HPVomics

A therapeutic and epitome resource for Human Papillomaviruses

Efficient putative LR-HPVs E4 protein epitopes (MHC-I Binders)

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S.No.	HPV type	Target region	Peptide seuences	Start	End	Length	Allele	Percentile rank	ann_ic50	smm_ic50
1	HPV6	E4	SPLATPCVW	68	76	9	HLA-B*53:01	0.2	7.58	31.83
2	HPV6	E4	HLYLALHKK	20	28	9	HLA-A*03:01	0.2	16.1	21.42
3	HPV6	E4	YVMAAQLYV	9	17	9	HLA-A*02:06	0.2	3.46	6.02
4	HPV6	E4	AQLYVLLHL	13	21	9	HLA-A*02:06	0.25	8.39	10.27
5	HPV6	E4	YVMAAQLYV	9	17	9	HLA-A*02:01	0.3	4.02	10.55
6	HPV6	E4	SSLTITTSTK	89	98	10	HLA-A*11:01	0.3	17.07	21.32
7	HPV6	E4	YVMAAQLYV	9	17	9	HLA-A*68:02	0.3	4.22	14.61
8	HPV6	E4	YVLLHLYLA	16	24	9	HLA-A*02:06	0.4	9.28	19.7
9	HPV6	E4	YVMAAQLYVL	9	18	10	HLA-A*02:01	0.4	15.93	37.45
10	HPV6	E4	CVWPTLDPW	74	82	9	HLA-B*58:01	0.4	23.45	38.93
11	HPV6	E4	VMAAQLYVL	10	18	9	HLA-A*02:01	0.5	13.3	27.87
12	HPV6	E4	AQLYVLLHLY	13	22	10	HLA-B*15:01	0.55	17.55	7.33
13	HPV6	E4	YVMAAQLYV	9	17	9	HLA-A*02:03	0.55	5.1	22.59
14	HPV6	E4	VMAAQLYVL	10	18	9	HLA-A*02:03	0.8	21.9	28.9
15	HPV11	E4	YVMAAQLYV	9	17	9	HLA-A*02:06	0.2	3.46	6.02
16	HPV11	E4	YLALYEKYPL	22	31	10	HLA-A*02:01	0.25	12.57	23.9
17	HPV11	E4	AQLYVLLHL	13	21	9	HLA-A*02:06	0.25	8.39	10.27
18	HPV11	E4	YVMAAQLYV	9	17	9	HLA-A*02:01	0.3	4.02	10.55
19	HPV11	E4	SSLTITTSTK	88	97	10	HLA-A*11:01	0.3	17.07	21.32
20	HPV11	E4	YVMAAQLYV	9	17	9	HLA-A*68:02	0.3	4.22	14.61
21	HPV11	E4	MVVPIIGKYV	1	10	10	HLA-A*68:02	0.35	3.44	29.06
22	HPV11	E4	YVLLHLYLA	16	24	9	HLA-A*02:06	0.4	9.28	19.7
23	HPV11	E4	YVMAAQLYVL	9	18	10	HLA-A*02:01	0.4	15.93	37.45
24	HPV11	E4	VMAAQLYVL	10	18	9	HLA-A*02:01	0.5	13.3	27.87
25	HPV11	E4	ALYEKYPLL	24	32	9	HLA-A*02:01	0.5	6.3	27.93
26	HPV11	E4	AQLYVLLHLY	13	22	10	HLA-B*15:01	0.55	17.55	7.33
27	HPV11	E4	YVMAAQLYV	9	17	9	HLA-A*02:03	0.55	5.1	22.59
28	HPV11	E4	ALYEKYPLL	24	32	9	HLA-A*02:03	0.55	6.17	24.26
