HSPMdb Accession NoHSPMDB002187
PMID26083639
TargetHsp100
HSP NameClpP
OrganismHuman
LocalizationCytosol
Enzymatic activityInhibition of peptidase activity
Compound NameE2
IUPAC Name3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one
SMILESCOC1=CC=C(C=C1)C1C(CCCC#C)OC1=O
ClassNon beta lactone inhibitor
% Enzymatic Inhibition/Fold Change10% at 1 uM
Site of InteractionNucleotide binding domain
Type of Enzymatic AssayPeptidase assay (SLY-AMC)

Structure



HSPMDB002187

E2

Physicochemical Properties