Hsp40 data display in Table. Kd, Ki, IC50, EC50, GI50 values are in μM.

HSPMdb Accession Number PMID Target HSP Name of HSP Organism Localization Enzymatic Activity Cellular Activity Compound Name IUPAC Name SMILES Class Enzymatic Inhibition Kd Value Ki Value IC50 EC50 GI50 Site of Interaction Type of Enzymatic Assay % Cell Growth Inhibition Cellular Assay Cell Lines Disease
HSPMDB01016721948801Hsp40TAg (Large T antigen)VirusNAInhibition of ATPase activityNASID852812155-[dichloro(1-phenyl-1H-1,2,3,4-tetrazol-5-yl)methyl]-1-phenyl-1H-1,2,3,4-tetrazoleClC(Cl)(C1=NN=NN1C1=CC=CC=C1)C1=NN=NN1C1=CC=CC=C1Bisphenol derivativeNANANA7.3NANANANANAATPase assay NANA
HSPMDB01016821948801Hsp40TAg (Large T antigen)VirusNAInhibition of ATPase activityNASID852812176-(piperidine-1-sulfonyl)-1,3-benzothiazol-2-amineNC1=NC2=CC=C(C=C2S1)S(=O)(=O)N1CCCCC1Bisphenol derivativeNANANA14.7NANANANANAATPase assay NANA
HSPMDB01016921948801Hsp40TAg (Large T antigen)VirusNAInhibition of ATPase activityNASID852812182-(3-chloro-2-methylphenyl)-N-{4,6-dimethyl-3-oxo-2H,3H-[1,2]thiazolo[5,4-b]pyridin-2-yl}acetamideCC1=CC(C)=C2C(=O)N(NC(=O)CC3=CC=CC(Cl)=C3C)SC2=N1Bisphenol derivativeNANANA26.2NANANANANAATPase assay NANA
HSPMDB01017021948801Hsp40TAg (Large T antigen)VirusNAInhibition of ATPase activityNAMAL2-11B6-{5-[(benzyloxy)carbonyl]-4-{[1,1'-biphenyl]-4-yl}-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidin-1-yl}hexanoic acidCC1=C(C(NC(=O)N1CCCCCC(O)=O)C1=CC=C(C=C1)C1=CC=CC=C1)C(=O)OCC1=CC=CC=C1Bisphenol derivativeNANANA19.5NANANANANAATPase assay NANA
HSPMDB01017121948801Hsp40TAg (Large T antigen)VirusNAInhibition of ATPase activityNASID92277586 4-[2-(4-hydroxyphenyl)propan-2-yl]phenolCC(C)(C1=CC=C(O)C=C1)C1=CC=C(O)C=C1Bisphenol derivativeNANANA41.4NANANANANAATPase assay NANA
HSPMDB01017221948801Hsp40TAg (Large T antigen)VirusNAInhibition of ATPase activityNASID960220784-[2-(3-hydroxyphenyl)propan-2-yl]phenolCC(C)(C1=CC=C(O)C=C1)C1=CC=CC(O)=C1Bisphenol derivativeNANANA>100NANANANANAATPase assay NANA
HSPMDB01017321948801Hsp40TAg (Large T antigen)VirusNAInhibition of ATPase activityNASID992065864-(2-phenylpropan-2-yl)phenolCC(C)(C1=CC=CC=C1)C1=CC=C(O)C=C1Bisphenol derivativeNANANA>100NANANANANAATPase assay NANA
HSPMDB01017421948801Hsp40TAg (Large T antigen)VirusNAInhibition of ATPase activityNASID922065664-(2-(4-chlorophenyl)propan-2-yl)phenolClC1=CC=C(C=C1)C(C)(C)C1=CC=C(C=C1)OBisphenol derivativeNANANA100NANANANANAATPase assay NANA
HSPMDB01017521948801Hsp40TAg (Large T antigen)VirusNAInhibition of ATPase activityNASID935755874,4'-(propane-2,2-diyl)bis(methoxybenzene)CC(C)(C1=CC=C(C=C1)OC)C1=CC=C(C=C1)OCBisphenol derivativeNANANA>100NANANANANAATPase assay NANA
