HPVomics

A therapeutic and epitome resource for Human Papillomaviruses

Efficient putative HR-HPVs E4 protein epitopes (MHC-II Binders)


S.No. HPV type Target region Peptide seuences Start End Allele Method Percentile rank
1 HPV53 E4 MRAYIIYMTAIKRII 1 15 HLA-DRB5*01:01 Consensus 0.02
2 HPV53 E4 RAYIIYMTAIKRIIQ 2 16 HLA-DRB5*01:01 Consensus 0.02
3 HPV53 E4 AYIIYMTAIKRIIQT 3 17 HLA-DRB5*01:01 Consensus 0.02
4 HPV53 E4 YIIYMTAIKRIIQTL 4 18 HLA-DRB5*01:01 Consensus 0.02
5 HPV53 E4 IIYMTAIKRIIQTLK 5 19 HLA-DRB5*01:01 Consensus 0.02
6 HPV58 E4 LYLVIKYPLLKLLTQ 6 20 HLA-DPA1*03:01/DPB1*04:02 Consensus 0.02
7 HPV58 E4 HLYLVIKYPLLKLLT 5 19 HLA-DPA1*03:01/DPB1*04:02 Consensus 0.03
8 HPV58 E4 YLVIKYPLLKLLTQR 7 21 HLA-DPA1*03:01/DPB1*04:02 Consensus 0.04
9 HPV58 E4 LHLYLVIKYPLLKLL 4 18 HLA-DPA1*03:01/DPB1*04:02 Consensus 0.06
10 HPV58 E4 LVIKYPLLKLLTQRP 8 22 HLA-DPA1*03:01/DPB1*04:02 Consensus 0.08
11 HPV66 E4 DTTYPLLRLLTNTTT 83 97 HLA-DRB1*04:01 Consensus 0.11
12 HPV66 E4 TTYPLLRLLTNTTTT 84 98 HLA-DRB1*04:01 Consensus 0.11
13 HPV66 E4 TYPLLRLLTNTTTTG 85 99 HLA-DRB1*04:01 Consensus 0.11
14 HPV66 E4 YPLLRLLTNTTTTGP 86 100 HLA-DRB1*04:01 Consensus 0.11
15 HPV58 E4 LYLVIKYPLLKLLTQ 6 20 HLA-DPA1*02:01/DPB1*01:01 Consensus 0.15
16 HPV58 E4 HLYLVIKYPLLKLLT 5 19 HLA-DPA1*02:01/DPB1*01:01 Consensus 0.16
17 HPV56 E4 TYPLLKLLTNTTPTR 48 62 HLA-DRB1*04:01 Consensus 0.17
18 HPV82 E4 PRHPLLQLLNSYRTP 8 22 HLA-DRB1*15:01 Consensus 0.17
19 HPV53 E4 TYPLLKLLTNTTPIR 53 67 HLA-DRB1*04:01 Consensus 0.18
20 HPV53 E4 YPLLKLLTNTTPIRP 54 68 HLA-DRB1*04:01 Consensus 0.18
21 HPV56 E4 YPLLKLLTNTTPTRP 49 63 HLA-DRB1*04:01 Consensus 0.18
22 HPV82 E4 RHPLLQLLNSYRTPP 9 23 HLA-DRB1*15:01 Consensus 0.18
23 HPV53 E4 YIIYMTAIKRIIQTL 4 18 HLA-DRB1*11:01 Consensus 0.19
24 HPV53 E4 IIYMTAIKRIIQTLK 5 19 HLA-DRB1*11:01 Consensus 0.19
25 HPV58 E4 YLVIKYPLLKLLTQR 7 21 HLA-DPA1*02:01/DPB1*01:01 Consensus 0.19
26 HPV82 E4 APRHPLLQLLNSYRT 7 21 HLA-DRB1*15:01 Consensus 0.19
27 HPV66 E4 DTTYPLLRLLTNTTT 83 97 HLA-DRB1*04:05 Consensus 0.21
28 HPV66 E4 TTYPLLRLLTNTTTT 84 98 HLA-DRB1*04:05 Consensus 0.21
29 HPV66 E4 TYPLLRLLTNTTTTG 85 99 HLA-DRB1*04:05 Consensus 0.21
30 HPV66 E4 YPLLRLLTNTTTTGP 86 100 HLA-DRB1*04:05 Consensus 0.21
31 HPV58 E4 VLHLYLVIKYPLLKL 3 17 HLA-DRB1*11:01 Consensus 0.23
