HSPMdb Accession NoHSPMDB002398
PMID23892893
TargetHsp100
HSP Namep97
OrganismYeast
LocalizationCytosol, Mitochondria, Endoplasmic reliculum, Nucleous
Enzymatic activityInhibition of ATPase activity
Compound NameNMS-485A
IUPAC NameN 4 -benzyl-N 2 -(3-fluorophenyl)quinazoline-2,4-diamine
SMILESFc1cccc(Nc2nc(NCc3ccccc3)c4ccccc4n2)c1
ClassSmall molecule
IC50 (µM)0.45 uM at 60 uM ATP
Site of InteractionNucleotide binding domain (D2)
Type of Enzymatic AssayPeptidase assay (SLY-AMC)

Structure



HSPMDB002398

NMS-485A

Physicochemical Properties