RNAi screen analysis of viral host genes
| Gene | vhfRNAi Accession | Vhf10882 |
| Gene Symbol | MRE11A | |
| Gene Description | Double-strand break repair protein MRE11A | |
| Gene Name in Paper | MRE11A | |
| Group | Host Factor | |
| Ensembl Gene ID | ENSG00000020922 | |
| UniProt ID | P49959 | |
| Entrez Gene ID | 4361 | |
| GO | View | |
| Host | Organism | Homo sapiens |
| Virus | Virus full name | Sindbis virus |
| Virus Abbreviation | SiV | |
| Taxonomy | View | |
| Results | Phenotype | Increased infection |
| Hits Number* | 459 | |
| Confirmed Hits Number | 111 | |
| Score | 1.15 | |
| Unit | Z-score | |
| Methods | Assay Type | Cell-based |
| BioModel Description | Human U-2 OS cells for screening an arrayed library targeting 21,687 human genes in pools of 3 siRNAs per gene (Ambion Silencer human genome siRNA library V3) | |
| Confirmatory Screen Description | Confirmed hits were validated by cell viability test and single round siRNA for inhibition of single-cycle SINV infection. | |
| Primary Screen Description# | Hits were defined as genes with z-scores and >=2/3 siRNAs inhibited or promoted SINV infection. | |
| Note/Comment | Increased infection(54) | |
| References | Pubmed ID | 24367265 |