HSPMdb Accession NoHSPMDB001798
PMID30571121
TargetHsp100
HSP NameClpP
OrganismBacteria
LocalizationCytosol
Enzymatic activityInhibition of peptidase activity
Compound Name56
IUPAC Name(Perfluorophenyl)methyl (1-(Diphenoxyphosphoryl)-2-(4-guanidinophenyl)ethyl)carbamate 2,2,2-Trifluoroacetate
SMILESO=C(OCC1=C(F)C(F)=C(F)C(F)=C1F)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)CC4=CC=C(NC(N)=N)C=C4
ClassSerine protease inhibitor library
% Enzymatic Inhibition/Fold Change25% at 200 uM
Site of InteractionNucleotide binding domain
Type of Enzymatic AssayPeptidase assay (SLY-AMC)
DiseaseBacterial infection

Structure



HSPMDB001798

56

Physicochemical Properties