HPVomics

Efficient putative HR-HPVs E4 protein epitopes (MHC-I Binders)

S.No.	HPV type	Target region	Peptide seuences	Start	End	Length	Allele	Percentile rank	ann_ic50	smm_ic50
1	HPV16	E4	LSCCTETQW	62	70	9	HLA-B*58:01	0.2	4.43	10.6
2	HPV16	E4	STWPTTPPR	21	29	9	HLA-A*31:01	0.25	8.81	19.34
3	HPV16	E4	TTPPRPIPK	25	33	9	HLA-A*11:01	0.35	21.99	33.75
4	HPV16	E4	SSLHLTAHTK	75	84	10	HLA-A*11:01	0.35	29.94	27.53
5	HPV18	E4	RPTARRRLL	38	46	9	HLA-B*07:02	0.1	4.92	4.33
6	HPV18	E4	YPLLSLLNSY	12	21	10	HLA-B*35:01	0.2	20.76	33.72
7	HPV18	E4	VPVTTRYPL	6	14	9	HLA-B*07:02	0.3	7.74	26.36
8	HPV18	E4	RLLHDLDTV	44	52	9	HLA-A*02:06	0.4	5.91	19.48
9	HPV18	E4	CAVPVTTRY	4	12	9	HLA-B*35:01	0.5	14.89	24.02
10	HPV18	E4	RLLHDLDTV	44	52	9	HLA-A*02:01	0.6	16.88	32.22
11	HPV18	E4	RLLHDLDTV	44	52	9	HLA-A*02:03	0.95	15.66	37.67
12	HPV26	E4	WTIQTTTYTV	79	88	10	HLA-A*68:02	0.15	7.62	15.75
13	HPV26	E4	LPHSPDSQW	71	79	9	HLA-B*53:01	0.2	13.75	12.24
14	HPV26	E4	YTVQVEAITR	86	95	10	HLA-A*68:01	0.2	12	6.7
15	HPV26	E4	APRKPRRHT	40	48	9	HLA-B*07:02	0.2	11.45	18.15
16	HPV26	E4	SQWTIQTTTY	77	86	10	HLA-B*15:01	0.25	13.73	2.33
17	HPV26	E4	EAITREGTR	91	99	9	HLA-A*68:01	0.3	17.28	18.47
18	HPV26	E4	QTTTYTVQV	82	90	9	HLA-A*68:02	0.5	12.95	32.48
19	HPV26	E4	VLNLYLVPA	3	11	9	HLA-A*02:03	0.55	12	16.75
20	HPV26	E4	NLYLVPAAA	5	13	9	HLA-A*02:03	0.75	16.85	24.21
21	HPV26	E4	SVVLNLYLV	1	9	9	HLA-A*02:06	0.75	13.42	33.69
22	HPV26	E4	YLVPAAATKY	7	16	10	HLA-B*15:01	0.9	20.38	17.11
23	HPV31	E4	YPLLGLLQSY	13	22	10	HLA-B*35:01	0.25	28.45	31.04
24	HPV31	E4	TTPPHRIPK	26	34	9	HLA-A*11:01	0.3	18.21	20.57
25	HPV31	E4	WTVSTVGLSV	75	84	10	HLA-A*68:02	0.5	37.24	27.31
26	HPV31	E4	YLAVTKYPL	7	15	9	HLA-A*02:01	0.5	9.48	20.95
27	HPV31	E4	FLNLYLAVT	3	11	9	HLA-A*02:03	0.65	14.2	19.1
28	HPV33	E4	YPLLKLLTY	12	20	9	HLA-B*35:01	0.3	5.5	12.9
29	HPV33	E4	LYLATKYPLL	6	15	10	HLA-A*23:01	0.35	14.85	35.38
30	HPV33	E4	YLATKYPLLK	7	16	10	HLA-A*03:01	0.35	15.47	33.28
31	HPV33	E4	YLATKYPLL	7	15	9	HLA-A*02:03	0.45	4.42	18.24
32	HPV33	E4	YLATKYPLL	7	15	9	HLA-A*02:01	0.5	5.65	20.85
33	HPV35	E4	YLAAQNYPL	7	15	9	HLA-A*02:01	0.2	3.46	5.24
34	HPV35	E4	APQKPRRQI	38	46	9	HLA-B*07:02	0.2	9.89	21.82
35	HPV35	E4	YPLLKLLHSY	13	22	10	HLA-B*35:01	0.25	38.76	36.97
36	HPV35	E4	RQITNDFEGV	44	53	10	HLA-A*02:06	0.25	13.01	16.94
