HPVomics

A therapeutic and epitome resource for Human Papillomaviruses

Efficient putative LR-HPVs E4 protein epitopes (MHC-II Binders)

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S.No.	HPV type	Target region	Peptide seuences	Start	End	Allele	Method	Percentile rank
1	HPV54	E4	DSGRCVWAAASFFLL	30	44	HLA-DPA1*01:03/DPB1*02:01	Consensus	0.01
2	HPV54	E4	SGRCVWAAASFFLLH	31	45	HLA-DPA1*01:03/DPB1*02:01	Consensus	0.01
3	HPV54	E4	GRCVWAAASFFLLHL	32	46	HLA-DPA1*01:03/DPB1*02:01	Consensus	0.01
4	HPV54	E4	RCVWAAASFFLLHLY	33	47	HLA-DPA1*01:03/DPB1*02:01	Consensus	0.01
5	HPV54	E4	CVWAAASFFLLHLYL	34	48	HLA-DPA1*01:03/DPB1*02:01	Consensus	0.01
6	HPV54	E4	VWAAASFFLLHLYLV	35	49	HLA-DPA1*01:03/DPB1*02:01	Consensus	0.01
7	HPV54	E4	WAAASFFLLHLYLVP	36	50	HLA-DPA1*01:03/DPB1*02:01	Consensus	0.01
8	HPV54	E4	VWAAASFFLLHLYLV	35	49	HLA-DPA1*03:01/DPB1*04:02	Consensus	0.01
9	HPV54	E4	WAAASFFLLHLYLVP	36	50	HLA-DPA1*03:01/DPB1*04:02	Consensus	0.01
10	HPV54	E4	AAASFFLLHLYLVPK	37	51	HLA-DPA1*03:01/DPB1*04:02	Consensus	0.01
11	HPV54	E4	AASFFLLHLYLVPKR	38	52	HLA-DPA1*03:01/DPB1*04:02	Consensus	0.01
12	HPV54	E4	DSGRCVWAAASFFLL	30	44	HLA-DPA1*01/DPB1*04:01	Consensus	0.01
13	HPV54	E4	SGRCVWAAASFFLLH	31	45	HLA-DPA1*01/DPB1*04:01	Consensus	0.01
14	HPV54	E4	GRCVWAAASFFLLHL	32	46	HLA-DPA1*01/DPB1*04:01	Consensus	0.01
15	HPV54	E4	RCVWAAASFFLLHLY	33	47	HLA-DPA1*01/DPB1*04:01	Consensus	0.01
16	HPV54	E4	CVWAAASFFLLHLYL	34	48	HLA-DPA1*01/DPB1*04:01	Consensus	0.01
17	HPV54	E4	VWAAASFFLLHLYLV	35	49	HLA-DPA1*01/DPB1*04:01	Consensus	0.01
18	HPV54	E4	WAAASFFLLHLYLVP	36	50	HLA-DPA1*01/DPB1*04:01	Consensus	0.01
19	HPV40	E4	GLLLWVHTLYVLLVL	7	21	HLA-DPA1*03:01/DPB1*04:02	Consensus	0.02
20	HPV40	E4	LLLWVHTLYVLLVLS	8	22	HLA-DPA1*03:01/DPB1*04:02	Consensus	0.02
21	HPV54	E4	AAASFFLLHLYLVPK	37	51	HLA-DPA1*01:03/DPB1*02:01	Consensus	0.02
22	HPV54	E4	AASFFLLHLYLVPKR	38	52	HLA-DPA1*01:03/DPB1*02:01	Consensus	0.02
23	HPV54	E4	ASFFLLHLYLVPKRH	39	53	HLA-DPA1*01:03/DPB1*02:01	Consensus	0.02
24	HPV54	E4	ASFFLLHLYLVPKRH	39	53	HLA-DPA1*03:01/DPB1*04:02	Consensus	0.02
25	HPV54	E4	RHCQYPLLALLNTPD	52	66	HLA-DRB1*04:05	Consensus	0.05
26	HPV54	E4	HCQYPLLALLNTPDQ	53	67	HLA-DRB1*04:05	Consensus	0.05
27	HPV54	E4	CQYPLLALLNTPDQP	54	68	HLA-DRB1*04:05	Consensus	0.05
28	HPV54	E4	QYPLLALLNTPDQPI	55	69	HLA-DRB1*04:05	Consensus	0.05
29	HPV54	E4	YPLLALLNTPDQPIP	56	70	HLA-DRB1*04:05	Consensus	0.05
