HSPMdb Accession NoHSPMDB002230
PMID26083639
TargetHsp100
HSP NameClpP
OrganismBacteria
LocalizationCytosol
Enzymatic activityInhibition of peptidase activity
Compound NameML68
IUPAC Namemethyl 4-{[3-(thiophen-2-yl)propanoyl]oxy}benzoate
SMILESCOC(=O)C1=CC=C(OC(=O)CCC2=CC=CS2)C=C1
ClassNon beta lactone inhibitor (AV170 derivative)
% Enzymatic Inhibition/Fold Change5% at 100 uM
Site of InteractionNucleotide binding domain
Type of Enzymatic AssayPeptidase assay (SLY-AMC)
DiseaseBacterial infection

Structure



HSPMDB002230

ML68

Physicochemical Properties