HSPMDB01017621948801Hsp40TAg (Large T antigen)VirusNAInhibition of ATPase activityNASID992065604,4'-(propane-2,2-diyl)bis(1-methoxy-2-methylbenzene)CC(C)(C1=CC(=C(C=C1)OC)C)C1=CC(=C(C=C1)OC)CBisphenol derivativeNANANA>100NANANANANAATPase assay NANA
HSPMDB01017721948801Hsp40TAg (Large T antigen)VirusNAInhibition of ATPase activityNASID992065611-methoxy-4-{2-[4-methoxy-3-(propan-2-yl)phenyl]propan-2-yl}-2-(propan-2-yl)benzeneCOC1=CC=C(C=C1C(C)C)C(C)(C)C1=CC(C(C)C)=C(OC)C=C1Bisphenol derivativeNANANA26.7NANANANANAATPase assay NANA
HSPMDB01017821948801Hsp40TAg (Large T antigen)VirusNAInhibition of ATPase activityNASID960220794,4'-(cyclopropane-1,1-diyl)diphenolC1(CC1)(C1=CC=C(C=C1)O)C1=CC=C(C=C1)OBisphenol derivativeNANANA18NANANANANAATPase assay NANA
HSPMDB01017921948801Hsp40TAg (Large T antigen)VirusNAInhibition of ATPase activityNASID99234230 4,4'-methylenediphenolC(C1=CC=C(C=C1)O)C1=CC=C(C=C1)OBisphenol derivativeNANANA70.1NANANANANAATPase assay NANA
HSPMDB01018021948801Hsp40TAg (Large T antigen)VirusNAInhibition of ATPase activityNASID992342344,4'-oxydiphenolO(C1=CC=C(C=C1)O)C1=CC=C(C=C1)OBisphenol derivativeNANANA37.7NANANANANAATPase assay NANA
HSPMDB01018121948801Hsp40TAg (Large T antigen)VirusNAInhibition of ATPase activityNASID992342336,6'-thiobis(2,4-dichlorophenol)NABisphenol derivativeNANANA35.7NANANANANAATPase assay NANA
HSPMDB01018222898086Hsp40TAg (Large T antigen)VirusNAInhibition of ATPase activityNABithionol2,4-dichloro-6-[(3,5-dichloro-2-hydroxyphenyl)sulfanyl]phenolOC1=C(Cl)C=C(Cl)C=C1SC1=C(O)C(Cl)=CC(Cl)=C1 MS2000 collection 100NANA3.3NANANANANAATPase assay NANA
HSPMDB01018322898086Hsp40TAg (Large T antigen)VirusNAInhibition of ATPase activityNAhexacholorophene3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxyphenyl)methyl]phenolOC1=C(CC2=C(Cl)C(Cl)=CC(Cl)=C2O)C(Cl)=C(Cl)C=C1Cl MS2000 collection 100NANA1.7NANANANANAATPase assay NANA
HSPMDB01018422898086Hsp40TAg (Large T antigen)VirusNAInhibition of ATPase activityNA5,7 Dihydroxyisoflavone5,7-dihydroxy-3-phenyl-4H-chromen-4-oneOC1=CC(O)=C2C(OC=C(C2=O)C2=CC=CC=C2)=C1 MS2000 collection 20NANANANANANANANAATPase assay NANA
HSPMDB01018522898086Hsp40TAg (Large T antigen)VirusNAInhibition of ATPase activityNAQuercetin2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-oneOC1=CC(O)=C2C(OC(=C(O)C2=O)C2=CC=C(O)C(O)=C2)=C1 MS2000 collection 40NANANANANANANANAATPase assay NANA
HSPMDB01018622898086Hsp40TAg (Large T antigen)VirusNAInhibition of ATPase activityNAchloraniltetrachlorocyclohexa-2,5-diene-1,4-dioneClC1=C(Cl)C(=O)C(Cl)=C(Cl)C1=O MS2000 collection 80NANANANANANANANAATPase assay NANA
HSPMDB01018722898086Hsp40TAg (Large T antigen)VirusNAInhibition of ATPase activityNAcompound 72-bromo-6-[(3-bromo-5-chloro-2-hydroxyphenyl)sulfanyl]-4-chlorophenolOC1=C(SC2=CC(Cl)=CC(Br)=C2O)C=C(Cl)C=C1BrBisphenol derivative30% at 30 uMNANANANANANANANAATPase assay NANA