32 HPV58 E4 LHLYLVIKYPLLKLL 4 18 HLA-DRB1*11:01 Consensus 0.23
33 HPV66 E4 PLLRLLTNTTTTGPP 87 101 HLA-DRB1*04:01 Consensus 0.23
34 HPV18 E4 TTRYPLLSLLNSYST 9 23 HLA-DRB1*04:05 Consensus 0.25
35 HPV58 E4 LHLYLVIKYPLLKLL 4 18 HLA-DPA1*02:01/DPB1*01:01 Consensus 0.25
36 HPV18 E4 VTTRYPLLSLLNSYS 8 22 HLA-DRB1*04:05 Consensus 0.26
37 HPV18 E4 TRYPLLSLLNSYSTP 10 24 HLA-DRB1*04:05 Consensus 0.26
38 HPV53 E4 PTYPLLKLLTNTTPI 52 66 HLA-DRB1*04:01 Consensus 0.26
39 HPV82 E4 HPLLQLLNSYRTPPR 10 24 HLA-DRB1*15:01 Consensus 0.26
40 HPV18 E4 RYPLLSLLNSYSTPP 11 25 HLA-DRB1*04:05 Consensus 0.27
41 HPV56 E4 TTYPLLKLLTNTTPT 47 61 HLA-DRB1*04:01 Consensus 0.27
42 HPV58 E4 VLHLYLVIKYPLLKL 3 17 HLA-DPA1*03:01/DPB1*04:02 Consensus 0.27
43 HPV18 E4 YPLLSLLNSYSTPPH 12 26 HLA-DRB1*04:05 Consensus 0.28
44 HPV35 E4 FVLNLYLAAQNYPLL 2 16 HLA-DRB1*01:01 Consensus 0.32
45 HPV52 E4 LVTKYPLLKLLSTYA 8 22 HLA-DRB1*15:01 Consensus 0.32
46 HPV52 E4 VTKYPLLKLLSTYAP 9 23 HLA-DRB1*15:01 Consensus 0.32
47 HPV53 E4 IYMTAIKRIIQTLKT 6 20 HLA-DRB1*11:01 Consensus 0.32
48 HPV52 E4 TKYPLLKLLSTYAPK 10 24 HLA-DRB1*15:01 Consensus 0.33
49 HPV26 E4 LNLYLVPAAATKYPL 4 18 HLA-DRB5*01:01 Consensus 0.34
50 HPV52 E4 KYPLLKLLSTYAPKP 11 25 HLA-DRB1*15:01 Consensus 0.34
51 HPV52 E4 YPLLKLLSTYAPKPP 12 26 HLA-DRB1*15:01 Consensus 0.35
52 HPV58 E4 LVIKYPLLKLLTQRP 8 22 HLA-DPA1*02:01/DPB1*01:01 Consensus 0.35
53 HPV35 E4 FVLNLYLAAQNYPLL 2 16 HLA-DRB1*07:01 Consensus 0.37
54 HPV58 E4 YVLHLYLVIKYPLLK 2 16 HLA-DRB5*01:01 Consensus 0.38
55 HPV58 E4 VLHLYLVIKYPLLKL 3 17 HLA-DRB5*01:01 Consensus 0.38
56 HPV58 E4 LHLYLVIKYPLLKLL 4 18 HLA-DRB5*01:01 Consensus 0.38
57 HPV58 E4 HLYLVIKYPLLKLLT 5 19 HLA-DRB5*01:01 Consensus 0.38
58 HPV58 E4 LYLVIKYPLLKLLTQ 6 20 HLA-DRB5*01:01 Consensus 0.38
59 HPV58 E4 YLVIKYPLLKLLTQR 7 21 HLA-DRB5*01:01 Consensus 0.38
60 HPV58 E4 LVIKYPLLKLLTQRP 8 22 HLA-DRB5*01:01 Consensus 0.38
61 HPV82 E4 PLLQLLNSYRTPPRP 11 25 HLA-DRB1*15:01 Consensus 0.41
62 HPV59 E4 TSKYPLLDLLSNYHT 32 46 HLA-DRB1*15:01 Consensus 0.43
63 HPV59 E4 KYPLLDLLSNYHTPP 34 48 HLA-DRB1*15:01 Consensus 0.43
64 HPV59 E4 YPLLDLLSNYHTPPQ 35 49 HLA-DRB1*15:01 Consensus 0.43
65 HPV66 E4 VDTTYPLLRLLTNTT 82 96 HLA-DRB1*04:05 Consensus 0.43
66 HPV53 E4 DPTYPLLKLLTNTTP 51 65 HLA-DRB1*04:01 Consensus 0.45
67 HPV56 E4 DTTYPLLKLLTNTTP 46 60 HLA-DRB1*04:01 Consensus 0.45
