HSPMdb Accession NoHSPMDB001841
PMID30571121
TargetHsp100
HSP NameClpP
OrganismBacteria
LocalizationCytosol
Enzymatic activityInhibition of peptidase activity
Compound Name107
IUPAC NameBenzyl ((Diphenoxyphosphoryl)(4-(piperazin-1-yl)phenyl)-methyl)carbamate 2,2,2-trifluoroacetate
SMILESO=C(OCC1=CC=CC=C1)NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C4=CC=C(N5CCNCC5)C=C4.O=C(O)C(F)(F)F
ClassSerine protease inhibitor library
% Enzymatic Inhibition/Fold Change100% at 200 uM
IC50 (µM)0.6
Site of InteractionNucleotide binding domain
Type of Enzymatic AssayPeptidase assay (SLY-AMC)
DiseaseBacterial infection

Structure



HSPMDB001841

107

Physicochemical Properties