HSPMdb Accession NoHSPMDB002422
PMID28917450
TargetHsp100
HSP NameClpP
OrganismPlasmodium falciparum
LocalizationCytosol
Enzymatic activityInhibition of protease activity
Compound Name1
IUPAC NameN-(5-Ethyl-1,3,4-thiadiazol-2-yl)-2-((5-(3-hydroxynaphthalen-2-yl)-4-(2-methoxyethyl)-4H-1,2,4-triazol-3-yl)thio)acetamide
SMILESCCc1sc(NC(=O)CSc2nnc(n2CCOC)c3cc4ccccc4cc3O)nn1
ClassLibrary of small molecule structures
IC50 (µM)30
Site of InteractionNucleotide binding domain
Type of Enzymatic AssayPeptidase assay (SLY-AMC)
Cellular ModelP. falciparum
DiseaseMalaria

Structure



HSPMDB002422

1

Physicochemical Properties