HSPMdb Accession No | HSPMDB002196 |
PMID | 26083639 |
Target | Hsp100 |
HSP Name | ClpP |
Organism | Bacteria |
Localization | Cytosol |
Enzymatic activity | Inhibition of protease activity |
Compound Name | AV126 |
IUPAC Name | 4-[(propan-2-yloxy)carbonyl]phenyl 3-methanesulfonyl-4-methylbenzoate |
SMILES | CC(C)OC(=O)C1=CC=C(OC(=O)C2=CC=C(C)C(=C2)S(C)(=O)=O)C=C1 |
Class | Non beta lactone inhibitor |
% Enzymatic Inhibition/Fold Change | 80% at 10 uM |
Site of Interaction | Nucleotide binding domain |
Type of Enzymatic Assay | Substrate degradation assay (GFP-ssrA) |
Disease | Bacterial infection |