Vhf10225 details

Gene vhfRNAi AccessionVhf10225
Gene SymbolTPIS
Gene DescriptionTriosephosphate isomerase (TIM) (EC 5.3.1.1) (Triose-phosphate isomerase)
Gene Name in PaperTPIS
GroupHost Factor
Ensembl Gene IDENST00000229270 ENST00000396705 ENST00000488464 ENST00000535434 ENST00000613953 
UniProt IDP60174
Entrez Gene ID7167
GOView
Host OrganismHomo sapiens
Virus Virus full namePoliovirus
Virus AbbreviationPV
TaxonomyView
Results PhenotypeIncreased infection
Hits Number*124
Confirmed Hits Number27 
ScoreNA
UnitNA
Methods Assay Type Cell-based
BioModel DescriptionHEp-2C and Vero cells
Confirmatory Screen DescriptionELISA
Primary Screen Description#Z-score of ≥ 3.0
Note/CommentA collection of host virus resistance genes that was identified upon silencing increased poliovirus and enterovirus 71 production
References Pubmed ID26581994
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*Replicates that are beyond 2-3 standard deviation values from the mean (Sharma 2009)
#A strong signal/background ratio with low variation in the assay (Zhang 1999)