RNAi screen analysis of viral host genes
| Gene | vhfRNAi Accession | Vhf09907 |
| Gene Symbol | NRG1 | |
| Gene Description | Pro-neuregulin-1, membrane-bound isoform (Pro-NRG1) [Cleaved into: Neuregulin-1 (Acetylcholine receptor-inducing activity) (ARIA) (Breast cancer cell differentiation factor p45) (Glial growth factor) (Heregulin) (HRG) (Neu differentiation factor) (Sensory and motor neuron-derived factor)] | |
| Gene Name in Paper | NRG1 | |
| Group | Host Factor | |
| Ensembl Gene ID | ENST00000287842 ENST00000356819 ENST00000405005 ENST00000519301 ENST00000520407 ENST00000520502 ENST00000521670 ENST00000523079 | |
| UniProt ID | Q02297 | |
| Entrez Gene ID | 3084 | |
| GO | View | |
| Host | Organism | Homo sapiens |
| Virus | Virus full name | Poliovirus |
| Virus Abbreviation | PV | |
| Taxonomy | View | |
| Results | Phenotype | Increased infection |
| Hits Number* | 124 | |
| Confirmed Hits Number | 27 | |
| Score | NA | |
| Unit | NA | |
| Methods | Assay Type | Cell-based |
| BioModel Description | HEp-2C and Vero cells | |
| Confirmatory Screen Description | ELISA | |
| Primary Screen Description# | Z-score of ≥ 3.0 | |
| Note/Comment | A collection of host virus resistance genes that was identified upon silencing increased poliovirus and enterovirus 71 production | |
| References | Pubmed ID | 26581994 |