30	HPV44	E4	IKPIIQILKRRPKNM	6	20	HLA-DRB1*11:01	Consensus	0.09
31	HPV44	E4	KPIIQILKRRPKNMG	7	21	HLA-DRB1*11:01	Consensus	0.1
32	HPV6	E4	LHLYLALHKKYPFLN	19	33	HLA-DRB1*11:01	Consensus	0.11
33	HPV6	E4	LLHLYLALHKKYPFL	18	32	HLA-DRB1*11:01	Consensus	0.15
34	HPV6	E4	AQLYVLLHLYLALHK	13	27	HLA-DRB1*15:01	Consensus	0.15
35	HPV6	E4	YVLLHLYLALHKKYP	16	30	HLA-DRB1*11:01	Consensus	0.17
36	HPV6	E4	QLYVLLHLYLALHKK	14	28	HLA-DRB1*15:01	Consensus	0.17
37	HPV6	E4	LYVLLHLYLALHKKY	15	29	HLA-DRB1*15:01	Consensus	0.17
38	HPV44	E4	MVGIKPIIQILKRRP	3	17	HLA-DRB1*11:01	Consensus	0.17
39	HPV6	E4	HLYLALHKKYPFLNL	20	34	HLA-DRB1*11:01	Consensus	0.19
40	HPV6	E4	YVLLHLYLALHKKYP	16	30	HLA-DRB1*15:01	Consensus	0.19
41	HPV44	E4	VGIKPIIQILKRRPK	4	18	HLA-DRB5*01:01	Consensus	0.19
42	HPV6	E4	VLLHLYLALHKKYPF	17	31	HLA-DRB1*15:01	Consensus	0.2
43	HPV44	E4	GIKPIIQILKRRPKN	5	19	HLA-DRB5*01:01	Consensus	0.2
44	HPV44	E4	IKPIIQILKRRPKNM	6	20	HLA-DRB5*01:01	Consensus	0.2
45	HPV44	E4	KPIIQILKRRPKNMG	7	21	HLA-DRB5*01:01	Consensus	0.21
46	HPV44	E4	GIKPIIQILKRRPKN	5	19	HLA-DRB1*11:01	Consensus	0.21
47	HPV44	E4	PIIQILKRRPKNMGT	8	22	HLA-DRB1*11:01	Consensus	0.21
48	HPV54	E4	RCVWAAASFFLLHLY	33	47	HLA-DPA1*02:01/DPB1*01:01	Consensus	0.21
49	HPV54	E4	CIMWILKRKHLSMGN	14	28	HLA-DRB1*11:01	Consensus	0.22
50	HPV54	E4	KCIMWILKRKHLSMG	13	27	HLA-DRB1*11:01	Consensus	0.24
51	HPV54	E4	PLLALLNTPDQPIPH	57	71	HLA-DRB1*04:05	Consensus	0.25
52	HPV54	E4	LLALLNTPDQPIPHH	58	72	HLA-DRB1*04:05	Consensus	0.25
53	HPV44	E4	PIIQILKRRPKNMGT	8	22	HLA-DRB5*01:01	Consensus	0.26
54	HPV54	E4	TKCIMWILKRKHLSM	12	26	HLA-DRB1*11:01	Consensus	0.27
55	HPV54	E4	IMWILKRKHLSMGNM	15	29	HLA-DRB1*11:01	Consensus	0.29
56	HPV54	E4	CVWAAASFFLLHLYL	34	48	HLA-DPA1*02:01/DPB1*01:01	Consensus	0.29
57	HPV54	E4	VWAAASFFLLHLYLV	35	49	HLA-DPA1*02:01/DPB1*01:01	Consensus	0.3
58	HPV44	E4	IIQILKRRPKNMGTL	9	23	HLA-DRB1*11:01	Consensus	0.32
59	HPV54	E4	GRCVWAAASFFLLHL	32	46	HLA-DPA1*02:01/DPB1*01:01	Consensus	0.32
60	HPV11	E4	LALYEKYPLLNLLHT	23	37	HLA-DPA1*03:01/DPB1*04:02	Consensus	0.35
61	HPV54	E4	NTKCIMWILKRKHLS	11	25	HLA-DRB1*11:01	Consensus	0.38
62	HPV54	E4	MWILKRKHLSMGNMD	16	30	HLA-DRB1*11:01	Consensus	0.38
63	HPV6	E4	VLLHLYLALHKKYPF	17	31	HLA-DRB1*11:01	Consensus	0.42
64	HPV44	E4	VGIKPIIQILKRRPK	4	18	HLA-DRB1*11:01	Consensus	0.44
65	HPV43	E4	KYPLLRLLNLTPDQR	28	42	HLA-DRB1*04:05	Consensus	0.45
