HSPMdb Accession NoHSPMDB001528
PMID23961953
TargetHsp100
HSP NameClpB
OrganismBacteria
LocalizationCytosol
Enzymatic activityInhibition of chaperone activity
Compound Name5
IUPAC Name(4Z)-1-(4-Chlorophenyl)-4-{4-[(4-fluorobenzyl)oxy]-3- methoxybenzylidene}-3,5-pyrazolidinedione
SMILESCOc1cc(ccc1OCc2ccc(F)cc2)/C=C3/C(=O)NN(C3=O)c4ccc(Cl)cc4
ClassMyriaScreen diversity collection
IC50 (µM)7.5
Site of InteractionNucleotide binding domain
Type of Enzymatic AssayLuciferase aggregate reactivation assay
DiseaseBacterial infection

Structure



HSPMDB001528

5

Physicochemical Properties