| HSPMdb Accession No | HSPMDB002073 |
| PMID | 21383145 |
| Target | Hsp100 |
| HSP Name | p97 |
| Organism | Human |
| Localization | Cytosol |
| Cellular activity | Substrate degradation activity |
| Compound Name | Eeyarestatin I (Eerl) |
| IUPAC Name | 2-[3-(4-chlorophenyl)-4-[(4-chlorophenyl)carbamoyl-hydroxyamino]-5,5-dimethyl-2-oxoimidazolidin-1-yl]-N-[(E)-[(E)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]acetamide |
| SMILES | CC1(C(N(C(=O)N1CC(=O)NN=CC=CC2=CC=C(O2)[N+](=O)[O-])C3=CC=C(C=C3)Cl)N(C(=O)NC4=CC=C(C=C4)Cl)O)C |
| Class | Maybridge, Hitfinder, and NIH molecular libraries |
| IC50 (µM) | 3.7 |
| Site of Interaction | Nucleotide binding domain |
| Cellular assay | Reporter degradation assay (UbG76V-GFP) |
| Cellular Model | HeLa |
| Disease | Cancer |
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