37	HPV35	E4	AAQNYPLLK	9	17	9	HLA-A*11:01	0.35	13.95	29.33
38	HPV35	E4	TTPPRPIPK	25	33	9	HLA-A*11:01	0.35	21.99	33.75
39	HPV35	E4	STLHLTAQTK	76	85	10	HLA-A*11:01	0.35	25.94	27.09
40	HPV35	E4	YLAAQNYPL	7	15	9	HLA-A*02:03	0.55	6.67	20.65
41	HPV35	E4	FVLNLYLAA	2	10	9	HLA-A*02:06	0.75	10.41	38.6
42	HPV39	E4	YPLLNLLPNY	15	24	10	HLA-B*35:01	0.15	14.25	26.42
43	HPV39	E4	FIVLTLCAV	1	9	9	HLA-A*02:06	0.2	5.23	5.14
44	HPV39	E4	IVLTLCAVPV	2	11	10	HLA-A*02:06	0.35	27.12	31.84
45	HPV39	E4	ILTTHSTVTV	69	78	10	HLA-A*02:03	0.5	24.8	15.75
46	HPV39	E4	GTSVVVTLR	85	93	9	HLA-A*68:01	0.5	17.02	32.17
47	HPV39	E4	FIVLTLCAV	1	9	9	HLA-A*02:03	0.5	13.14	14.93
48	HPV39	E4	WTILTTHSTV	67	76	10	HLA-A*68:02	0.55	25.21	35.02
49	HPV39	E4	CAVPVTDRY	7	15	9	HLA-B*35:01	0.6	17.81	29.69
50	HPV39	E4	TQDGTSVVV	82	90	9	HLA-A*02:06	0.9	32.55	34.24
51	HPV45	E4	NPTSRRRLL	38	46	9	HLA-B*07:02	0.2	23.88	25.11
52	HPV45	E4	VPVTTRYPL	6	14	9	HLA-B*07:02	0.3	7.74	26.36
53	HPV45	E4	RLLSDLDSV	44	52	9	HLA-A*02:06	0.35	5.83	17.36
54	HPV45	E4	RLLSDLDSV	44	52	9	HLA-A*02:01	0.5	9.41	22.55
55	HPV45	E4	CAVPVTTRY	4	12	9	HLA-B*35:01	0.5	14.89	24.02
56	HPV45	E4	RLLSDLDSV	44	52	9	HLA-A*02:03	0.65	9.81	24.32
57	HPV51	E4	VPAATRYPL	4	12	9	HLA-B*07:02	0.1	4.73	7.76
58	HPV51	E4	RPIPLPPAW	24	32	9	HLA-B*53:01	0.2	12.56	35.31
59	HPV51	E4	MYLVPAATR	1	9	9	HLA-A*33:01	0.25	10.57	30.41
60	HPV51	E4	QTTKYTVEV	63	71	9	HLA-A*68:02	0.5	18.16	29.42
61	HPV51	E4	WTIQTTKYTV	60	69	10	HLA-A*68:02	0.55	12.51	33.75
62	HPV51	E4	GTKVQLRLR	78	86	9	HLA-A*31:01	0.6	34.76	37.97
63	HPV52	E4	KTHTYNHHR	36	44	9	HLA-A*31:01	0.15	4.96	5.08
64	HPV52	E4	YPLLKLLSTY	12	21	10	HLA-B*35:01	0.2	21.67	30.82
65	HPV52	E4	STYAPKPPR	19	27	9	HLA-A*31:01	0.25	10.28	14.3
66	HPV52	E4	KLLSTYAPK	16	24	9	HLA-A*30:01	0.5	10.98	29.44
67	HPV52	E4	YLVTKYPLL	7	15	9	HLA-A*02:01	0.6	8.79	33.35
68	HPV52	E4	YLVTKYPLL	7	15	9	HLA-A*02:03	0.8	10.21	36.47
69	HPV53	E4	FIVPTLCPV	40	48	9	HLA-A*02:06	0.1	1.98	1.55
70	HPV53	E4	YIIYMTAIKR	4	13	10	HLA-A*68:01	0.15	9.66	10.81
71	HPV53	E4	CPVPLDPTY	46	54	9	HLA-B*35:01	0.2	3.76	3.11
72	HPV53	E4	KTRPPNMGV	19	27	9	HLA-A*30:01	0.2	2.48	7.11
73	HPV53	E4	KLLTNTTPI	58	66	9	HLA-A*32:01	0.2	6.31	5.15
74	HPV53	E4	FIVPTLCPV	40	48	9	HLA-A*02:03	0.25	2.69	7.41
