HSPMdb Accession NoHSPMDB001832
PMID30571121
TargetHsp100
HSP NameClpP
OrganismBacteria
LocalizationCytosol
Enzymatic activityInhibition of peptidase activity
Compound Name90
IUPAC NameB e n z y l ( ( 6 - C a r b a m i m i d o y l n a p h t h a l e n - 2 - y l ) -(diphenoxyphosphoryl)methyl)carbamate
SMILESO=C(OCC1=CC=CC=C1)NC(C2=CC=C3C=C(C(N)=N)C=CC3=C2)P(OC4=CC=CC=C4)(OC5=CC=CC=C5)=O
ClassSerine protease inhibitor library
% Enzymatic Inhibition/Fold Change81% at 200 uM
IC50 (µM)79.7
Site of InteractionNucleotide binding domain
Type of Enzymatic AssayPeptidase assay (SLY-AMC)
DiseaseBacterial infection

Structure



HSPMDB001832

90

Physicochemical Properties