HSPMdb Accession NoHSPMDB002415
PMID23892893
TargetHsp100
OrganismHuman
Cellular activityAntiproliferative activity
Compound NameNMS-873
IUPAC Name3-[3-cyclopentylsulfanyl-5-(4'-methanesulfonyl-2-methyl-biphenyl-4-yloxymethyl)- [1,2,4]triazol-4-yl]-pyridine
SMILESCc1cc(OCc2nnc(SC3CCCC3)n2c4cccnc4)ccc1c5ccc(cc5)[S](C)(=O)=O
ClassSmall molecule
IC50 (µM)0.4
Site of InteractionNucleotide binding domain (D2)
Cellular assayLuminescence based viability assay
Cellular ModelHCT116
DiseaseCancer

Structure



HSPMDB002415

NMS-873

Physicochemical Properties