HSPMdb Accession No | HSPMDB002205 |
PMID | 26083639 |
Target | Hsp100 |
HSP Name | ClpP |
Organism | Bacteria |
Localization | Cytosol |
Enzymatic activity | Inhibition of protease activity |
Compound Name | AV127 |
IUPAC Name | 4-(2-oxopyrrolidin-1-yl)phenyl 1-(2,2-dimethylpropanoyl)piperidine-4-carboxylate |
SMILES | CC(C)(C)C(=O)N1CCC(CC1)C(=O)OC1=CC=C(C=C1)N1CCCC1=O |
Class | Non beta lactone inhibitor |
% Enzymatic Inhibition/Fold Change | 0-5% at 1 uM |
Site of Interaction | Nucleotide binding domain |
Type of Enzymatic Assay | Substrate degradation assay (GFP-ssrA) |
Disease | Bacterial infection |