75	HPV53	E4	VPLDPTYPL	48	56	9	HLA-B*07:02	0.3	13.78	32.43
76	HPV53	E4	TTPENTSLV	125	133	9	HLA-A*68:02	0.3	7.29	17.93
77	HPV53	E4	ENTSLVELR	128	136	9	HLA-A*68:01	0.35	19.29	18.6
78	HPV53	E4	FIVPTLCPV	40	48	9	HLA-A*02:01	0.5	6.29	21.09
79	HPV53	E4	IIYMTAIKR	5	13	9	HLA-A*68:01	0.6	36.01	33.15
80	HPV53	E4	FIVPTLCPV	40	48	9	HLA-A*68:02	0.6	21.96	35.86
81	HPV56	E4	IVLTLCLVPV	36	45	10	HLA-A*02:06	0.15	10.13	10.14
82	HPV56	E4	TTTLVIRLR	126	134	9	HLA-A*68:01	0.15	12.9	11
83	HPV56	E4	KTYGKYIWK	23	31	9	HLA-A*03:01	0.15	7.78	11.72
84	HPV56	E4	TTTTTLVIR	124	132	9	HLA-A*68:01	0.2	12.06	14.34
85	HPV56	E4	FIVLTLCLV	35	43	9	HLA-A*02:06	0.2	7.14	6.22
86	HPV56	E4	KTYGKYIWK	23	31	9	HLA-A*11:01	0.25	11.11	9.51
87	HPV56	E4	KTYGKYIWK	23	31	9	HLA-A*30:01	0.3	5.87	13.87
88	HPV56	E4	EVSTTTTTLV	121	130	10	HLA-A*68:02	0.35	22.16	17.51
89	HPV56	E4	HTTQTLNKR	8	16	9	HLA-A*68:01	0.45	20.51	21.6
90	HPV56	E4	TTTTLVIRLR	125	134	10	HLA-A*68:01	0.45	15.4	25
91	HPV56	E4	VLTLCLVPV	37	45	9	HLA-A*02:01	0.5	32.48	21.58
92	HPV56	E4	FIVLTLCLV	35	43	9	HLA-A*02:03	0.6	26.75	16.29
93	HPV56	E4	VLTLCLVPV	37	45	9	HLA-A*02:03	0.75	24.46	24.04
94	HPV56	E4	VLTLCLVPV	37	45	9	HLA-A*02:06	0.85	25.32	32.7
95	HPV56	E4	LCLVPVDTTY	40	49	10	HLA-B*15:01	1.2	20.85	27.62
96	HPV58	E4	KLLTQRPPR	16	24	9	HLA-A*31:01	0.3	11.84	12.37
97	HPV58	E4	LVIKYPLLK	8	16	9	HLA-A*11:01	0.35	12.29	27.25
98	HPV58	E4	TVQLTVHTK	69	77	9	HLA-A*11:01	0.4	34.84	39.2
99	HPV58	E4	VLKFHLSCI	83	91	9	HLA-A*02:03	0.6	12.38	18.41
100	HPV59	E4	LLIVMTLCAV	20	29	10	HLA-A*02:06	0.2	33.94	12.64
101	HPV59	E4	HTPPQRPPK	45	53	9	HLA-A*30:01	0.2	9.29	13.46
102	HPV59	E4	YPLLDLLSNY	35	44	10	HLA-B*35:01	0.25	35.57	16.4
103	HPV59	E4	IVMTLCAVPV	22	31	10	HLA-A*02:06	0.3	18.73	28.5
104	HPV59	E4	LIVMTLCAV	21	29	9	HLA-A*02:06	0.35	9.7	16.85
105	HPV59	E4	LLIVMTLCAV	20	29	10	HLA-A*02:03	0.4	23.06	6.63
106	HPV59	E4	TTVTTQSSV	89	97	9	HLA-A*68:02	0.5	13.14	31.09
107	HPV59	E4	SSVCIQATTR	95	104	10	HLA-A*68:01	0.6	24.9	35.97
108	HPV59	E4	CAVPVTSKY	27	35	9	HLA-B*35:01	0.6	18.85	29.55
109	HPV59	E4	IIMARLLIV	15	23	9	HLA-A*02:06	0.65	20.63	21.21
110	HPV59	E4	IIMARLLIV	15	23	9	HLA-A*02:03	0.65	13.01	19.72
111	HPV59	E4	SLPACQWTTV	82	91	10	HLA-A*02:03	0.7	21.77	27.62
112	HPV59	E4	LIVMTLCAV	21	29	9	HLA-A*02:03	0.95	37.63	36.14