66	HPV43	E4	SVKYPLLRLLNLTPD	26	40	HLA-DRB1*04:05	Consensus	0.46
67	HPV43	E4	VKYPLLRLLNLTPDQ	27	41	HLA-DRB1*04:05	Consensus	0.46
68	HPV43	E4	YPLLRLLNLTPDQRP	29	43	HLA-DRB1*04:05	Consensus	0.48
69	HPV11	E4	ALYEKYPLLNLLHTP	24	38	HLA-DPA1*03:01/DPB1*04:02	Consensus	0.54
70	HPV40	E4	HTLYVLLVLSRNTDY	13	27	HLA-DRB1*04:05	Consensus	0.55
71	HPV44	E4	IQILKRRPKNMGTLY	10	24	HLA-DRB1*11:01	Consensus	0.55
72	HPV54	E4	WAAASFFLLHLYLVP	36	50	HLA-DPA1*02:01/DPB1*01:01	Consensus	0.56
73	HPV40	E4	VHTLYVLLVLSRNTD	12	26	HLA-DRB1*04:05	Consensus	0.57
74	HPV40	E4	WVHTLYVLLVLSRNT	11	25	HLA-DRB1*04:05	Consensus	0.58
75	HPV40	E4	TLYVLLVLSRNTDYP	14	28	HLA-DRB1*04:05	Consensus	0.58
76	HPV11	E4	YLALYEKYPLLNLLH	22	36	HLA-DPA1*03:01/DPB1*04:02	Consensus	0.59
77	HPV54	E4	LLHLYLVPKRHCQYP	43	57	HLA-DRB1*11:01	Consensus	0.63
78	HPV54	E4	DSGRCVWAAASFFLL	30	44	HLA-DPA1*02:01/DPB1*01:01	Consensus	0.63
79	HPV54	E4	SGRCVWAAASFFLLH	31	45	HLA-DPA1*02:01/DPB1*01:01	Consensus	0.63
80	HPV54	E4	LHLYLVPKRHCQYPL	44	58	HLA-DRB1*11:01	Consensus	0.65
81	HPV6	E4	AQLYVLLHLYLALHK	13	27	HLA-DRB5*01:01	Consensus	0.7
82	HPV6	E4	QLYVLLHLYLALHKK	14	28	HLA-DRB5*01:01	Consensus	0.7
83	HPV6	E4	LYVLLHLYLALHKKY	15	29	HLA-DRB5*01:01	Consensus	0.7
84	HPV6	E4	YVLLHLYLALHKKYP	16	30	HLA-DRB5*01:01	Consensus	0.7
85	HPV40	E4	KQIGGLLLWVHTLYV	3	17	HLA-DRB1*07:01	Consensus	0.73
86	HPV43	E4	DNGTLLWAQTSYILL	5	19	HLA-DRB1*07:01	Consensus	0.74
87	HPV43	E4	LVPSVKYPLLRLLNL	23	37	HLA-DPA1*03:01/DPB1*04:02	Consensus	0.75
88	HPV40	E4	QIGGLLLWVHTLYVL	4	18	HLA-DRB1*07:01	Consensus	0.76
89	HPV43	E4	VPSVKYPLLRLLNLT	24	38	HLA-DPA1*03:01/DPB1*04:02	Consensus	0.8
90	HPV40	E4	IGGLLLWVHTLYVLL	5	19	HLA-DRB1*07:01	Consensus	0.83
91	HPV43	E4	LDNGTLLWAQTSYIL	4	18	HLA-DRB1*07:01	Consensus	0.85
92	HPV6	E4	IGKYVMAAQLYVLLH	6	20	HLA-DPA1*02:01/DPB1*14:01	NetMHCIIpan	0.77
93	HPV11	E4	IGKYVMAAQLYVLLH	6	20	HLA-DPA1*02:01/DPB1*14:01	NetMHCIIpan	0.77
94	HPV6	E4	QLYVLLHLYLALHKK	14	28	HLA-DPA1*02:01/DPB1*14:01	NetMHCIIpan	0.8
95	HPV6	E4	LYVLLHLYLALHKKY	15	29	HLA-DPA1*02:01/DPB1*14:01	NetMHCIIpan	0.82
96	HPV11	E4	IIGKYVMAAQLYVLL	5	19	HLA-DPA1*02:01/DPB1*14:01	NetMHCIIpan	0.82
97	HPV6	E4	GKYVMAAQLYVLLHL	7	21	HLA-DPA1*02:01/DPB1*14:01	NetMHCIIpan	0.97
98	HPV11	E4	GKYVMAAQLYVLLHL	7	21	HLA-DPA1*02:01/DPB1*14:01	NetMHCIIpan	0.97
99	HPV6	E4	NIGKYVMAAQLYVLL	5	19	HLA-DPA1*02:01/DPB1*14:01	NetMHCIIpan	0.99