HSPMdb Accession NoHSPMDB002027
PMID21383145
TargetHsp100
HSP Namep97
OrganismHuman
LocalizationCytosol
Cellular activitySubstrate degradation activity
Compound NameJFD02342
IUPAC Name1-(4-Methylphenyl)-3-phenyl-2-propyn-1-one
SMILESCC1=CC=C(C=C1)C(=O)C#CC2=CC=CC=C2
ClassMaybridge, Hitfinder, and NIH molecular libraries
IC50 (µM)3.4
Site of InteractionNucleotide binding domain
Cellular assayReporter degradation assay (UbG76V-GFP)
Cellular ModelHeLa
DiseaseCancer

Structure



HSPMDB002027

JFD02342

Physicochemical Properties