HSPMdb Accession No | HSPMDB002360 |
PMID | 25944857 |
Target | Hsp100 |
HSP Name | ClpP1P2 |
Organism | Bacteria |
Localization | Cytosol |
Cellular activity | Antibacterial activity |
Compound Name | Bz-al |
IUPAC Name | (2S)-N-[(2S)-4-methyl-1-oxopentan-2-yl]-3-phenyl-2-[(pyrazin-2-yl)formamido]propanamide |
SMILES | CC(C)C[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C1=NC=CN=C1)C=O |
Class | Bortezomib derivative |
Site of Interaction | Nucleotide binding domain |
Percentage Cell Growth Inhibition | 5% at 50 uM |
Cellular assay | Bacterial growth inhibition assay (OD based) |
Cellular Model | M. smegmatis (mc2155) |
Disease | Tuberculosis |