HSPMdb Accession NoHSPMDB002147
PMID26083639
TargetHsp100
HSP NameClpP
OrganismBacteria
LocalizationCytosol
Enzymatic activityInhibition of peptidase activity
Compound NameE2
IUPAC Name3-(4-methoxyphenyl)-4-(pent-4-yn-1-yl)oxetan-2-one
SMILESCOC1=CC=C(C=C1)C1C(CCCC#C)OC1=O
ClassNon beta lactone inhibitor
% Enzymatic Inhibition/Fold Change100% at 100 uM
Site of InteractionNucleotide binding domain
Type of Enzymatic AssayPeptidase assay (SLY-AMC)
DiseaseBacterial infection

Structure



HSPMDB002147

E2

Physicochemical Properties