NS5 Protein

NS5, the largest non-structural protein at 103 kDa, consists of an N-terminal methyltransferase (MTase) domain with three activities essential for cap synthesis (guanylyltransferase, guanine-N7-methyltransferase, and nucleoside-2’O-methyltransferase) and a C-terminal RNA-dependent RNA polymerase (RdRp) domain responsible for de novo RNA synthesis. The NS5 protein displays high conservation across the four virus serotypes, and due to the absence of human enzymes with RdRp activity, NS5 has been identified as a suitable target for anti-dengue drug development.

i-DENV NS5 Predictor

This submission from allows user to submit one or more chemical compounds in SDF format. If the user is not having SDF file format and would like to convert the format, it can be done by using the conversion tool available on our website and paste it here.

User can visit the HELP page to see how to use this predictive algorithm.

Click on the example option to see how it works

Paste your structure(s) in SDF format

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