68 HPV26 E4 VVLNLYLVPAAATKY 2 16 HLA-DRB5*01:01 Consensus 0.48
69 HPV26 E4 VLNLYLVPAAATKYP 3 17 HLA-DRB5*01:01 Consensus 0.51
70 HPV35 E4 VLNLYLAAQNYPLLK 3 17 HLA-DRB1*07:01 Consensus 0.53
71 HPV26 E4 NLYLVPAAATKYPLL 5 19 HLA-DRB5*01:01 Consensus 0.54
72 HPV35 E4 LFVLNLYLAAQNYPL 1 15 HLA-DRB1*01:01 Consensus 0.54
73 HPV53 E4 AYIIYMTAIKRIIQT 3 17 HLA-DRB1*11:01 Consensus 0.54
74 HPV53 E4 PTYPLLKLLTNTTPI 52 66 HLA-DRB1*04:05 Consensus 0.54
75 HPV53 E4 TYPLLKLLTNTTPIR 53 67 HLA-DRB1*04:05 Consensus 0.55
76 HPV56 E4 TTYPLLKLLTNTTPT 47 61 HLA-DRB1*04:05 Consensus 0.55
77 HPV68 E4 TEKYPLLNLLPTYRT 12 26 HLA-DRB5*01:01 Consensus 0.55
78 HPV53 E4 DPTYPLLKLLTNTTP 51 65 HLA-DRB1*04:05 Consensus 0.58
79 HPV53 E4 YPLLKLLTNTTPIRP 54 68 HLA-DRB1*04:05 Consensus 0.58
80 HPV56 E4 TYPLLKLLTNTTPTR 48 62 HLA-DRB1*04:05 Consensus 0.58
81 HPV66 E4 VDTTYPLLRLLTNTT 82 96 HLA-DRB1*04:01 Consensus 0.58
82 HPV33 E4 LRLYLATKYPLLKLL 4 18 HLA-DPA1*01/DPB1*04:01 Consensus 0.59
83 HPV56 E4 DTTYPLLKLLTNTTP 46 60 HLA-DRB1*04:05 Consensus 0.59
84 HPV35 E4 LNLYLAAQNYPLLKL 4 18 HLA-DRB1*07:01 Consensus 0.61
85 HPV56 E4 YPLLKLLTNTTPTRP 49 63 HLA-DRB1*04:05 Consensus 0.66
86 HPV26 E4 SVVLNLYLVPAAATK 1 15 HLA-DRB1*01:01 Consensus 0.77
87 HPV26 E4 VVLNLYLVPAAATKY 2 16 HLA-DRB1*01:01 Consensus 0.77
88 HPV26 E4 VLNLYLVPAAATKYP 3 17 HLA-DRB1*01:01 Consensus 0.77
89 HPV53 E4 IYMTAIKRIIQTLKT 6 20 HLA-DRB5*01:01 Consensus 0.86
90 HPV53 E4 YMTAIKRIIQTLKTR 7 21 HLA-DRB5*01:01 Consensus 0.86
91 HPV53 E4 MTAIKRIIQTLKTRP 8 22 HLA-DRB5*01:01 Consensus 0.86
92 HPV53 E4 TAIKRIIQTLKTRPP 9 23 HLA-DRB5*01:01 Consensus 0.86
93 HPV73 E4 YLAPVKYPFLKLLTH 6 20 HLA-DPA1*03:01/DPB1*04:02 Consensus 0.87
94 HPV59 E4 KCIIMARLLIVMTLC 13 27 HLA-DPA1*03:01/DPB1*04:02 Consensus 0.92
95 HPV31 E4 LFFLNLYLAVTKYPL 1 15 HLA-DPA1*01:03/DPB1*02:01 Consensus 0.94
96 HPV35 E4 NLYLAAQNYPLLKLL 5 19 HLA-DRB1*07:01 Consensus 0.94
97 HPV53 E4 LDPTYPLLKLLTNTT 50 64 HLA-DRB1*04:05 Consensus 0.94
98 HPV56 E4 VDTTYPLLKLLTNTT 45 59 HLA-DRB1*04:05 Consensus 0.94
99 HPV26 E4 LNLYLVPAAATKYPL 4 18 HLA-DRB1*01:01 Consensus 0.96
100 HPV59 E4 GKCIIMARLLIVMTL 12 26 HLA-DPA1*03:01/DPB1*04:02 Consensus 0.96
101 HPV26 E4 SVVLNLYLVPAAATK 1 15 HLA-DRB5*01:01 Consensus 0.97
102 HPV66 E4 TYPLLRLLTNTTTTG 85 99 HLA-DRB1*01:01 Consensus 0.97