HSPMDB01018822898086Hsp40TAg (Large T antigen)VirusNAInhibition of ATPase activityNAcompound 9 2-bromo-6-[(3-bromo-5-chloro-2-hydroxyphenyl)methyl]-4-chlorophenolOC1=C(CC2=CC(Cl)=CC(Br)=C2O)C=C(Cl)C=C1BrBisphenol derivative50% at 30 uMNANANANANANANANAATPase assay NANA
HSPMDB01018925440730Hsp40TAg (Large T antigen)VirusNAInhibition of ATPase activityNAMAL2-11B tetrazole 6-{5-[(benzyloxy)carbonyl]-4-{[1,1'-biphenyl]-4-yl}-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidin-1-yl}hexanoic acidCC1=C(C(NC(=O)N1CCCCCC(O)=O)C1=CC=C(C=C1)C1=CC=CC=C1)C(=O)OCC1=CC=CC=C1 Pyrimidinone-peptoid hybrid 95%NANA20-50NANANANANAATPase assay NANA
HSPMDB01019025440730Hsp40TAg (Large T antigen)VirusNAInhibition of ATPase activityNAML281-56benzyl 4-{[1,1'-biphenyl]-4-yl}-6-methyl-2-oxo-1-{[4-(1H-1,2,3,4-tetrazol-5-yl)phenyl]methyl}-2,3-dihydro-1??-pyrimidine-5-carboxylateCC1=[N](CC2=CC=C(C=C2)C2=NN=NN2)C(=O)NC(C2=CC=C(C=C2)C2=CC=CC=C2)=C1C(=O)OCC1=CC=CC=C1 Pyrimidinone-peptoid hybrid 99%NANANANANANANANAATPase assay NANA
HSPMDB01019125440730Hsp40TAg (Large T antigen)VirusNAInhibition of ATPase activityNAML282-61benzyl 4-{[1,1'-biphenyl]-4-yl}-6-methyl-2-oxo-1-[2-(1H-1,2,3,4-tetrazol-5-yl)ethyl]-2,3-dihydro-1??-pyrimidine-5-carboxylateCC1=[N](CCC2=NN=NN2)C(=O)NC(C2=CC=C(C=C2)C2=CC=CC=C2)=C1C(=O)OCC1=CC=CC=C1 Pyrimidinone-peptoid hybrid 88%NANANANANANANANAATPase assay NANA
HSPMDB01019225440730Hsp40TAg (Large T antigen)VirusNAInhibition of ATPase activityNAML282-59methyl 4-{[1,1'-biphenyl]-4-yl}-6-methyl-2-oxo-1-[2-(1H-1,2,3,4-tetrazol-5-yl)ethyl]-2,3-dihydro-1??-pyrimidine-5-carboxylateCOC(=O)C1=C(NC(=O)[N](CCC2=NN=NN2)=C1C)C1=CC=C(C=C1)C1=CC=CC=C1 Pyrimidinone-peptoid hybrid 12%NANANANANANANANAATPase assay NANA
HSPMDB01019325440730Hsp40TAg (Large T antigen)VirusNAInhibition of ATPase activityNAML282-60methyl 4-{[1,1'-biphenyl]-4-yl}-6-methyl-2-oxo-1-{[4-(1H-1,2,3,4-tetrazol-5-yl)phenyl]methyl}-2,3-dihydro-1??-pyrimidine-5-carboxylateCOC(=O)C1=C(NC(=O)[N](CC2=CC=C(C=C2)C2=NN=NN2)=C1C)C1=CC=C(C=C1)C1=CC=CC=C1 Pyrimidinone-peptoid hybrid 51%NANANANANANANANAATPase assay NANA
HSPMDB01019425440730Hsp40TAg (Large T antigen)VirusNAInhibition of ATPase activityNALR340-001benzyl 4-{4'-fluoro-[1,1'-biphenyl]-4-yl}-6-methyl-2-oxo-1-[5-(1H-1,2,3,4-tetrazol-5-yl)pentyl]-2,3-dihydro-1??-pyrimidine-5-carboxylateCC1=[N](CCCCCC2=NN=NN2)C(=O)NC(C2=CC=C(C=C2)C2=CC=C(F)C=C2)=C1C(=O)OCC1=CC=CC=C1 Pyrimidinone-peptoid hybrid 99%NANANANANANANANAATPase assay NANA
HSPMDB01019525440730Hsp40TAg (Large T antigen)VirusNAInhibition of ATPase activityNALR340-003benzyl 4-[4-(2H-1,3-benzodioxol-5-yl)phenyl]-6-methyl-2-oxo-1-[5-(1H-1,2,3,4-tetrazol-5-yl)pentyl]-2,3-dihydro-1??-pyrimidine-5-carboxylateCC1=[N](CCCCCC2=NN=NN2)C(=O)NC(C2=CC=C(C=C2)C2=CC=C3OCOC3=C2)=C1C(=O)OCC1=CC=CC=C1 Pyrimidinone-peptoid hybrid 99%NANANANANANANANAATPase assay NANA
