HSPMdb Accession NoHSPMDB002165
PMID26083639
TargetHsp100
HSP NameClpP
OrganismHuman
LocalizationCytosol
Enzymatic activityInhibition of peptidase activity
Compound NameAV127
IUPAC Name4-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylate
SMILESCC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=O
ClassNon beta lactone inhibitor
% Enzymatic Inhibition/Fold Change25% at 100 uM
Site of InteractionNucleotide binding domain
Type of Enzymatic AssayPeptidase assay (SLY-AMC)

Structure



HSPMDB002165

AV127

Physicochemical Properties