Vhf09874 details

Gene vhfRNAi AccessionVhf09874
Gene SymbolLY6E
Gene DescriptionLymphocyte antigen 6E (Ly-6E) (Retinoic acid-induced gene E protein) (RIG-E) (Stem cell antigen 2) (SCA-2) (Thymic shared antigen 1) (TSA-1)
Gene Name in PaperLY6E
GroupHost Factor
Ensembl Gene IDENST00000292494 ENST00000429120 ENST00000520466 ENST00000521003 ENST00000521699 ENST00000522024 ENST00000522971 ENST00000619718 ENST00000631568 ENST00000632424 ENST00000632516 ENST00000632519 ENST00000632812 ENST00000633451 
UniProt IDQ16553
Entrez Gene ID4061
GOView
Host OrganismHomo sapiens
Virus Virus full namePoliovirus
Virus AbbreviationPV
TaxonomyView
Results PhenotypeIncreased infection
Hits Number*124
Confirmed Hits Number27 
ScoreNA
UnitNA
Methods Assay Type Cell-based
BioModel DescriptionHEp-2C and Vero cells
Confirmatory Screen DescriptionELISA
Primary Screen Description#Z-score of ≥ 3.0
Note/CommentA collection of host virus resistance genes that was identified upon silencing increased poliovirus and enterovirus 71 production
References Pubmed ID26581994
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*Replicates that are beyond 2-3 standard deviation values from the mean (Sharma 2009)
#A strong signal/background ratio with low variation in the assay (Zhang 1999)