Vhf10806 details

Gene vhfRNAi AccessionVhf10806
Gene SymbolNUP93
Gene DescriptionNuclear pore complex protein Nup93
Gene Name in PaperNUP93
GroupHost Factor
Ensembl Gene IDENSG00000102900 
UniProt IDQ8N1F7
Entrez Gene ID9688
GOView
Host OrganismHomo sapiens
Virus Virus full nameSendai virus
Virus AbbreviationSeV
TaxonomyView
Results PhenotypeIncreased infection
Hits Number*581
Confirmed Hits Number59
Score83.20%
UnitTarget gene inhibition
Methods Assay Type Cell-based
BioModel DescriptionEmbryonic kidney HEK 293T cells for screening lentiviral-based short hairpin RNA (shRNA) human library of ~15,000 human genes (3 shRNAs per gene).
Confirmatory Screen DescriptionConfirmed hits were validated using independent siRNA and qRT-PCR.
Primary Screen Description#Assessing the transcriptional response at the SeV-induced interferon-b (IFNB1) promoter activity
Note/CommentIncreased infection(46)
References Pubmed ID23785285
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*Replicates that are beyond 2-3 standard deviation values from the mean (Sharma 2009)
#A strong signal/background ratio with low variation in the assay (Zhang 1999)