HSPMdb Accession NoHSPMDB002363
PMID25944857
TargetHsp100
HSP NameClpP1P2
OrganismBacteria
LocalizationCytosol
Cellular activityAntibacterial activity
Compound NameMG-132
IUPAC Namebenzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate
SMILESCC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1
ClassBortezomib derivative
Site of InteractionNucleotide binding domain
Percentage Cell Growth Inhibition10% at 50 uM
Cellular assayBacterial growth inhibition assay (OD based)
Cellular ModelM. smegmatis (mc2155)
DiseaseTuberculosis

Structure



HSPMDB002363

MG-132

Physicochemical Properties