HPVomics

A therapeutic and epitome resource for Human Papillomaviruses

Efficient putative HR-HPVs E6 protein epitopes (MHC-II Binders)

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S.No.	HPV type	Target region	Peptide seuences	Start	End	Allele	Method	Percentile rank
1	HPV56	E6	TELKLVYRDDFPYAV	51	65	HLA-DRB3*01:01	Consensus	0.01
2	HPV56	E6	ELKLVYRDDFPYAVC	52	66	HLA-DRB3*01:01	Consensus	0.01
3	HPV56	E6	LKLVYRDDFPYAVCR	53	67	HLA-DRB3*01:01	Consensus	0.01
4	HPV56	E6	KLVYRDDFPYAVCRV	54	68	HLA-DRB3*01:01	Consensus	0.01
5	HPV56	E6	LVYRDDFPYAVCRVC	55	69	HLA-DRB3*01:01	Consensus	0.01
6	HPV56	E6	VYRDDFPYAVCRVCL	56	70	HLA-DRB3*01:01	Consensus	0.01
7	HPV56	E6	YRDDFPYAVCRVCLL	57	71	HLA-DRB3*01:01	Consensus	0.01
8	HPV68	E6	ITNTKLYNLLIRCMS	93	107	HLA-DRB1*11:01	Consensus	0.07
9	HPV68	E6	TNTKLYNLLIRCMSC	94	108	HLA-DRB1*11:01	Consensus	0.07
10	HPV68	E6	NTKLYNLLIRCMSCL	95	109	HLA-DRB1*11:01	Consensus	0.07
11	HPV68	E6	TKLYNLLIRCMSCLK	96	110	HLA-DRB1*11:01	Consensus	0.07
12	HPV68	E6	KLYNLLIRCMSCLKP	97	111	HLA-DRB1*11:01	Consensus	0.07
13	HPV18	E6	LNEKRRFHNIAGHYR	121	135	HLA-DRB5*01:01	Consensus	0.09
14	HPV18	E6	NEKRRFHNIAGHYRG	122	136	HLA-DRB5*01:01	Consensus	0.1
15	HPV18	E6	EKRRFHNIAGHYRGQ	123	137	HLA-DRB5*01:01	Consensus	0.1
16	HPV18	E6	KRRFHNIAGHYRGQC	124	138	HLA-DRB5*01:01	Consensus	0.1
17	HPV73	E6	DLCIVYRKDKPYGVC	50	64	HLA-DRB3*01:01	Consensus	0.1
18	HPV18	E6	RRFHNIAGHYRGQCH	125	139	HLA-DRB5*01:01	Consensus	0.11
19	HPV73	E6	SDLCIVYRKDKPYGV	49	63	HLA-DRB3*01:01	Consensus	0.12
20	HPV73	E6	LCIVYRKDKPYGVCQ	51	65	HLA-DRB3*01:01	Consensus	0.12
21	HPV73	E6	CIVYRKDKPYGVCQP	52	66	HLA-DRB3*01:01	Consensus	0.14
22	HPV45	E6	LKDKRRFHSIAGQYR	121	135	HLA-DRB5*01:01	Consensus	0.15
23	HPV45	E6	KDKRRFHSIAGQYRG	122	136	HLA-DRB5*01:01	Consensus	0.15
24	HPV45	E6	DKRRFHSIAGQYRGQ	123	137	HLA-DRB5*01:01	Consensus	0.15
25	HPV45	E6	KRRFHSIAGQYRGQC	124	138	HLA-DRB5*01:01	Consensus	0.15
26	HPV45	E6	RRFHSIAGQYRGQCN	125	139	HLA-DRB5*01:01	Consensus	0.15