113	HPV66	E4	TVLTLCLVPV	73	82	10	HLA-A*02:06	0.15	10.38	12.19
114	HPV66	E4	KPRVFTVLTL	68	77	10	HLA-B*07:02	0.15	9.87	21.77
115	HPV66	E4	YIIMESVGGV	16	25	10	HLA-A*02:03	0.15	4.03	7.89
116	HPV66	E4	IIMESVGGV	17	25	9	HLA-A*02:03	0.25	3.41	5.98
117	HPV66	E4	FTVLTLCLV	72	80	9	HLA-A*02:06	0.25	6.02	8.74
118	HPV66	E4	QTYGKYIWK	60	68	9	HLA-A*11:01	0.3	20.95	22.1
119	HPV66	E4	YIIMESVGGV	16	25	10	HLA-A*02:06	0.35	13.9	32.95
120	HPV66	E4	IIMESVGGV	17	25	9	HLA-A*02:06	0.4	7.71	21.11
121	HPV66	E4	SVTTPTVEV	147	155	9	HLA-A*68:02	0.4	7.99	28.75
122	HPV66	E4	TTPTVEVHV	149	157	9	HLA-A*68:02	0.4	5.02	22.42
123	HPV66	E4	NMWCGNLYI	9	17	9	HLA-A*02:01	0.5	6.93	26.37
124	HPV66	E4	VLTLCLVPV	74	82	9	HLA-A*02:01	0.5	32.48	21.58
125	HPV66	E4	NLYIIMESV	14	22	9	HLA-A*02:03	0.5	17.75	9.7
126	HPV66	E4	FTVLTLCLV	72	80	9	HLA-A*68:02	0.6	38.23	26.95
127	HPV66	E4	VLTLCLVPV	74	82	9	HLA-A*02:03	0.75	24.46	24.04
128	HPV66	E4	VLTLCLVPV	74	82	9	HLA-A*02:06	0.85	25.32	32.7
129	HPV66	E4	LCLVPVDTTY	77	86	10	HLA-B*15:01	1.2	20.85	27.62
130	HPV68	E4	YPLLNLLPTY	15	24	10	HLA-B*35:01	0.15	12.58	24.04
131	HPV68	E4	WTVSTSHSSV	67	76	10	HLA-A*68:02	0.35	16.06	17.8
132	HPV68	E4	LLNLLPTYR	17	25	9	HLA-A*31:01	0.45	14.68	24.29
133	HPV68	E4	STSHSSVEV	70	78	9	HLA-A*68:02	0.5	6.91	39.14
134	HPV68	E4	VQAKTKDGAF	78	87	10	HLA-B*15:01	0.55	13.72	8.98
135	HPV73	E4	YVVLLYLAPV	1	10	10	HLA-A*02:06	0.1	6.79	4.54
136	HPV73	E4	LYLAPVKYPF	5	14	10	HLA-A*24:02	0.15	27.87	24.19
137	HPV73	E4	LYLAPVKYPF	5	14	10	HLA-A*23:01	0.2	6.57	6.62
138	HPV73	E4	VVLLYLAPV	2	10	9	HLA-A*02:06	0.25	6.82	9.54
139	HPV73	E4	YVVLLYLAPV	1	10	10	HLA-A*02:01	0.4	25.09	38.24
140	HPV73	E4	GPWIVCITY	53	61	9	HLA-B*35:01	0.4	15.39	24.35
141	HPV73	E4	YVVLLYLAPV	1	10	10	HLA-A*02:03	0.45	14.31	12.63
142	HPV73	E4	YVVLLYLAPV	1	10	10	HLA-A*68:02	0.45	29.36	24.96
143	HPV73	E4	VVLLYLAPV	2	10	9	HLA-A*02:01	0.6	23.82	31.49
144	HPV82	E4	APRHPLLQL	7	15	9	HLA-B*07:02	0.1	5.6	6.14
145	HPV82	E4	MYLVPTAPR	1	9	9	HLA-A*33:01	0.2	6.31	13.37
146	HPV82	E4	VPTAPRHPL	4	12	9	HLA-B*07:02	0.2	4.78	9.86
147	HPV82	E4	SPRCPWTPA	56	64	9	HLA-B*07:02	0.2	5.9	11.58
148	HPV82	E4	WTPATTKYTV	61	70	10	HLA-A*68:02	0.3	8.83	24.17
149	HPV82	E4	MYLVPTAPR	1	9	9	HLA-A*31:01	0.35	12.43	16.5
150	HPV82	E4	LLQLLNSYR	12	20	9	HLA-A*31:01	0.6	19.82	37.8