Vhf10063 details

Gene vhfRNAi AccessionVhf10063
Gene SymbolCUL3
Gene DescriptionCullin-3 (CUL-3)
Gene Name in PaperCUL3
GroupHost Factor
Ensembl Gene IDENST00000264414 ENST00000344951 ENST00000409096 ENST00000409777 
UniProt IDQ13618
Entrez Gene ID8452
GOView
Host OrganismHomo sapiens
Virus Virus full namePoliovirus
Virus AbbreviationPV
TaxonomyView
Results PhenotypeIncreased infection
Hits Number*124
Confirmed Hits Number27 
ScoreNA
UnitNA
Methods Assay Type Cell-based
BioModel DescriptionHEp-2C and Vero cells
Confirmatory Screen DescriptionELISA
Primary Screen Description#Z-score of ≥ 3.0
Note/CommentA collection of host virus resistance genes that was identified upon silencing increased poliovirus and enterovirus 71 production
References Pubmed ID26581994
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*Replicates that are beyond 2-3 standard deviation values from the mean (Sharma 2009)
#A strong signal/background ratio with low variation in the assay (Zhang 1999)