5-carboxamide
SMILESO=C(NCCCc1ccccc1)C2=CN=C(SCCN3CCOCC3)N(Cc4ccccc4)C2=O
ClassLibrary of small molecule structures
IC50 (µM)72.6
Site of InteractionNucleotide binding domain
Type of Enzymatic AssayPeptidase assay (SLY-AMC)
Cellular ModelP. falciparum
DiseaseMalaria

Structure



HSPMDB002442

32

Physicochemical Properties