HSPMdb Accession NoHSPMDB001831
PMID30571121
TargetHsp100
HSP NameClpP
OrganismBacteria
LocalizationCytosol
Enzymatic activityInhibition of peptidase activity
Compound Name89
IUPAC NameBenzyl ((5-Chloro-1H-indol-3-yl)(diphenoxyphosphoryl)methyl)-carbamate
SMILESO=C(OCC1=CC=CC=C1)NC(C2=CNC3=C2C=C(Cl)C=C3)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=O
ClassSerine protease inhibitor library
% Enzymatic Inhibition/Fold Change88% at 200 uM
IC50 (µM)100.5
Site of InteractionNucleotide binding domain
Type of Enzymatic AssayPeptidase assay (SLY-AMC)
DiseaseBacterial infection

Structure



HSPMDB001831

89

Physicochemical Properties