HSPMDB01019625440730Hsp40TAg (Large T antigen)VirusNAInhibition of ATPase activityNALR340-006benzyl 6-methyl-4-{2'-methyl-[1,1'-biphenyl]-4-yl}-2-oxo-1-[5-(1H-1,2,3,4-tetrazol-5-yl)pentyl]-2,3-dihydro-1??-pyrimidine-5-carboxylateCC1=CC=CC=C1C1=CC=C(C=C1)C1=C(C(=O)OCC2=CC=CC=C2)C(C)=[N](CCCCCC2=NN=NN2)C(=O)N1 Pyrimidinone-peptoid hybrid 99%NANANANANANANANAATPase assay NANA
HSPMDB01019725440730Hsp40TAg (Large T antigen)VirusNAInhibition of ATPase activityNASMALBenzyl 1-(4-(1H-tetrazol-5-yl)benzyl)-6-methyl-4-(2'-methyl-[1,1'-biphenyl]-4-yl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylateN1N=NN=C1C1=CC=C(CN2C(NC(C(=C2C)C(=O)OCC2=CC=CC=C2)C2=CC=C(C=C2)C2=C(C=CC=C2)C)=O)C=C1 Pyrimidinone-peptoid hybrid NANANA5NANANANANAATPase assay NANA
HSPMDB01019819200446Hsp40TAg (Large T antigen)VirusNA Inhibition of ATPase activity (DnaJ stimulated)NAMAL3-11B6-{5-[(benzyloxy)carbonyl]-4-{[1,1'-biphenyl]-4-yl}-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidin-1-yl}hexanoic acidCC1=C(C(NC(=O)N1CCCCCC(O)=O)C1=CC=C(C=C1)C1=CC=CC=C1)C(=O)OCC1=CC=CC=C1 Pyrimidinone-peptoid hybrid 75% at 300 uMNANA100NANANANANAATPase assay NANA
HSPMDB0101999575139Hsp40DnaJBacteriaCytosol Inhibition of ATPase activity (DnaJ stimulated)NAall-L-alpha-p5'NANAPeptides12% inhibition of DnaK ATPase NANANANANANANADnaJATPase assayNANA
HSPMDB0102009575139Hsp40DnaJBacteriaCytosol Inhibition of ATPase activity (DnaJ stimulated)NAnormal all-D alpha-p5'NANAPeptides44% inhibition of DnaK ATPase NANANANANANANADnaJATPase assayNANA
HSPMDB0102019575139Hsp40DnaJBacteriaCytosol Inhibition of ATPase activity (DnaJ stimulated)NAretro all-D p5'NANAPeptidesNANANANANANANANADnaJATPase assayNANA
HSPMDB0102029575139Hsp40DnaJBacteriaCytosolBinding affinityNAall-L alpha-p5NANAPeptidesNA37NANANANANANADnaJFluorescence based binding assayNANA
HSPMDB0102039575139Hsp40DnaJBacteriaCytosolBinding affinityNAnormal all-D alpha-p5'NANAPeptidesNA6.8NANANANANANADnaJFluorescence based binding assayNANA
HSPMDB0102049575139Hsp40DnaJBacteriaCytosolBinding affinityNAall-L-alpha-p5'NANAPeptidesNA9.2NANANANANANADnaJFluorescence based binding assayNANA
HSPMDB0102059575139Hsp40DnaJBacteriaCytosolBinding affinityNAretro all-D p5'-alphaNANAPeptidesNA0.9NANANANANANADnaJFluorescence based binding assayNANA
HSPMDB0102069575139Hsp40DnaJBacteriaCytosolBinding affinityNAretro all-D alpha-p5''NANAPeptidesNA1.9NANANANANANADnaJFluorescence based binding assayNANA
HSPMDB01020712637539Hsp40DnaJBacteriaCytosolInhibition of chaperone activityNARI1-17NANAPeptidesNA1.4NANA2NANANADnaJRefolding assay (luciferase)NANA
HSPMDB01020812637539Hsp40DnaJBacteriaCytosolInhibition of chaperone activityNARI1-10NANAPeptidesNA0.8NANA1NANANADnaJRefolding assay (luciferase)NANA
