HSPMdb Accession No | HSPMDB002171 |
PMID | 26083639 |
Target | Hsp100 |
HSP Name | ClpP |
Organism | Human |
Localization | Cytosol |
Enzymatic activity | Inhibition of peptidase activity |
Compound Name | E2 |
IUPAC Name | 3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one |
SMILES | COC1=CC=C(C=C1)C1C(CCCC#C)OC1=O |
Class | Non beta lactone inhibitor |
% Enzymatic Inhibition/Fold Change | 45% at 100 uM |
Site of Interaction | Nucleotide binding domain |
Type of Enzymatic Assay | Peptidase assay (SLY-AMC) |