HSPMdb Accession No | HSPMDB002364 |
PMID | 25944857 |
Target | Hsp100 |
HSP Name | ClpP1P2 |
Organism | Bacteria |
Localization | Cytosol |
Cellular activity | Antibacterial activity |
Compound Name | MLN-2238 (Ixazomib) |
IUPAC Name | [(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]boronic acid |
SMILES | B(C(CC(C)C)NC(=O)CNC(=O)C1=C(C=CC(=C1)Cl)Cl)(O)O |
Class | Bortezomib derivative |
Site of Interaction | Nucleotide binding domain |
Percentage Cell Growth Inhibition | 60% at 50 uM |
Cellular assay | Bacterial growth inhibition assay (OD based) |
Cellular Model | M. smegmatis (mc2155) |
Disease | Tuberculosis |