HSPMdb Accession NoHSPMDB002289
PMID26083639
TargetHsp100
HSP NameClpP
OrganismBacteria
LocalizationCytosol
Enzymatic activityInhibition of peptidase activity
Compound NameAV137
IUPAC Name1-(2,2-dimethylpropanoyl)-N-[4-(2-oxopyrrolidin-1-yl)phenyl]piperidine-4-carboxamide
SMILESCC(C)(C)C(=O)N1CCC(CC1)C(=O)Nc2ccc(cc2)N3CCCC3=O
ClassNon beta lactone inhibitor (AV170 derivative)
% Enzymatic Inhibition/Fold Change0-5% at 1 uM
Site of InteractionNucleotide binding domain
Type of Enzymatic AssayPeptidase assay (SLY-AMC)
DiseaseBacterial infection

Structure



HSPMDB002289

AV137

Physicochemical Properties