About i-DENV

Dengue virus (DENV) is a single positive-stranded RNA virus from genus Flavivirus and Flaviviridae family. It has four serotypes, viz. DENV-1, DENV-2, DENV-3, and DENV-4. DENV comprises 10723 nucleotides and polyprotein precursors containing ~3391 amino acid residues. Experimental studies have been performed to determine the activity of drugs against the DENV. However, there is a limited number of antivirals currently undergoing clinical trials. Hence, it is imperative to investigate additional chemicals or inhibitors to develop a more effective and potent antiviral against the DENV. To reduce time and cost, computational approaches have been used to predict antivirals against DENV as it could be beneficial to accelerate the drug discovery process. In this endeavour, we developed a platform, i-DENV to predict the repurposed drugs targeting NS3 and NS5 proteins of DENV using machine learning technique. i-DENV webserver allows the user to predict anti-dengue activity of a molecule in terms of IC50/pIC50 value (μM). It will assist the user to identify the inhibitors against DENV.


Overall Workflow of i-DENV


Not available

Predict

  • The best-characterized dengue virus (DENV) nonstructural proteins, NS3 and NS5, are multifunctional proteins with several enzymatic activities.
  • These proteins are the most conserved across all four dengue virus serotypes.
  • Due to their multifunctional nature and high conservation, NS3 and NS5 are considered attractive targets for developing dengue antiviral chemotherapeutics.

    • To predict the efficacy of a query molecule against the NS3 protein of the dengue virus, users can visit the link provided below: i-DENV_NS3

    • To predict the efficacy of a query molecule against the NS5 protein of the dengue virus, users can visit the link provided below: i-DENV_NS5


    Contact Us

    Dr. Manoj Kumar

    Senior Principal Scientist,
    Virology Unit & Bioinformatics Centre,
    CSIR-Institute of Microbial Technology,
    Sector 39A, Chandigarh,
    India - 160036
    Phone: +91-172-2880158
    Fax: +91-172-2690585, 2690632
    Website: http://bioinfo.imtech.res.in/manojk/
    E-mail: manojk@imtech.res.in