HSPMdb Accession NoHSPMDB010189
PMID25440730
TargetHsp40
HSP NameTAg (Large T antigen)
OrganismVirus
Enzymatic activityInhibition of ATPase activity
Compound NameMAL2-11B tetrazole
IUPAC Name6-{5-[(benzyloxy)carbonyl]-4-{[1,1'-biphenyl]-4-yl}-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidin-1-yl}hexanoic acid
SMILESCC1=C(C(NC(=O)N1CCCCCC(O)=O)C1=CC=C(C=C1)C1=CC=CC=C1)C(=O)OCC1=CC=CC=C1
Class Pyrimidinone-peptoid hybrid
% Enzymatic Inhibition/Fold Change95%
IC50 (µM)20-50
Type of Enzymatic AssayATPase assay
DiseaseViral infection

Structure



HSPMDB010189

MAL2-11B tetrazole

Physicochemical Properties