HSPMdb Accession NoHSPMDB001489
PMID25299406
TargetHsp100
HSP NameHsp104
OrganismYeast
LocalizationCytosol
Enzymatic activityInhibition of ATPase activity
Compound NameSuramin
IUPAC Name8-[[4-methyl-3-[[3-[[3-[[2-methyl-5-[(4,6,8-trisulfonatonaphthalen-1-yl)carbamoyl]phenyl]carbamoyl]phenyl]carbamoylamino]benzoyl]amino]benzoyl]amino]naphthalene-1,3,5-trisulfonate
SMILESCC1=C(C=C(C(=O)NC2=CC=C(C=3C=C(C=C(C23)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])C=C1)NC(C1=CC(=CC=C1)NC(NC1=CC(=CC=C1)C(NC1=C(C=CC(=C1)C(NC1=CC=C(C2=CC(=CC(=C12)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])=O)C)=O)=O)=O
ClassNIH, Spectrum, and Hit finder collection
% Enzymatic Inhibition/Fold Change50.83% at 10 uM
Site of InteractionNucleotide binding domain
Type of Enzymatic AssayATPase assay

Structure



HSPMDB001489

Suramin

Physicochemical Properties