HSPMdb Accession NoHSPMDB001771
PMID30571121
TargetHsp100
HSP NameClpP
OrganismBacteria
LocalizationCytosol
Enzymatic activityInhibition of peptidase activity
Compound Name16
IUPAC NameBenzyl (1-(Diphenoxyphosphoryl)-2-(4-(trifluoromethyl)phenyl)-ethyl) carbamate
SMILESO=C(OC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)CC3=CC=C(C(F)(F)F)C=C3)NCC4=CC=CC=C4
ClassSerine protease inhibitor library
% Enzymatic Inhibition/Fold Change100% at 200 uM
IC50 (µM)14.2
Site of InteractionNucleotide binding domain
Type of Enzymatic AssayPeptidase assay (SLY-AMC)
DiseaseBacterial infection

Structure



HSPMDB001771

16

Physicochemical Properties