29	HPV11	E4	VMAAQLYVL	10	18	9	HLA-A*02:03	0.8	21.9	28.9
30	HPV40	E4	KQIGGLLLWV	3	12	10	HLA-A*02:06	0.1	5.57	5.33
31	HPV40	E4	LLLWVHTLYV	8	17	10	HLA-A*02:01	0.15	9.42	6.91
32	HPV40	E4	LLWVHTLYV	9	17	9	HLA-A*02:01	0.2	4.58	4.45
33	HPV40	E4	KQIGGLLLW	3	11	9	HLA-B*58:01	0.3	16.31	30.85
34	HPV40	E4	LLLWVHTLYV	8	17	10	HLA-A*02:06	0.35	30.25	35.64
35	HPV40	E4	LLLWVHTLYV	8	17	10	HLA-A*02:03	0.45	16.44	13.37
36	HPV40	E4	GLLLWVHTL	7	15	9	HLA-A*02:01	0.5	21.15	22.6
37	HPV40	E4	TVVEVLLHL	106	114	9	HLA-A*02:06	0.6	7.88	32.48
38	HPV40	E4	LLWVHTLYV	9	17	9	HLA-A*02:06	0.7	20.97	24.24
39	HPV40	E4	LLWVHTLYV	9	17	9	HLA-A*02:03	0.75	13.39	26.91
40	HPV42	E4	YPLLDLLSW	17	25	9	HLA-B*53:01	0.2	4.81	9.5
41	HPV42	E4	SPASPAHPW	85	93	9	HLA-B*53:01	0.2	32.63	37.57
42	HPV42	E4	YPLLDLLSWY	17	26	10	HLA-B*35:01	0.25	32.86	29.64
43	HPV42	E4	HPPTQRYPL	11	19	9	HLA-B*07:02	0.3	28.81	38.18
44	HPV43	E4	LPRSPTWPEL	72	81	10	HLA-B*07:02	0.15	10.86	34.18
45	HPV43	E4	HLYLVPSVK	20	28	9	HLA-A*03:01	0.15	7.96	7.83
46	HPV43	E4	YILLHLYLV	16	24	9	HLA-A*02:06	0.15	5.66	4.22
47	HPV43	E4	YILLHLYLV	16	24	9	HLA-A*02:01	0.2	5.89	6.11
48	HPV43	E4	LLHLYLVPSV	18	27	10	HLA-A*02:01	0.3	15.41	28.09
49	HPV43	E4	YLVPSVKYPL	22	31	10	HLA-A*02:01	0.35	9.71	36.6
50	HPV43	E4	LLWAQTSYI	9	17	9	HLA-A*02:01	0.4	7.17	19.5
51	HPV43	E4	LLHLYLVPSV	18	27	10	HLA-A*02:03	0.5	18.57	15.25
52	HPV43	E4	LLEEGQWTV	81	89	9	HLA-A*02:01	0.6	8.42	30.7
53	HPV43	E4	YILLHLYLV	16	24	9	HLA-A*02:03	0.7	25.52	20.89
54	HPV44	E4	CPLAPPRTAW	72	81	10	HLA-B*53:01	0.1	15.11	31.47
55	HPV44	E4	TTSSLTVTTV	116	125	10	HLA-A*68:02	0.15	6.56	15.04
56	HPV44	E4	SSLTVTTVTK	118	127	10	HLA-A*11:01	0.15	12.65	14.99
57	HPV44	E4	YVLLHLYLV	35	43	9	HLA-A*02:06	0.15	3.92	3.46
58	HPV44	E4	YVLAAVSYV	28	36	9	HLA-A*02:06	0.2	3.01	5.25
59	HPV44	E4	YLVLCKTYPL	41	50	10	HLA-A*02:01	0.3	6.11	31.3
60	HPV44	E4	YVLLHLYLV	35	43	9	HLA-A*02:01	0.3	8.4	9.51
61	HPV44	E4	YVLAAVSYV	28	36	9	HLA-A*02:01	0.4	5.18	17.99
