HSPMdb Accession NoHSPMDB002364
PMID25944857
TargetHsp100
HSP NameClpP1P2
OrganismBacteria
LocalizationCytosol
Cellular activityAntibacterial activity
Compound NameMLN-2238 (Ixazomib)
IUPAC Name[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]boronic acid
SMILESB(C(CC(C)C)NC(=O)CNC(=O)C1=C(C=CC(=C1)Cl)Cl)(O)O
ClassBortezomib derivative
Site of InteractionNucleotide binding domain
Percentage Cell Growth Inhibition60% at 50 uM
Cellular assayBacterial growth inhibition assay (OD based)
Cellular ModelM. smegmatis (mc2155)
DiseaseTuberculosis

Structure



HSPMDB002364

MLN-2238 (Ixazomib)

Physicochemical Properties