27	HPV45	E6	RFHSIAGQYRGQCNT	126	140	HLA-DRB5*01:01	Consensus	0.15
28	HPV45	E6	FHSIAGQYRGQCNTC	127	141	HLA-DRB5*01:01	Consensus	0.18
29	HPV53	E6	FCLLFYSKVRKLRYY	69	83	HLA-DRB1*07:01	Consensus	0.19
30	HPV39	E6	LCPAEKLRHLNSKRR	112	126	HLA-DRB5*01:01	Consensus	0.2
31	HPV39	E6	CPAEKLRHLNSKRRF	113	127	HLA-DRB5*01:01	Consensus	0.2
32	HPV39	E6	PAEKLRHLNSKRRFH	114	128	HLA-DRB5*01:01	Consensus	0.2
33	HPV39	E6	AEKLRHLNSKRRFHK	115	129	HLA-DRB5*01:01	Consensus	0.2
34	HPV39	E6	EKLRHLNSKRRFHKI	116	130	HLA-DRB5*01:01	Consensus	0.2
35	HPV39	E6	KLRHLNSKRRFHKIA	117	131	HLA-DRB5*01:01	Consensus	0.2
36	HPV39	E6	LRHLNSKRRFHKIAG	118	132	HLA-DRB5*01:01	Consensus	0.2
37	HPV52	E6	CLRFLSKISEYRHYQ	66	80	HLA-DRB5*01:01	Consensus	0.2
38	HPV53	E6	KFCLLFYSKVRKLRY	68	82	HLA-DRB1*07:01	Consensus	0.2
39	HPV52	E6	REVYKFLFTDLRIVY	40	54	HLA-DPA1*03:01/DPB1*04:02	Consensus	0.21
40	HPV53	E6	VCKFCLLFYSKVRKL	66	80	HLA-DRB1*07:01	Consensus	0.21
41	HPV53	E6	CKFCLLFYSKVRKLR	67	81	HLA-DRB1*07:01	Consensus	0.21
42	HPV53	E6	CLLFYSKVRKLRYYN	70	84	HLA-DRB1*07:01	Consensus	0.21
43	HPV33	E6	CLRFLSKISEYRHYN	66	80	HLA-DRB5*01:01	Consensus	0.23
44	HPV58	E6	AVCKVCLRLLSKISE	61	75	HLA-DRB1*11:01	Consensus	0.26
45	HPV58	E6	VCKVCLRLLSKISEY	62	76	HLA-DRB1*11:01	Consensus	0.26
46	HPV58	E6	CKVCLRLLSKISEYR	63	77	HLA-DRB1*11:01	Consensus	0.26
47	HPV58	E6	KVCLRLLSKISEYRH	64	78	HLA-DRB1*11:01	Consensus	0.26
48	HPV58	E6	VCLRLLSKISEYRHY	65	79	HLA-DRB1*11:01	Consensus	0.26
49	HPV31	E6	LTIVYRDDTPHGVCT	50	64	HLA-DRB3*01:01	Consensus	0.27
50	HPV31	E6	DLTIVYRDDTPHGVC	49	63	HLA-DRB3*01:01	Consensus	0.28
51	HPV33	E6	LCLRFLSKISEYRHY	65	79	HLA-DRB5*01:01	Consensus	0.28
52	HPV52	E6	MCLRFLSKISEYRHY	65	79	HLA-DRB5*01:01	Consensus	0.28
53	HPV31	E6	TIVYRDDTPHGVCTK	51	65	HLA-DRB3*01:01	Consensus	0.29
54	HPV52	E6	REVYKFLFTDLRIVY	40	54	HLA-DRB1*03:01	Consensus	0.29
55	HPV52	E6	EVYKFLFTDLRIVYR	41	55	HLA-DRB1*03:01	Consensus	0.29
56	HPV52	E6	VYKFLFTDLRIVYRD	42	56	HLA-DRB1*03:01	Consensus	0.29