HSPMDB01020922546203Hsp40Hsp70-DnaJBacteria Cytosol and membraneInhibition of chaperone activityNA1pentyl 3a,8b-dihydroxy-2-methyl-4-methylidene-1H,3aH,4H,8bH-indeno[1,2-b]pyrrole-3-carboxylateCCCCCOC(=O)C1=C(C)NC2(O)C3=C(C=CC=C3)C(=C)C12OPhenoxy-N-arylacetamidesNANANA>30NANANANADnaJRefolding assay (luciferase)NANA
HSPMDB01021022546203Hsp40Hsp70-DnaJBacteria Cytosol and membraneInhibition of chaperone activityNA2N-(4-chlorophenyl)-4-(thiophen-2-yl)-1,3-thiazol-2-amineClC1=CC=C(NC2=NC(=CS2)C2=CC=CS2)C=C1Phenoxy-N-arylacetamidesNANANA>100NANANANADnaJRefolding assay (luciferase)NANA
HSPMDB01021122546203Hsp40Hsp70-DnaJBacteria Cytosol and membraneInhibition of chaperone activityNA37-(2-chlorophenyl)-4-(furan-2-yl)-8-oxa-5,6-diazatricyclo[7.4.0.0²,?]trideca-1(9),4,10,12-tetraeneClC1=C(C=CC=C1)C1OC2=C(C=CC=C2)C2CC(=NN12)C1=CC=CO1Phenoxy-N-arylacetamidesNANANA>100NANANANADnaJRefolding assay (luciferase)NANA
HSPMDB01021222546203Hsp40Hsp70-DnaJBacteria Cytosol and membraneInhibition of chaperone activityNA4N-(cyclohexa-1,5-dien-1-yl)-4-(thiophen-2-yl)-1,3-thiazol-2-amineC1CC=C(NC2=NC(=CS2)C2=CC=CS2)C=C1Phenoxy-N-arylacetamidesNANANA22NANANANADnaJRefolding assay (luciferase)NANA
HSPMDB01021322546203Hsp40Hsp70-DnaJBacteria Cytosol and membraneInhibition of chaperone activityNA5ethyl 3-[2-(2-chlorophenoxy)acetamido]benzoateCCOC(=O)C1=CC=CC(NC(=O)COC2=CC=CC=C2Cl)=C1Phenoxy-N-arylacetamidesNANANA0.62NANANANADnaJRefolding assay (luciferase)NANA
HSPMDB01021422546203Hsp40Hsp70-DnaJBacteria Cytosol and membraneInhibition of chaperone activityNA6butyl 3-[2-(2,4-dichlorophenoxy)acetamido]benzoateCCCCOC(=O)C1=CC(NC(=O)COC2=CC=C(Cl)C=C2Cl)=CC=C1Phenoxy-N-arylacetamidesNANANA0.13NANANANADnaJRefolding assay (luciferase)NANA
HSPMDB01021522546203Hsp40Hsp70-DnaJBacteria Cytosol and membraneInhibition of chaperone activityNA7methyl 3-[2-(2,4-dichlorophenoxy)acetamido]benzoateCOC(=O)C1=CC(NC(=O)COC2=CC=C(Cl)C=C2Cl)=CC=C1Phenoxy-N-arylacetamidesNANANA>32NANANANADnaJRefolding assay (luciferase)NANA
HSPMDB01021622546203Hsp40Hsp70-DnaJBacteria Cytosol and membraneInhibition of chaperone activityNA8methyl 3-[2-(2,5-dichlorophenoxy)acetamido]benzoateCOC(=O)C1=CC=CC(NC(=O)COC2=C(Cl)C=CC(Cl)=C2)=C1Phenoxy-N-arylacetamidesNANANA0.95NANANANADnaJRefolding assay (luciferase)NANA
HSPMDB01021722546203Hsp40Hsp70-DnaJBacteria Cytosol and membraneInhibition of chaperone activityNA9propyl 3-[2-(2-chlorophenoxy)acetamido]benzoateCCCOC(=O)C1=CC(NC(=O)COC2=CC=CC=C2Cl)=CC=C1Phenoxy-N-arylacetamidesNANANA0.6NANANANADnaJRefolding assay (luciferase)NANA
HSPMDB01021822546203Hsp40Hsp70-DnaJBacteria Cytosol and membraneInhibition of chaperone activityNA10ethyl 3-[2-(4-chlorophenoxy)acetamido]benzoateCCOC(=O)C1=CC(NC(=O)COC2=CC=C(Cl)C=C2)=CC=C1Phenoxy-N-arylacetamidesNANANA>30NANANANADnaJRefolding assay (luciferase)NANA
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