HSPMdb Accession NoHSPMDB002238
PMID26083639
TargetHsp100
HSP NameClpP
OrganismBacteria
LocalizationCytosol
Enzymatic activityInhibition of peptidase activity
Compound NameML16
IUPAC NameMethyl 4-((3-(3,5-dimethoxy-4-(prop-2-yn-1-yloxy)phenyl)propanoyl)oxy)benzoate
SMILESCOC(=O)c1ccc(OC(=O)CCc2cc(OC)c(OCC#C)c(OC)c2)cc1
ClassNon beta lactone inhibitor (AV170 derivative)
% Enzymatic Inhibition/Fold Change0-5% at 10 uM
Site of InteractionNucleotide binding domain
Type of Enzymatic AssayPeptidase assay (SLY-AMC)
DiseaseBacterial infection

Structure



HSPMDB002238

ML16

Physicochemical Properties