57	HPV52	E6	YKFLFTDLRIVYRDN	43	57	HLA-DRB1*03:01	Consensus	0.29
58	HPV58	E6	SEVYDFVFADLRIVY	40	54	HLA-DRB1*03:01	Consensus	0.29
59	HPV58	E6	EVYDFVFADLRIVYR	41	55	HLA-DRB1*03:01	Consensus	0.29
60	HPV58	E6	VYDFVFADLRIVYRD	42	56	HLA-DRB1*03:01	Consensus	0.29
61	HPV58	E6	YDFVFADLRIVYRDG	43	57	HLA-DRB1*03:01	Consensus	0.29
62	HPV58	E6	DFVFADLRIVYRDGN	44	58	HLA-DRB1*03:01	Consensus	0.29
63	HPV45	E6	YSRIRELRYYSNSVY	72	86	HLA-DRB1*15:01	Consensus	0.3
64	HPV45	E6	SRIRELRYYSNSVYG	73	87	HLA-DRB1*15:01	Consensus	0.3
65	HPV45	E6	RIRELRYYSNSVYGE	74	88	HLA-DRB1*15:01	Consensus	0.3
66	HPV68	E6	LCPAEKLRHLTTKRR	112	126	HLA-DRB5*01:01	Consensus	0.3
67	HPV68	E6	CPAEKLRHLTTKRRL	113	127	HLA-DRB5*01:01	Consensus	0.3
68	HPV68	E6	PAEKLRHLTTKRRLH	114	128	HLA-DRB5*01:01	Consensus	0.3
69	HPV68	E6	AEKLRHLTTKRRLHK	115	129	HLA-DRB5*01:01	Consensus	0.3
70	HPV68	E6	EKLRHLTTKRRLHKI	116	130	HLA-DRB5*01:01	Consensus	0.3
71	HPV73	E6	IVYRKDKPYGVCQPC	53	67	HLA-DRB3*01:01	Consensus	0.32
72	HPV33	E6	GICKLCLRFLSKISE	61	75	HLA-DRB1*11:01	Consensus	0.34
73	HPV33	E6	ICKLCLRFLSKISEY	62	76	HLA-DRB1*11:01	Consensus	0.34
74	HPV33	E6	CKLCLRFLSKISEYR	63	77	HLA-DRB1*11:01	Consensus	0.34
75	HPV33	E6	KLCLRFLSKISEYRH	64	78	HLA-DRB1*11:01	Consensus	0.34
76	HPV33	E6	LCLRFLSKISEYRHY	65	79	HLA-DRB1*11:01	Consensus	0.34
77	HPV45	E6	IRELRYYSNSVYGET	75	89	HLA-DRB1*15:01	Consensus	0.34
78	HPV52	E6	GVCIMCLRFLSKISE	61	75	HLA-DRB1*11:01	Consensus	0.34
79	HPV52	E6	VCIMCLRFLSKISEY	62	76	HLA-DRB1*11:01	Consensus	0.34
80	HPV52	E6	CIMCLRFLSKISEYR	63	77	HLA-DRB1*11:01	Consensus	0.34
81	HPV52	E6	IMCLRFLSKISEYRH	64	78	HLA-DRB1*11:01	Consensus	0.34
82	HPV31	E6	TDLTIVYRDDTPHGV	48	62	HLA-DRB3*01:01	Consensus	0.35
83	HPV52	E6	LRFLSKISEYRHYQY	67	81	HLA-DRB5*01:01	Consensus	0.37
84	HPV52	E6	RREVYKFLFTDLRIV	39	53	HLA-DPA1*02:01/DPB1*01:01	Consensus	0.37
85	HPV66	E6	LSEVLQIPLLDLRLS	18	32	HLA-DPA1*03:01/DPB1*04:02	Consensus	0.37
86	HPV66	E6	HLSEVLQIPLLDLRL	17	31	HLA-DPA1*03:01/DPB1*04:02	Consensus	0.38
