HSPMdb Accession NoHSPMDB002360
PMID25944857
TargetHsp100
HSP NameClpP1P2
OrganismBacteria
LocalizationCytosol
Cellular activityAntibacterial activity
Compound NameBz-al
IUPAC Name(2S)-N-[(2S)-4-methyl-1-oxopentan-2-yl]-3-phenyl-2-[(pyrazin-2-yl)formamido]propanamide
SMILESCC(C)C[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C1=NC=CN=C1)C=O
ClassBortezomib derivative
Site of InteractionNucleotide binding domain
Percentage Cell Growth Inhibition5% at 50 uM
Cellular assayBacterial growth inhibition assay (OD based)
Cellular ModelM. smegmatis (mc2155)
DiseaseTuberculosis

Structure



HSPMDB002360

Bz-al

Physicochemical Properties