HSPMdb Accession NoHSPMDB002192
PMID26083639
TargetHsp100
HSP NameClpP
OrganismBacteria
LocalizationCytosol
Enzymatic activityInhibition of protease activity
Compound NameAV168
IUPAC Name4-(1,3,4-oxadiazol-2-yl)phenyl 3-[methyl(3-sulfanylphenyl)sulfamoyl]benzoate
SMILESCN(C1=CC=CC(S)=C1)S(=O)(=O)C1=CC=CC(=C1)C(=O)OC1=CC=C(C=C1)C1=NN=CO1
ClassNon beta lactone inhibitor
% Enzymatic Inhibition/Fold Change20% at 100 uM
Site of InteractionNucleotide binding domain
Type of Enzymatic AssaySubstrate degradation assay (GFP-ssrA)
DiseaseBacterial infection

Structure



HSPMDB002192

AV168

Physicochemical Properties