87	HPV33	E6	LRFLSKISEYRHYNY	67	81	HLA-DRB5*01:01	Consensus	0.39
88	HPV52	E6	RREVYKFLFTDLRIV	39	53	HLA-DPA1*03:01/DPB1*04:02	Consensus	0.39
89	HPV52	E6	REVYKFLFTDLRIVY	40	54	HLA-DPA1*02:01/DPB1*01:01	Consensus	0.4
90	HPV66	E6	IELKLVYRNNWPYAV	51	65	HLA-DRB3*01:01	Consensus	0.41
91	HPV66	E6	ELKLVYRNNWPYAVC	52	66	HLA-DRB3*01:01	Consensus	0.42
92	HPV53	E6	LLFYSKVRKLRYYNC	71	85	HLA-DRB1*11:01	Consensus	0.44
93	HPV68	E6	YSESVYATTLETITN	81	95	HLA-DPA1*03:01/DPB1*04:02	Consensus	0.44
94	HPV33	E6	KLCLRFLSKISEYRH	64	78	HLA-DRB5*01:01	Consensus	0.45
95	HPV52	E6	IMCLRFLSKISEYRH	64	78	HLA-DRB5*01:01	Consensus	0.45
96	HPV53	E6	CLLFYSKVRKLRYYN	70	84	HLA-DRB1*11:01	Consensus	0.46
97	HPV66	E6	LLFYSKVRKYRYYKY	70	84	HLA-DRB1*11:01	Consensus	0.46
98	HPV66	E6	LKLVYRNNWPYAVCR	53	67	HLA-DRB3*01:01	Consensus	0.5
99	HPV68	E6	SESVYATTLETITNT	82	96	HLA-DPA1*03:01/DPB1*04:02	Consensus	0.52
100	HPV66	E6	KLVYRNNWPYAVCRV	54	68	HLA-DRB3*01:01	Consensus	0.54
101	HPV31	E6	IVYRDDTPHGVCTKC	52	66	HLA-DRB3*01:01	Consensus	0.56
102	HPV66	E6	CLLFYSKVRKYRYYK	69	83	HLA-DRB1*11:01	Consensus	0.56
103	HPV52	E6	RFLSKISEYRHYQYS	68	82	HLA-DRB5*01:01	Consensus	0.57
104	HPV66	E6	HHLSEVLQIPLLDLR	16	30	HLA-DPA1*03:01/DPB1*04:02	Consensus	0.59
105	HPV66	E6	SEVLQIPLLDLRLSC	19	33	HLA-DPA1*03:01/DPB1*04:02	Consensus	0.59
106	HPV33	E6	RFLSKISEYRHYNYS	68	82	HLA-DRB5*01:01	Consensus	0.6
107	HPV56	E6	LLFYSKVRKYRYYDY	70	84	HLA-DRB1*11:01	Consensus	0.67
108	HPV33	E6	CKLCLRFLSKISEYR	63	77	HLA-DRB5*01:01	Consensus	0.69
109	HPV53	E6	FCLLFYSKVRKLRYY	69	83	HLA-DRB1*11:01	Consensus	0.69
110	HPV35	E6	CLKFYSKISEYRWYR	66	80	HLA-DRB5*01:01	Consensus	0.72
111	HPV52	E6	CIMCLRFLSKISEYR	63	77	HLA-DRB5*01:01	Consensus	0.72
112	HPV53	E6	LFYSKVRKLRYYNCS	72	86	HLA-DRB1*11:01	Consensus	0.76
113	HPV68	E6	YYSESVYATTLETIT	80	94	HLA-DPA1*03:01/DPB1*04:02	Consensus	0.76
114	HPV68	E6	ESVYATTLETITNTK	83	97	HLA-DPA1*03:01/DPB1*04:02	Consensus	0.76
115	HPV16	E6	CLKFYSKISEYRHYC	73	87	HLA-DRB5*01:01	Consensus	0.81
