HSPMdb Accession No | HSPMDB002363 |
PMID | 25944857 |
Target | Hsp100 |
HSP Name | ClpP1P2 |
Organism | Bacteria |
Localization | Cytosol |
Cellular activity | Antibacterial activity |
Compound Name | MG-132 |
IUPAC Name | benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate |
SMILES | CC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1 |
Class | Bortezomib derivative |
Site of Interaction | Nucleotide binding domain |
Percentage Cell Growth Inhibition | 10% at 50 uM |
Cellular assay | Bacterial growth inhibition assay (OD based) |
Cellular Model | M. smegmatis (mc2155) |
Disease | Tuberculosis |