HSPMdb Accession NoHSPMDB002358
PMID25944857
TargetHsp100
HSP NameClpP1P2
OrganismBacteria
LocalizationCytosol
Cellular activityAntibacterial activity
Compound Name100, (Bortezomib) + Amikacin
IUPAC Name[(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid
SMILESB(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O
ClassPHARMAKON1600 library
Site of InteractionNucleotide binding domain
Percentage Cell Growth Inhibition90%
Cellular assayBacterial growth inhibition assay (OD based)
Cellular ModelM. smegmatis (mc2155)
DiseaseTuberculosis

Structure



HSPMDB002358

100, (Bortezomib) + Amikacin

Physicochemical Properties