116	HPV56	E6	CLLFYSKVRKYRYYD	69	83	HLA-DRB1*11:01	Consensus	0.83
117	HPV31	E6	CLRFYSKVSEFRWYR	66	80	HLA-DRB5*01:01	Consensus	0.87
118	HPV31	E6	YRYSVYGTTLEKLTN	79	93	HLA-DPA1*03:01/DPB1*04:02	Consensus	0.95
119	HPV35	E6	LKFYSKISEYRWYRY	67	81	HLA-DRB5*01:01	Consensus	0.97
120	HPV66	E6	LFYSKVRKYRYYKYS	71	85	HLA-DRB1*11:01	Consensus	0.97
121	HPV16	E6	KCLKFYSKISEYRHY	72	86	HLA-DRB5*01:01	Consensus	1
122	HPV31	E6	LRFYSKVSEFRWYRY	67	81	HLA-DRB5*01:01	Consensus	1
123	HPV59	E6	EREVFEFAFNDLFIV	41	55	HLA-DPA1*02:01/DPB1*01:01	Consensus	1
124	HPV73	E6	CLKFYSKIREYRRYR	67	81	HLA-DRB5*01:01	Consensus	1
125	HPV52	E6	EVYKFLFTDLRIVYR	41	55	HLA-DPA1*02:01/DPB1*14:01	NetMHCIIpan	0.05
126	HPV52	E6	REVYKFLFTDLRIVY	40	54	HLA-DPA1*02:01/DPB1*14:01	NetMHCIIpan	0.06
127	HPV52	E6	VYKFLFTDLRIVYRD	42	56	HLA-DPA1*02:01/DPB1*14:01	NetMHCIIpan	0.07
128	HPV53	E6	FCLLFYSKVRKLRYY	69	83	HLA-DRB3*02:02	NetMHCIIpan	0.1
129	HPV52	E6	RREVYKFLFTDLRIV	39	53	HLA-DPA1*02:01/DPB1*14:01	NetMHCIIpan	0.17
130	HPV53	E6	KFCLLFYSKVRKLRY	68	82	HLA-DPA1*02:01/DPB1*14:01	NetMHCIIpan	0.18
131	HPV53	E6	CLLFYSKVRKLRYYN	70	84	HLA-DRB3*02:02	NetMHCIIpan	0.21
132	HPV53	E6	KFCLLFYSKVRKLRY	68	82	HLA-DRB3*02:02	NetMHCIIpan	0.23
133	HPV52	E6	YKFLFTDLRIVYRDN	43	57	HLA-DPA1*02:01/DPB1*14:01	NetMHCIIpan	0.33
134	HPV53	E6	CKFCLLFYSKVRKLR	67	81	HLA-DPA1*02:01/DPB1*14:01	NetMHCIIpan	0.35
135	HPV68	E6	AEKLRHLTTKRRLHK	115	129	HLA-DRB3*02:02	NetMHCIIpan	0.36
136	HPV53	E6	FCLLFYSKVRKLRYY	69	83	HLA-DPA1*02:01/DPB1*14:01	NetMHCIIpan	0.38
137	HPV53	E6	VCKFCLLFYSKVRKL	66	80	HLA-DPA1*02:01/DPB1*14:01	NetMHCIIpan	0.65
138	HPV66	E6	LELYRFACIELKLVY	43	57	HLA-DPA1*02:01/DPB1*14:01	NetMHCIIpan	0.78
139	HPV53	E6	CLLFYSKVRKLRYYN	70	84	HLA-DPA1*02:01/DPB1*14:01	NetMHCIIpan	0.79
140	HPV58	E6	EVYDFVFADLRIVYR	41	55	HLA-DPA1*02:01/DPB1*14:01	NetMHCIIpan	0.8
141	HPV52	E6	QRREVYKFLFTDLRI	38	52	HLA-DPA1*02:01/DPB1*14:01	NetMHCIIpan	0.92
142	HPV66	E6	ELYRFACIELKLVYR	44	58	HLA-DPA1*02:01/DPB1*14:01	NetMHCIIpan	0.95