HSPMdb Accession NoHSPMDB001494
PMID25299406
TargetHsp100
HSP NameHsp104
OrganismYeast
LocalizationCytosol
Enzymatic activityInhibition of ATPase activity
Compound NameMethacycline hydrochloride
IUPAC Name4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methylidene-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide hydrochloride
SMILESCl.CN(C1C(C(=C(C2(C(C3=C(C4=C(C=CC=C4C(C3C(C12)O)=C)O)O)=O)O)O)C(=O)N)=O)C
ClassNIH, Spectrum, and Hit finder collection
% Enzymatic Inhibition/Fold Change33.33% at 10 uM
Site of InteractionNucleotide binding domain
Type of Enzymatic AssayATPase assay

Structure



HSPMDB001494

Methacycline hydrochloride

Physicochemical Properties