HSPMdb Accession NoHSPMDB001492
PMID25299406
TargetHsp100
HSP NameHsp104
OrganismYeast
LocalizationCytosol
Enzymatic activityInhibition of ATPase activity
Compound NameGossypol
IUPAC Name7-(8-formyl-1,6,7-trihydroxy-3-methyl-5-propan-2-ylnaphthalen-2-yl)-2,3,8-trihydroxy-6-methyl-4-propan-2-ylnaphthalene-1-carbaldehyde
SMILESCC(C)c1c(O)c(O)c(C=O)c2c(O)c(c(C)cc12)c3c(C)cc4c(C(C)C)c(O)c(O)c(C=O)c4c3O
ClassNIH, Spectrum, and Hit finder collection
% Enzymatic Inhibition/Fold Change42.33% at 10 uM
Site of InteractionNucleotide binding domain
Type of Enzymatic AssayATPase assay

Structure



HSPMDB001492

Gossypol

Physicochemical Properties