HSPMdb Accession NoHSPMDB001804
PMID30571121
TargetHsp100
HSP NameClpP
OrganismBacteria
LocalizationCytosol
Enzymatic activityInhibition of peptidase activity
Compound Name62
IUPAC NameDiphenyl ((4-Guanidinophenyl)((4-(trifluoromethyl)phenyl)-sulfonamido)methyl)phosphonate
SMILESO=S(NC(P(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O)C3=CC=C(NC(N)=N)C=C3)(C4=CC=C(C(F)(F)F)C=C4)=O
ClassSerine protease inhibitor library
% Enzymatic Inhibition/Fold Change27% at 200 uM
Site of InteractionNucleotide binding domain
Type of Enzymatic AssayPeptidase assay (SLY-AMC)
DiseaseBacterial infection

Structure



HSPMDB001804

62

Physicochemical Properties