62	HPV44	E4	VLAAVSYVL	29	37	9	HLA-A*02:01	0.5	20.11	29.25
63	HPV44	E4	YVLAAVSYV	28	36	9	HLA-A*02:03	0.5	4.86	19.68
64	HPV44	E4	ETPSVSETA	100	108	9	HLA-A*68:02	0.5	8.39	39.41
65	HPV44	E4	YVLLHLYLV	35	43	9	HLA-A*02:03	1	39.88	37.41
66	HPV54	E4	WILKRKHLSM	17	26	10	HLA-B*08:01	0.1	3.23	29.97
67	HPV54	E4	ASFFLLHLY	39	47	9	HLA-A*30:02	0.15	9.4	36.68
68	HPV54	E4	ILKRKHLSM	18	26	9	HLA-B*08:01	0.2	3.28	9.61
69	HPV54	E4	NTKCIMWILK	11	20	10	HLA-A*68:01	0.3	13.64	13.84
70	HPV54	E4	CQYPLLALL	54	62	9	HLA-A*02:06	0.4	10.19	18.35
71	HPV54	E4	WAAASFFLL	36	44	9	HLA-A*68:02	0.5	10.76	39.68
72	HPV54	E4	RTKDGTQVV	121	129	9	HLA-A*30:01	0.6	9.24	34.27
73	HPV54	E4	WAAASFFLL	36	44	9	HLA-A*02:06	0.7	11.63	37.12
74	HPV61	E4	HPPRCRRRL	45	53	9	HLA-B*07:02	0.2	28.83	33.41
75	HPV61	E4	TTVTVTVHL	96	104	9	HLA-A*68:02	0.3	2.94	20.97
76	HPV61	E4	STVTVTAQK	85	93	9	HLA-A*11:01	0.3	8.39	26.5
77	HPV61	E4	STVTVTAQK	85	93	9	HLA-A*68:01	0.4	8.19	32.25
78	HPV61	E4	SSSPTQHKK	64	72	9	HLA-A*11:01	0.4	33.9	27.18
79	HPV61	E4	VLTSGSTVTV	80	89	10	HLA-A*02:03	0.7	27.79	29.6
80	HPV70	E4	KLSRRRLASV	41	50	10	HLA-A*02:03	0.2	8.55	6.97
81	HPV70	E4	FIVLTLCTV	1	9	9	HLA-A*02:06	0.2	7.24	7.01
82	HPV70	E4	KQTECSWTL	57	65	9	HLA-A*02:06	0.2	4.66	5.59
83	HPV70	E4	IVLTLCTVPV	2	11	10	HLA-A*02:06	0.3	21.27	27.03
84	HPV70	E4	VLTLCTVPV	3	11	9	HLA-A*02:01	0.4	29.95	34.44
85	HPV70	E4	TQYPLLSLL	13	21	9	HLA-A*02:06	0.45	8.63	22.11
86	HPV70	E4	FIVLTLCTV	1	9	9	HLA-A*02:03	0.65	20.47	17.99
87	HPV72	E4	ETSAGNGVTV	72	81	10	HLA-A*68:02	0.15	9.64	11.36
88	HPV72	E4	HPPQCRRRL	44	52	9	HLA-B*07:02	0.2	29.82	30.9
89	HPV72	E4	STVTVTAHNK	86	95	10	HLA-A*11:01	0.25	19.69	19.14
90	HPV72	E4	VLTSGSTVTV	81	90	10	HLA-A*02:03	0.7	27.79	29.6
91	HPV81	E4	RPQCRRRLA	46	54	9	HLA-B*07:02	0.2	23.51	29.3
92	HPV81	E4	HATLYLAPR	3	11	9	HLA-A*68:01	0.3	12.07	28.09
93	HPV81	E4	HATLYLAPR	3	11	9	HLA-A*33:01	0.3	18.56	32.14
94	HPV81	E4	HATLYLAPR	3	11	9	HLA-A*31:01	0.55	35.72	32.32